[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Michelle Zeller\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":57},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100580704",false,"NCT06840756","Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes","Effects of Donor-recipient Sex-matched Versus Sex-mismatched Red Blood Cell Transfusion on Outcomes in Critically Ill Adult Patients","SexMATTERS RCT","Inclusion Criteria:\n\n* Adults (age ≥18);\n* Admission to a participating ICU;\n* Requiring RBC transfusion.\n\nExclusion Criteria:\n\n* Requirement for a specialized RBC product or unit not readily available in inventory (e.g., rare blood type, washed RBCs, complex RBC antibodies, etc.);\n* Massively bleeding patient (i.e., ≥4 units of blood ordered at one time, or Massive Hemorrhage Protocol initiated, or an urgent blood request made);\n* Sex unknown or sex other than male or female (i.e. intersex);\n* Do not have a valid Ontario Health Insurance Plan (OHIP) health card number.","ALL","18 Years",{"count":19,"type":20},11082,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Red blood cell (RBC) transfusions are selected based upon matching donor and recipient blood group: donor and recipient sex are not considered when selecting blood for transfusion. Hence, transfused patients can currently receive sex-matched and\u002For unmatched RBCs when transfusions are given. Sex-matched stem cell transplants, and some solid organ transplants, have shown that sex-matching donor to recipient improves patient outcomes. Recent exploratory studies have also suggested that patient outcomes could be improved by sex-matching for RBC transfusion. There is emerging evidence of underlying biologic mechanism(s) to support these observations. This study is designed as a randomized controlled trial and will explore the impact on patients who receive RBC transfusions from donors of the same sex (\"sex-matched\") compared with donors of the opposite sex (\"sex-mismatched\").\n\nThe trial will study adult patients admitted to the Intensive Care Unit who require an RBC transfusion. Patients will be assigned (through a process called randomization) to receive sex-matched RBCs or sex-mismatched RBCs to determine if there is a difference in mortality between those receiving matched versus mismatched RBCs. The results of this trial could have direct implications on resources, blood inventory, and RBC transfusion ordering practices.",[26,27,28,29,30,31],"Red Blood Cell Transfusions","Sex Differences","Health Services","Critically Ill Intensive Care Unit Patients","Hematology","Cardiovascular",[33,34,35,36,37,38,39,40,41,42,43],"transfusions","red blood cell transfusions","sex-matched","sex-mismatched","intensive care unit","ICU","cardiovascular","circulatory","hematology","mortality","blood donor characteristics","RECRUITING","2026-03-10",{"date":47,"type":48},"2026-03-12","ACTUAL",{"date":50,"type":48},"2025-09-11",{"date":52,"type":20},"2029-03-31",{"name":54,"class":55},"Michelle Zeller","OTHER",8,""]