[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Miguel Pampaloni\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100378288",false,"NCT04205604","18FluoroLDOPA PET Imaging for the Detection and Localization of Focal Congenital Hyperinsulinism","18F-Fluoro-L- DOPA PET Imaging for the Detection and Localization of Focal Congenital Hyperinsulinism","DOPA PET","Inclusion Criteria:\n\n* Any age, but primarily infants 0-6 months given typical age of initial presentation.\n* Children with diagnosis of FoHI or DiHI based on clinical criteria (fasting hypoglycemia accompanied by inadequate suppression of plasma insulin, inappropriately low plasma free fatty acid and plasma-hydroxybutyrate concentrations, and an inappropriate glycemic response to glucagon injection)\n\n  o confirmed by genetic testing for mutations in ABCC8 and KCNJ1 was1.\n* Hypoglycemia uncontrolled with medical management (diazoxide, octreotide).\n* Able to withdraw medications in time to wash out prior to the scheduled PET scan.\n* Patients fulfilling criteria above but with uncontrolled hypoglycemia after initial surgical management (partial or near-total pancreatectomy)\n* Normal hepatic and renal function.\n\nExclusion Criteria:\n\n* Treatment with other, third-line, medications for hyperinsulinism (nifedipine, glucagon).\n* Patients with hepatic or renal insufficiency.","ALL","0 Days","18 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The goal of this project is to determine the role of FDOPA\u002FPET as a pre-operative diagnostic imaging procedure for differentiating focal and diffuse forms of congenital hyperinsulinism and locating focal lesions in the pancreas to guide surgical resection.",[27],"Congenital Hyperinsulinism","RECRUITING","2026-04-27",{"date":31,"type":32},"2026-05-01","ACTUAL",{"date":34,"type":32},"2016-11-03",{"date":36,"type":21},"2026-12-01",{"name":38,"class":39},"Miguel Pampaloni","OTHER",""]