[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Paolo Pesce\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100599253",false,"NCT07082088","Abutment Hydrophilicity on Soft Tissue Morphogenesis","Effect of Abutment Hydrophilicity on Soft Tissue Morphogenesis: Histological CCT","Inclusion Criteria:\n\n* presence of at least 4 mm of keratinized mucosa around the implants\n* patients aged 18 years or older\n* medically healthy patients (ASA I), or patients with mild systemic disease (ASA II)\n* partially edentulous state\n* healthy periodontal condition (also including periodontal health on reduced periodontium) according to the referent case definition\n\nExclusion Criteria:\n\n* ASA physical status 3\n* severe smokers (\\> 10 cig\u002Fday)\n* patients undergoing bisphosphonate therapy\n* pregnant or lactating women\n* estrogen-related hormonal disorders or hormonal substitution therapy\n* untreated periodontitis (pocket depth 4mm with positive bleeding on probing)\n* multiple gingival recession\n* patients with a history of head and neck cancers and radiotherapy in this region.",true,"ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to evaluate the effect of abutment surface bioactivation via argon plasma treatment on peri-implant soft tissue healing and integration in adult patients undergoing implant therapy.\n\nThe main questions it aims to answer are:\n\nDoes argon plasma treatment of healing abutments improve the quality and organization of peri-implant connective tissue compared to untreated abutments?\n\nDoes the treatment influence histological parameters such as epithelial regeneration, vascularization, inflammatory infiltrate, and keratin layer thickness?\n\nResearchers will compare plasma-treated healing abutments to untreated machined-surface abutments to determine whether the bioactivated surface improves soft tissue morphogenesis.\n\nParticipants will:\n\nUndergo implant placement with immediate connection of either a treated or untreated healing abutment.\n\nHave plaque and bleeding indices recorded at 3 months.\n\nUndergo a soft tissue biopsy at 3 months for histological analysis (including evaluation of inflammation, connective tissue, epithelial morphology, vascularization, and keratinization).",[26],"Missing Tooth\u002FTeeth","NOT_YET_RECRUITING","2025-07-15",{"date":30,"type":31},"2025-07-24","ACTUAL",{"date":33,"type":20},"2025-07-31",{"date":35,"type":20},"2025-10-30",{"name":37,"class":38},"Paolo Pesce","OTHER",""]