[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Paul Kim\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100293612",false,"NCT03102125","Allograft Dysfunction in Heart Transplant","Defining Mechanisms for Cardiac Allograft Dysfunction to Improve Allograft Longevity and Survival in Heart-Transplant Patients","Inclusion Criteria:\n\n* Age greater than or equal to 18 years old.\n* At least three months status post heart transplantation.\n\nExclusion Criteria:\n\n* Biopsy proven acute rejection episode in the past 3 months.\n* Patients with symptoms or signs of acute myocardial ischemia or recent acute coronary syndrome in the past 3 months.\n* Uncontrolled obstructive ventilatory disease including asthma and COPD.\n* History of generalized tonic-clonic seizures.\n* Second or third degree AV nodal block.\n* Sinus node dysfunction.\n* Contraindications to MRI including cardiovascular implantable electronic devices.\n* Renal dysfunction with an estimated GFR less than 30 mL\u002Fmin\u002F1.73m2.\n* Prior adverse reaction to either regadenoson or gadolinium contrast. Prior adverse reaction to adenosine or dipyridamole will be assessed on a case-by-case basis.\n* Systolic blood pressure greater than 180 or less than 85 mmHg.\n* Diastolic blood pressure greater than 120 or less than 40 mmHg.\n* Resting heart rate greater than 120 or less than 45 beats per minute. - Severe claustrophobia.","ALL","18 Years",{"count":18,"type":19},376,"ESTIMATED","INTERVENTIONAL",[22],"PHASE4","The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.",[25],"Heart Transplant Failure and Rejection",[27,28,29],"heart transplant","acute graft rejection","chronic graft rejection","RECRUITING","2026-04-27",{"date":33,"type":34},"2026-05-01","ACTUAL",{"date":36,"type":34},"2019-10-01",{"date":38,"type":19},"2027-01-02",{"name":40,"class":41},"Paul Kim","OTHER",""]