[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Pyatigorsk City Clinical Hospital Number 1\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100641874",false,"NCT07601867","Effect of Dapagliflozin on Right Ventricular-Pulmonary Artery Coupling After Off-Pump Coronary Atery Bypass Grafting","Effect of Dapagliflozin on Right Ventricular-Pulmonary Artery Coupling After Off-Pump Coronary Artery Bypass Grafting: a Prospective Single-Center Study","DAPA-RV-CABG","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Elective isolated off-pump coronary artery bypass grafting (OPCAB)\n* Left ventricular ejection fraction (LVEF) \\\u003C 50% documented on pre-operative echocardiography\n* Written informed consent\n\nExclusion Criteria:\n\n* Concomitant valve surgery\n* Emergency or urgent CABG\n* Conversion to on-pump during surgery\n* Perioperative myocardial infarction (as defined by the Fourth Universal Definition of MI)\n* Cardiogenic shock\n* More than moderate valvular heart disease\n* Persistent atrial fibrillation or atrial flutter at the time of echocardiographic examination)\n* Previous CABG or any prior cardiac surgery\n* Severe chronic kidney disease (eGFR \\\u003C 25 mL\u002Fmin\u002F1.73 m²)\n* Contraindication to SGLT2 inhibitors\n* Inability to obtain adequate echocardiographic windows\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":19,"type":20},72,"ESTIMATED","OBSERVATIONAL","This prospective, single-center observational study evaluates the effect of dapagliflozin 10 mg\u002Fday on right ventricular-pulmonary artery coupling measured by the TAPSE\u002FPASP ratio in 72 patients with left ventricular ejection fraction \\\u003C50% after off-pump coronary artery bypass grafting (OPCAB). The primary outcome is the change in TAPSE\u002FPASP ratio from 1 month after surgery (before dapagliflozin) to 7 months after surgery (after 6 months of dapagliflozin therapy).",[24,25],"Heart Failure","Coronary Arterial Disease",[27,28,29,30,31,32,33,34,35],"OPCAB","Right Ventricle","SGLT2 inhibitor","Dapagliflozin","TAPSE\u002FPASP","Pulmonary vascular resistance","KCCQ-23","CABG","RV-PA coupling","RECRUITING","2026-06-15",{"date":39,"type":40},"2026-06-17","ACTUAL",{"date":42,"type":20},"2026-07-01",{"date":44,"type":20},"2028-07-01",{"name":46,"class":47},"Pyatigorsk City Clinical Hospital Number 1","OTHER_GOV",""]