[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Research Center of Periodontal-Systemic Interactions\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100630759",false,"NCT07491848","Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D","Oral-Periodontal Evaluation and Assessment of Biomarkers in Oral Fluids in Patients With Hepatitis B+D Treated With Bulevirtide","Inclusion Criteria:\n\n* Adults (≥18 years old) capable of providing informed consent.\n* For Hepatitis B+D groups: confirmed hepatitis B and D co-infection.\n* Bulevirtide group: receiving bulevirtide therapy as prescribed.\n* No Bulevirtide group: not receiving bulevirtide.\n* For Healthy Control group: systemically healthy adults without hepatitis B or D infection.\n* Willingness to undergo oral-periodontal examination, saliva and gingival crevicular fluid collection, and oral cavity photography.\n\nExclusion Criteria:\n\n* Patients with other systemic diseases that could influence periodontal health (e.g., uncontrolled diabetes, autoimmune diseases).\n* Patients currently receiving other experimental therapies that may affect oral or systemic inflammation.\n* Pregnancy or lactation.\n* Inability or unwillingness to provide informed consent.\n* History of oral or periodontal surgery within the last 6 months that could affect measurements.",true,"ALL","18 Years",{"count":19,"type":20},25,"ESTIMATED","OBSERVATIONAL","Periodontal disease is a chronic inflammatory condition associated with systemic diseases, highlighting the concept of periodontal medicine. This study aims to investigate the relationship between periodontal inflammation, oral lesions, and hepatitis B+D infection, with or without bulevirtide treatment. Oral-periodontal clinical parameters and targeted inflammatory biomarkers in saliva and gingival crevicular fluid will be evaluated in three groups: patients with hepatitis B+D receiving bulevirtide, patients with hepatitis B+D not receiving bulevirtide, and healthy controls.",[24,25,26],"HEPATITIS B CHRONIC","Hepatitis D","Periodontitis","RECRUITING","2026-03-19",{"date":30,"type":31},"2026-03-25","ACTUAL",{"date":33,"type":31},"2026-02-15",{"date":35,"type":20},"2027-02-15",{"name":37,"class":38},"Research Center of Periodontal-Systemic Interactions","OTHER",2,""]