[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Robert Tighe, MD\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100498649",false,"NCT05773001","Macrophage Regulation of Ozone-Induced Lung Inflammation","MOLI","Inclusion Criteria:\n\n* Individuals between 18-55 yrs. of age (No subject will be excluded from the study on the basis of gender or ethnicity)\n* Individuals with knowledge of prior respiratory viral infection history allowing them to be segregated into one of three cohorts\n\n  * Cohort 1 - No history of respiratory viral infection (defined as no symptoms consistent with respiratory viral infection nor history of a positive respiratory viral test)\n  * Cohort 2 - Documented mild respiratory viral infection (a positive test, either PCR- or antigen-based) but with mild to no symptoms and no evidence of a lower respiratory tract infection (including no hospitalization, and no oxygen use)\n  * Cohort 3 - History of respiratory viral infection and symptoms\u002Fimaging consistent with a lower respiratory tract infection who have recovered, are \\>6 months out from their infection, and have normal lung function (spirometry with FVC, FEV1 and FEV1\u002FFVC)\n\n    * There will be no maximal period from respiratory viral infection for inclusion in the study, the minimal period will be \\>6 months out from infection\n\nExclusion Criteria:\n\n* Individuals with prior respiratory viral pneumonia who have ongoing respiratory symptoms, are still using supplemental oxygen, or have abnormal lung function\n* Current smokers of tobacco products including e-cigarettes or those with previous smoking history within the prior 5 years\n* Pregnant women and women who are presently lactating.\n* Subjects that have received antibiotic administration or an upper respiratory infection within the previous 4 weeks\n* College and graduate students or employees who are under direct supervision by any of the investigators in this protocol\n* Alcohol or illicit substance abuse\n* Chronic cardio\u002Fpulmonary respiratory disorders or other medical conditions as determined by the investigator\n* Increased airway hyperresponsiveness at baseline as measured by a positive methacholine challenge response (methacholine PC20 FEV1 \\\u003C 4 mg\u002Fml)\n* Subjects will be requested to refrain from antihistamines, nonsteroidal anti-inflammatory agents, antioxidants (e.g. beta-carotene, selenium, and lutein) and supplemental vitamins (e.g. C and E), for 1 week prior to, and during testing.",true,"ALL","18 Years","55 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","The purpose of this research study to understand how prior respiratory infections affect the susceptibility to lung inflammation following environmental exposures.",[27],"Respiratory Viral Infection","RECRUITING","2026-05-13",{"date":31,"type":32},"2026-05-15","ACTUAL",{"date":34,"type":32},"2023-05-18",{"date":36,"type":21},"2028-05",{"name":38,"class":39},"Robert Tighe, MD","OTHER",""]