[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Copenhagen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":714},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,40,0,25,[9,46,76,107,144,175,198,223,247,272,298,326,358,379,404,437,467,496,526,562,589,615,645,670,694],{"id":10,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100644895",false,"NCT07677332","Mandibular Advancement Device (MAD) and Continuous Positive Airway Pressure (CPAP) for Treatment of Adult Patients Diagnosed With Moderate Obstructive Sleep Apnea","Mandibular Advancement Device (MAD) and Continuous Positive Airway Pressure (CPAP) for Treatment of Obstructive Sleep Apnea","Inclusion Criteria:\n\n* Objectively diagnosed with moderate OSA (AHI 15-29)\n* \\>\u002F= 18 years\n* BMI \\\u003C\u002F= 35 and neck circumference \\\u003C44cm\n* Fully sanitised at their own dentist (no periodontitis or caries requiring treatment. Periodontal bone loss \\\u003C50%)\n* \\>\u002F= 20 teeth.\n* Evenly distributed occlusal contacts\n\nExclusion Criteria:\n\n* Known craniofacial anomalies\n* General inflammatory joint diseases\n* Maximal protrusion of the mandible \\\u003C 6 mm\n* Severe deep bite\n* Anterior open bite\n* Severe attrition\n* Severe bruxism and involuntary mandibular movements\n* Conditions demanding treatment such as temporomandibular disorders (TMD)\n* Chronically pronounced nasal stenosis\n* Hypertrophic tonsils (tonsil size 3-4)\n* Prior blood clot in the brain or in the heart\n* Heart arrythmias\n* Other severe systemic diseases\n* Epilepsia\n* Allergies towards peanuts, soy or egg\n* Consumption of morphine or other sedatives which cannot be paused\n* Pregnant or breast-feeding women","ALL","18 Years",{"count":19,"type":20},70,"ESTIMATED","INTERVENTIONAL",[23],"NA","Obstructive sleep apnea (OSA) is a frequent illness related to sleep and breathing with many symptoms and complications. The primary choices of treatment are continuous positive airway pressure (CPAP) and removable appliance for protruding the mandible when sleeping (MAD). Treatment with CPAP is superior to treatment with MAD but many patients don't tolerate CPAP why they seek treatment with MAD. In Denmark, treatment with MAD is not free of charge unlike treatment with CPAP and MAD is therefore not offered systematically to the patients. The same applies to adjustment, control and effect of the MAD treatment. MAD treatment has a positive effect on OSA in general but the effect varies due to differences in selection of patients and lack of specifying who performs and evaluates MAD treatment, the effect on sleep and possible side effects in muscles and the temporomandibular joint as well as the occlusion during treatment. It is therefore of great importance to investigate the effect of MAD treatment as well as short- and long-term side effects. The aim is therefore to compare the treatment effect of MAD and CPAP and how significant the investigation of the airways and the face is for the treatment effect and possible side effects. The project is a 4-year investigation and 70 adult patients diagnosed with moderate OSA are included. The results from the investigation will be of great importance for the choice of treatment and prognosis for the individual patient and socio-economic since the treatment of OSA could be tailored the individual patient and the treatment effect optimised.",[26],"Obstructive Sleep Apnea (OSA)",[28,29,30,31,32],"Obstructive sleep apnea","OSA","MAD","CPAP","Orthodontics","NOT_YET_RECRUITING","2026-06-29",{"date":36,"type":37},"2026-06-30","ACTUAL",{"date":39,"type":20},"2026-08",{"date":41,"type":20},"2029-08",{"name":43,"class":44},"University of Copenhagen","OTHER",1,{"id":47,"slug":4,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":45},"100645164","NCT07679516","Postprandial Regulation of Bone Perfusion in Healthy Individuals","GA-27","Inclusion Criteria:\n\n1. Age 25-50 years.\n2. BMI between 18.5-30 kg\u002Fm2.\n3. Normal gait.\n4. Premenopausal (if female).\n5. Informed consent.\n\nExclusion Criteria:\n\n1. Bone disease incl. confirmed osteopenia.\n2. Fracture within the last 6 months at the time of inclusion.\n3. Amputation or congenital defect of extremities.\n4. HbA1c\\>41.9 mmol\u002Fmol and\u002For diagnosed type 1 or type 2 diabetes.\n5. Any ongoing or prior medication that the investigator evaluates could interfere with the endpoints of the study (e.g. glucocorticoids or other medications that may compromise bone health).\n6. Pregnancy or breastfeeding (or plans thereof within the study duration).\n7. Not using effective hormonal contraceptives or an intra uterine device within study duration (e.g. oral contraceptives, transdermal patch, vaginal ring, Depo-Provera injections, Nexplanon implant).\n8. Ongoing or prior alcohol abuse (defined per ICD-10 classification for alcohol dependence syndrome, F10.21) or daily alcohol intake\n9. Use of any illicit substance or narcotics within three months of inclusion, including within study duration.\n10. Any physical or psychological condition that the investigator evaluates would interfere with trial participation.\n11. Recent (three months prior to inclusion), ongoing or planned weight loss within study duration (weight loss defined as exceeding -5% bodyweight, or intentional hypocaloric dieting)",true,"25 Years","50 Years",{"count":56,"type":20},15,[23],"The goal of this clinical trial is to learn whether certain natural hormones - Glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-2, (GLP-2), and amylin - affect blood flow to the bones.",[60,61,62,63,64,65,66,67],"Healthy Adult Participants","Bone Physiology","Bone Blood Flow Regulation","GLP-2","GIP","Amylin","Peptide Hormones","Gut Hormones","2026-06-25",{"date":70,"type":37},"2026-07-01",{"date":72,"type":20},"2026-07-19",{"date":74,"type":20},"2028-05",{"name":43,"class":44},{"id":77,"slug":4,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":45},"100543158","NCT06352229","The Playful Learning in Infancy Program","The Playful Learning in Infancy Program (PLIP): A Pilot Feasibility Study of an Universal Educational Parenting Program Using a Parallel Group Design","PLIP","Inclusion Criteria:\n\n* Residence address in the Danish municipalities of Hvidovre or Billund\n* Residence address with child or legal custody of the child\n* Child is between 1-7 months old\n* Understands Danish or English\n\nExclusion Criteria:\n\n* Parental age under the age of 18 when the child is born\n* Multiple pregnancy",{"count":84,"type":20},2327,[23],"In the Playful Learning in Infancy Program, parents receive research-based educational guidance on playful interactions with their infants aged 0-1 year. They learn to recognize their infants' cues indicating readiness to engage in play and they are introduced to specific, developmentally appropriate activities for interactive engagement. The guidance is delivered to parents during routine home visits by public health visitors.\n\nThe aims of the Playful Learning in Infancy Program are to 1) promote playful interactions between infants and parents, parental attitudes towards play, and infant socioemotional development; 2) enhance the language and knowledge of playful learning in infancy among frontline staff; and 3) evaluate the Playful Learning in Infancy Program for potential testing in a future large-scale RCT study.\n\nEvaluation is based on a parallel group study design, with half of the participants receiving care as usual and half of the participants receiving care as usual along with the Playful Learning in Infancy Program.",[88,89],"Parent-Child Relations","Infant Development",[91,92,93,94,95,96,97],"Universal intervention","Playful Learning","Infant","Parental competence","Socioemotional","Public health visitors","Prevention","RECRUITING","2026-05-20",{"date":101,"type":37},"2026-05-26",{"date":103,"type":37},"2023-06-01",{"date":105,"type":20},"2026-11-30",{"name":43,"class":44},{"id":108,"slug":4,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":52,"sex":114,"minAge":115,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":119,"phases":4,"briefSummary":120,"conditions":121,"keywords":129,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":45},"100635631","NCT07555197","Association of Seafood Consumption and Nutritional Status Among Adolescent Girls","Association of Seafood Consumption and Nutritional Status Among Adolescent Girls Living in Different Aquatic Ecological Zones in Southwestern Bangladesh","AQUAFOOD","Inclusion Criteria:\n\n* Adolescent girls aged between 12-16 years\n* Residing in the same study area as the 2017 IMMANA study\n* Willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* Any health condition that may affect anthropometric measurements\n* Severe illness that may interfere with physical or biochemical assessments","FEMALE","12 Years","17 Years",{"count":118,"type":20},300,"OBSERVATIONAL","This study examines how seafood consumption, social changes, and climate change affect the nutrition and well-being of adolescent girls in south-western Bangladesh. Many adolescent girls face poor nutrition, early marriage, and limited access to adequate diets. Adolescent girls have high nutritional needs due to growth and potential early motherhood. Seafood, including fish, shrimp, and prawns, provides important nutrients such as omega-3 fatty acids, but little is known about how its consumption relates to nutritional status in this population.\n\nThe study will collect new data from adolescent girls in the same area as a 2017 study (IMMANA study), assessing dietary pattern, nutritional status, socioeconomic conditions, and female autonomy. It will also explore how climate change affects household food access and nutrition to provide policies linking food systems and public health.",[122,123,124,125,126,127,128],"Nutritional Status","Omega 3 Fat Status","Micronutrient Status","Fish Consumption","Dietary Pattern","Female Autonomy","Climate Change",[130,131,132,133,134,135],"Adolescent nutrition","Aquaculture","Climate change","Fish consumption","Female autonomy","Nutritional status","2026-04-30",{"date":138,"type":37},"2026-05-06",{"date":140,"type":20},"2026-04-25",{"date":142,"type":20},"2026-12-15",{"name":43,"class":44},{"id":145,"slug":4,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":112,"eligibilityCriteria":149,"healthyVolunteers":52,"sex":16,"minAge":150,"maxAge":151,"enrollmentInfo":152,"targetDuration":154,"studyType":119,"phases":4,"briefSummary":155,"conditions":156,"keywords":161,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":169,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":45},"100634596","NCT07541742","Health and Nutritional Outcomes Among Young Females and Children in Southwest Bangladesh","Health and Nutritional Outcomes Among Young Females and Children in Southwest Bangladesh: A Cohort Study","Inclusion Criteria:\n\n* Young women aged 22-27 years who previously participated in the 2017 study. See study description.\n* If the women has a child age between 6 months to 5 years, the child child is included to be assessed\n\nExclusion Criteria:\n\n* Participants with serious health conditions that may interfere with study procedures or data collection.","5 Months","27 Years",{"count":153,"type":20},240,"2 Years","This study aims to examine how societal and climate changes influence the nutritional status and fish consumption of young women over a 10 year period in southern Bangladesh, and how these factors affect their children's health. A cohort of 240 adolescents first studied in 2017 will be followed to assess changes in their dietary patterns, nutritional status, climate perceptions and mitigation practices, as well as the nutritional status of their children aged 6 months to 5 years.\n\nThe study in 2017 sampled 60 adolescent girls in each of four rural communities, plus a semi-rural community around a fish processing plant, representing in total 5 communities. Of these 60 X 5 = 300 girls, the current study follows up the individuals in the rural communities representing a cohort of 240.\n\nBangladesh faces high rates of adolescent malnutrition, with many girls married before 18 and suffering from chronic nutrient deficiencies. These issues have long-term impacts on health, productivity, and intergenerational well-being. By linking the fisheries and aquaculture sector, a key to Bangladesh's economy with public health and nutrition, this research aims to guide targeted policies for vulnerable coastal communities.",[122,124,123,157,158,159,160],"Diet Diversity","Markers of Inflammation","Climate Adaptation","Climate Change Awareness",[162,163,164,165,166,167,168],"Aquatic foods","adolescent nutrition","fish intake assessment","dietary biomarkers","climate adaptation","intergenerational nutrition","Bangladesh",{"date":138,"type":37},{"date":171,"type":20},"2026-04-15",{"date":173,"type":20},"2026-12-10",{"name":43,"class":44},{"id":176,"slug":4,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":52,"sex":16,"minAge":181,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":21,"phases":185,"briefSummary":186,"conditions":187,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":45},"100616228","NCT07302880","The Acute Interference of Biotin in Blood Analysis","ABBA","Inclusion criteria:\n\n* Male or female between 20-70 years of age at time of screening\n* Body mass index of 18.6-25 kg\u002Fm2\n\nExclusion criteria:\n\n* Severe liver disease (estimated by FIB4 score \\> 3.25)\n* Type 2 diabetes according to ADA criteria (estimated by HbA1c levels of ≥ 48 mmol\u002Fmol)\n* Significant history of alcoholism or drug\u002Fchemical abuse as per investigators judgement\n* Kidney disease defined as serum creatinine levels ≥ 126 μmol\u002FL for male and ≥ 111 μmol\u002FL for female or eGFR \\\u003C 60 ml\u002Fmin\u002F1.73 m2\n* Cardiac problems (defined as troponin T levels \\> 10 ng\u002FL for woman and \\>19 ng\u002FL for men) or including any of the following, based on medical history:\n\n  * Classified as being in New York Heart Association (NYHA) class III or IV\n  * Angina pectoris (chest pain) within the last 6 months\n  * Acute myocardial infarction (heart attack) within last 2 years\n* Cancer within the past 1 year\n* Anemia (hemoglobin \\\u003C8.3 mmol\u002FL for men and \\\u003C7.3 mmol\u002FL for women)\n* Pregnancy (requires negative pregnancy test) or breast feeding\n* Smoking\n* Any medicine, acute illness (within the last two weeks) or other circumstances that in the opinion of the investigator might endanger the participants' safety or compliance with the protocol","20 Years","70 Years",{"count":184,"type":20},24,[23],"Biotin, also known as vitamin B7, is a water-soluble vitamin. It is essential for several metabolic processes in the body, including glucose, lipid, and protein metabolism, as it acts as a coenzyme in several carboxylation reactions. Biotin, available as an over the counter supplement, is widely used to improve nail and hair growth. The use of biotin supplements can interfere with various laboratory tests, due to the use of the streptavidin-biotin interaction in several immunoassays. The investigators therefore wish to assess the acute impact of biotin supplementation on various laboratory assays, with focus on the immediate post-ingestion effects and the time frame in which biotin interference is most pronounced.",[188,189,190],"Blood Sample","Interference With Routine Analyical Tests","Biotin Ingestion","2026-04-29",{"date":138,"type":37},{"date":194,"type":37},"2026-03-17",{"date":196,"type":20},"2030-10-01",{"name":43,"class":44},{"id":199,"slug":4,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":52,"sex":16,"minAge":182,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":21,"phases":207,"briefSummary":208,"conditions":209,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":222},"100594099","NCT07015034","Developing and Testing a Model to Identify Preventive Vision Loss Among Older Patients in General Practice","Developing and Testing a Model to Identify Preventive Vision Loss Among Older Patients in General Practice (DETECT)","DETECT","Inclusion Criteria:\n\n* +70 years\n* One or more chronic diseases\n* Are followed by GP du to chronic disease\n\nExclusion Criteria:\n\n* Dementia diagnosis\n* Known eye-diseases or are currently followed by private ophtalmologist\n* Not able to understand Danish",{"count":206,"type":20},460,[23],"In this cohort study, the investigators will test vision screenings in Danish general practice for patients over 70 years of age with minimum one chronic condition. The main outcome is detection of vision impairment and secondary outcome is detection of conditions needing ophthalmologic follow-up but not presenting vision impairment at present time.",[210,211,212,213,214],"Vision Impairment and Blindness","Glaucoma","Age-Related Macular Degeneration","Cataract","Diabetic Retinopathy","2026-04-23",{"date":191,"type":37},{"date":218,"type":37},"2024-05-15",{"date":220,"type":20},"2027-07-15",{"name":43,"class":44},2,{"id":224,"slug":4,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":226,"acronym":227,"eligibilityCriteria":228,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":229,"enrollmentInfo":230,"targetDuration":4,"studyType":21,"phases":232,"briefSummary":233,"conditions":234,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":45},"100607048","NCT07183488","Metabolic Effects of Short-Chain Fatty Acids in Healthy Individuals","SCFA","Inclusion Criteria:\n\n* Male or female.\n* Age between 18-40 years old\n* BMI between 18.5-29\n\nExclusion Criteria:\n\n* Diabetes\n* Kidney- or liver disease\n* Pregnant, lactating or planning to become pregnant within the study period\n* Supplementation with SCFAs\n* Supplementation with B12 vitamin\n* Special dietary habits (e.g. vegan\u002Fketogenic diet)\n* Ongoing cancer treatment\n* Metabolic or absorptive disorders, gastric bypass operation, or use of medication affecting metabolism or food absorption\n* Crohn's disease, ulcerative colitis or short bowel syndrome\n* Inability, physically or mentally, to comply with the procedure required by the study protocol as evaluated by the primary investigator, study manager or clinical responsible","40 Years",{"count":231,"type":20},10,[23],"The primary objective of this study is to investigate the acute physiological and metabolic effects of ingesting the short-chain fatty acids (SCFA)s propionate (three carbon atoms long; C3:0) and butyrate (C4:0) in healthy men and women. This aim will be addressed through a block-randomized cross-over study including two visits with acute intake of propionate and butyrate, respectively.\n\nThe hypothesis is that plasma ketone body levels will increase during the first three hours after intake of butyrate, but not propionate, in healthy individuals in the overnight fasted state.",[235,236,237,238],"Healhty","Other: Short-Chain Fatty Acid (SCFA)","Other: Butyrate (C4)","Other: Propionate (C3)","2026-03-09",{"date":241,"type":37},"2026-03-10",{"date":243,"type":37},"2025-09-10",{"date":245,"type":20},"2030-09-01",{"name":43,"class":44},{"id":248,"slug":4,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":250,"acronym":251,"eligibilityCriteria":252,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":253,"enrollmentInfo":254,"targetDuration":4,"studyType":21,"phases":256,"briefSummary":257,"conditions":258,"keywords":260,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":266,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":45},"100563966","NCT06623032","Metabolic Effects of Medium-Chain Fatty Acids in Patients With Medium-Chain Acyl-CoA Dehydrogenase Deficiency and Healthy Individuals","MEMCADD","Inclusion Criteria MCADD patients:\n\n* Male or female\n* Age between 18-80 years old\n* Diagnosed Medium-chain acyl-CoA dehydrogenase deficiency (MCADD\n\nInclusion Criteria Healthy Participants:\n\n* Male or female\n* Age between 18-80 years old\n\nExclusion Criteria both MCADD patients and healthy participants:\n\n* Diabetes\n* Kidney- or liver disease\n* Use of beta blockers or diuretics\n* Pregnant, lactating or planning to become pregnant within the study period\n* Regular intake of substantial amounts of coconut oil, palm kernel oil or any other source abundant in MCFA\n* Ongoing cancer treatment\n* Metabolic or absorptive disorders, gastric bypass operation, or use of medication affecting metabolism or food absorption\n* Inability, physically or mentally, to comply with the procedure required by the study protocol as evaluated by the primary investigator, study manager or clinical responsible","80 Years",{"count":255,"type":20},30,[23],"The aim of this project is to investigate the physiological effects of intake of long-chain fatty acids (LCFA) and medium-chain fatty acids (MCFA) in patients with Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) and healthy individuals",[259],"Medium-chain Acyl-CoA Dehydrogenase Deficiency",[261,262,263,264,265],"MCADD","Lipid metabolism","Ketone bodies","Medium-Chain Fatty Acid (MCFA)","Long-Chain Fatty Acid (LCFA)",{"date":241,"type":37},{"date":268,"type":37},"2024-10-18",{"date":270,"type":20},"2027-09",{"name":43,"class":44},{"id":273,"slug":4,"hasResults":11,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":52,"sex":16,"minAge":278,"maxAge":4,"enrollmentInfo":279,"targetDuration":281,"studyType":119,"phases":4,"briefSummary":282,"conditions":283,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":222},"100628414","NCT07461324","Surgeons' Prediction of Dental Surgery Complications and the Influence of Patient Characteristics: Development of an AI Model","Systematic Risk Assessment Prior to Oral Surgery","Inclusion Criteria:\n\n* Patients reffered from a general dentist practicioner for the following surgeries: third molar removal, apicoectomy, dental implant placement.\n* Patients \\>15 years of age\n* A valid diagnosis prior to the surgery\n* Cases with fully completed questionnaires.\n\nExclusion Criteria\n\n* Pathological condition requiring hospital refferal\n* Complications following re-surgery\n* Re-assesment of the diagnosis from the general dentist practicioner\n\nSpecific for apical surgery:\n\n* Root fracture present.\n* Buccal bone height \\\u003C3mm.\n\nSpecific for third molar removal:\n\n\\- if coronectomy is conducted instead of total root removal.\n\nSpecific for dental implant:\n\n* if an implant has been placed before in the same region of interest.\n* Health conditions were dental implants are contraindicated.","15 Years",{"count":280,"type":20},3000,"1 Year","The goal of this observational study is to learn how to better predict and prevent intra- and postoperative complications in oral surgery in adult patients referred for oral surgical procedures. The study aims to understand how accurately surgeons can foresee complications and which patient, tooth, and surgery related factors influence the outcomes.\n\nThe research questions are:\n\n* What is the incidence of intra and postoperative complications in oral surgery?\n* Which factors predict these complications, and how accurately can surgeons anticipate them?\n* Can the development of an AI tool reduce postoperative complications?\n\nParticipants will:\n\n* Receive standard oral surgery treatment at a private referral clinic (Specialtandlægerne Sjælland).\n* Have clinical information collected about their procedure, medical history, and personal characteristics (including anxiety level).\n* Conduct a short questionnaire, the STAI-6 and the I-PANAS-SF.\n* Have the surgeon record their prediction of whether complications are expected.\n* Be followed in the postoperative lapse to document whether complications occur after surgery.",[284,285,286,287,288,289,290],"Postoperative Infections","Mandibular Nerve Injuries","Alveolar Osteitis","Complication","Dental Implantation","Tooth Extraction","Apical Surgery","2026-03-04",{"date":241,"type":37},{"date":294,"type":20},"2026-04-01",{"date":296,"type":20},"2030-06-01",{"name":43,"class":44},{"id":299,"slug":4,"hasResults":11,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":303,"eligibilityCriteria":304,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":305,"targetDuration":4,"studyType":21,"phases":307,"briefSummary":308,"conditions":309,"keywords":312,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":325,"locationsCount":45},"100627596","NCT07450690","Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy","Deciphering Muscle-Nerve Communication Via Mitochondrial Myopathy Insights: Exploring the Effects of Exercise Training","MM-EX","Eligibility criteria for Mitochondrial Myopathy-group:\n\nInclusion Criteria\n\n* Known mtDNA or nuclear (nDNA) mutations\n* Age above or equal to 18 years\n\nExclusion Criteria:\n\n* Medical conditions which deem the MM patient unfit to complete the study\n* Current use of medications known to interact with outcome measures. (see below)\n* Pregnancy\n* The participant is for any other reason unlikely to complete the study\n\nInclusion Criteria for healthy controls\n\n* Age above or equal to 18 years\n\nExclusion Criteria:\n\n* Chronic medical conditions suspected to influence outcome measures\n* Frequent use of medicine\n* Pregnancy\n* The participant is for any other reason unlikely to complete the study",{"count":306,"type":20},22,[23],"The goal of this observational study is to learn how exercise training affects molecular processes in skeletal muscle in adults with mitochondrial myopathy, compared with healthy adults.\n\nThe main questions it aims to answer are:\n\n* How does exercise training affect mitochondrial activity and energy production pathways in skeletal muscle in people with mitochondrial myopathy?\n* How does exercise training affect molecular signals related to muscle growth, stress responses, and muscle-nerve communication in people with mitochondrial myopathy?\n\nResearchers will compare the trained leg to the untrained leg within the same participant, and also compare responses between participants with mitochondrial myopathy and healthy control participants, to see how molecular responses to exercise differ between groups.\n\nThe participants will:\n\n* Complete a 3-4-week supervised exercise training program using one leg.\n* Undergo muscle biopsies from both the trained and untrained leg.\n* Complete basic muscle strength and physical function tests.",[310,311],"Mitochondrial Diseases","Mitochondrial Myopathy",[313,314,315,316,317],"Exercise training","Mitochondrial function","Skeletal Muscle","Neuromuscular Junction","Muscle Plasticity","2026-03-01",{"date":320,"type":37},"2026-03-05",{"date":322,"type":37},"2026-01-09",{"date":324,"type":20},"2030-10-30",{"name":43,"class":44},{"id":327,"slug":4,"hasResults":11,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":52,"sex":16,"minAge":332,"maxAge":333,"enrollmentInfo":334,"targetDuration":4,"studyType":21,"phases":336,"briefSummary":337,"conditions":338,"keywords":345,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":357,"locationsCount":4},"100622884","NCT07389421","School Meals in Denmark","School Meals in Denmark: Evaluation of a National School Meal Pilot Program on Children's Health, Learning and Well-being - a Natural Experiment","Inclusion Criteria:\n\n* All children attending 3rd, 4th or 7th grade in the recruited schools\n\nExclusion Criteria:\n\n* No exclusion criteria will be applied","9 Years","14 Years",{"count":335,"type":20},3200,[23],"This study looks at how a national school meal program affects the health, well-being, and learning of Danish schoolchildren aged 10 to 15 years.\n\nThe study is part of the Danish National School Meal Pilot Program (2025-2028), which provides free school meals at selected public schools. Some school classes receive free school meals, while other classes do not and are used for comparison.\n\nChildren are followed for about 1.5 years. Information is collected before and after the program using simple health measurements, questionnaires about well-being, and age-appropriate cognitive tests.\n\nThe study also uses information from Danish national registers to better understand the children's background and to study longer-term outcomes related to health, education, and social conditions. In addition, the study examines whether school meal programs are cost-effective by comparing their costs with potential benefits for children and society.\n\nThe goal of the study is to find out whether free school meals can improve children's health, well-being, and learning, and help reduce social differences.",[339,340,341,342,343,344],"Childhood Obesity","Childhood Obesity Pevention","Well-being\u002FQuality of Life","Diet Habits","Cognitive Abilities","Healthy",[346,347,348,349],"physical health","well-being","learning","diet","2026-01-28",{"date":352,"type":37},"2026-02-05",{"date":354,"type":20},"2026-02-11",{"date":356,"type":20},"2029-12-31",{"name":43,"class":44},{"id":359,"slug":4,"hasResults":11,"nctId":360,"briefTitle":361,"officialTitle":362,"acronym":363,"eligibilityCriteria":364,"healthyVolunteers":52,"sex":16,"minAge":181,"maxAge":4,"enrollmentInfo":365,"targetDuration":4,"studyType":21,"phases":366,"briefSummary":367,"conditions":368,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":45},"100608860","NCT07207044","FAXAGE: Fasting And Exercise To Slow Aging In Humans","FAXAGE: A Randomized, Controlled Clinical Trial Of Fasting And Exercise To Slow Aging In Humans","FAXAGE","Inclusion Criteria:\n\n* Provision of signed and dated informed consent\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Aged \\>20 years\n* In good general health meaning maximally 1 well-managed chronic disease\n* Non-smoker.\n\nExclusion Criteria:\n\n* Inability or unwillingness to adhere to the TRF regiment\n* Inability or unwillingness to perform the prescribed physical exercise\n* Treatment with other investigational drug or intervention within 1 year\n* \\>1 hour of systematic strenuous exercise or strength training a week\n* Current time-restricted eating habits\n* Severe or dysregulated medical disease (i.e. active cancer, uncontrolled diabetes, severe pulmonary or heart disease)\n* \\>1 well-managed chronic disease\n* Smoker\n* Use of systemic glucocorticoids, androgens or antiandrogens.",{"count":153,"type":20},[23],"FAXAge is a randomized controlled trial investigating the effects of fasting and exercise on human aging. 240 participants over the age of 65 will be divided into 4 groups - an exercise group, a fasting group, a combined exercise and fasting group and a control group. The intervention will last for one year, and tests of biomarkers of aging will be performed at baseline, after 3 months, 6 months and at the end of the intervention. A reference group of participants over the age of 20 equally distributed by age and sex will be used to train an algorithm for determination of biological age. The study will include both physical, molecular and digital biomarkers including DNA-methylation, VO2max, body composition and face- and voice-age. The main outcome of the project is DNA-methylation age at week 52. Secondary outcomes are the rest of the tested biomarkers at week 52. It is hypothesised that the intervention groups will have similar superior benefits after the 52 weeks of intervention.",[369,370,371],"Aging","Healthy Aging","Aging Frailty","2026-01-26",{"date":350,"type":37},{"date":375,"type":37},"2025-10-01",{"date":377,"type":20},"2042-08-30",{"name":43,"class":44},{"id":380,"slug":4,"hasResults":11,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":384,"eligibilityCriteria":385,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":386,"enrollmentInfo":387,"targetDuration":4,"studyType":21,"phases":389,"briefSummary":390,"conditions":391,"keywords":393,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":403,"locationsCount":222},"100617829","NCT07323706","Ayurvedic Diet in Myxedema","Ayurvedic Diet as a Supplement to Levothyroxine Treatment of Myxedema","AYUS-MYX","Inclusion Criteria:\n\n* diagnosed with primary hypothyroidism\n* primary digestive type Vishamagni\n* under medical treatment for hypothyroidism\n* unchanged medication for the past 6 months\n\nExclusion Criteria:\n\n* previous Ayurvedic treatment\n* prescription drugs other than medication for hypothyroidism\n* pregnancy\n* lactating women.","90 Years",{"count":388,"type":20},88,[23],"Primary hypothyroidism is diagnosed by elevated thyroid stimulating hormone (TSH) level and a reduced thyroxine (T4) level in plasma. Some of the most common symptoms of hypothyroidism are fatigue, weight gain and reduced cognition and is associated with reduced quality of life and increased days of sick leave. Levothyroxine, a synthetic form of T4, is clinically recommended as first-line treatment for hypothyroidism. When normalizing TSH\u002FT4 with levothyroxine, the prevalence of persistent symptoms is present in 15% of patients. The composition of our gut bacteria, the microbiome, plays a significant role for a healthy thyroid gland and metabolism and is influenced by our diet. The Indian medical system, Ayurveda, is based on generations of experience and knowledge in disease prevention and treatment, including various diet plans, exercise and lifestyles that are put into context for physical and mental health. Ayurveda works with four different types of digestion and is based on a vegetarian diet. The purpose of this study is to investigate the effect of an Ayurvedic diet plan, as a supplement to medical treatment, among people with hypothyroidism.",[392],"Hypothyroidism Primary",[394,395,396],"hypothyroidism","Vegetarian diet","Ayurveda","2025-12-31",{"date":399,"type":37},"2026-01-07",{"date":401,"type":37},"2024-10-01",{"date":356,"type":20},{"name":43,"class":44},{"id":405,"slug":4,"hasResults":11,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":4,"eligibilityCriteria":409,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":410,"targetDuration":412,"studyType":119,"phases":4,"briefSummary":413,"conditions":414,"keywords":419,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":436,"locationsCount":222},"100617004","NCT07312981","The CPH-MBD Cohort Dietary Substudy - Comparison of Methods for Dietary Registrations","The CPH-MBD Cohort - Substudy on Dietary History","Inclusion Criteria:\n\n* A glomerular filtration rate of \\\u003C30 ml ml\u002Fmin\u002F1.73m2\n* 18 years and above\n\nExclusion Criteria:\n\nNone",{"count":411,"type":20},50,"3 Days","The aim of the study is to assess the association between the calcium and phosphorus balance and the stage of kidney disease measured by creatinine clearence in patients with chronic kidney disease stage 4 and 5. The balance is measured a measurement between the recorded diatery intake and the urinary excretion. Additionally a comparison between image based diatery accessment and weighted records will be measured",[415,416,417,418],"CKD","Renal Insufficiency Chronic","CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder","Pre-dialysis",[420,421,422,423,424,425,426,427,428,429],"Diet","Humans","Observational","Cohort","Phosphate\u002Furine","Calcium\u002Furine","Mineral bone disorder","Elderly","Calcium Balance","Phosphate Balance","2025-12-17",{"date":397,"type":37},{"date":433,"type":37},"2025-12-15",{"date":435,"type":20},"2029-05-15",{"name":43,"class":44},{"id":438,"slug":4,"hasResults":11,"nctId":439,"briefTitle":440,"officialTitle":441,"acronym":442,"eligibilityCriteria":443,"healthyVolunteers":52,"sex":16,"minAge":444,"maxAge":182,"enrollmentInfo":445,"targetDuration":4,"studyType":21,"phases":447,"briefSummary":448,"conditions":449,"keywords":451,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":45},"100607524","NCT07189676","Sustainable Diets and Cardiometabolic Health","PLANETDIET: Sustainable Diets and Cardiometabolic Health: a Multi-omics Approach in a Randomized Controlled Trial (RCT)","PlanetDiet","Inclusion Criteria:\n\n* Adults (males and females) between 45 and 70 years of age at the time of inclusion.\n* Participants must have at least two metabolic alterations: 1) Waist Circumference (WC) \\>102 cm (males) or \\>88 cm (females); 2) self-reported medication for blood pressure or blood pressure \\>130\u002F85 mmHg; 3) self-reported prediabetes or non-fasting plasma glucose 140-199 mg\u002FdL (prediabetes); 4) self-reported lipid-lowering medication or diagnosis of impaired blood lipids (triglycerides: ≥ 150 mg\u002FdL; and HDL: men: \\\u003C 40 mg\u002FdL and women: \\\u003C 50 mg\u002FdL).\n* Participants are not institutionalized, able to read and provide consent before participation, and willing to attend in-person visits at the study site.\n* Participants should have access to a smartphone and computer, or tablet and must be internet-literate.\n* Understand Danish both in writing and when spoken.\n\nExclusion Criteria:\n\n* Participants with any serious illness or history of cancer within the past 5 years (except adequately treated localized basal cell skin cancer or in situ uterine cervical cancer).\n* Diagnosed with diabetes mellitus, CVD event (myocardial infarction, revascularization procedure, or stroke), or atrial fibrillation.\n* Participants with diagnosed psychiatric conditions or cognitive impairment.\n* Current smokers including all kinds of nicotine-containing products.\n* BMI \\>35 kg\u002Fm2.\n* Known or suspected abuse of alcohol or recreational drugs. Regular alcohol consumption exceeding the Danish national guidelines (i.e., more than 10 standard drinks per week or more than 4 drinks on any single day) will be excluded.\n* Pregnancy or planning a pregnancy in the next year.\n* Not willing to consume chicken and fish or not willing to make dietary changes related to the intervention.\n* Participants with multiple food allergies that could hinder adherence to the intervention.\n* Any other issue that makes the project responsible (PI or medical responsible) doubt the eligibility of the volunteer.","45 Years",{"count":446,"type":20},180,[23],"This study aims to investigate the effects of sustainable diets on traditional and novel cardiometabolic risk factors.\n\nThe primary objective is:\n\n• To test the effects of a sustainable diet on traditional cardiometabolic risk factors, specifically, a metabolic health score.\n\nThe secondary objectives are:\n\n* To test the effects of sustainable diets on blood lipids, inflammatory markers, glucose markers, and anthropometric and body composition markers.\n* To test the effect of sustainable diets on circulating metabolomic profiles.\n* To test the effects of sustainable diets on circulating proteomic profiles.\n\nParticipants will receive dietary interventions of a sustainable health diet, namely the PHD diet (Planetary Health Diet), an ovo-lacto-vegetarian diet, or a habitual diet following general recommendations for a healthy diet without advice on consumption of animal products. The three-arm parallel RCT will involve adults (45-70 years old) at cardiovascular risk.\n\nThe primary hypothesis is that targeted interventions to adopt sustainable diets will have beneficial effects on cardiometabolic biomarkers, metabolomic, and proteomic profiles, compared to the habitual diet in individuals at cardiovascular risk.",[450],"Cardiometabolic Diseases",[452,453,454,455,456,457,458,459],"metabolomics","proteomics","sustainable diets","cardiometabolic health","nordic diet","randomised controlled trial","cardiometabolic risk factors","planetary health diet",{"date":461,"type":37},"2025-12-24",{"date":463,"type":37},"2025-11-24",{"date":465,"type":20},"2027-04",{"name":43,"class":44},{"id":468,"slug":4,"hasResults":11,"nctId":469,"briefTitle":470,"officialTitle":471,"acronym":4,"eligibilityCriteria":472,"healthyVolunteers":52,"sex":473,"minAge":474,"maxAge":475,"enrollmentInfo":476,"targetDuration":4,"studyType":21,"phases":478,"briefSummary":479,"conditions":480,"keywords":482,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":45},"100575731","NCT06776094","Physical Activity and Insulin Sensitivity Dynamics","The Significance of Physical Activity for Insulin Signaling Dynamics and Insulin Sensitivity","Inclusion Criteria:\n\n* Healthy individuals (no known diseases)\n* No use of medication\n* Non-smokers\n* Male\n* Aged 22-35 years\n* Fitness level (VO2max, i.e., maximal oxygen uptake) between 30-50 mL O2\u002Fmin\u002Fkg\n* BMI between 28 and 35\n\nExclusion Criteria:\n\n* Women\n* Failure to meet all inclusion criteria\n* Physical activity level (e.g., running, cycling, fitness, etc.) exceeding 6 hours per week\n* Acute illness within 2 weeks prior to the study days\n* Use of recreational drugs within 2 weeks prior to the study days","MALE","22 Years","35 Years",{"count":477,"type":20},8,[23],"The study investigates the role of one single bout of exercise in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. Furthermore, the study is aiming to elucidate the temporal development in insulin signaling, at the early timepoints of insulin stimulation that may be responsible for the enhanced muscle insulin sensitivity.\n\nThis will be investigated in young healthy males subjected to a one-legged knee-extensor exercise followed by a hyperinsulinemic-euglycemic clamp, a setup known to enhance muscle insulin sensitivity.",[481],"Insulin Sensitivity",[483,484,485,486,487],"Exercise","Muscle insulin sensitivity","Muscle glucose uptake","GLUT4","Phosphoproteomics","2025-12-01",{"date":490,"type":37},"2025-12-02",{"date":492,"type":37},"2025-05-05",{"date":494,"type":20},"2027-01",{"name":43,"class":44},{"id":497,"slug":4,"hasResults":11,"nctId":498,"briefTitle":499,"officialTitle":500,"acronym":501,"eligibilityCriteria":502,"healthyVolunteers":52,"sex":16,"minAge":53,"maxAge":503,"enrollmentInfo":504,"targetDuration":4,"studyType":21,"phases":506,"briefSummary":507,"conditions":508,"keywords":511,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":520,"lastUpdatePostDateStruct":521,"startDateStruct":522,"completionDateStruct":523,"leadSponsor":525,"locationsCount":45},"100612609","NCT07255807","Defining the Human Insulin Resistance Molecular Network; SIGNATURE","sIgnatuRe: Defining the Human Insulin Resistance Molecular Network","SIGNATURE","Inclusion Criteria:\n\n* Age: 25-55 years\n* Body Mass Index (BMI): 18-30 kg\u002Fm²\n* Healthy (no diagnosed chronic diseases)\n* Able and willing to comply with study procedures\n\nExclusion Criteria:\n\n* Smoking or nicotine use, current or within the past 5 years\n* Alcohol intake exceeding 10 units per week\n* Hemoglobin A1c (HbA1c) \\> 48 mmol\u002Fmol (indicative of diabetes or prediabetes)\n* Chronic diseases (e.g., cardiovascular disease, diabetes, etc.)\n* Chronic medication use, including hormonal treatments\n* High physical activity levels (more than 3 hours per week of moderate to vigorous exercise)\n* Pregnancy or within 3 months postpartum\n* Breastfeeding or within 3 months of cessation\n* Abnormal routine blood markers (as defined in lab screening)\n* Blood donation within the past 2 months","55 Years",{"count":505,"type":20},80,[23],"The goal of this intervention study is to learn more about what causes insulin resistance in otherwise healthy adults, and how short-term changes in physical activity or diet may influence it. The study includes healthy male and female participants aged 25 to 55 years, who meet specific health criteria.\n\nThe main questions it aims to answer are:\n\nDoes the cause of insulin resistance vary between individuals due to their genes and lifestyle?\n\nCan the investigators identify different types (sub-phenotypes) of insulin resistance at the molecular level?\n\nResearchers will compare groups who either reduce their physical activity for 14 days or consume a high-fat diet for 3 days, to see how these changes affect insulin sensitivity and related biological markers.\n\nParticipants will:\n\n* Complete a health screening and be assessed for eligibility\n* Undergo baseline testing to measure insulin sensitivity, physical activity, diet, and metabolic health\n* Be randomly assigned to one of two short-term interventions (14 days of reduced physical activity, or 3 days of a high-fat, high-calorie diet)\n* Repeat selected tests after the intervention to assess changes\n\nThis study will help researchers better understand how lifestyle and biology interact in the development of insulin resistance, even in people who are otherwise healthy.",[509,510],"Metabolic Health","Insulin Sensitivity\u002FResistance",[512,509,513,514,515,516,517,481,518,519],"Insulin Resistance","Glucose Metabolism","Lifestyle Interventions","Physical Inactivity","High-Fat Diet","Molecular Mechanisms","Metabolic Phenotyping","Human Intervention Study","2025-11-20",{"date":488,"type":37},{"date":488,"type":20},{"date":524,"type":20},"2038-06-30",{"name":43,"class":44},{"id":527,"slug":4,"hasResults":11,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":531,"eligibilityCriteria":532,"healthyVolunteers":52,"sex":16,"minAge":533,"maxAge":115,"enrollmentInfo":534,"targetDuration":4,"studyType":21,"phases":536,"briefSummary":537,"conditions":538,"keywords":543,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":561},"100542308","NCT06341179","Effect of Sleep Extension on Body Weight and Learning in Children (More2Sleep)","A Randomized Controlled Trial of Sleep Extension to Regulate Body Weight and Improve Learning in School-aged Children","More2Sleep","Inclusion Criteria:\n\n* Age: 6-12 years old (inclusive range).\n* Weight status: having a BMI above average, defined as an age- and sex-specific BMI Z-score above zero using reference standards from the WHO.\n* Sleep duration: sleeping ≤9 h\u002Fnight on the basis of sleep diaries filled in by the children's parents, based on recommendations by the American Academy of Sleep Medicine and the Sleep Health Foundation.\n\nExclusion Criteria:\n\n* Any genetic, neurological, endocrinological or psychiatric condition that affects growth, metabolism, eating behaviors, cognitive function, or body weight (for example: dwarfism, epilepsy, attention deficit hyperactivity disorder, head trauma, β-thalassemia, hypothyroid-ism, hyperthyroidism, type I diabetes).\n* Any sleep-related disorder (for example: obstructive sleep apnea, parasomnias, narcolepsy, restless leg syndrome).\n* Regular use of prescribed or over-the-counter medications that influence study outcomes.\n* Irregular school schedule.\n* If a child's parents live separately, the child is allowed to sleep at both households. How-ever, if one of the parents does not wish to carry out the sleep intervention and follow given instructions, then the child should only sleep at their household Friday, Saturday and\u002For Sunday night.\n* In the circumstance where the child does not speak or understand Danish, the child's parents do not have to speak or understand Danish, as long as both parties can speak and understand English.\n* Participation in other research studies.\n* Metal implants and claustrophobia (only for substudy-II).","6 Years",{"count":535,"type":20},142,[23],"More2Sleep is a randomized, controlled, parallel trial with two groups (sleep extension vs control) including 142 school-aged children (6-12 years) who have a BMI above average, defined as age- and sex-specific BMI Z-score above zero using WHO reference standards, and habitually sleep for ≤ 9 h\u002Fnight. Data will be collected before and after a 3-month sleep extension intervention, and after a 6-month follow-up (at months 0, 3, and 9). The collection of data is mainly related to the main study. However, some optional examinations will be conducted on a first come, first serve basis, consisting of substudy-I (metabolic mechanisms, n=60) and substudy-II (learning mechanisms, n=142).\n\nThe primary objective is to assess the effects of sleep extension by \\~45 min\u002Fnight, achieved by going to bed 60-90 min earlier, on adiposity and learning ability in school-aged children who have a BMI for age and sex above average, and sleep less than recommended for their age.",[539,540,541,542],"Sleep Duration","Child Obesity","Child Development","Child Behavior",[544,545,546,547,548,549,550,551,552],"Sleep duration","Sleep quality","Overweight and Obesity","Energy Intake","Child Development and Behavior","Well-being","Cognitive Function","Learning Ability","Memory","2025-11-19",{"date":555,"type":37},"2025-11-25",{"date":557,"type":37},"2024-08-13",{"date":559,"type":20},"2028-12-31",{"name":43,"class":44},3,{"id":563,"slug":4,"hasResults":11,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":567,"eligibilityCriteria":568,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":569,"targetDuration":4,"studyType":21,"phases":571,"briefSummary":572,"conditions":573,"keywords":575,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":581,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":588,"locationsCount":45},"100586519","NCT06916429","The Effectiveness of Psychological Interventions for Common Mental Disorders","The Effectiveness of Psychological Interventions for Common Mental Disorders (EPIC): A Randomized Waitlist-controlled Superiority Trial.","EPIC","Inclusion Criteria:\n\nClients:\n\n* All clients who meet the criteria for one of the eleven referral reasons for psychotherapeutic treatment in the Danish primary sector.\n* Clients who read and speak proficient Danish to fill in the questionnaires.\n* Clients who agree to be randomized through their informed consent.\n\nPsychologists:\n\n* All practicing psychologists employed by the Danish primary sector.\n* Psychologists who can commit to the deadlines for beginning treatment.\n* Psychologists with at waiting time of approximately four months or longer.\n\nExclusion Criteria:\n\n\\- Clients considered unfit for participation or urgently needing psychological or medical help, as determined by the therapist.",{"count":570,"type":20},308,[23],"The primary aim of \"the Effectiveness of Psychological Interventions for Common mental disorders\" (EPIC) randomized controlled trial is to investigate whether a significantly larger symptom improvement is observed after approximately four months of psychotherapeutic treatment in the Danish primary sector compared to in a waiting list control group. The secondary aim of the study is to identify specific client and therapy characteristics that may predict the effectiveness of the therapy or the symptom development in the waiting list control group. The main hypothesis of the EPIC trial is:\n\n1\\) Four and a half months after randomization, we will find a significantly lower level of symptoms on the primary outcome measure (PHQ-ADS) among clients who receive psychotherapy, compared to clients in the waiting list control group. In addition, we hypothesize to find significantly better outcomes in the psychotherapy group on all secondary outcome measures, four and a half months after randomization.\n\nResearchers will compare:\n\n* Psychotherapy starting within 14 days after the randomization date with\n* Placement on a waiting list for psychotherapy with treatment starting approximately four and a half months after the randomization date\n\nto investigate whether a larger symptom improvement is observed in the group receiving psychotherapy compared to the waiting list control group.\n\nParticipants will:\n\n* Be referred by their general practitioner (GP) for publicly subsidized psychotherapy treatment in the primary care sector in Denmark, based on one of 11 referral reasons.\n* Complete the baseline questionnaire containing background information, the primary and secondary outcome measures, and predictor questionnaires, and subsequently be randomized to either psychotherapy beginning within two weeks or a waiting list control group.\n* Receive a brief symptom questionnaire (the PHQ-ADS) every other week after the randomization date via an SMS-based solution provided by REDCap.\n* Complete the primary and secondary outcome measures approximately four and a half, eight and a half, and 16 and a half months after the randomization date.",[574],"Common Mental Disorders and\u002For Stress Related Symptoms",[576,577,578,579,580],"psychotherapy","common mental disorders","depression","anxiety","randomized controlled trial","2025-09-30",{"date":583,"type":37},"2025-10-06",{"date":585,"type":37},"2025-04-01",{"date":587,"type":20},"2027-04-30",{"name":43,"class":44},{"id":590,"slug":4,"hasResults":11,"nctId":591,"briefTitle":592,"officialTitle":593,"acronym":594,"eligibilityCriteria":595,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":596,"enrollmentInfo":597,"targetDuration":4,"studyType":21,"phases":599,"briefSummary":600,"conditions":601,"keywords":603,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":607,"lastUpdatePostDateStruct":608,"startDateStruct":610,"completionDateStruct":612,"leadSponsor":614,"locationsCount":45},"100596145","NCT07041645","Bioavailability of Different Vitamin K Vitamers Studied Using 13C-labelled Vitamin K Vitamers","Bioavailability of Micronutrients With a Special Focus on Vitamin K - Study Part I: K-vitamin","BioMicro","Inclusion Criteria:\n\n* Men and women\n* Between 18 and 65 years old (including both 18 and 65 year olds)\n* Danish-speaking\n* Willingness to consume\u002Fcomply with consumption of study-related intervention products\u002Fdiet\n* Willing to take 10 µg vitamin D3\u002Fday and omit intake of all other (vitamins and mineral) supplements before and during the trial\n* BMI ≤ 30.0 kg\u002Fm2\n\nExclusion Criteria:\n\n* Daily smokers\u002Fusers of all kinds of nicotine-containing products. Occasional smokers\u002Fuser can be included if they are willing to refrain from all kinds of nicotine-containing products during the trial (from screening to end of trial)\n* Blood donation \\\u003C3 months prior to study-related blood sampling\n* Intensive physical training (\\> 10 hours of strenuous physical activity per week)\n* Participation in other clinical studies at the time of the study\n* Pregnant, lactating or planning to become pregnant within the study period\n* Habitual alcohol intake above current recommendation (\\> 10 alcoholic units\u002Fweek)\n* History of cancer within the past five (5) years except basal cell skin cancer and cervix\n* Diagnosed with chronic inflammation disorders\n* Diagnosed with gastrointestinal diseases\n* Diagnosed with bone related diseases\n* Diagnosed with psychiatric disorder including depression that requires medical treatment\n* Medical treatment of diabetes\n* Medical treatment of cardiovascular related disease\n* Surgical change of the gastrointestinal tract (removal of appendix is allowed)\n* Use of prescription medication that can affect their safety or impact on data\n* Inability, physically or mental, to comply with the procedure required by the study protocol and evaluated by the principal investigator (PI), study manager or clinical responsible\n* Medical treatment with anticoagulation medication (warfarin-like types)\n* Allergy or intolerance related to intervention products","65 Years",{"count":598,"type":20},20,[23],"Objectives\n\nThe main objectives are:\n\nStudy part I: to investigate the bioavailability of vitamin K vitamers (PK, MK-4, MK-7 and MK-9) in humans using 13C-labelled compounds\n\nHypotheses Study part I: it is hypothesized that there is a difference between the bioavailability of the different vitamers, with MK-9 having the highest bioavailability followed by MK-7, and then PK, while MK-4 will have the lowest bioavailability.\n\nParticipants will:\n\nStudy part I: In the pilot study and study part I, participants will visit NEXS for a test period where a 6.5-hour test day will be carried out and followed up with two short visits on the 2 consecutive days. In the pilot study, there will be one test period with frequent blood sampling (before and after ingestion of a labelled vitamin K vitamer) and urine and faeces sampling. The minimum duration for each participant in the pilot study will be 2.5 weeks. After analyses of the bioavailability of the vitamin K vitamers in the pilot study, results will be used to determine the time points for biological sampling (mainly blood) in study part I. Study part I is a cross-over study with 4 test periods and washout periods in between. The minimum duration for each participant will be 6 weeks.",[602],"Bioavailability of Vitamin K",[604,605,606],"Bioavailability","vitamin K","13C-labelled vitamin K","2025-06-19",{"date":609,"type":37},"2025-06-27",{"date":611,"type":20},"2025-07-01",{"date":613,"type":20},"2031-06-30",{"name":43,"class":44},{"id":616,"slug":4,"hasResults":11,"nctId":617,"briefTitle":618,"officialTitle":619,"acronym":620,"eligibilityCriteria":621,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":622,"targetDuration":4,"studyType":21,"phases":623,"briefSummary":624,"conditions":625,"keywords":627,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":637,"lastUpdatePostDateStruct":638,"startDateStruct":640,"completionDateStruct":642,"leadSponsor":644,"locationsCount":45},"100594444","NCT07019519","POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS","Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS","GA22","Inclusion Criteria POTS patients:\n\n* Previously diagnosed with POTS in tilt test or active stand-test (either newly diagnosed within last 3 months or in new tilt test\u002Factive stand test during screenings visit)\n* Reproducible orthostatic intolerance with raise in HR on \\>30 bpm when standing within 10 minutes of change of supine to standing in age \\>19 years or \\>40 bpm in age 18-19 years.\n* POTS symptoms\u002Forthostatic intolerance\n* Age 18-50\n* Waist ratio \\\u003C180 cm\n\nExclusion Criteria:\n\n* Chronic illness\n* Metallic implants\n* Above 10 alcoholic drinks or week or substance abuse\n* Other types of sinus tachycardia or heart disease\n* Liverenzymes two times above normal values\n* Decreased kidney function eGFR \\\u003C90 or elevated kreatinkinasis\n* Thyroid disease or TSH out of reference\n* Uncontrollable low or high blood pressure\n* Blood vessels that cannot be visualized on MR\n* Any disease that might influence the health of the participant during the study or participants that receives medicine that cannot be paused for 36 hours\n\nInclusion Criteria:\n\n* Age 18-50\n* Waist ratio \\\u003C180 cm\n* Matched a POTS patient in age, sex and BMI\n\nExclusion Criteria:\n\n* Chronic illness\n* Metallic implants\n* Above 10 alcoholic drinks or week or substance abuse\n* POTS; other types of sinus tachycardia or heart disease\n* Liverenzymes two times above normal values\n* Decreased kidney function eGFR \\\u003C90 or elevated kreatinkinasis\n* Thyroid disease or TSH out of reference\n* Uncontrollable low or high blood pressure, Orthostatic hypotension\n* Blood vessels that cannot be visualized on MR\n* Any disease that might influence the health of the participant during the study or participants that receives medicine that cannot be paused for 36 hours",{"count":255,"type":20},[23],"This study will describe the interplay between the gut hormones GIP and CCK and their regulation of blood flow to the large vessels in patients with Postural Orthostatic Tachycardia Syndrome (POTS) and GIP, CCK and GLP-1 in healthy. This is addressed by hormone infusions during MR-scans of the abdomen and intake of oral glucose.",[626,344],"Postural Orthostatic Tachycardia Syndrome (POTS)",[628,629,630,64,631,632,633,63,634,635,636],"Postural Orthostatic Tachycardia Syndrome","POTS","Glucose-dependent insulinotropic polypeptide","Glucagon-like peptide-1","Glucagon-like peptide-2","GLP-1","CCK-8","Cholecystokinin","Splanchnic Blood Flow","2025-06-10",{"date":639,"type":37},"2025-06-13",{"date":641,"type":37},"2025-03-15",{"date":643,"type":20},"2026-09-30",{"name":43,"class":44},{"id":646,"slug":4,"hasResults":11,"nctId":647,"briefTitle":648,"officialTitle":649,"acronym":650,"eligibilityCriteria":651,"healthyVolunteers":11,"sex":16,"minAge":278,"maxAge":53,"enrollmentInfo":652,"targetDuration":4,"studyType":21,"phases":653,"briefSummary":654,"conditions":655,"keywords":657,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":663,"lastUpdatePostDateStruct":664,"startDateStruct":666,"completionDateStruct":667,"leadSponsor":669,"locationsCount":45},"100590069","NCT06962618","Home-Based Training With Feedback to Improve Outcomes in Adolescents and Young Adults With Cerebral Palsy..","The THRIVE-CP Trial - Targeted Home-Based Training With Real-Time Feedback to Improve Versatile Movement Behaviors and Enhance Outcomes in Adolescents and Young Adults With Cerebral Palsy: Protocol for a Randomized Controlled Trial.","THRIVE-CP","Inclusion Criteria:\n\n* Clinical diagnosis of cerebral palsy\n* Sensorimotor deficits in at least one limb\n* Demonstrated motivation to develop or regain motor skills, indicated by the expression of specific goals\n* Ability to follow instructions independently or with caregiver support\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Diagnosis of dyskinetic cerebral palsy\n* Presence of significant health risks that could interfere with participation\n* Surgery or first Botox injection within one month before the trial or during the trial period",{"count":19,"type":20},[23],"This clinical trial aims to determine whether extrinsic feedback through music enhances the effects of home-based motor training for adolescents and young adults with cerebral palsy (CP) and whether feedback improves adherence to the training program.\n\nThe main questions it aims to answer are:\n\n* Does extrinsic feedback improve real-world movement more than home training alone?\n* Do participants receiving extrinsic feedback adhere more closely to their training program?\n\nTo determine its effectiveness, the investigators will compare home-based training with and without real-time music feedback.\n\nParticipants will:\n\n* Engage in a home-based motor training program for 12 weeks, tailored to their individual needs and goals.\n* Receive real-time music feedback during training or no feedback (control group).\n* Attend weekly virtual coaching sessions to discuss short-term goals and training progress.\n* Undergo movement assessments before training, at 12 weeks (T2) and 24 weeks (T3).\n* Wear movement sensors for 72 hours at T2 and T3 to track real-world movement behavior.",[656],"Cerebral Palsy",[658,659,660,661,662],"cerebral palsy","Home-based training","Extrinsic feedback","Movement behavior","Motor learning","2025-04-29",{"date":665,"type":37},"2025-05-08",{"date":488,"type":20},{"date":668,"type":20},"2029-02-01",{"name":43,"class":44},{"id":671,"slug":4,"hasResults":11,"nctId":672,"briefTitle":673,"officialTitle":674,"acronym":594,"eligibilityCriteria":675,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":596,"enrollmentInfo":676,"targetDuration":4,"studyType":21,"phases":677,"briefSummary":678,"conditions":679,"keywords":680,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":688,"lastUpdatePostDateStruct":689,"startDateStruct":691,"completionDateStruct":692,"leadSponsor":693,"locationsCount":45},"100586871","NCT06921018","Bioavailability of Micronutrients With a Special Focus on Vitamin K Dependent on Consumed Diet","Bioavailability of Micronutrients With a Special Focus on Vitamin K - Study Part II: PLANTEKOST","Inclusion Criteria:\n\n* Men and women\n* Between 18 and 65 years old (including both 18 and 65 year olds)\n* Danish-speaking\n* Willingness to consume\u002Fcomply with consumption of study-related intervention products\u002Fdiet\n* Willing to take 10 µg vitamin D3\u002Fday and omit intake of all other (vitamins and mineral) supplements before and during the trial\n* BMI ≤ 30.0 kg\u002Fm2\n* Habitual consumption of meat at dinner minimum 5 times per week. Meat is defined as red meat and poultry, where red meat is consumed at dinner at least 2 out of 5 times per week (fish consumption is not included in the \"5 per week\" meat definition).\n\nExclusion Criteria:\n\n* Daily smokers\u002Fusers of all kinds of nicotine-containing products.\n* Occasional smokers\u002Fuser can be included if they are willing to refrain from all kinds of nicotine-containing products during the trial (from screening to end of trial)\n* Blood donation \\\u003C3 months prior to study-related blood sampling\n* Intensive physical training (\\> 10 hours of strenuous physical activity per week)\n* Participation in other clinical studies at the time of the study\n* Pregnant, lactating or planning to become pregnant within the study period\n* Habitual alcohol intake above current recommendation (\\> 10 alcoholic units\u002Fweek)\n* History of cancer within the past five (5) years except basal cell skin cancer and cervix\n* Diagnosed with chronic inflammation disorders\n* Diagnosed with gastrointestinal diseases\n* Diagnosed with bone related diseases\n* Diagnosed with psychiatric disorder including depression that requires medical treatment\n* Medical treatment of diabetes\n* Medical treatment of cardiovascular related disease\n* Surgical change of the gastrointestinal tract (removal of appendix is allowed)\n* Use of prescription medication that can affect their safety or impact on data\n* Inability, physically or mental, to comply with the procedure required by the study protocol and evaluated by the principal investigator (PI), study manager or clinical responsible",{"count":598,"type":20},[23],"Objectives\n\nThe main objectives are:\n\n• Study part II: to investigate the effect of a plant-based diet on micronutrient status compared to an average Danish diet\n\nHypotheses Study part II: it is hypothesised that the status of some micronutrients is lower after intake of a plant-based diet compared to an average Danish diet.\n\nParticipants will:\n\nStudy part II: consume either a vegan diet or an average danish diet with a high meat intake for 4 weeks. The total study period for the participants is estimated to 6 weeks (from screening to paticipants last visit)",[124],[604,681,682,683,684,685,686,687],"Micronutrients","Vitamin K","vitamin B2","Vitamin B12","zinc","iodine","haemoglobin","2025-04-07",{"date":690,"type":37},"2025-04-10",{"date":585,"type":20},{"date":613,"type":20},{"name":43,"class":44},{"id":695,"slug":4,"hasResults":11,"nctId":696,"briefTitle":697,"officialTitle":698,"acronym":4,"eligibilityCriteria":699,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":229,"enrollmentInfo":700,"targetDuration":4,"studyType":21,"phases":701,"briefSummary":702,"conditions":703,"keywords":704,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":688,"lastUpdatePostDateStruct":707,"startDateStruct":709,"completionDateStruct":711,"leadSponsor":713,"locationsCount":45},"100566620","NCT06657547","Urinary Concentration After Salmeterol","Urinary Concentration After Salmeterol in Well-trained Men and Females","Inclusion Criteria:\n\n* Inclusion Criteria:\n* Age 18-40\n* Physically active \\>5 hours a week\n* Maximum oxygen uptake classified as high or very high\n\nExclusion Criteria:\n\n* Active smoker currently or within the past 5 years\n* Regular intake of medication deemed by the responsible study physician to affect the test parameters (hormonal contraception is accepted for women)\n* Chronic or acute illness deemed by the responsible study physician to affect the test parameters\n* Deviation from the study protocol\n* Lean mass index \\>21 kg\u002Fm²\n* Pregnancy\n* Smoker\n* Blood donation during the past 3 months",{"count":184,"type":20},[23],"The purpose of the project is to investigate urine concentration after inhalation of salmeterol. This will be examined following acute physical activity under both normal conditions and heated conditions.",[344],[705,706],"Urinary concentration","Beta2-adrenergic stimulation",{"date":708,"type":37},"2025-04-09",{"date":710,"type":37},"2024-10-31",{"date":712,"type":20},"2026-12-31",{"name":43,"class":44},""]