[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Xingui Dai\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100608202",false,"NCT07198490","Construction of a Prognostic Model for Severe Brain-Injured Patients Based on Integrated Metabolic-Neurological Monitoring","Construction of a Prognostic Model for Severe Brain-Injured Patients Based on Integrated Metabolic-Neurological Monitoring: A Prospective Observational Study","CPM-Brain","Inclusion Criteria:\n\n* Diagnosis of severe TBI, large-volume stroke, or HIE\n* Expected ICU stay \\>72 hours\n* Informed consent from legal surrogate\n\nExclusion Criteria:\n\n* Terminal organ failure\n* Pre-existing severe neurological disease\n* Skull defect preventing monitoring\n* Pregnancy or lactation","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","8 Months","OBSERVATIONAL","This is a prospective, observational cohort study aimed at constructing a machine learning-based prognostic model for severe brain-injured patients. The study will synchronously collect continuous glucose monitoring (CGM), electroencephalography (EEG), near-infrared spectroscopy (fNIRS), transcranial Doppler (TCD), and serum neuronal injury biomarkers (NSE, S100β) within 72 hours post-injury. The goal is to investigate the correlation between glycemic variability (GV) and neurological function and to develop an integrated model for early prediction of 3-6 month neurological outcomes (GOSE score).",[25],"Brain Injuries",[27],"continuous glucose monitoring,Neurological Multimodal Monitoring,Brain Injury,Intensive Care Unit","NOT_YET_RECRUITING","2025-09-29",{"date":31,"type":32},"2025-09-30","ACTUAL",{"date":34,"type":20},"2025-10-01",{"date":36,"type":20},"2026-12-31",{"name":38,"class":39},"Xingui Dai","OTHER",""]