[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Yang Li\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":4,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100522854",false,"NCT06088030","Arsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Pediatric Cancer","Clinical Research on Efficacy and Safety of Arsenic Trioxide Combined With Chemotherapy in p53-mutated Pediatric Cancer Patients：A Prospective，Single-arm, Multi-center Study","Inclusion Criteria:\n\n1. Pathological diagnosis basis of malignant tumor；\n2. Patients not more than 18 years old;\n3. Patient has either germline or somatic p53 mutations, which was shown to be partially\u002Fcompletely restored to function by ATO in in vitro experiments (http:\u002F\u002Fwww.rescuep53.net);\n4. There are measurable lesions;\n5. Guardians agreed and signed informed consent.\n\nExclusion Criteria:\n\nPatients with one or more critical organs failure such as heart, brain, kidney failure.","ALL","18 Years",{"count":18,"type":19},50,"ESTIMATED","INTERVENTIONAL",[22],"PHASE2","This prospective, single-arm, multi-center clinical trial aims to explore and evaluate the efficacy and safety of arsenic trioxide combined with chemotherapy for pediatric cancer with p53 mutation.",[25,26,27],"Pediatric Cancer","Li-Fraumeni Syndrome","p53 Mutations",[29],"Arsenic Trioxide","RECRUITING","2024-01-02",{"date":33,"type":34},"2024-01-03","ACTUAL",{"date":36,"type":34},"2023-12-13",{"date":38,"type":19},"2031-12-14",{"name":40,"class":41},"Yang Li","OTHER",""]