[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Yuhui Qiu\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":14,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100599535",false,"NCT07085754","Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes","Inclusion Criteria:\n\n* Age 18-40 years, gender not limited\n* Healthy (with no clinically significant abnormal findings in the physical examination report or self-reporting as healthy) and not on medications\n* Cognitively normal (Mini-Mental State Examination (MMSE) score \\> 28)\n* Sleep duration of 7-9 hours per night, good sleep quality (Pittsburgh Sleep Quality Index (PSQI) ≤ 5 points)\n* Written informed consent, voluntarily participate in this study, and be able to cooperate with the physician to complete the clinical study\n\nExclusion Criteria:\n\n* Presence of day-night sleep reversal\n* Shift work within the past 6 months\n* Travel across time zones or experience of jet lag within the past three weeks\n* Current smoking or nicotine use; alcohol consumption exceeding five standard units per week (one standard alcohol unit is defined as 10 mL \\[or 8 g\\] of pure alcohol)\n* Consumption of strong tea, coffee, or caffeine-containing foods and beverages within one week before study participation\n* Family history of early-onset dementia\n* Self-Rating Depression Scale (SDS) score ≥ 53, Self-Rating Anxiety Scale (SAS) score ≥ 50\n* Female participants who are currently pregnant or breastfeeding\n* Individuals who need to drive or operate vehicles or machinery during the study period",true,"ALL","18 Years","40 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep deprivation in AD risk.",[26,27],"Sleep","Sleep Deprivation","RECRUITING","2025-12-18",{"date":31,"type":32},"2025-12-24","ACTUAL",{"date":34,"type":32},"2025-08-08",{"date":36,"type":20},"2026-12-31",{"name":38,"class":39},"Yuhui Qiu","OTHER",""]