[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-myocardial-ischemia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-myocardial-ischemia":38},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100588910",false,"NCT06947551","The Mechanism of Endogenous Nociceptin\u002FOrphanin FQ(N\u002FOFQ) and β1-adrenoceptor Autoantibody in Promoting Ischemic Arrhythmia in Rats","tmoenabaaipiai","Inclusion Criteria:1) Inclusion criteria for patients with diabetes: refer to the diagnostic criteria for type 2 diabetes (T2DM) in the Chinese Guidelines for the Prevention and Treatment of Type 2 diabetes (2017) 2) Inclusion criteria for patients with coronary heart disease: patients with clinically diagnosed coronary heart disease according to the 1979 WHO Diagnostic Criteria for Ischemic Heart Disease, and exclusion criteria include heart failure, tumor, immune disease and diabetes. -\n\nExclusion Criteria:Exclusion criteria for patients with coronary heart disease: including heart failure, tumor, immune disease and diabetes. -",true,"ALL","18 Years","85 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","In the early stage of ischemic arrhythmia, endogenous N\u002FOFQ regulates the expression of β 1-AA, mediates the internalization of β 1-AR by PKC\u002FERK1\u002F2, and thus affects the occurrence of arrhythmia. Further clarify the regulatory mechanism of N\u002FOFQ on β 1-AR internalization and arrhythmia, providing experimental basis for drug development and target exploration of clinical ischemic arrhythmia; To observe the relationship between endogenous N\u002FOFQ and β 1-AA in serum of patients with coronary heart disease and diabetes.",[25],"Acute Myocardial Ischemia","NOT_YET_RECRUITING","2025-04-25",{"date":29,"type":30},"2025-04-27","ACTUAL",{"date":32,"type":21},"2025-05-01",{"date":34,"type":21},"2026-06-01",{"name":36,"class":37},"Second Hospital of Shanxi Medical University","OTHER",""]