[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-respiratory-failure-arf\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-respiratory-failure-arf":366},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,49,77,105,131,158,183,220,244,264,287,312,339],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100638514",false,"NCT07603037","EIT Evaluation of Different Antihypertensive Agents on the Ventilation-Perfusion Ratio in Patients With Acute Respiratory Failure","Effect of Nicardipine and Nitroglycerin on the Ventilation-Perfusion Ratio in Patients With Acute Respiratory Failure Using Electrical Impedance Tomography: A Prospective Pilot Study","Inclusion Criteria Diagnosis of acute respiratory failure with PaO₂\u002FFiO₂ ≤ 300 mmHg, requiring invasive mechanical ventilation.\n\nRequires intravenous antihypertensive infusion (such as nicardipine or nitroglycerin) to maintain controlled and stable blood pressure during ICU treatment.\n\nWritten informed consent obtained from the patient or the legally authorized representative.\n\nExclusion Criteria:\n\nBody mass index (BMI) ≥ 50 kg\u002Fm² or presence of massive subcutaneous edema interfering with EIT signal acquisition.\n\nImplanted cardiac pacemaker, defibrillator, or any metallic thoracic device that may distort impedance measurements.\n\nHemodynamic instability or severe hypotension occurring during drug titration. Pregnancy or lactation. Known hypersensitivity or contraindication to nicardipine or nitroglycerin. Use of phosphodiesterase-5 inhibitors, such as sildenafil, tadalafil, or vardenafil, within the clinically relevant washout period.\n\nSevere anemia, markedly increased intracranial pressure, or other clinical conditions in which nitroglycerin administration is considered inappropriate by the treating physician.\n\nIncomplete clinical documentation preventing accurate evaluation of primary endpoints.","ALL","18 Years",{"count":18,"type":19},12,"ESTIMATED","INTERVENTIONAL",[22],"NA","This prospective, single-center interventional study aims to evaluate the effect of two commonly used intravenous antihypertensive agents - nicardipine and nitroglycerin - on lung ventilation-perfusion (V\u002FQ) distribution in patients with acute respiratory failure complicated by hypertension. Electrical Impedance Tomography (EIT) will be used for noninvasive monitoring of pulmonary ventilation and perfusion distribution before and after drug administration.\n\nThe study will compare the changes in V\u002FQ ratio, oxygenation index, and hemodynamic variables after administration of the two drugs. The findings are expected to provide evidence for the optimal antihypertensive strategy in critically ill patients with respiratory failure and to clarify whether specific vasodilators exacerbate or improve ventilation-perfusion mismatch.",[25,26,27,28],"Acute Respiratory Failure (ARF)","Hypertension","Pulmonary Perfusion Imbalance","Aortic Dissection (Subset)",[30,31,32,33,34,35],"Electrical Impedance Tomography","Ventilation-Perfusion Ratio","Nicardipine","Acute Respiratory Failure","Intensive Care Unit","Nitroglycerin","NOT_YET_RECRUITING","2026-06-30",{"date":39,"type":40},"2026-07-02","ACTUAL",{"date":42,"type":19},"2026-07-15",{"date":44,"type":19},"2027-07-30",{"name":46,"class":47},"First Affiliated Hospital of Wannan Medical College","OTHER",1,{"id":50,"slug":4,"hasResults":10,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":56,"targetDuration":58,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":48},"100642241","NCT07644637","BELLRICU PROJECT: Precision Medicine in Respiratory Intermediate Care Units","BELLRICU PROJECT: Precision Medicine in Respiratory Intermediate Care Units. Improvement of Risk Stratification, Mortality Prediction and clínical Decision-making (UCRI-CAT Team).","BELLRICU","Inclusion Criteria:\n\n* Acute or acute-on-chronic respiratory failure requiring non-invasive respiratory suport (NIRS) (Non-invasive ventilation or high flow nasal cannulae)\n* Neuromuscular patients requiring tracheostomy and ventilation invasive adaptation\n* Life-treating hemoptysis requiring emergent or urgent bronchial embolization (\\\u003C24 hours)\n* 4\\. Pulmonary embolism of high-intermediate risk requiring monitoring during first 24-48h of hospital admission on anticoagulation\n* Patients derived from Intensive care unit (ICU) requiring intermediate Medical step before transferred safely to conventional ward (complex respiratory weaning from invasive ventilation, high-dependency nurse cures due to limiting post-critical myopathy\n* Patients with thoracic cancer (onset or complication) of vital risk (major hemoptysis, massive pleural effusion, pericardial effusion on pre or cardiac arrest, pneumonitis related to oncological treatment with severe acute respiratory failure requiring NIRS, cava vein syndrome requiring emergent prothesis, etc...)\n* Respiratory complications after a complex interventional bronchoscopy requiring NIRS and\u002For strict monitoring: after significant bleeding, bronchial laceration, severe bronchospasm, non-controlled arrhythmia\n* Respiratory or\u002Fand cardiac intercurrent instability in a patient initially admitted to respiratory conventional ward.\n\nExclusion Criteria:\n\n* Patient's express negative to participate in the study\n* Patient already included in other simultaneous and competitive study\n* Patient cognitive deterioration that unable him to understand the study.",{"count":57,"type":19},624,"30 Days","OBSERVATIONAL","A respiratory intermediate care unit (RICU) is a monitoring and treatment area of respiratory patients who do not required admission to intensive care unit (ICU) but due to complexity, they could not be managed in conventional ward. Aim: To investigate those patients that could better benefit from RICU stay. Hypothesis: a comprehensive and integrative knowledge of all factors that intervene during the RICU admission allow determining probability of survival. Primary outcome: 1. To construct a predictive model of mortality at 30-days after RICU admission for patients admitted to the coordinator RICU based on standard biostatistics: The BELLRICU Model. Secondary outcomes: 2.1. To validate the model in another cohort of patients admitted at the same RICU. 2.2. To validate the model in an external cohort (patients admitted at the rest of Catalan active RICUs at the time of the study). 2.3. To compare the predictive capacity of the BELLRICU model with other previous validated scales but in ICU setting. 2. 4. To explore a new predictive model using artificial intelligence (AI) techniques. 2.4. To design a quick app to implement the BELLRICU model. Methodology: Longitudinal prospective study (3 years), recording variables at baseline, at RICU admission and 30-days follow-up. During the first two years, variables will be collected from the coordinator RICU to construct the BELLRICU model, being \"mortality after 30-day of RICU admission\" the dependent varialbe and using regression of cox proportional risks analysis. During the third year of the study, the BELLRICU model will be applicated to the rest of the participants RICUs in order to validate the model. Further, the predictive capacity of the BELLRICU model will be compared with the predictive capacity of previous validated scales in ICU setting and with a exploratory model using AI from BELLRICU data base.",[25,62,63,64,65],"Intermediate Respiratory Care Unit","Respiratory Precision Medicine","Mortality Prediction","Stratification Risk",[33,67,62,34],"Non-invasive Respiratory Support","2026-06-12",{"date":70,"type":40},"2026-06-16",{"date":72,"type":19},"2026-06-10",{"date":74,"type":19},"2029-05-30",{"name":76,"class":47},"Hospital Universitari de Bellvitge",{"id":78,"slug":4,"hasResults":10,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":20,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100643637","NCT07638293","Effect of High Flow Nasal Therapy (HFNC) Weaning Protocols vs Standard of Care on Respiratory Outcomes in Patients With Acute Respiratory Failure","Effect of High Flow Nasal Therapy (HFNC) Weaning Protocols vs Standard of Care on Respiratory Outcomes in Patients With Acute Respiratory Failure: A Randomized Clinical Trial","WHIP","Inclusion Criteria:\n\n* Age ≥18 years\n* Presence of acute respiratory failure (ARF)\n* Receiving HFNC treatment for ≥24 hours\n\nExclusion Criteria:\n\n* Post-extubation HFNC use or tracheostomized patients\n* Respiratory acidosis (pH \\\u003C7.35) or clinically significant acute hypercapnia (pCO₂ \\>50 mmHg with worsening from baseline)\n* Long-term home NIV or home CPAP use\n* Do-not-intubate (DNI) orders precluding escalation to invasive mechanical ventilation\n* Life expectancy ≤48-72 hours due to terminal non-respiratory disease\n* Neurological impairment or deep sedation preventing safe HFNC use (e.g. coma or severe uncontrolled delirium)\n* Technical contraindications to HFNC (i.e. facial trauma, maxillofacial surgery, severe nasal obstruction)\n* Refusal to participate or inability to provide informed consent",{"count":85,"type":19},148,[22],"High-flow nasal cannula (HFNC) is a widely used noninvasive respiratory support technique for patients with acute respiratory failure (ARF). It provides heated and humidified oxygen at high flow rates, improving oxygenation, reducing respiratory effort, and enhancing patient comfort. International guidelines recommend HFNC over conventional oxygen therapy in hypoxemic ARF. However, there is significant variability in clinical practice regarding HFNC discontinuation, and no standardized weaning criteria currently exist. Prolonged HFNC use may increase hospital stay and healthcare costs, while premature discontinuation may lead to respiratory deterioration and the need for further ventilatory support. Previous studies suggest that successful HFNC weaning may be predicted by a Fraction of inspired oxygen (FiO₂) ≤40% and a Respiratory rate-Oxygenation index (ROX index) ≥9.2. The ROX index is calculated as the ratio of peripheral oxygen saturation (SpO₂) divided by fraction of inspired oxygen (FiO₂) to respiratory rate. The primary objective of this study is to compare a standardized HFNC weaning strategy based on ROX index and FiO₂ thresholds with usual clinical practice based on physician judgment. The primary outcome is weaning failure at the first attempt, defined as the need for HFNC reinstitution, noninvasive or invasive mechanical ventilation, or death within 48 hours after discontinuation.",[25],[90,91,92,93,94],"ARF","HFNC","acute respiratory failure","weaning","ROX INDEX","RECRUITING","2026-06-04",{"date":72,"type":40},{"date":99,"type":19},"2026-05-15",{"date":101,"type":19},"2028-05",{"name":103,"class":47},"University of Milan",2,{"id":106,"slug":4,"hasResults":10,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":20,"phases":114,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":104},"100625492","NCT07423338","Monitoring Respiratory Muscle Function in Acute Respiratory Failure Patients on Non Invasive Respiratory Support","Monitoring Respiratory Muscle Function in Acute Respiratory Failure Patients Requiring Non-invasive Respiratory Support (MONITOR-NIV): A Prospective Observational Study","MONITOR-NIV","Inclusion Criteria:\n\n* Adult (≥18 years old)\n* with acute respiratory failure with hypoxia (i.e. arterial oxygen tension (PaO2) of \\\u003C8.0 kPa), and\u002For with or without hypercapnia (i.e. arterial carbon dioxide tension (PaCO2) of \\>6.0 kPa) from any underlying disease or cause\n* requiring any non-invasive respiratory support (i.e. HFNO, CPAP, BiPAP)\n* Multidisciplinary critical care staff involved in the management of those recruited patients with acute respiratory failure requiring non-invasive respiratory supports. Staff will possibly have an interview and are also required to complete a questionnaire.\n\nExclusion Criteria:\n\n* Patients in respiratory arrest defined as the total cessation of airflow and breathing effort and absent ventilation (24,25)\n* Patients requiring immediate intubation\n* Patients with Glasgow Coma Scale (GCS) \\\u003C 8\n* Patients with severe facial trauma or burns\n* Patients with fixed upper airway obstruction or inability to protect the airway\n* Patients with severe agitation and\u002For confusion that prevent use of the device mask\n* Patients with severe vomiting\n* Pregnancy\n* Patients with pacemakers and other electronic devices in the thorax\n* Patients on end-of-life care or palliative care (defined as expected to die and\u002For not receiving active treatment)\n* Contra-indication to EIT or ultrasound monitoring (e.g. burns, severe obesity, thoracic wounds limiting instrument placement, and thoracic drain)",{"count":113,"type":19},50,[22],"Acute respiratory failure is a common, life-threatening condition where the lungs cannot provide enough oxygen to the body. Many patients are treated with non-invasive respiratory support (NRS) such as high-flow nasal oxygen (HFNO), continuous positive airway pressure (CPAP), or bilevel positive airway pressure (BiPAP). However, up to half of patients receiving NRS still deteriorate and require intubation and invasive ventilation, which is linked to longer hospital stays, more complications, and slower recovery.\n\nA major challenge in caring for these patients is that clinicians currently cannot directly see how well the breathing muscles (especially the diaphragm and parasternal intercostal muscles) and the lungs are working while the patient is using NRS. Existing bedside measures, such as respiratory rate or oxygen levels, only show part of the picture. They do not indicate how hard the patient is working to breathe or whether their respiratory muscles are becoming fatigued. This lack of information may delay important decisions about adjusting NRS settings or switching to other treatments.\n\nThis study aims to find out whether two advanced but non-invasive, radiation-free bedside monitoring tools can be used effectively in routine care:\n\n1. Ultrasound, which can measure breathing muscle thickness, movement, and lung aeration\n2. Electrical impedance tomography (EIT), which uses a soft belt of small electrodes around the chest to measure changes in air and blood flow within different regions of the lungs in real time\n\nThese tools have shown promise in earlier research, and interviews with patients and clinicians suggest they are comfortable, well-tolerated, and potentially useful. However, they have not yet been evaluated together in a real-world hospital environment where many acute respiratory failure patients are cared for outside the ICU.\n\nWhat the study will involve:\n\nUp to 100 adults with acute respiratory failure requiring any type of non invasive respiratory support will be recruited with the goal of obtaining complete data from at least 50 patients. Each participant will undergo ultrasound and EIT assessments up to seven times during the first 72 hours after starting NRS, plus an additional measurement if they improve enough to stop NRS or if they deteriorate and require intubation. These assessments take place at the bedside, require brief exposure of the upper chest, and last approximately 15-45 minutes. Routine clinical data-such as heart rate, oxygen levels, and breathing measures-will also be recorded.\n\nIn parallel, clinical staff caring for these patients will complete a short Healthcare System Usability Scale questionnaire to rate how useful, understandable, and practical they find the information generated by ultrasound and EIT. Some staff may also take part in optional interviews to explore usability in more depth.\n\nWhat the study is trying to learn:\n\nThe primary aim is to determine the usability of these monitoring methods meaning understanding if they are practical, easy to use, and helpful for clinicians making decisions about NRS treatment.\n\nSecondary aims include understanding:\n\n* how the respiratory muscles and lungs change over time during NRS\n* whether these changes are linked to treatment settings (e.g., flow rate, pressure support)\n* whether certain patterns are associated with treatment success or failure (intubation or death)\n* whether these tools could help identify patients at risk of deterioration earlier\n\nRisks and benefits:\n\nBoth ultrasound and EIT are widely used, safe, and non-invasive. They involve no radiation, needles, or harmful exposure. Minor temporary discomfort from the gel or belt placement is possible. Participation will not change any clinical treatments. Although patients may not directly benefit, the study may help future patients by improving understanding of breathing muscle function and supporting more personalised respiratory care.\n\nBy contributing to this research, patients and clinicians will help determine whether advanced monitoring can be realistically implemented in busy hospital settings and whether it could lay the groundwork for future trials aimed at improving outcomes for people with acute respiratory failure.",[25,117],"Non Invasive Ventilation",[92,119,120,121],"non-invasive respiratory support","ultrasonography","electrical impedance tomography","2026-05-20",{"date":124,"type":40},"2026-05-22",{"date":126,"type":40},"2026-02-26",{"date":128,"type":19},"2027-05-02",{"name":130,"class":47},"Queen Mary University of London",{"id":132,"slug":4,"hasResults":10,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":20,"phases":138,"briefSummary":139,"conditions":140,"keywords":143,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":48},"100626896","NCT07441590","Evaluation of the Clinical and Prognostic Value of Non-invasive Analysis of Mandibular Movements (MM) as a Marker of Inspiratory Effort in the Spontaneously Breathing Intensive Care Patient","MM-ICU","Inclusion Criteria:\n\n* Adult patients (≥ 18 years)\n* Admitted to the Intensive Care Unit for acute respiratory failure\n* On invasive mechanical ventilation for more than 24 hours with:\n\n  * A respiratory rate ≤ 35 breaths\u002Fminute;\n  * Adequate oxygenation, defined as either an oxygen saturation of at least 90% (obtained during ventilation with a fraction of inspired oxygen \\[FiO2\\] ≤ 40% and a positive end-expiratory pressure \\[PEEP\\] ≤ 8 cm of water) or an arterial partial pressure of oxygen (PaO2) (measured in mmHg) \u002F FiO2 ratio \\> 150 (obtained during ventilation with a PEEP ≤ 8 cm of water);\n  * Respiratory muscle capacity allowing for an effective cough;\n  * A state of wakefulness, defined as a Richmond Agitation and Sedation Scale (RASS) score of -2 to +1;\n  * No use of continuous sedation;\n  * No use of vasopressors (or use of minimal doses).\n* At high risk of weaning failure defined by at least one of the following criteria (5):\n\n  * Age \\> 65 years\n  * A cardiac comorbidity among: systolic dysfunction (ejection fraction ≤45%), permanent atrial fibrillation, or a history of cardiogenic pulmonary edema or myocardial ischemia\n  * A respiratory comorbidity among: COPD, restrictive lung disease, or obesity hypoventilation syndrome\n* Written informed consent obtained from the patient, or in case of incapacity, from the next of kin\u002Ftrusted person\n* Patient covered by social security\n\nExclusion Criteria:\n\n* Absolute contraindication to NIV (patient refusal, undrained pneumothorax, intractable vomiting, upper airway obstruction, upper gastrointestinal bleeding, severe craniofacial trauma)\n* Absolute contraindication to nasogastric tube placement (upper gastrointestinal bleeding, epistaxis, skull base trauma)\n* Persons referred to in Articles L1121-5 to L1121-8 of the CSP (corresponds to all protected persons: pregnant woman, parturient woman, breastfeeding mother, person deprived of liberty by judicial or administrative decision, persons receiving psychiatric care under Articles L. 3212-1 and L. 3213-1 who do not fall under the provisions of Article L. 1121-8, persons admitted to a health or social establishment for purposes other than research, minors, person subject to a legal protection measure or unable to express their consent).",{"count":113,"type":19},[22],"Evaluate the performance for measuring inspiratory effort of non-invasive mandibular movement analysis compared to the reference technique oesophageal pressure (PES) variation, in ventilated and spontaneously breathing Intensive Care Unity (ICU) patients, during weaning from mechanical ventilation and within 48 hours after extubation.\n\nThe investigators hypothesis is that the assessment of respiratory effort by MM analysis could represent a non-invasive and reliable alternative to the measurement of PES in critically ill patients.",[25,141,142],"Intensive Care Unit (ICU) Patients","Invasive Mechanical Ventilation",[144,92,145,146,147,148],"intensive care unit","invasive mechanical ventilation","weaning from mechanical ventilation","ventilatory control","Breathing efforts","2026-02-23",{"date":151,"type":40},"2026-03-02",{"date":153,"type":19},"2026-02",{"date":155,"type":19},"2027-04",{"name":157,"class":47},"University Hospital, Grenoble",{"id":159,"slug":4,"hasResults":10,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":48},"100622101","NCT07379242","Lung Recruitment Assessed by 2D\u002F3D-EIT and R\u002FI Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation","Lung Recruitment Assessed by Two-Dimensional\u002FThree-Dimensional Electrical Impedance Tomography and Recruitment-to-Inflation Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation","Inclusion Criteria:\n\n* Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing.\n* Oxygenation index \\\u003C 300 mmHg.\n* Patients who are clinically judged by the attending doctor to require the PEEP titration.\n\nExclusion Criteria:\n\n* Aged under 18 years.\n* Pregnancy.\n* Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others).\n* No informed consent obtained.\n* Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor.\n* High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.",{"count":113,"type":19},"The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R\u002FI ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is:\n\nAre the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R\u002FI ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R\u002FI ratios measured at high and low PEEP levels.",[25],[168,169,170,171,172,173],"Acute respiratory failure","PEEP titration","3D-EIT","2D-EIT","Lung recruitability","R\u002FI ratio","2026-01-23",{"date":176,"type":40},"2026-01-30",{"date":178,"type":40},"2025-09-01",{"date":180,"type":19},"2026-09-30",{"name":182,"class":47},"Peking Union Medical College Hospital",{"id":184,"slug":4,"hasResults":10,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":20,"phases":192,"briefSummary":195,"conditions":196,"keywords":203,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":48},"100615474","NCT07293078","Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial","Prospective Evaluation of a Point-of-Care Artificial Intelligence Model in Critical Care Outcomes","POC-AI-ICU","Inclusion Criteria:\n\n1. Adult patients (≥ 18 years) admitted to the medical intensive care unit (MICU) at participating hospitals.\n2. Direct admissions from the emergency department or transfers from medical wards to the MICU.\n3. Critically ill patients meeting local ICU admission criteria.\n\nExclusion Criteria:\n\n1. Transfers to the MICU from outside hospitals, operating room, or post-anesthesia care unit.\n2. Age \\\u003C 18 years.\n3. Incomplete or missing essential clinical information at admission (e.g., key labs or documentation not yet available).\n4. Primary surgical or cardiac (e.g., STEMI) patients.\n5. Pregnant or postpartum women.\n6. Prisoners.",{"count":191,"type":19},1000,[193,194],"PHASE1","PHASE2","This is a prospective, unmasked, randomized, multicenter clinical trial evaluating the impact of point-of-care large language model (LLM)-based decision support on diagnostic accuracy and clinical outcomes in adult medical intensive care unit (MICU) patients.\n\nConsecutive adult ICU admissions at participating community hospitals (initially MetroWest Medical Center and St. Vincent Hospital) will be screened for eligibility. Eligible patients will be randomized 1:1 to standard care or an AI-assisted group. In both arms, initial evaluation and management will follow usual practice. For patients randomized to AI assistance, de-identified admission data (history and physical, labs, imaging reports, and other relevant documentation) will be formatted and submitted to a state-of-the-art LLM (ChatGPT-5) at the time of admission. The AI-generated differential diagnosis and therapeutic recommendations will be provided to the admitting team for consideration. For the standard care arm, LLM output will be generated but not shared with clinicians.\n\nAfter discharge, a masked chart review will determine the \"ground truth\" primary diagnosis and extract outcomes including: Primary Outcome - a composite of medical errors (from time of ICU admission through day 7 of ICU stay, or ICU discharge, whichever comes first); Secondary Outcomes - 90-day mortality, ICU and hospital length of stay, and ventilator-free days.",[197,198,25,199,200,201,202],"Critical Illness","Sepsis","Multi-organ Failure","Acute Kidney Injury","Delirium Confusional State","Shock",[204,34,205,206,207,208,209,198,202,33,210],"Critical Care","Large Language Model","Artificial Intelligence","Diagnostic Accuracy","Clinical Decision Support","Critical Care Outcomes","Multiorgan Failure","2025-12-15",{"date":213,"type":40},"2025-12-18",{"date":215,"type":19},"2026-01-01",{"date":217,"type":19},"2029-06-30",{"name":219,"class":47},"MetroWest Artificial Intelligence Research Workgroup",{"id":221,"slug":4,"hasResults":10,"nctId":222,"briefTitle":223,"officialTitle":223,"acronym":224,"eligibilityCriteria":225,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":226,"enrollmentInfo":227,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":229,"conditions":230,"keywords":231,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":48},"100613384","NCT07265882","Bed Side Assessment in Patients With Acute Respiratory Failure Under Invasive Mechanical Ventilation","BAM","Inclusion Criteria:\n\n* patients undergoing passive mechanical ventilation\n\nExclusion Criteria:\n\n* hemodynamic instability\n* confirmed intracranial hypertension","90 Years",{"count":228,"type":19},100,"The goal of this study is to learn about the respiratory mechanics in patients undergoing mechanical ventilation. The investigators can achieve this through the offline analysis of data provided by the ventilator. Within the field of respiratory mechanics, the study focuses particularly on the quantification of lung instability.\n\nWhat does lung instability mean? By this definition, the investigators refer to the part of lung tissue that opens during inspiration and then collapses during the subsequent expiration. The more diseased the lung (for example, in the case of viral pneumonia), the greater the quantity of this tissue.\n\nHow is lung instability measured? In the context of the study analysis, lung instability is measured through the analysis of the low flow pressure-volume loop during ventilation. This graph illustrates how the volume of air in the lungs varies in response to the pressures applied by the ventilator during slow inflation and deflation phases. This maneuver is considered quick and safe and has been an integral part of our clinical practice for several years. Through this maneuver, investigators can examine the range of pressures provided by the ventilator during tidal ventilation. To assess lung instability, hysteresis is analyzed, which represents a distinctive characteristic of the pressure-volume loop. Greater hysteresis indicates a higher degree of lung instability.\n\nDuring the study, investigators will record not only hysteresis but also classical respiratory mechanics parameters (for example, elastance of the respiratory system, i.e., how stiff the lung is), parameters regarding gas exchange (blood oxygen and carbon dioxide levels), biometric data (for example, height and weight), and imaging (CT scans, lung ultrasound, and electrical impedance tomography) to relate them to the degree of lung instability.",[25],[232,233,234],"respiratory mechanics","ARDS","mechanical ventilation","2025-12-04",{"date":237,"type":40},"2025-12-05",{"date":239,"type":40},"2022-11-14",{"date":241,"type":19},"2026-11-01",{"name":243,"class":47},"Fondazione IRCCS Policlinico San Matteo di Pavia",{"id":245,"slug":4,"hasResults":10,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":20,"phases":252,"briefSummary":253,"conditions":254,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":4},"100611956","NCT07247318","The Effects of Different Non-invasive Respiratory Support","The Physiological Effects of Different Non-invasive Respiratory Support in Patients With Acute Hypoxemic Respiratory","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* PaO₂\u002FFiO₂ ≤ 300 mmHg or SpO₂\u002FFiO₂ ≤ 315 (with SpO₂ ≤ 97%);\n* Requiring one of the following respiratory supports:\n\n  1. Noninvasive positive pressure ventilation with PEEP ≥ 5 cmH₂O, or\n  2. High-flow nasal oxygen therapy with a flow rate ≥ 30 L\u002Fmin, or\n  3. Conventional oxygen therapy with an oxygen flow ≥ 10 L\u002Fmin, where FiO₂ is calculated using the formula: FiO₂ = 0.21 + (oxygen flow rate × 0.03).\n\nExclusion Criteria:\n\n* Received CPAP or NIV for more than 24 hours prior to screening.\n* Received invasive mechanical ventilation during the current hospitalization.\n* Presence of chronic underlying pulmonary disease, or PaCO₂ ≥ 45 mmHg.\n* Presence of cardiogenic pulmonary edema.\n* Hemodynamic instability, defined as systolic blood pressure \\\u003C 90 mmHg or norepinephrine-equivalent dose \\> 0.3 µg\u002Fkg\u002Fmin.\n* Impaired consciousness (GCS ≤ 12).\n* Patients requiring urgent intubation, including those with respiratory or cardiac arrest, apnea with loss of consciousness or gasping, or severe hypoxemia (defined as SpO₂ \\\u003C 90% despite 100% oxygen).\n* Contraindications to NIV: cardiac or respiratory arrest, coma, untreated pneumothorax, uncontrollable vomiting, upper airway obstruction, hematemesis or severe facial trauma, or thoracic\u002Fabdominal surgery within the past 7 days.\n* Contraindications to EIT: implanted cardiac pacemaker, unstable spinal injury or fracture, or open chest trauma.\n* Refusal of endotracheal intubation.\n* Pregnancy.",{"count":251,"type":19},60,[22],"Patients with acute hypoxemic respiratory failure (AHRF) typically present with pathophysiological alterations characterized by the coexistence of respiratory dysfunction and hypoxemia. Respiratory dysfunction leads to dyspnea, increased work of breathing, use of accessory respiratory muscles, and hypercapnia, while gas exchange impairment results in hypoxemia. Studies have shown that hypercapnia, acidosis, and hypoxemia can all enhance inspiratory effort, which further increases negative intrathoracic pressure. In these patients, regional differences in airway resistance and lung compliance are often present, causing redistribution of air within the lungs. This redistribution manifests as gas movement from non-dependent to dependent regions, known as \"pendelluft,\" which amplifies regional alveolar strain and ventilation heterogeneity. This phenomenon becomes more pronounced during noninvasive respiratory support when spontaneous breathing is preserved.\n\nNoninvasive respiratory support strategies mainly include high-flow nasal oxygen (HFNO), noninvasive positive pressure ventilation (NIV), and continuous positive airway pressure (CPAP). HFNO delivers high-flow gas through nasal cannulas, generating a certain level of positive end-expiratory pressure (PEEP) and flushing out anatomical dead space to improve gas exchange, thereby reducing inspiratory effort, lowering the work of breathing, and enhancing oxygenation. NIV, typically using pressure support ventilation (NIV-PSV), is a patient-triggered, pressure-targeted mode that provides inspiratory positive pressure above PEEP. By augmenting tidal volume and reducing inspiratory effort, NIV improves gas exchange; however, leaks may limit the effective delivery of PEEP, and full inspiratory synchronization can increase transpulmonary driving pressure and tidal volume. CPAP, by contrast, delivers a constant positive pressure during both inspiration and expiration. Compared with HFNO, CPAP generates higher PEEP, which facilitates alveolar recruitment and more effectively improves oxygenation. Relative to NIV, CPAP may reduce transpulmonary driving pressure and tidal volume.\n\nDifferent noninvasive respiratory support strategies exert varying effects on respiratory drive and regional lung strain, leading to differences in the occurrence and magnitude of pendelluft. Physiological studies have suggested that CPAP may offer greater benefits in improving oxygenation and reducing inspiratory effort; however, whether it can mitigate the occurrence and extent of pendelluft remains uncertain. Therefore, this study was conducted to visualize and quantitatively assess pendelluft in real time using electrical impedance tomography (EIT), aiming to verify whether CPAP has a superior effect in reducing pendelluft in patients with AHRF.",[25],"2025-11-20",{"date":257,"type":40},"2025-11-25",{"date":259,"type":19},"2025-11-30",{"date":261,"type":19},"2026-12-31",{"name":263,"class":47},"Southeast University, China",{"id":265,"slug":4,"hasResults":10,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":269,"eligibilityCriteria":270,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":271,"enrollmentInfo":272,"targetDuration":4,"studyType":20,"phases":274,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":283,"leadSponsor":285,"locationsCount":4},"100605067","NCT07157696","Advanced Respiratory Monitoring and Oxygen Therapy in Chronically Ill Patients With Acute Respiratory Failure","Advanced Bedside Lung Imaging and Respiratory Muscle Monitoring for Respiratory Support Management in Chronically Ill Patients With Acute Respiratory Failure: From Hospital to Home","HOME- Oxygen","Inclusion Criteria: Adults (≥18 years) with chronic respiratory (e.g., COPD, interstitial lung disease) and\u002For cardiac disease (e.g., heart failure), Clinical indication for long-term oxygen therapy, Capability to manage home-based devices independently or with caregiver assistance Signed informed consent\n\nExclusion Criteria:\n\nLife expectancy \\\u003C 3 months Inability to comply with home follow-up procedures.","80 Years",{"count":273,"type":19},16,[22],"This study is testing whether a new type of home oxygen therapy, called high-flow nasal cannula (HFNC), can improve breathing comfort and quality of life for people with long-term lung or heart conditions who need oxygen after leaving the hospital.\n\nHFNC delivers warm, humidified oxygen at higher flow rates than standard oxygen therapy, which may reduce shortness of breath, improve sleep, and make daily activities easier. The therapy will be provided using the myAirvo™3 device, which also allows doctors to check patients' oxygen levels, heart rate, and symptoms remotely. All patients will also wear a small device (RootiREX) to monitor heart rhythm, sleep quality, and detect breathing pauses at night.\n\nParticipants will try both treatments - HFNC and standard oxygen therapy - for short periods, in random order, so that researchers can directly compare the effects within the same patient. Each treatment period will last two weeks, with a short break in between.\n\nThe main goal of the study is to see whether HFNC reduces shortness of breath (measured by the modified Medical Research Council scale). Other outcomes include comfort, sleep quality, quality of life, oxygen levels, and how well patients are able to use the devices at home.\n\nThe study will last six weeks in total for each participant. Researchers expect that HFNC will improve breathing comfort, stabilize oxygen levels, and reduce the need for hospital visits during this time.",[277,278,25],"Chronic Respiratory Failure","Cardiac Disease, Pulmonary Disease","2025-10-02",{"date":281,"type":40},"2025-10-03",{"date":281,"type":19},{"date":284,"type":19},"2027-01-30",{"name":286,"class":47},"Università degli Studi di Ferrara",{"id":288,"slug":4,"hasResults":10,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":4,"eligibilityCriteria":292,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":226,"enrollmentInfo":293,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":295,"conditions":296,"keywords":298,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":4},"100606987","NCT07182695","Cervical Erector Spinae Plane Block for Dyspnea in Acute Respiratory Failure: A Prospective Cohort","Effect of Bilateral Cervical Erector Spinae Plane Block on Dyspnea in Patients With Acute Respiratory Failure: A Prospective Single-Cohort Study","Inclusion Criteria:\n\n* ICU admission with acute respiratory failure.\n* Patient or legally authorized representative provides consent.\n* Cervical ESP block performed for dyspnea treatment\n\nExclusion Criteria:\n\n* Infection at block site.\n* Known diaphragm paralysis.\n* Known allergy to local anesthetics.\n* Refusal of consent (patient or representative).",{"count":294,"type":19},30,"Dyspnea is common and distressing in patients with acute respiratory failure. In our intensive care unit, some patients receive a cervical erector spinae plane (ESP) block to help relieve dyspnea. This study will observe patients who receive bilateral cervical ESP blocks and measure changes in dyspnea using validated scales at predefined time points over 24 hours. We will also track vital signs, arterial blood gas values, and diaphragm movement on ultrasound.",[25,297],"Dyspnea",[299,300,301,302],"Cervical ESP block","Diaphragm ultrasound","Intensive care","Ultrasound-guided regional anesthesia","2025-09-12",{"date":305,"type":40},"2025-09-19",{"date":307,"type":19},"2025-09-15",{"date":309,"type":19},"2026-03-15",{"name":311,"class":47},"Hacettepe University",{"id":313,"slug":4,"hasResults":10,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":319,"targetDuration":4,"studyType":20,"phases":321,"briefSummary":322,"conditions":323,"keywords":328,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":48},"100492233","NCT05689476","Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVA","Evaluation of the Relationship Between Electrical Activity of the Diaphragm and Respiratory Mechanics During Neurally Adjusted Ventilatory Assist in Lung Transplant Patients and in Patients Affected by Acute Respiratory Failure.","NAVAMECH","Inclusion Criteria:\n\n* Age \\> 18 y.o.\n* Admission to ICU for post-operative monitoring after LTx or acute respiratory failure needing invasive mechanical ventilation\n* Presence of spontaneous breathing activity\n* Sedation titrated to a target RASS between 0 and -2\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Contraindication to nasogastric tube insertion (gastroesophageal surgery in the previous 3 months, gastroesophageal bleeding in the previous 30 days, history of esophageal varices, facial trauma)\n* Increased risk of bleeding with nasogastric tube insertion, due to severe coagulation disorders and severe thrombocytopenia ( i.e., INR \\> 2 and platelets count \\\u003C 70.000\u002Fmm3)\n* Severe hemodynamic instability (noradenaline \\> 0.3 μg\u002Fkg\u002Fmin and\u002For use of vasopressin)\n* Postoperative extracorporeal respiratory support (ECMO)\n* Pre-operative reconditioning of the transplanted lungs by means of ex-vivo lung perfusion (EVLP)\n* Lung retransplantation\n* Failure to obtain a stable EAdi signal",{"count":320,"type":19},40,[22],"Protective ventilatory strategy should be applied to reduce ventilator-induced lung injury (VILI) after Lung Transplantation (LTx) or in case of acute respiratory failure requiring invasive mechanical ventilation. Neurally Adjusted Ventilatory Assist (NAVA) is an assisted ventilation mode in which respiratory support is coordinated by the electrical activity of the diaphragm (EAdi). Aim of the study is to assess the physiological relationship between neural respiratory drive, as assessed by EAdi, and tidal volume, driving pressure, and mechanical power, at different levels of ventilatory assist, in the absence of pulmonary vagal afferent feedback or during acute respiratory failure. Additional parameters will be collected: Pmus, Pocc, transpulmonary pressure etc.",[324,325,326,327,25],"Work of Breathing","Lung Transplantation","Neurally Adjusted Ventilatory Assist","Ventilator-Induced Lung Injury",[329,327,326],"Lung Injury","2025-07-01",{"date":332,"type":40},"2025-07-08",{"date":334,"type":40},"2022-12-27",{"date":336,"type":19},"2025-12-27",{"name":338,"class":47},"University of Padova",{"id":340,"slug":4,"hasResults":10,"nctId":341,"briefTitle":342,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":10,"sex":15,"minAge":4,"maxAge":345,"enrollmentInfo":346,"targetDuration":4,"studyType":20,"phases":348,"briefSummary":349,"conditions":350,"keywords":352,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":48},"100581277","NCT06848218","Music Therapy During NIV Implantation in Pediatric Intensive Care Units","MusiNIV","Target population : Children aged 0 to 17, hospitalized in the pediatric intensive care unit for respiratory failure with indication for NIV.\n\nInclusion Criteria:\n\n* Children aged 0 to 17 inclusive\n* Children hospitalized in pediatric intensive care unit\n* Indication for NIV\n\nExclusion Criteria:\n\n* \\- Severe deafness\n* Clinical condition requiring immediate initiation of NIV\n* Refusal to allow the child to be photographed\n* Child not assessable by FLACC score (paralysis of lower limbs, etc.)\n* Child already receiving NIV respiratory support at home\n* Participation in other ongoing research involving the human person at major risk and constraint (RIPH category 1) or a drug trial according to European regulation 536\u002F2014.\n* Absence of affiliation to a French social security scheme or beneficiary of such a scheme.\n* Subject deprived of liberty (art.L. 1121-6 du CSP)\n* Failure to obtain free and informed written or oral consent and authorization to take photographs from both parents (or from a single parent if the patient is accompanied by only one parent, in accordance with article 1122-2 of the French Public Health Code) or from the legal guardian and\u002For child.","17 Years",{"count":347,"type":19},88,[22],"Non-invasive ventilation makes it possible to avoid intubation and improve patients' quality of life. However, pain is associated with discomfort and could lead to failure of this technique.\n\nThe aim of this study is to measure the effectiveness of music therapy on pain levels during non-invasive ventilation in critically ill children.\n\nTo this end, a pain score (Face Legs Activity Cry Consolability FLACC) will be assessed by raters blinded to the randomization arm during NIV initiation.\n\nThe FLACC score will be compared before and during implementation of NIV between two groups: a control group (without music therapy) and an experimental group (with music therapy).",[25,351],"Non Invasive Ventilation (NIV)",[353,354,355,356,357],"Music Therapy","Non invasive Ventilation","Pediatric intensive care unit","Pain","Comfort","2025-06-30",{"date":330,"type":40},{"date":361,"type":40},"2025-06-18",{"date":363,"type":19},"2027-04-01",{"name":365,"class":47},"University Hospital, Montpellier",""]