[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"countryName\":\"Egypt\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":574},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,2668,0,25,[9,44,78,107,126,147,167,191,209,235,253,276,294,313,330,349,365,384,406,432,451,466,493,520,541],{"id":10,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100054207",false,"NCT07640516","The Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Ultrasound Guided Peripheral Nerve Blocks as a Solo Anesthetic Technique in High Risk Patients Undergoing Unilateral Above Knee Amputation .","The Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Ultrasound Guided Peripheral Nerve Blocks as a Solo Anesthetic Technique in High Risk Patients Undergoing Unilateral Above Knee Amputation : A Randomized Double Blinded Study","Inclusion Criteria:\n\n* \\- Age ≥18 years\n* Both sexes\n* ASA III-IV\n* Documented cardiac disease (e.g., EF \\\u003C 40%, NYHA II or higher)\n* Documented pulmonary disease (e.g., COPD with FEV1 \\\u003C 60%)\n* Scheduled for above-knee amputations\n\nExclusion Criteria:\n\n* Neurological or intellectual disability\n* Drug abuse\n* Allergy to study drugs\n* Pregnancy\n* Contraindications to regional anesthesia (e.g., coagulopathy, local infection)\n* Significant renal or hepatic impairment( plts \\\u003C75000 or INR \\>1.5)\n* Current anticoagulant therapy\n* severe haemodynamically unstability at the time of block performance, defined as map \\> 65 mmhg but achieved by high-dose vasopressors (e.g., norepinephrine ≥ 0.1 mcg\u002Fkg\u002Fmin) after fluid ressuscitation .","ALL","18 Years",{"count":19,"type":20},64,"ESTIMATED","INTERVENTIONAL",[23],"NA","The aim of this study is to compare the analgesic efficacy and safety of dexmedetomidine versus fentanyl as adjuvants to bupivacaine in ultrasound-guided combined supra-inguinal fascia iliaca and proximal sciatic nerve blocks used as a solo anesthetic technique in high-risk patients undergoing unilateral above knee amputation.",[26,27,28],"Analgesia Assessment","Above Knee Amputation","Fentanyl vs Dexmedetomidine",[30],"dexmedetomidine vs fentanyl PNBs AKA","RECRUITING","2026-07-10",{"date":34,"type":35},"2026-07-13","ACTUAL",{"date":37,"type":20},"2026-07-01",{"date":39,"type":20},"2027-03-01",{"name":41,"class":42},"Kasr El Aini Hospital","OTHER",1,{"id":45,"slug":4,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":64,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":43},"100053488","NCT07698925","Diaphragmatic Breathing Exercises on Sleep Disorders un Polycystic Ovarian Syndrome","Effect of Diaphragmatic Breathing on Sleep Disorders in Polycystic Ovarian Syndrome","Inclusion Criteria:\n\n* Women aged from 25-35 years old, Diagnosed with PCOS by gynecologist, diagnosis of PCOS will be based on the 2003 Rotterdam criteria.\n\n  * They have a Pittsburgh sleep quality index (PSQI) score greater than 5.\n  * Not participating in any physical exercise for the previous 3 months.\n  * They have an insomnia severity index score greater than 15.\n  * They have a fatigue severity scale score greater than 36.\n  * Ability to use internet and phone services\n\nExclusion Criteria:\n\n* • Women with autoimmune diseases and cancer.\n\n  * Women with neurological, mental, cardiopulmonary and musculoskeletal disorders.\n  * Pregnant or lactating women.\n  * Women who showed regular adherence to sleeping pills, antidepressants and hormonal replacement agents.\n  * Inability to perform diaphragmatic breathing due to physical limitations.\n  * Women who participate or receive any interventions that could affect their sleep","FEMALE","25 Years","35 Years",{"count":54,"type":20},54,[23],"Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in females in reproductive age and not completely understood. Women with PCOS appear to have an increased frequency of sleep problems. Diaphragmatic Breathing (DB) exercises has positive effects on improving sleep quality. The purpose of this study will evaluate the effect of diaphragmatic breathing exercises on improving sleep quality in polycystic ovarian syndrome women.",[58,59,60,61,62,63],"Polycystic Ovarian Syndrome (PCOS)","Pittsburg Sleep Quality Index","Fatigue Severity Scale","Insomnia Severity Index","Diaphragmatic Breathing Exercise","Sleep Disorders",[65,66,67,68,69,70],"Polycystic ovary syndrome","Diaphragmatic breathing exercises","Sleep disorders","Pittsburg sleep quality index","Insomnia severity index","Fatigue severity scale",{"date":34,"type":35},{"date":73,"type":35},"2025-08-01",{"date":75,"type":20},"2026-08-30",{"name":77,"class":42},"Adly A Adam",{"id":79,"slug":4,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":100,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":43},"100053808","NCT07627360","PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery","Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial","PRO STRESS","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Scheduled for elective laparoscopic major abdominal surgery under general anesthesia with an expected duration greater than 2 hours.\n* Patients with ARISCAT score ≥ 45 indicating high risk for postoperative pulmonary complications.\n\nExclusion Criteria:\n\n* Known hypersensitivity to norepinephrine.\n* Severe left ventricular dysfunction with ejection fraction \\\u003C 35%.\n* Significant cardiac arrhythmia.\n* Uncontrolled hypertension defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg.\n* End-stage renal disease.\n* Requirement for vasopressor support before induction of anesthesia.\n* Emergency surgery.",{"count":86,"type":20},130,[23],"Intraoperative hypotension is commonly treated with fluid administration; however, excessive fluid therapy may contribute to postoperative pulmonary complications. This randomized double-blind controlled trial evaluates whether proactive administration of fixed low-dose norepinephrine reduces intraoperative crystalloid administration while maintaining hemodynamic stability in high-risk patients undergoing laparoscopic abdominal surgery. One hundred and thirty patients will be randomized to receive either norepinephrine infusion (0.03 µg\u002Fkg\u002Fmin) or placebo from induction until skin closure within a protocolized hemodynamic strategy guided by mean arterial pressure and pulse pressure variation.",[90,91,92],"Intraoperative Hypotension","Postoperative Pulmonary Complications (PPCs)","Fluid Over-load",[94,95,96,97,98],"Norepinephrine","Fluid Therapy","Pulmonary Complications","Abdominal Surgery","Vasopressor","NOT_YET_RECRUITING",{"date":34,"type":35},{"date":102,"type":20},"2026-07-15",{"date":104,"type":20},"2026-11",{"name":106,"class":42},"Suez Canal University",{"id":108,"slug":4,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":113,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":43},"100054121","NCT07692425","Internal Jugular Vein Collapsibility Index as a Predictor of Hypotension","Internal Jugular Vein Collapsibility Index as a Predictor of Hypotension After The Induction of General Anesthesia in Geriatric Patients Undergoing Laparoscopic Colorectal Surgeries: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged ≥ 60 years.\n* Scheduled for elective laparoscopic colorectal surgeries under general anesthesia.\n\nExclusion Criteria:\n\n* Patients' refusal of procedure or participation in the study.\n* Severe aortic stenosis, irregular ventricular rhythm (atrial fibrillation or frequent premature ventricular contractions), or any contraindication to perform passive leg raise (PLR).","60 Years",{"count":115,"type":20},70,"OBSERVATIONAL","The internal jugular vein (IJV) collapsibility index has been proposed as a practical alternative of of the inferior vena cava collapsibility index (IVC-CI), as it is easily accessible using bedside ultrasonography. Several studies have demonstrated a correlation between IJV collapsibility and central venous pressure as well as right atrial pressure.",[90],{"date":34,"type":35},{"date":121,"type":20},"2026-07-11",{"date":123,"type":20},"2027-02-11",{"name":125,"class":42},"Ain Shams University",{"id":127,"slug":4,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":132,"maxAge":17,"enrollmentInfo":133,"targetDuration":4,"studyType":21,"phases":135,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":43},"100053347","NCT07694518","Role of Endoscopic Third Ventriculostomy Imanagement of Hydrocephalus in Pediatric Age Group; Clinical and Surgical Outcome","Role of Endoscopic Third Ventriculostomy in Management of Hydrocephalus in Pediatric Age Group; Clinical and Surgical Outcome","Inclusion Criteria:\n\n* cases hydrocephalus diagnosed by CT or MRI.in pediatric age group up to 18 years\n* Both sex (males and females) will be included.\n\nExclusion Criteria:\n\n* cases with hydrocephalus associated with csf infection or hemorrhage\n* Previously operated VP shunt or ETV .\n* Mult cystic hydrocephalus","6 Months",{"count":134,"type":20},30,[23],"Endoscopic third ventriculostomy in cases of hydrocephalus provide less invasive and safe technique than ventriculoperitoneal Shunt also decrease complications of ventriculoperitoneal Shunt",[138],"Hydrocephalus","2026-07-09",{"date":34,"type":35},{"date":142,"type":20},"2026-07-12",{"date":144,"type":20},"2026-12-24",{"name":146,"class":42},"Sohag University",{"id":148,"slug":4,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":50,"minAge":17,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":21,"phases":156,"briefSummary":157,"conditions":158,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":160,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":43},"100053251","NCT07694830","Core-Based Movement and Nutritional Counselling for Stress and Metabolic Outcomes in Overweight Women With Functional Constipation","Effects of Core-Based Movement and Nutritional Counselling on Stress, Cortisol, and Lipid Profiles in Overweight Women With Functional Constipation","Inclusion Criteria:\n\n* Female participants diagnosed with functional constipation according to Rome IV diagnostic criteria.\n* Age between 18 and 45 years.\n* Body mass index between 25 and 29.9 kg\u002Fm².\n* Ability to participate safely in the core-based movement exercise program.\n* Willingness to follow the nutritional counselling program and study procedures.\n\nExclusion Criteria:\n\n* Participants will be excluded if they have any organic gastrointestinal disorder or any disease that may affect gastrointestinal transit or colonic function.\n* Participants with inflammatory bowel disease, concurrent infectious enteritis, malignant tumors, or a history of gastrointestinal surgery, including resection of the stomach, small intestine, or large intestine, will be excluded.\n* Participants receiving steroids, antibiotics, immunosuppressive medications, or routinely using laxatives will be excluded.\n* Participants with hyperthyroidism, hypothyroidism, or other endocrine or metabolic disorders that may affect gastrointestinal function will be excluded.\n* Participants with serious cardiovascular, respiratory, renal, hepatic, hematological, neurological, or psychiatric disorders will be excluded.\n* Participants with a history or current evidence of alcohol abuse within the previous year will be excluded.\n* Participants currently engaged in an intense workout regimen will be excluded.\n* Participants with a musculoskeletal disability that may interfere with exercise applicability, such as cervical or lumbar radiculopathy, will be excluded.","45 Years",{"count":155,"type":20},60,[23],"This study will investigate the effect of core-based movement and nutritional counselling on stress, serum cortisol, and lipid profile in overweight women with functional constipation.\n\nSixty overweight women with functional constipation will be randomly assigned into two equal groups. The study group will include 30 participants who will receive a core-based movement exercise program for 8 weeks, two sessions per week, in addition to guideline-based nutritional counselling. The control group will include 30 participants who will receive guideline-based nutritional counselling only for 8 weeks.\n\nThe outcomes will include perceived stress, serum cortisol level, lipid profile, stool form, sleep quality, and quality of life.",[159],"Functional Constipation",{"date":34,"type":35},{"date":162,"type":20},"2026-08-25",{"date":164,"type":20},"2027-03-30",{"name":166,"class":42},"Cairo University",{"id":168,"slug":4,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":16,"minAge":174,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":21,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":43},"100054154","NCT07698392","Dynamic Neuromuscular Stabilization Versus Corrective Exercises in Upper Cross Syndrome","Effect of Dynamic Neuromuscular Stabilization Versus Corrective Exercises on Pain, Functional Disability, and Postural Alignment in Upper Crossed Syndrome.","DNS\u002FNASM","Inclusion Criteria:\n\n1. Having non-specfic neck Pain.\n2. Patients having a CVA of \\\u003C 52 .\n3. Forward shoulder angle \\> 52 degrees.\n\nExclusion Criteria:\n\n* Participants having conditions such as osteoporosis, blood disease, congestive heart disease, cancer, severe skin sensitization, major mental disease, and frozen shoulder, will be excluded from the study. Neck pain has a specific underlying pathology such as fractures, rheumatoid arthritis, osteoporosis, or whiplash injuries as well as neck pain associated with radiculopathy.","20 Years","40 Years",{"count":177,"type":20},45,[23],"The purpose of the study will be to investigate dynamic neuromuscular stabilization versus National American Academy of Sports Medicine (NASM) corrective exercises on pain, functional disability, cranio-vertebral angle, forward shoulder angle, and thoracic kyphosis in upper cross syndrome.",[181,182,183],"Upper Crossed Syndrome","Upper Cross Syndrome","Upper Crossed Syndorme","2026-07-08",{"date":34,"type":35},{"date":187,"type":20},"2026-11-01",{"date":189,"type":20},"2028-09-30",{"name":166,"class":42},{"id":192,"slug":4,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":21,"phases":199,"briefSummary":200,"conditions":201,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":205,"completionDateStruct":206,"leadSponsor":208,"locationsCount":43},"100054016","NCT07699458","Impact of Adding Integrated Neuromuscular Inhibition Technique to Cervical Stabilization Exercise in Chronic Mechanical Neck Pain","Inclusion Criteria:\n\n1. Age from 18-44 year\n2. Their body mass index will be ranging from (18-25) Kg\u002Fm2\n3. All patient has active cervical trigger point of the upper fiber of the Trapezius detected by pincer palpation\n4. Subjects must have characteristics of trigger points hardened, thickened taut bands in MPS patients.\n\nExclusion Criteria:\n\n1. Individuals with a recent history of neck or back surgery.\n2. Individuals with recent history of trauma or fracture.\n3. Individuals with congenital and pathological disorders of the cervical spine.\n4. Individuals with any psychiatric diseases","44 Years",{"count":198,"type":20},63,[23],"the goal of this clinical trial is to study the Impact of adding integrated neuromuscular inhibition technique to cervical stabilization exercise in chronic mechanical neck pain",[202],"Mechanical Neck Pain","2026-07-07",{"date":34,"type":35},{"date":162,"type":20},{"date":207,"type":20},"2027-01-25",{"name":166,"class":42},{"id":210,"slug":4,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":215,"sex":16,"minAge":174,"maxAge":113,"enrollmentInfo":216,"targetDuration":4,"studyType":21,"phases":218,"briefSummary":219,"conditions":220,"keywords":224,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":228,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":234},"100053656","NCT07698665","Ketamine Versus Dexmedetomidine as an Adjuvant in Scalp Block in Supratentorial Brain Tumor Excision Surgeries","Efficacy of Ketamine Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block in Adults Undergoing Supratentorial Brain Tumor Excision Surgeries for Hemodynamics and Pain Control, Double-blinded Randomized Study","Inclusion Criteria:\n\n* Age from 20 to 60 years, both sexes, American Society of Anesthesiologists (ASA) physical status II-III, Supratentorial tumor excision, Supine Position.\n\nand operation time: less than 6 hours.\n\nExclusion Criteria:\n\n* Patient refusal, disturbed consciousness level (Glasgow Coma Scale \\[GCS\\] \\\u003C 15). Patients who required reintubation during the study period, those not extubated. immediately after surgery, or those who awoke with neurological deficits impairing. pain assessments were excluded from the final analysis, history of psychotic disorders or previous surgeries, Poor cognitive function.\n\nPostictal state or uncontrolled\u002Frecurrent seizures, known allergy to dexmedetomidine or ketamine, difficult intubation (Mallampati score \\> III) or multiple intubation attempts, operation duration \\> 6 hours, renal dysfunction (creatinine \\> 1.2 mg\u002FdL, BUN \\> 20 mg\u002FdL), heart block and patients with chronic headache disorders or those receiving chronic analgesic therapy (for \\>3 months) were excluded.",true,{"count":217,"type":20},90,[23],"Supratentorial brain tumor surgeries are associated with significant nociceptive stimulation and postoperative pain, which may adversely affect patient outcomes. Scalp block has emerged as an effective regional anesthetic technique to improve analgesia and reduce opioid consumption.\n\nObjective: To compare efficacy of ketamine versus dexmedetomidine as adjuvants to bupivacaine in scalp blocks for supratentorial brain tumor surgeries, focusing on analgesia, opioid consumption, and hemodynamic stability.\n\nMethods:\n\nThis randomized double-blinded controlled trial included 80 patients undergoing supratentorial tumor excision, allocated equally into two groups: Group K received bupivacaine with ketamine (2 mg\u002Fkg), and Group D received bupivacaine with dexmedetomidine (1 µg\u002Fkg). Intraoperative hemodynamics, fentanyl consumption, postoperative pain scores (NRS), analgesic requirements, and complications were assessed.",[221,222,223],"Regional Anesthesia Morbidity","Supratentorial Brain Tumor","Acute Pain",[225,226,227],"Scalp block","Dexemetomedine","Supratentorial",{"date":34,"type":35},{"date":230,"type":35},"2026-01-01",{"date":232,"type":20},"2026-07-30",{"name":166,"class":42},2,{"id":236,"slug":4,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":215,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":242,"targetDuration":4,"studyType":21,"phases":243,"briefSummary":244,"conditions":245,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":249,"startDateStruct":250,"completionDateStruct":251,"leadSponsor":252,"locationsCount":43},"100053580","NCT07698652","Diaphragmatic and Box Breathing on Heart Rate Variability and Perceived Stress","Enhancing Physiological and Psychological Resilience: A Comparative Study of Diaphragmatic and Box Breathing in Physical Therapy Students.","HRV DB BB PSS","Inclusion Criteria:\n\n* Academic Status: Currently enrolled, full-time undergraduate Physical Therapy students\n* Age Range: 18-25 years\n* Health Status: Generally healthy individuals with no known chronic respiratory or cardiovascular diseases.\n* Informed Consent: Ability and willingness to provide written informed consent and commit to the 4-week protocol (6 sessions\u002Fweek).\n* Stress Level: A baseline score on the Perceived Stress Scale (PSS) indicating at least moderate stress.\n\nExclusion Criteria:\n\n* Pre-existing Breathing Expertise: Individuals with professional training in yoga (Pranayama), formal meditation, or advanced breath work that might bias the baseline results.\n* Medical Conditions: Diagnosed respiratory conditions (e.g., Asthma, COPD).\n* Cardiovascular issues (e.g., Arrhythmias, Hypertension).\n* Clinical psychological disorders (e.g., Generalized Anxiety Disorder or Panic Disorder) that may require medication.\n* Pharmacological Factors: Use of medications that influence the Autonomic Nervous System (e.g., Beta-blockers, antidepressants, or heavy use of stimulants\u002Fsedatives).\n* Substance Use: Smokers\u002FVapers\n* Excessive Caffeine \"Participants consuming more than 400 mg of caffeine per day (equivalent to approximately 4 standard cups of brewed coffee) will be excluded.\n* Recent Acute Illness: Any respiratory tract infection or fever within two weeks prior to the start of the study",{"count":155,"type":20},[23],"The goal of this clinical trial is to learn if diaphragmatic breathing and box breathing work to enhance resilience and manage stress in physical therapy students. It will also learn about their effects on overall physiological and psychological parameters. The main questions it aims to answer are:\n\nDo these breathing techniques improve heart rate variability (HRV)?\n\nHow do these interventions affect participants' perceived stress levels, cognitive performance, and academic achievement?\n\nResearchers will compare diaphragmatic breathing and box breathing to a control group to see if these non-invasive methods work to improve physiological adaptation and manage stress.\n\nParticipants will:\n\nBe randomly assigned to practice diaphragmatic breathing, practice box breathing, or join a control group Have their heart rate variability (HRV) measured as a primary sign of physiological adaptation Complete assessments to evaluate their perceived stress, cognitive performance, and academic achievement",[246,247,248],"Stress","Psychological Resilience","Healthy Students",{"date":34,"type":35},{"date":37,"type":20},{"date":39,"type":20},{"name":166,"class":42},{"id":254,"slug":4,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":215,"sex":16,"minAge":113,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":21,"phases":262,"briefSummary":263,"conditions":264,"keywords":266,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":271,"startDateStruct":272,"completionDateStruct":273,"leadSponsor":275,"locationsCount":43},"100053918","NCT07699419","Impairment Based Treatment Versus Modified Functional Restoration Program in Chronic Low Back Pain Patients","FIRM-CLBP: a Randomized Controlled Feasibility Trial Comparing Impairment-based Treatment With a Modified Functional Restoration Program in Older Adults With Chronic Low Back Pain","FIRM-CLBP","Inclusion Criteria:\n\n* ≥ 60 years\n* Chronic Non-Specific Low Back Pain (CNSLBP)\n* Pain duration ≥ 12 weeks\n* No identifiable specific spinal pathology\n* Pain Location\n* Pain localized between the 12th rib and gluteal folds\n* With or without non-dermatomal referred pain not extending below the knee\n* Pain Intensity\n* Mean pain intensity ≥ 4\u002F10 on the Numeric Rating Scale (NRS) over the past 7 days\n* Functional Disability\n* Oswestry Disability Index (ODI) ≥ 20% (moderate disability or higher)\n* Mechanical Pain Characteristics\n* Presence of ≥ 2 of the following:\n* Pain aggravated by movement, loading, or prolonged postures\n* Pain relieved by rest or positional change\n* Morning stiffness \\\u003C 30 minutes\n* Absence of constant, non-mechanical night pain Functional Capacity\n* Able to ambulate independently (with or without assistive device)\n* Able to actively participate in an exercise-based rehabilitation program\n* Clinical Stability\n* Stable medication regimen (analgesics, anti-inflammatories, or related drugs) for ≥ 4 weeks\n* No planned changes in pharmacological treatment during the study period\n* Cognitive \\& Communication Ability\n* Able to understand study procedures and follow instructions\n* MMSE ≥ 24 (or equivalent cognitive screening)\n* Consent\n* Provides written informed consent\n\nExclusion Criteria:\n\n* 1\\. Specific Spinal Pathology (\"Red Flags\")\n\n  * Suspected or confirmed:\n  * Spinal fracture\n  * Malignancy\n  * Spinal infection\n  * Inflammatory spondyloarthropathy\n\nClinical indicators:\n\nUnexplained weight loss Fever or systemic illness History of significant trauma\n\n2\\. Radicular or Neurological Involvement\n\n* Radiculopathy defined by ANY of:\n* Dermatomal pain radiating below the knee\n* Progressive motor weakness\n* Objective neurological deficit (sensory, reflex, or motor)\n\n  3\\. Lumbar Spinal Stenosis (Severe)\n* Neurogenic claudication limiting walking to \\\u003C 100 meters, OR\n* Symptoms not relieved by rest or flexion\n\n  4\\. Prior Surgical or Structural Conditions Lumbar spine surgery within the past 12 months\n\n  5\\. Medical Contraindications to Exercise\n* Severe osteoporosis with high fracture risk\n* Uncontrolled cardiovascular, respiratory, or metabolic disease\n* Any condition precluding safe participation in rehabilitation\n\n  6\\. Cognitive or Behavioral Barriers\n* Severe cognitive impairment (MMSE \\\u003C 24)\n* Inability to comply with study procedures\n\n  7\\. Confounding Treatment Factors\n* Participation in structured physiotherapy or rehabilitation within the past 3 months\n* Planned concurrent rehabilitation during the study\n\n  8\\. Psychosocial Confounders Ongoing litigation or compensation claims related to low back pain",{"count":261,"type":20},18,[23],"The aim of this feasibility study is to evaluate the practicality of conducting a future randomized controlled trial comparing two rehabilitation approaches for older adults with degenerative chronic low back pain: impairment-based treatment (IBT) and a modified short Functional Restoration Program (FRP).\n\nImpairment-based treatment is an individualized approach in which interventions are tailored to the patient's specific physical deficits, such as limitations in mobility, strength, and motor control. In contrast, the Functional Restoration Program is a structured, standardized approach focusing on improving overall functional capacity through progressive exercise, movement retraining, and activity-based rehabilitation.\n\nParticipants will be randomly allocated to one of the two groups. Both interventions will be delivered by trained physiotherapists following standardized protocols over a 6-week period, with supervised sessions conducted according to a predefined rehabilitation schedule.",[265],"Chronic Low Back Pain (CLBP)",[267,268,269,270],"LBP","Old age","Impairment","Functional",{"date":34,"type":35},{"date":37,"type":20},{"date":274,"type":20},"2027-01-10",{"name":166,"class":42},{"id":277,"slug":4,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":281,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":283,"conditions":284,"keywords":286,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":289,"startDateStruct":290,"completionDateStruct":291,"leadSponsor":293,"locationsCount":43},"100053931","NCT07698691","The Correlation Between Central Conduction Time and Central Pain Syndrome in Chronic Neck Pain","Inclusion Criteria:\n\n* Participants aged 18-35 years.\n* Normal Body Mass Index (BMI) less than 25 kg\u002Fm2.\n* Both genders were included.\n* having chronic neck pain lasting for more than three months.\n\nExclusion Criteria:\n\n* signs of serious pathology (e.g., malignancy, inflammatory disorders, infection).\n* history of cervical spine surgery.\n* history of trauma or fractures in the cervical spine.\n* presence of vascular syndromes such as vertebrobasilar insufficiency.",{"count":282,"type":20},120,"To investigate the neurophysiological relationship between Central Conduction Time measured via Somatosensory evoked potentials and pain intensity in individuals suffering from chronic neck pain",[285],"Chronic Neck Pain",[287,288,285],"Central Conduction Time","Central Pain Syndrome",{"date":34,"type":35},{"date":32,"type":20},{"date":292,"type":20},"2026-09-01",{"name":166,"class":42},{"id":295,"slug":4,"hasResults":11,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":4,"eligibilityCriteria":299,"healthyVolunteers":11,"sex":16,"minAge":174,"maxAge":300,"enrollmentInfo":301,"targetDuration":4,"studyType":21,"phases":303,"briefSummary":304,"conditions":305,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":307,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":311,"locationsCount":43},"100053707","NCT07700095","Three-Dimensional Bone Augmentation of Severely Atrophied Posterior Mandibular Alveolar Ridges Using Customized-3D Zirconia Barriers Versus Pre-bent Titanium Mesh","Assessment of Three-Dimensional Bone Augmentation of Severely Atrophied Posterior Mandibular Alveolar Ridges Using Customized-3D Zirconia Barriers Versus Pre-bent Titanium Mesh: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients are systemically medically free according to the American Society of Anesthesiologists (ASA) considered as ASA I.\n* Ability to maintain good oral hygiene as evidenced in recall visits.\n* patients who had a partial or completely edentulous alveolar ridge with apparent 3D defect following teeth loss.\n* All patients were free from any local or general disease that may interfere with bone healing and had no history of previous grafting procedure at the designated edentulous ridge.\n* The ridge had to exhibit severe vertical and horizontal (3D) alveolar ridge deficiency with alveolar ridge height less than 7 mm from the alveolar crest to the inferior alveolar canal and width less than 5 mm which was firstly measured by CBCT, or a clinically apparent increase in inter-arch space relative to the adjacent natural teeth.\n* Pre-operative clinical assessment of soft tissue coverage was done to cover the graft and its membrane, in addition to assessment of occlusion and inter-arch distance should allow for the graft, membrane, implan and the future prosthesis.\n\nExclusion Criteria:\n\n* Smoker (\\> 25 cigarettes\u002F day).\n* Patients undergoing radiotherapy or chemotherapy\n* Patients having infection or local lesions in the area of surgery.\n* Patients with diabetes mellitus or bone diseases which may compromise the results.\n* Patient with poor oral hygiene or active periodontal disease.\n* Patient with limited mouth opening.\n* Participation in other clinical trials","50 Years",{"count":302,"type":20},16,[23],"Zirconia can be considered as an alternative and innovative material suitable for GBR because it has high biocompatibility, together with a scarce tissue integration. Zirconia barriers could be a predictable and alternative barrier material for GBR in terms of (i) biocompatibility, (ii) ease of use and removal, (iii) exposure management, (iv) bone regeneration outcomes.",[306],"Mandibular Atrophy",{"date":34,"type":35},{"date":309,"type":35},"2024-08-03",{"date":292,"type":20},{"name":312,"class":42},"Hams Hamed Abdelrahman",{"id":314,"slug":4,"hasResults":11,"nctId":315,"briefTitle":316,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":11,"sex":16,"minAge":175,"maxAge":113,"enrollmentInfo":318,"targetDuration":4,"studyType":21,"phases":319,"briefSummary":320,"conditions":321,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":325,"completionDateStruct":326,"leadSponsor":328,"locationsCount":43},"100053683","NCT07697313","High-intensity Interval Training Versus Moderate Intensity Continuous Training on Gut Microbiota in Non-alcoholic Fatty Liver","Inclusion Criteria:\n\n1. Patients from both genders aged 40 - 60 years old diagnosed with Non-alcoholic Fatty Liver disease by ultrasonography.\n2. Body mass index will range from 30 to 34.9 kg\u002Fm².\n3. Patients with central obesity (waist circumference 90 cm for men and 85 cm for women).\n4. Patients who have taken no regular exercise in the last year (\\\u003C3 times\u002Fweek and 30 min\u002Ftime.\n5. No antibiotic or probiotic use for at least last 3 months.\n6. Medical drugs such as metformin, sulfonylureas, statins, and blood pressure medication were eligible, as well as stable.\n\nExclusion Criteria:\n\n1. History of liver cirrhosis or other chronic liver diseases.\n2. Use of medications affecting gut microbiota (e.g., laxatives, metformin, proton pump inhibitors).\n3. Recent gastrointestinal infections or surgeries.\n4. Diabetes Mellitus type 1 or uncontrolled type 2.\n5. Cardiovascular, respiratory, or musculoskeletal disorders limiting exercise capacity.\n6. Active smokers.\n7. Pregnancy or breastfeeding.\n8. Uncontrolled hypertension.\n9. Communication disorders.\n10. Bleeding disorders.",{"count":155,"type":20},[23],"To compare High-Intensity Interval Training versus moderate intensity continuous training on gut microbiota in Non- Alcoholic Fatty Liver.",[322],"Non-alcoholic Fatty Liver","2026-07-05",{"date":34,"type":35},{"date":32,"type":20},{"date":327,"type":20},"2026-10-10",{"name":329,"class":42},"Horus University",{"id":331,"slug":4,"hasResults":11,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":4,"eligibilityCriteria":335,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":336,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":338,"conditions":339,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":43},"100645410","NCT07681999","Detection of Early Scapular Dyskinesis","Detection of Early Inflammatory Versus Early Mechanical Scapular Dyskinesis","Inclusion Criteria:\n\n* treatment-naïve patients with ankylosing spondylitis (AS), who fulfilled the Assessment of Spondylarthritis Society (ASAS) criteria for axial spondyloarthritis (ax-SpA)\n* Inclusion criterion for the second group (non-AS individuals) was patients complaining of discomfort upon activity.\n\nExclusion Criteria:\n\n* The exclusion criteria of the first group included:\n\n  1. patients with a history of local trauma\n  2. and\u002For surgical intervention,\n  3. neuromascular deficits,\n  4. chronic chest disease and\n  5. other inflammatory autoimmune\u002Frheumatologic conditions.\n* Exclusion criteria for the second group were:\n\n  1. a history of AS or\n  2. other systemic autoimmune\u002F rheumatologic disease.",{"count":337,"type":20},100,"This study is a prospective blind contrast between periscapular muscle thickness measured with MSUS in patients with early AS in comparison to patients with mechanical dyskinesis and to correlate it with EMG findings.",[340],"Scapular Dyskinesis",{"date":342,"type":35},"2026-07-02",{"date":344,"type":35},"2026-06-19",{"date":346,"type":20},"2026-07",{"name":348,"class":42},"Tanta University",{"id":350,"slug":4,"hasResults":11,"nctId":351,"briefTitle":352,"officialTitle":352,"acronym":4,"eligibilityCriteria":353,"healthyVolunteers":11,"sex":16,"minAge":175,"maxAge":113,"enrollmentInfo":354,"targetDuration":4,"studyType":21,"phases":355,"briefSummary":356,"conditions":357,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":359,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":43},"100641257","NCT07661290","Effect of High-Power Laser Therapy on Disc Morphology and Functional Outcome in Patients With Cervical Radiculopathy","Inclusion Criteria:\n\n\\- Adults aged between 40 to 60 years.\n\n• A Body Mass Index (BMI) range of 18.5-35 (normal to overweight) will be required.\n\n• Diagnosed with cervical radiculopathy, confirmed by clinical examination and diagnostic imaging (e.g., MRI).\n\n• Pain intensity level of at least 4 on the Visual Analog Scale (VAS).\n\n• No previous history of surgery on the cervical spine.\n\n• Able to provide informed consent and participate in the study protocol.\n\nExclusion Criteria:\n\n* Pregnant women or those planning to become pregnant. • Individuals with severe comorbidities that could interfere with the study, such as uncontrolled diabetes, cancer, or systemic inflammatory diseases.\n\nIndividuals with severe cervical stenosis or spinal cord compression.\n\n• Individuals any form of malignancy, active infection, or dermatological issues on the neck.\n\n• Patients using opioid analgesics or other strong pain medications that could alter the results.\n\n• Previous treatment with high-power laser therapy within the last six months.",{"count":155,"type":20},[23],"The study aims to evaluate the effectiveness of high-power laser therapy (HPLT) in patients with cervical radiculopathy, focusing on its impact on disc morphology, and overall functional activity",[358],"Radiculopathy",{"date":342,"type":35},{"date":361,"type":35},"2026-06-30",{"date":363,"type":20},"2026-11-20",{"name":166,"class":42},{"id":366,"slug":4,"hasResults":11,"nctId":367,"briefTitle":368,"officialTitle":369,"acronym":4,"eligibilityCriteria":370,"healthyVolunteers":215,"sex":16,"minAge":174,"maxAge":371,"enrollmentInfo":372,"targetDuration":4,"studyType":21,"phases":373,"briefSummary":374,"conditions":375,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":377,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":43},"100635288","NCT07550738","Effect of Pressure-Controlled Volume Guaranteed Versus Volume-Controlled Ventilation Modes on Hemodynamic Outcomes e.g ( SV, CO ) and Respiratory Mechanics During Laparoscopic Abdominal Cancer Surgeries With Exaggerated Trendelenberg Postion","Effect of Pressure-Controlled Volume Guaranteed Versus Volume-Controlled Ventilation Modes on Hemodynamic Outcomes and Respiratory Mechanics During Laparoscopic Abdominal Cancer Surgeries With Exaggerated Trendelenberg Postion : A Randomized Controlled Trial","Inclusion Criteria:\n\n1 - All patients who will be scheduled for elective laparoscopic abdominal cancer surgeries 2- patients aged 20-80 years 3- patients have an American Society of Anesthesiologists (ASA) physical status I-II\n\nExclusion Criteria:\n\n1 - Patients with severe systemic disease (history of myocardial infarction, chronic obstructive, or restrictive lung disease) 2- Obese patients (BMI \\> 30) 3- patients with neurologic or neuromuscular diseases.","80 Years",{"count":155,"type":20},[23],"The primary outcome is to compare the hemodynamic outcomes ( e.g SV , CO and CI ) using The ICON of two different modes of ventilation ( VCV and PC-VG ) during laparoscopic abdominal cancer surgeries with exaggerated trendelenburg position.\n\nAnd the secondary outcomes is to compare the respiratory effects ( e.g atelectasis development , plateau pressure(Pplat) , peak inspiratory pressure(PIP) , dyn. compliance and postoperative inflammatory indicators e.g CRP and WBCs ) of two different modes of ventilation ( VCV and PC-VG ) during laparoscopic abdominal cancer surgeries with exaggerated trendelenburg position.",[376],"PCV-VG Versus VCV Ventilation Mode Effects on Hemodynamics",{"date":342,"type":35},{"date":379,"type":35},"2026-04-01",{"date":381,"type":20},"2027-06",{"name":383,"class":42},"Assiut University",{"id":385,"slug":4,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":389,"eligibilityCriteria":390,"healthyVolunteers":215,"sex":16,"minAge":17,"maxAge":153,"enrollmentInfo":391,"targetDuration":4,"studyType":21,"phases":393,"briefSummary":394,"conditions":395,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":43},"100645064","NCT07677826","Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation","Ffect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation a Randomized Clinical Study","Effect of Coe","Inclusion Criteria:\n\n* Systemically healthy patient of both genders aged from 18-45 years.\n* Presence of bilateral physiologic gingival pigmentation in the anterior maxillary or mandibular region DOPI grades III-IV only.\n* Good oral hygiene.\n* Thick gingival phenotype.\n\nExclusion Criteria:\n\n* Patient clinically diagnosed with periodontitis.\n* Pregnant or lactating females.\n* Patient with previous treatment of gingival hyperpigmentation.\n* History of hypersensitivity to any study material.\n* Patients who are active or previous smokers.",{"count":392,"type":20},20,[23],"This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation.",[396,397],"Depigmentation Treatment","Depigmentation","2026-06-29",{"date":37,"type":35},{"date":401,"type":35},"2026-03-02",{"date":403,"type":20},"2026-12-20",{"name":405,"class":42},"Al-Azhar University",{"id":407,"slug":4,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":4,"eligibilityCriteria":411,"healthyVolunteers":215,"sex":16,"minAge":412,"maxAge":413,"enrollmentInfo":414,"targetDuration":4,"studyType":21,"phases":416,"briefSummary":417,"conditions":418,"keywords":421,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":425,"startDateStruct":426,"completionDateStruct":427,"leadSponsor":429,"locationsCount":43},"100629380","NCT07473921","Supracrestal Socket Shield Technique in Anterior Maxilla. A Case Series","Supracrestal Socket Shield Technique in Anterior Maxilla. A Case Report.","Inclusion Criteria:\n\n* Patients who have a single bounded non-restorable maxillary anterior tooth with opposing natural dentition with no periapical pathosis.\n* Adults above the age of 21.\n* Good oral hygiene.\n* Patient accepts to provide informed consent.\n* Thin intact labial plate of bone (1 mm or less), assessed by CBCT.\n* Intact gingival tissue with at least 2 mm keratinized tissue.\n* Teeth with intact labial root surfaces.\n* Minimum of 3-4 mm of apical bone for primary stability\n\nExclusion Criteria: • Smokers.\n\n* Pregnant and lactating females.\n* Medically compromised patients.\n* Patients with untreated active periodontal diseases.\n* Patients with active infection related to the implant site","21 Years","55 Years",{"count":415,"type":20},5,[23],"Post-extraction labio-palatal ridge collapse is a significant challenge in restorative and implant dentistry particularly in anterior maxilla. Following tooth extraction, marked dimensional alveolar ridge changes occur. The buccal plate of bone in the anterior zone is primarily composed of bundle bone, a tooth dependent structure that derives its blood supply from the periodontal ligament (PDL). The PDL loss after tooth extraction results in rapid resorption of the bundle bone, leading to horizontal and vertical ridge reduction (Araújo and Lindhe, 2005, Schropp et al., 2003). Studies have shown that 50% of ridge width reduction occurs within 12 months, with two thirds of this reduction occurring within the first 3 months (Schropp et al., 2003). Moreover, the labial plate thickness in the anterior maxilla is frequently thinner than 1 mm in the majority of cases (Huynh-Ba et al., 2010). The high incidence of mid-facial recession and soft tissue volume loss is attributed to those biological events.\n\nAlthough IIP has become increasingly popular due to its short treatment time, it doesn't prevent physiological remodeling associated with bundle bone resorption (Araújo and Lindhe, 2005). Consequently, soft tissue collapse and midfacial recession remain common complications, especially in thin periodontal phenotypes (Chappuis et al., 2013, Cosyn et al., 2012). In order to overcome the inevitable consequences of tooth extraction, a variety of ridge preservation techniques were proposed in the literature including; flapless implant placement, bone grafting, soft tissue augmentation procedures, immediate provisionalization, a more palatal orientation of the implant in the socket and the socket shield technique.",[419,420],"Immediate Dental Implant Placement","Anterior Maxilla",[422,423,424],"Esthetic zone","immediate implant placement","socket shield",{"date":37,"type":35},{"date":292,"type":20},{"date":428,"type":20},"2027-11-01",{"name":430,"class":431},"International Dental Contiuing Education","NETWORK",{"id":433,"slug":4,"hasResults":11,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":215,"sex":16,"minAge":17,"maxAge":438,"enrollmentInfo":439,"targetDuration":4,"studyType":21,"phases":440,"briefSummary":441,"conditions":442,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":444,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":43},"100623993","NCT07403851","Effect of Scanning Technology on the Accuracy of Digitally Customized Intraradicular Attachments","Effect of Scanning Technology on the Accuracy of Digitally Customized Intraradicular Attachments: A Cross Overstudy","Inclusion Criteria:\n\n1. Patients aged 18-65 years.\n2. Endodontically treated teeth requiring intra-radicular attachments.\n3. Adequate oral hygiene .\n4. Periodontally Compromised Teeth: When some teeth have reduced bone support but can still be maintained as overdenture abutments with proper treatment.\n\nExclusion Criteria:\n\n1. Severely Compromised Remaining Teeth: If the remaining teeth have poor prognosis due to extensive decay or severe periodontal disease.\n2. Severe Bone Loss Around Abutment Teeth: If the remaining teeth do not provide adequate support, they may fail early, leading to additional complications.\n3. Severe Malocclusion: Where occlusal discrepancies make overdenture placement difficult.\n4. Limited inter-arch Space: cann't accommodate the overdenture components. 5 . Poor Oral Hygiene: increase the risk of decay or periodontal issues in retained abutments.","65 Years",{"count":155,"type":20},[23],"This study aims to evaluate the accuracy of intra-radicular attachments fabricated by direct scanning using three different scanners in vivo. The primary outcome will be the accuracy of the fabricated attachments, while secondary outcomes will includepatient-reported comfort during procedure of taking intraradicular attachment conventional impression and direct scanning.",[443],"Scanning Devices",{"date":37,"type":35},{"date":446,"type":35},"2026-05-01",{"date":448,"type":20},"2026-08-01",{"name":450,"class":42},"October 6 University",{"id":452,"slug":4,"hasResults":11,"nctId":453,"briefTitle":454,"officialTitle":454,"acronym":4,"eligibilityCriteria":455,"healthyVolunteers":215,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":456,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":458,"conditions":459,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":461,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":465,"locationsCount":43},"100585095","NCT06897904","Basic Hematological Parameters and Coagulation Profile in Type 1 Diabetic Children","Inclusion Criteria:\n\n* Age from one month to 18 year.\n* Both sexes.\n* Patients known to have type 1 diabetes.\n\nExclusion Criteria:\n\n* Patients less than one month and more than 18years.\n* history of bleeding disorders or anemia unrelated to diabetes.\n* Otherc types of diabetes .",{"count":457,"type":20},110,"Diabetes mellitus is a group of chronic metabolic diseases characterized by hyperglycemia .Type 1 diabetes is a heterogeneous disease related to the destruction of pancreatic beta cells and is a result of absolute lack of insulin\n\n* Diabetes mellitus has been traditionally looked upon as a disease of adults (except Type I diabetes), however it can affect individuals of any age. Given the peculiarities and problems that it carries, diabetes in children and adolescents poses special challenges to the entire society. Diabetes is the second commonest chronic disease occurring in 1 in every 1500 children by age 5 and in 1 in 350 children by age 8 . Microvascular (retinopathy, neuropathy, and nephropathy) Aim of the research to assess basic hematological parameters and coagulation profiles among type 1 diabetic children and compare them with healthy controls and macrovascular (coronary artery disease, peripheral vascular disease, and cerebrovascular disease) atherothrombotic complications may occur in children and adolescents, depending on the duration of diabetes, the degree of metabolic control, and other factorssuch as genetics . Diabetes mellitus can cause blood disorders such as deformity of red blood cells and increase their adhesion \\[6\\].It has an effect on the function of red blood cells through the interaction with the membrane and intracellular components . Red blood cell distribution width (RDW) is a measure of the difference in the size of red blood cells. An increase in RDW can be caused by anemia or nutritional deficiencies related to anemia\n* Studies have shown that the average number of red blood cells, hemoglobin and hematocrit in diabetic patients is lower than the control group, which indicates the presence of anemia in diabetic patients .",[460],"Type 1 Diabetes Mellitus",{"date":361,"type":35},{"date":463,"type":35},"2025-04-01",{"date":448,"type":20},{"name":383,"class":42},{"id":467,"slug":4,"hasResults":11,"nctId":468,"briefTitle":469,"officialTitle":470,"acronym":471,"eligibilityCriteria":472,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":473,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":475,"conditions":476,"keywords":478,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":484,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":489,"locationsCount":492},"100540241","NCT06314282","INTERSTELLAR - International Study Evaluating Lupus Outcomes After Anifrolumab Real World Use","INTERSTELLAR - Multi-National, Observational, Prospective, Post-Launch, Effectiveness Study Among SLE Patients Receiving Anifrolumab in Routine Clinical Practice","INTERSTELLAR","Inclusion Criteria:\n\n1. Aged 18 years or older at study enrolment.\n2. Fulfilled the 2019 EULAR\u002FACR criteria1 for SLE at the time of study entry.\n3. Prescribed anifrolumab for their SLE treatment for the first time, according to approved country-specific label.\n4. It is important to note that a physician decision to prescribe anifrolumab will need to occur prior to any study-related discussion.\n5. In countries where prescription reimbursements are authorized on a case-by-case basis, authorization (ie, patient access to treatment) will be required for study entry.\n6. Provided informed consent to participate in the study.\n7. Willing and able to participate in all required study evaluations and procedures.\n\nExclusion Criteria:\n\n1. Currently participating in an anifrolumab early access\u002Fcompassionate use program or an interventional clinical trial with an investigational product.\n2. Previous exposure to anifrolumab as part of a clinical trial or early access program.\n3. Documented diagnosis of severe or rapidly progressive Class III or IV glomerulonephritis requiring induction therapy (mycophenolate mofetil \\[MMF\\]\u002Fcyclophosphamide \\[CYC\\] + high dose steroids), isolated Class V lupus nephritis, or active severe or unstable neuropsychiatric lupus.\n4. Any other condition which the investigator deems to limit a patient's ability to understand the informed consent or complete the PROs.",{"count":474,"type":20},200,"INTERSTELLAR study will generate critical prospective real-world evidence on the benefits of adding Anifrolumab to standard of care treatment for SLE in routine clinical practice, to inform physicians, payers and patients. The study will use clinical assessments that are relevant for SLE-treating physicians in routine clinical practice, as well as introduce a specific measure for skin manifestations to affirm the potency of anifrolumab in treating SLE-related skin manifestations. The study will use standardized objectives, inclusion\u002Fexclusion criteria and outcome measures across all countries participating in this study including GCC (Qatar, KSA), Mexico, CAMCAR (Costa Rica, Panama, Dominican Republic), Colombia, Argentina, Taiwan, and Egypt, and any other countries that may be included in the study, in order to facilitate a comparison and analysis across all countries included in this study.",[477],"Systemic Lupus Erythematosus (SLE)",[479,480,481,482,483],"SLE","Systemic lupus erythematosus","autoimmune disease","Lupus","Anifrolumab",{"date":361,"type":35},{"date":486,"type":35},"2024-10-22",{"date":488,"type":20},"2027-12-31",{"name":490,"class":491},"AstraZeneca","INDUSTRY",32,{"id":494,"slug":4,"hasResults":11,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":498,"eligibilityCriteria":499,"healthyVolunteers":11,"sex":16,"minAge":500,"maxAge":501,"enrollmentInfo":502,"targetDuration":4,"studyType":21,"phases":504,"briefSummary":505,"conditions":506,"keywords":508,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":514,"startDateStruct":515,"completionDateStruct":517,"leadSponsor":519,"locationsCount":43},"100644916","NCT07676695","Twin-Block and LIPUS for TMJ Outcomes in Skeletal Class II Patients","Evaluation of the Efficacy of Early Treatment of Skeletal Class II Patients With Twin-block in Conjunction With Low Intensity Pulsed Ultrasound on Temporomandibular Joint Region: a Prospective Clinical Trial","AlAzharU","Inclusion Criteria:\n\n* Skeletal class II due to retrognathic mandible.\n* Angle's class II Molar relationship.\n* All patients involved in the study were in stages II and III based on the modified cervical vertebral maturation stages (CVMS) by Bacetti et al.5\n* Proclined upper incisors\n* Increased overjet \\> 5 mm.\n* Aligned lower arch or average inclination\n* Minimal crowding of lower arch.\n* No history of previous orthodontic treatment.\n\nExclusion Criteria:\n\n* Skeletal class II due to prognathic maxilla.\n* Patient with gross facial asymmetry.\n* Previous orthodontic or orthopedic treatment.\n* Clinical signs and symptoms of any Temporomandibular joint disorders.\n* Increased anterior facial vertical dimension.\n* Poor oral hygiene.","10 Months","14 Months",{"count":503,"type":20},24,[23],"Evaluation of the efficacy of early treatment of skeletal class II patients with twin-block in conjunction with low intensity pulsed ultrasound on temporomandibular joint region: a prospective clinical trial",[507],"CLASS II DIVISION 1 MALOCCLUSION",[509,510,511,512],"Class II div 1","Twin Block","CBCT","LIPUS","2026-06-27",{"date":361,"type":35},{"date":516,"type":35},"2026-06-18",{"date":518,"type":20},"2027-06-30",{"name":405,"class":42},{"id":521,"slug":4,"hasResults":11,"nctId":522,"briefTitle":523,"officialTitle":524,"acronym":4,"eligibilityCriteria":525,"healthyVolunteers":11,"sex":16,"minAge":174,"maxAge":175,"enrollmentInfo":526,"targetDuration":4,"studyType":21,"phases":528,"briefSummary":529,"conditions":530,"keywords":532,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":536,"startDateStruct":537,"completionDateStruct":539,"leadSponsor":540,"locationsCount":43},"100645024","NCT07675655","Mulligan Mobilization Versus PNF Technique in SIS","Shoulder Mulligan Mobilization Versus Proprioceptive Neuromuscular Facilitation Technique In Subacromial Impingement Syndrome","Inclusion Criteria:\n\n1. Sixty nine Males and females subjects with SIS, age between 20-40 years old and body mass index (BMI) 18-27.9 kg\u002Fm2\n2. The SIS group will be limited to patients who had history of shoulder pain of \\>1-week duration.\n3. Pain localized at the proximal anterolateral shoulder region.\n4. Patients with subacromial pain syndrome with positive results of 3 of 5 tests: painful arc, pain or weakness with resisted external rotation, Neer test, Hawkins Kennedy test, and Jobe\u002Fempty can test.\n\nExclusion Criteria:\n\n* Patients will be excluded if they had any of the following conditions:\n\n  1. Open wounds, infection, acute injuries, swelling, rheumatoid arthritis, reflex sympathetic syndrome, or adhesive capsulitis.\n  2. BMI greater than 28 kg\u002Fm².\n  3. History of shoulder girdle fractures and dislocation, shoulder surgery in the last 12 months or full thickness rotator cuff tear.\n  4. History of systemic or neurological disorder, cervical radiculopathy and subjects who had received physical therapy treatment for their shoulder within the past three months.\n  5. History of corticosteroid injection in the shoulder region less than 12 weeks previously.",{"count":527,"type":20},69,[23],"To investigate the differences between adding Mulligan mobilization and PNF to the conventional physical therapy program on shoulder pain, function, shoulder muscles strength, glenohumeral flexion, abduction, external rotation, and internal rotation ROM, scapular symmetry, and pectoralis minor length in patients with SIS.",[531],"Subacromial Impingement Syndrome",[533,534,535],"Rotator Cuff Impingement Syndrome","PROPRIOCEPTIVE NEUROMUSCLAR FACILITATION TECHNIQUE","mulligan mobilization",{"date":361,"type":35},{"date":538,"type":35},"2025-09-02",{"date":448,"type":20},{"name":166,"class":42},{"id":542,"slug":4,"hasResults":11,"nctId":543,"briefTitle":544,"officialTitle":545,"acronym":546,"eligibilityCriteria":547,"healthyVolunteers":215,"sex":16,"minAge":17,"maxAge":153,"enrollmentInfo":548,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":549,"conditions":550,"keywords":555,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":569,"startDateStruct":570,"completionDateStruct":571,"leadSponsor":573,"locationsCount":43},"100645326","NCT07682142","HAMSTRING TIGHTNESS AND LUMBAR LORDOSIS ANGLE ACROSS FUNCTIONAL SITTING POSTURES","CORRELATION BETWEEN HAMSTRING TIGHTNESS AND LUMBAR LORDOSIS ANGLE ACROSS FUNCTIONAL SITTING POSTURES IN SEDENTARY ADULTS.","LLA-HT","Inclusion Criteria:\n\n* Healthy adults aged 18-45 years.\n* Sedentary occupation requiring \\> 6 hours of sitting per day.\n* Active Knee Extension (AKE) angle \\>15°.\n* Bilateral hamstring tightness.\n* Sedentary individual as determined by IPAQ (MET≤ 600 min\u002Fweek).\n* Asymptomatic for low back pain at the time of testing.\n\nExclusion Criteria:\n\n* History of significant low back pain requiring medical treatment in the past 12 months.\n* Previous spinal surgery or structural spinal deformities.\n* Lower extremity injury or surgery within the past 6 months.\n* Neurological disorders affecting sensation or movement.\n* Pregnant female or get birth in the last year.\n* Body mass index (BMI) ≥ 30 kg\u002Fm².\n* postural deviations resulting from shortening of the iliopsoas and erector spinae or insufficiency of the core stabilizers and hip extensors",{"count":457,"type":20},"The goal of this observational study is to learn about the relationship between hamstring tightness and the lumbar lordosis angle in sedentary adults across different sitting postures. The main question it aims to answer is:\n\nIs hamstring tightness related to the lumbar lordosis angle across three functional sitting postures (upright, slumped, and forward-leaning)? It also asks whether hamstring tightness differs between men and women, whether it differs between the dominant and non-dominant leg, and whether the lumbar lordosis angle differs between men and women across the three postures.\n\nParticipants will have their hamstring tightness measured with the Active Knee Extension test and their lumbar lordosis angle measured with a bubble inclinometer while sitting in each of the three postures.",[551,552,553,554],"Hamstring Tightness","Lumbar Lordosis","Sedentary Behavior","Posture Sitting Position",[556,557,558,559,560,561,562,563,564,565,566,567,568],"Hamstring tightness","Lumbar lordosis","Sitting posture","Functional sitting postures","Sedentary adults","Active Knee Extension test","AKE test","bubble inclinometer","Pelvic tilt","Lumbopelvic rhythm","Limb dominance","Posterior pelvic tilt","Spinopelvic alignment",{"date":342,"type":35},{"date":448,"type":20},{"date":572,"type":20},"2026-12-01",{"name":166,"class":42},""]