[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"countryName\":\"Pakistan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":654},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,1124,0,25,[9,48,83,109,136,169,195,218,243,273,297,327,352,373,392,412,441,470,501,523,542,568,595,616,635],{"id":10,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100054206",false,"NCT06568315","Co-administration of Calcium and Multiple Micronutrient Supplements for Maternal and Newborn Hemoglobin and Iron Status","Co-administration of Calcium and Multiple Micronutrient Supplements for Maternal and Newborn Hemoglobin and Iron Status: A Randomized Non-inferiority Trial in Burkina Faso and Pakistan","CaMMS","Inclusion Criteria:\n\n* Burkina Faso: married or unmarried pregnant women aged ≥15 years\n* Pakistan: married pregnant women ≥18 years\n* Willing to receive all antenatal care at a study clinic\n* Willing to stop iron folic acid supplementation to receive the study intervention\n* Hb ≥70 g\u002FL\n* 6\\\u003C20 weeks of gestation based on fetal ultrasound\n\nExclusion Criteria:\n\n* Burkina Faso: \\\u003C15 years or unmarried pregnant women \\\u003C18 years without consent from parent \u002F guardian\n* Pakistan: pregnant women \\\u003C18 years.\n* Unwilling to receive antenatal care at a study clinic\n* Unwilling to stop iron folic acid supplementation to receive the study intervention\n* Hemoglobin \\\u003C 70 g\u002FL\n* \\\u003C6 weeks of gestation or ≥20 weeks of gestation\n* Non-viable or extrauterine pregnancy\n* Any contraindications to study supplements",true,"FEMALE","15 Years",{"count":21,"type":22},3200,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","The World Health Organization (WHO) currently recommends the pregnant women receive iron-containing supplements and, in settings where calcium intake is low, calcium supplements. Supplements are to be taken at two separate times of the day as calcium may interfere with iron absorption. The goal of this clinical trial is to learn whether taking daily calcium supplements and iron-containing multiple micronutrient supplements together, at the same time, has any negative impact on the hemoglobin or iron status of pregnant women or the woman's infants. Participants will be randomly assigned and counseled to either take the supplements together every morning or to take the multiple micronutrient supplement in the morning and the calcium supplement in the evening. Participants will visit the antenatal clinic monthly and be asked to provide a blood sample in early, mid, and late pregnancy. Researchers will also take blood samples from infants at the time of birth.",[28],"Anemia, Iron Deficiency",[30,31,32,33,34],"calcium","iron","supplementation","anemia","pregnancy","RECRUITING","2026-07-10",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":39},"2025-08-25",{"date":43,"type":22},"2026-08",{"name":45,"class":46},"Johns Hopkins Bloomberg School of Public Health","OTHER",2,{"id":49,"slug":4,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":54,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":60,"conditions":61,"keywords":67,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":75,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100053344","NCT07684989","Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia","Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia: Hemodynamic Stability and Recovery Profile in Elderly Patients Undergoing Lower Limb Orthopedic Surgery","Inclusion Criteria:\n\n* Male or female patients aged 65 years and above.\n* Patients scheduled for elective lower limb orthopedic surgery under spinal anesthesia.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Patients willing to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Refusal to participate in the study.\n* Contraindications to spinal anesthesia (e.g., infection at puncture site, coagulopathy, severe hypovolemia, raised intracranial pressure).\n* Known hypersensitivity or allergy to bupivacaine.\n* Severe valvular heart disease.\n* Significant cardiac arrhythmias.\n* Uncontrolled hypertension.\n* Severe hepatic or renal impairment.\n* Pre-existing neurological disorders affecting lower limb motor or sensory function.\n* Severe spinal deformity or previous lumbar spine surgery interfering with spinal anesthesia.\n* Cognitive impairment or inability to provide informed consent.\n* Emergency orthopedic procedures.","ALL","65 Years",{"count":57,"type":22},180,[59],"PHASE4","The goal of this randomized controlled trial is to determine whether low-dose hyperbaric bupivacaine provides better hemodynamic stability and postoperative recovery compared with standard-dose hyperbaric bupivacaine in elderly patients undergoing lower limb orthopedic surgery under spinal anesthesia.\n\nThe main questions it aims to answer are:\n\n* Does low-dose hyperbaric bupivacaine reduce the incidence of intraoperative hypotension and bradycardia compared with standard-dose hyperbaric bupivacaine?\n* Does low-dose hyperbaric bupivacaine improve postoperative recovery profile compared with standard-dose hyperbaric bupivacaine?\n\nResearchers will compare elderly patients receiving low-dose hyperbaric bupivacaine with those receiving standard-dose hyperbaric bupivacaine to determine whether a lower intrathecal dose improves cardiovascular stability and recovery without compromising the effectiveness of spinal anesthesia.\n\nParticipants will:\n\n* Provide written informed consent before enrollment.\n* Undergo elective lower limb orthopedic surgery under spinal anesthesia.\n* Be randomly assigned to receive either low-dose or standard-dose hyperbaric bupivacaine.\n* Have their blood pressure, heart rate, and other vital signs monitored throughout the surgical procedure.\n* Be assessed for intraoperative hypotension and bradycardia according to predefined study criteria.\n* Be evaluated for postoperative recovery parameters, including motor recovery and readiness for postoperative recovery and mobilization.\n\nThe information obtained from this study may help identify a safer and more effective spinal anesthetic technique for elderly patients undergoing orthopedic surgery.",[62,63,64,65,66],"Anesthesia, Spinal","Orthopedic Procedures","Postoperative Recovery in Elderly Patients","Hemodynamics","Bupivacaine",[68,69,70,71,72,73],"Low-Dose Hyperbaric Bupivacaine","Standard-Dose Hyperbaric Bupivacaine","Spinal Anesthesia","Geriatric Anesthesia","Lower Limb Orthopedic Surgery","Hemodynamic Stability","NOT_YET_RECRUITING",{"date":38,"type":39},{"date":77,"type":22},"2026-07-01",{"date":79,"type":22},"2027-06-30",{"name":81,"class":46},"Mayo Hospital Lahore",1,{"id":84,"slug":4,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":54,"minAge":89,"maxAge":55,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":102,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":82},"100053865","NCT07694999","Ice Packs Versus Cold Baths Combined With Standard Exercise Therapy for Plantar Fasciitis","Comparative Efficacy of Ice Packs Versus Cold Baths With Standard Exercise Therapy in the Management of Plantar Fasciitis","Inclusion Criteria:\n\n* Adults aged 18 to 65 years.\n* Clinical diagnosis of unilateral or bilateral Plantar Fasciitis.\n* Heel pain localized to the medial calcaneal tubercle.\n* Positive Windlass test.\n* Pain intensity of ≥4 on the Visual Analogue Scale (VAS) at baseline.\n* Willing and able to provide written informed consent.\n* Willing to comply with the study protocol and attend all treatment and assessment sessions.\n\nExclusion Criteria:\n\n* History of foot or ankle surgery within the previous 6 months.\n* Corticosteroid injection for plantar fasciitis within the previous month.\n* Neurological disorders affecting the lower limb.\n* Peripheral vascular disease or other vascular disorders affecting the lower limb.\n* Open wounds, skin infections, or contraindications to cryotherapy.\n* Pregnancy.\n* Participation in another interventional clinical trial during the study period.\n* Inability to follow the study protocol or complete outcome assessments.","18 Years",{"count":91,"type":22},40,[93],"NA","This randomized controlled trial aims to compare the effectiveness of ice pack therapy and cold bath immersion when combined with standard exercise therapy in adults with plantar fasciitis. Plantar fasciitis is a common cause of heel pain that can limit daily activities and reduce quality of life. Participants will be randomly assigned to receive either ice pack therapy or cold bath therapy in addition to the same standardized exercise program. The primary outcome will be pain intensity measured using the Visual Analogue Scale (VAS), and the secondary outcome will be foot function measured using the Foot Function Index (FFI). The findings of this study may help identify the more effective cryotherapy method for reducing pain and improving function in individuals with plantar fasciitis.",[96],"Plantar Fasciitis",[98,99,100,101],"Ice Pack","Cold Bath","Foot Function Index","Visual Analogue Scale",{"date":38,"type":39},{"date":104,"type":39},"2026-02-17",{"date":106,"type":22},"2026-07-07",{"name":108,"class":46},"Ibadat International University, Islamabad",{"id":110,"slug":4,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":54,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":125,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":131,"startDateStruct":132,"completionDateStruct":133,"leadSponsor":135,"locationsCount":82},"100054132","NCT07694804","Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy","Isolated Versus Combined Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy","PNF-TOT-CP","Inclusion Criteria:\n\n* Children aged 6 to 12 years.\n* Clinical diagnosis of spastic diplegic cerebral palsy.\n* Gross Motor Function Classification System (GMFCS) Levels I-III.\n* Ability to understand and follow simple verbal instructions.\n* Medically stable and able to participate in physiotherapy sessions.\n* Parent or legal guardian willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Orthopedic surgery involving the upper or lower extremities within the previous 6 months.\n* Botulinum toxin injections administered within the previous 6 months.\n* Severe visual, hearing, or cognitive impairments that would interfere with assessment or treatment.\n* Uncontrolled epilepsy or other unstable neurological or medical conditions.\n* Fixed upper extremity contractures or musculoskeletal deformities preventing participation in the intervention.\n* Participation in another structured upper extremity rehabilitation program during the study period.\n* Failure to obtain informed consent from a parent or legal guardian.","6 Years","12 Years",{"count":119,"type":22},63,[93],"Children with spastic diplegic cerebral palsy often experience upper extremity impairments, including reduced coordination, muscle control, and functional hand use, which limit independence in daily activities. Proprioceptive Neuromuscular Facilitation (PNF) and Task-Oriented Training (TOT) are commonly used rehabilitation approaches to improve motor function; however, evidence comparing their individual and combined effects on upper extremity function remains limited.\n\nThis randomized controlled trial aims to compare the effects of PNF alone, TOT alone, and a combined PNF plus TOT intervention on upper extremity function in children with spastic diplegic cerebral palsy. Sixty-three children aged 6 to 12 years with Gross Motor Function Classification System (GMFCS) levels I to III will be randomly assigned to one of three intervention groups. Each group will receive supervised 45-minute treatment sessions, three times per week for six weeks.\n\nUpper extremity function, functional independence, and joint range of motion will be assessed at baseline, mid-intervention (3 weeks), and post-intervention (6 weeks) using the Melbourne Assessment of Unilateral Upper Limb Function (MA2), Pediatric Evaluation of Disability Inventory-Functional Skills Scale (PEDI-FSS), and goniometric measurements. The findings of this study are expected to provide evidence regarding the most effective rehabilitation approach for improving upper extremity function in children with spastic diplegic cerebral palsy.",[123,124],"Cerebral Palsy","Spastic Diplegia",[126,127,128,129,130],"Spastic diplegic cerebral palsy","Proprioceptive neuromuscular facilitation","Task-oriented training","Motor function","Functional independence",{"date":38,"type":39},{"date":104,"type":39},{"date":134,"type":22},"2026-07-08",{"name":108,"class":46},{"id":137,"slug":4,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":150,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":47},"100053733","NCT07551011","Impact of Behavioural Modification Working Toolkit Among Women With Gestational Diabetes Mellitus and Hypertension","Impact of Behavioural Modification Working Toolkit Among Women With Gestational Diabetes Mellitus and Hypertension: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women aged 15-49 years.\n* Gestational age between 16 and 20 weeks at enrolment.\n* Diagnosed with both gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH).\n* At least one prior antenatal visit at the study site.\n\nExclusion Criteria:\n\n* Pre-existing diabetes mellitus or chronic hypertension prior to pregnancy.\n* Pre-existing renal disease, thyroid disease, or major hematological disorders.\n* Multiple pregnancy (e.g., twins, triplets).\n* Severe psychiatric illness.","49 Years",{"count":144,"type":22},220,[93],"This trial aims to evaluate the effectiveness of a Behavioral Modification Working (BMW) Toolkit in improving glycemic control and blood pressure among pregnant women diagnosed with both GDM and PIH.",[148,149],"Gestational Diabetes Mellitus in Pregnancy","Hypertension ,Pregnancy",[151,152,153,154,155,156,157,158,159,160],"Gestational Diabetes Mellitus","Pregnancy Induced Hypertension","Maternal health","Childbirth","Risk Factors","intervention","BMW Toolkit","Dietary habits","Physical activity","sleep pattern","2026-07-09",{"date":38,"type":39},{"date":164,"type":39},"2026-04-21",{"date":166,"type":22},"2027-01-15",{"name":168,"class":46},"University of the Punjab",{"id":170,"slug":4,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":54,"minAge":174,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":178,"phases":4,"briefSummary":179,"conditions":180,"keywords":182,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":194},"100268233","NCT02771236","Clinical and Molecular Studies in Families With Inherited Eye Disease","* INCLUSION CRITERIA:\n\nTo be eligible, the following inclusion criteria must be met, where applicable;\n\n1. Participant must be four years of age or older.\n2. Participant must understand and sign the protocol s informed consent document.\n3. Individuals or family members of individuals with inherited eye diseases, either congenital, childhood, or age related.\n4. All participants must be able to cooperate with study examination and phlebotomy.\n\nEXCLUSION CRITERIA:\n\nA participant is not eligible if any of the following exclusion criteria are present:\n\n1. Participant has a disease, infection, or trauma that mimics inherited cataracts, retinal degenerations, glaucoma, etc.\n2. Participant has a significant active infection (an infection requiring treatment as determined by the investigator) or a history of chronic or recurrent infections.\n3. Participant requires sedation for study purposes.","4 Years","120 Years",{"count":177,"type":22},5000,"OBSERVATIONAL","Background:\n\nGenes are the basic units of heredity. When genes are changed, certain cells don t work like they should. Researchers want to try to better understand the genetic conditions that are linked with inherited eye diseases.\n\nObjective:\n\nTo try to identify the genes linked to the development of inherited eye diseases.\n\nEligibility:\n\nPeople ages 4 and older who have or have a family member with an inherited eye disease\n\nDesign:\n\nParticipants will be screened with medical history and medical records.\n\nParticipants will have one visit that will take 3-4 hours. This will include:\n\nMedical and family history\n\nEye exam: This includes the pupil being dilated.\n\nElectroretinography: A small electrode is taped to the forehead. Participants sit in the\n\ndark with their eyes patched for 30 minutes. Then numbing drops and contact lenses are put in\n\nthe eyes. They will watch flashing lights.\n\nBlood tests\n\nSaliva sample: They will spit into a container or have the inside of their cheek swabbed.\n\nGenetic testing will be done on participants blood or saliva.\n\nParticipants may meet with the researchers to discuss their genetic tests.\n\n...",[181],"Inherited Eye Disease",[183,184],"Genetics","Natural History",{"date":186,"type":39},"2026-07-02",{"date":188,"type":39},"2016-10-04",{"date":190,"type":22},"2032-01-01",{"name":192,"class":193},"National Eye Institute (NEI)","NIH",10,{"id":196,"slug":4,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":54,"minAge":201,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":23,"phases":205,"briefSummary":206,"conditions":207,"keywords":209,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":82},"100645283","NCT07681661","Massage Gun vs Deep Friction Massage for Upper Trapezius Trigger Points","Effectiveness Of Massage Gun Therapy Versus Deep Friction Massage On Upper Trapezius Trigger Points","Inclusion Criteria: Presence of active trigger points in the upper trapezius (confirmed by palpation, referred pain pattern, and pain reproduction)(travell and simson's method).\n\nModerate to severe pain (VAS\\>4\u002F10). No prior treatment for neck\u002Fshoulder pain in past 4 weeks. Age 24-45 years (young adults according to WHO classification) Both genders Exclusion Criteria:History of cervical spine surgery or severe musculoskeletal pathology.\n\nNeurological deficits. Systemic disease (e.g., rheumatoid arthritis, fibromyalgia). Recent trauma or fractures in the neck\u002Fshoulder region. Current pregnancy.\n\n\\-","24 Years","45 Years",{"count":204,"type":22},46,[93],"This study compares the effectiveness of Massage Gun Therapy and Deep Friction Massage in individuals with upper trapezius myofascial trigger points. The interventions will be evaluated for their effects on pain intensity, pressure pain threshold, cervical range of motion, and neck disability. The aim is to determine which treatment is more effective in reducing pain and improving functional outcomes.",[208],"Myofacial Trigger Points of Upper Trapezius",[210],"Myofascial Pain Syndromes Trigger Points Neck Pain Massage Musculoskeletal Pain Physical Therapy Modalities Rehabilitation","2026-06-26",{"date":186,"type":39},{"date":214,"type":39},"2026-01-01",{"date":216,"type":22},"2026-09-01",{"name":108,"class":46},{"id":219,"slug":4,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":54,"minAge":89,"maxAge":224,"enrollmentInfo":225,"targetDuration":4,"studyType":23,"phases":227,"briefSummary":228,"conditions":229,"keywords":231,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":239,"startDateStruct":240,"completionDateStruct":241,"leadSponsor":242,"locationsCount":82},"100645385","NCT07681687","Sensory Motor Control and Muscle Energy Technique for Chronic Mechanical Neck","Effectiveness of Sensory Motor Control and Muscle Energy Techniques on Chronic Mechanical Neck Pain","Inclusion Criteria:Adults aged 18- 35years,Clinical diagnosis of cervical pain due to strain, degenerative changes of the spine, e.g., spondylosis.Willingness to participate and provide written informed consent,Presence of reduced cervical range of motion, especially in the upper cervical spine,Symptom duration in chronic patients is more than 3 months.\n\nExclusion Criteria:History of surgery to the cervical spine in the last 6 months,Neurological deficits or signs of cervical myelopathy,Presence of systemic conditions (e.g., rheumatoid arthritis, cancer, infections) affecting the spine,Pregnancy or known vestibular disorders,Inability to comply with study procedures or follow-up schedule\n\n\\-","35 Years",{"count":226,"type":22},52,[93],"A randomized controlled trial to evaluate the effectiveness of Sensory Motor Control training combined with Muscle Energy Technique in reducing pain and improving function, cervical range of motion, proprioception, and kinesiophobia in individuals with chronic mechanical neck pain",[230],"Chronic Mechanical Neck Pain",[232,233,234,235,236,237,238],"Cervical pain","neck pain","neck ache","chronic neck pain","mechanical neck pain","kinesiophobia","quality of life",{"date":186,"type":39},{"date":214,"type":39},{"date":216,"type":22},{"name":108,"class":46},{"id":244,"slug":4,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":54,"minAge":89,"maxAge":249,"enrollmentInfo":250,"targetDuration":4,"studyType":23,"phases":252,"briefSummary":253,"conditions":254,"keywords":257,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":266,"startDateStruct":267,"completionDateStruct":268,"leadSponsor":270,"locationsCount":82},"100645321","NCT07681531","Laser Ablation Versus Conventional Fistulectomy for Uncomplicated Perianal Fistula","Comparison Between Conventional Surgery and Laser Ablation for Uncomplicated Perianal Fistula","Inclusion Criteria:\n\n* Age 18 to 55 years.\n* Male and female patients.\n* Scheduled for surgical treatment of uncomplicated perianal fistula.\n* Single fistula tract.\n* Less than 30% involvement of the external anal sphincter.\n* Penetration of tract limited to subcutaneous tissue.\n\nExclusion Criteria:\n\n* Recurrent fistula.\n* Complex fistula.\n* History of gut malignancy.\n* History of inflammatory bowel disease.\n* Patients unfit for anesthesia.","55 Years",{"count":251,"type":22},72,[93],"This randomized controlled trial aims to compare conventional open fistulectomy and laser ablation in the treatment of uncomplicated perianal fistula. The study will evaluate postoperative recovery time and recurrence rates between the two procedures. A total of 72 patients with uncomplicated perianal fistula will be randomly assigned to either conventional open fistulectomy or laser ablation and followed for six months after surgery.",[255,256],"Perianal Fistula","Anal Fistula",[258,259,260,261,262,263,264,265],"Perianal fistula","Anal fistula","Laser ablation","Laser-assisted anal fistula surgery","FiLaC","Fistulectomy","Conventional surgery","Randomized controlled trial",{"date":186,"type":39},{"date":77,"type":22},{"date":269,"type":22},"2027-03-31",{"name":271,"class":272},"PNS Hafeez - Naval Hospital","OTHER_GOV",{"id":274,"slug":4,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":11,"sex":54,"minAge":202,"maxAge":278,"enrollmentInfo":279,"targetDuration":4,"studyType":23,"phases":280,"briefSummary":281,"conditions":282,"keywords":284,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":292,"completionDateStruct":293,"leadSponsor":295,"locationsCount":82},"100645161","NCT07679373","Effects of Clinical Based Versus Synchronized Telerehabilitation on Pain, Exercise Adherence, and Functional Disability Among Patients With Grade-II Cervical Spondylosis.","Inclusion Criteria:\n\n* Middle age adults (45-64) years\n* Both gender ( male and female )\n* Clinical daignosis of cervical spondylosis grade 2\n* Mild to moderate pain on NPRS\n* Sub acute stage ( 2-6 weeks) of grade 2 cervical spondylosis\n* Able to follow instructions and give informed consent (cognitively able) Neurologically stable\n\nExclusion Criteria:\n\n* Prior cervical spine surgery within the last 1 months or cervical instability.\n* Inflammtory or systemic rheumatologic disease affecting the cervical spine (e.g., active rheumatoid arthritis ) or infection, tumor, fracture.\n* Severe cardiopulmonary or other medical comorbidity that contraindicates exercise (unstable angina, uncontriolled hypertension, recent MI)\n* Severe hearing or visual impairment\n* No smoking and daibetic history","64 Years",{"count":226,"type":22},[93],"This randomized controlled trial aims to compare the effects of clinical-based rehabilitation and synchronized telerehabilitation on pain, exercise adherence, and functional disability in patients with Grade-II cervical spondylosis. A total of 52 participants will be randomly allocated into two parallel groups. Both groups will receive a standardized 6-week rehabilitation program, including cervical mobility exercises, strengthening, isometric exercises, stretching, and Mulligan self-mobilization techniques. The clinical group will receive in-person physiotherapy, while the telerehabilitation group will undergo real-time supervised sessions via video conferencing. Outcome measures will include pain (Numeric Pain Rating Scale), functional disability (Neck Disability Index), and exercise adherence (Exercise Adherence Rating Scale), assessed at baseline and post-intervention. The study aims to determine whether synchronized telerehabilitation is as effective as clinical-based rehabilitation and may provide a more accessible alternative for delivering physiotherapy care.",[283],"Grade-II Cervical Spondylosis",[285,286,287,288,289],"Telerehabilitation","Pain","Excercise Adherence","Functional Disability","Cervical Spondylosis","2026-06-25",{"date":77,"type":39},{"date":77,"type":22},{"date":294,"type":22},"2026-11-30",{"name":296,"class":46},"Lahore University of Biological and Applied Sciences",{"id":298,"slug":4,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":302,"eligibilityCriteria":303,"healthyVolunteers":11,"sex":54,"minAge":304,"maxAge":305,"enrollmentInfo":306,"targetDuration":4,"studyType":23,"phases":308,"briefSummary":309,"conditions":310,"keywords":314,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":323,"leadSponsor":325,"locationsCount":82},"100641879","NCT07661485","Comparing Two Soft Tissues Technique on Piriformis Syndrome Patients","Effect of Myofascial Release as Compared to Post Isometric Relaxation in Improving Pain and Lower Extremity Function in Piriformis Syndrome","MPR-PIR","Inclusion Criteria:\n\n* Positive Lasegue sign\n* Positive FAIR test\n* Grade 1-3 tenderness on palpation of piriformis between sacrum and greater trochanter of femur\n* 4 or more pain intensity on the VAS scale\n\nExclusion Criteria:\n\n* Lower extremity injuries including ligament, tendon injuries, muscle strains as well as nerve injuries\n\n  * Systemic diseases including tuberculosis, multiple sclerosis, Parkinson's disease as well as chronic inflammatory conditions\n  * Congenital deformities including hip dysplasia, limb length discrepancy, scoliosis and congenital pelvic asymmetry\n  * Cognitive issues including dementia, severe depression and severe psychotic disorders\n  * Lumbar Radiculopathy\n  * SIJ Dysfunction\n  * Lower Extremity Fractures\n  * Pregnancy\n  * Malignancy","20 Years","50 Years",{"count":307,"type":22},26,[93],"Piriformis Syndrome is a neuromuscular condition with symptoms of pain, numbness and tingling tracing the route of the sciatic nerve, due to the nerve impingement by the piriformis muscle. Two common manual therapy techniques used to treat musculoskeletal conditions are myofascial release and post-isometric relaxation. The intent of the research is to evaluate the effects of myofascial release (MFR) as compared to post-isometric relaxation (PIR) in improving pain and lower extremity function in piriformis syndrome (LEFS). The study population involved 32 individuals aged between 20 to 50 years who will be randomly assigned to two groups; a group that received MFR and a group that received PIR. Both groups received the baseline treatment for four weeks. The Visual Analog Scale (VAS) will be employed to gauge the amount of pain, while the LEFS was used to measure functional mobility",[311,312,313],"Piriformis Syndrome","Musculoskeletal Abnormalities","Sciatica",[315,316,317,318,319],"myofasical release","Post isometric relaxation","physiotherapy","Radiculopathy","Piriformis syndrome",{"date":321,"type":39},"2026-06-30",{"date":321,"type":22},{"date":324,"type":22},"2026-09-30",{"name":326,"class":46},"University of Faisalabad",{"id":328,"slug":4,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":11,"sex":54,"minAge":89,"maxAge":332,"enrollmentInfo":333,"targetDuration":4,"studyType":23,"phases":334,"briefSummary":335,"conditions":336,"keywords":338,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":82},"100644340","NCT07662850","Effects of Blood Flow Restriction Training and Instrument-Assisted Soft Tissue Mobilization for Pain, Strength, Range of Motion, and Kinesiophobia Among ACL Reconstruction Patients.","Inclusion Criteria:\n\n* Age between 18 and 40 years.\n* Both genders.\n* Undergoing Primary Unilateral ACLR (using autologous tendon graft).\n* Medically cleared for low load rehabilitation (Wound healed, stable graft per surgeon).\n* Active knee flexion of ≥100° on the operative limb.\n* 8-16 weeks after reconstructive surgery.\n* Willing to comply with all rehabilitation sessions and follow up assessments; give informed consent\n\nExclusion Criteria:\n\n* Significant meniscectomy requiring protected weight-bearing\n* Active DVT, vascular disease, uncontrolled hypertension or other BFR contraindications\n* Patients exhibiting extension lag (inability to achieve full active knee extension) on the operated limb.\n* Neuromuscular disorders\n* Skin lesions preventing IASTM\n* Pregnancy\n* Contraindications to exercise","40 Years",{"count":204,"type":22},[93],"This randomized clinical trial aims to compare the effects of Blood Flow Restriction Training (BFR) and Instrument-Assisted Soft Tissue Mobilization (IASTM) on pain, quadriceps muscle strength, knee range of motion (ROM), and kinesiophobia in patients following anterior cruciate ligament reconstruction (ACLR). ACLR patients commonly experience persistent muscle weakness, limited ROM, pain, and fear of movement, which can delay functional recovery and return to activity. A total of 46 participants (8-16 weeks post-ACLR) will be randomly allocated into two groups: a BFR group and an IASTM group. Both groups will receive interventions twice weekly for 8 weeks alongside standard physiotherapy. The BFR group will perform low-load resistance exercises under controlled vascular occlusion, while the IASTM group will receive soft tissue mobilization using specialized instruments combined with conventional rehabilitation. Outcome measures will include quadriceps strength (handheld dynamometer), pain (Numeric Pain Rating Scale), knee ROM (goniometer), and kinesiophobia (Tampa Scale of Kinesiophobia), assessed at baseline and post-intervention. The study aims to determine which intervention provides superior improvements in physical and psychological outcomes during early rehabilitation after ACL reconstruction.",[337],"ACL Reconstruction",[339,340,341,342,343,286,344],"Anterior Cruciate Ligament Reconstruction","Blood Flow Restriction Training","Instrument-Assisted Soft Tissue Mobilization","Quadriceps Strength","Range Of Motion","Kinesiophobia",{"date":346,"type":39},"2026-06-29",{"date":348,"type":22},"2026-06-12",{"date":350,"type":22},"2026-11-20",{"name":296,"class":46},{"id":353,"slug":4,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":355,"acronym":356,"eligibilityCriteria":357,"healthyVolunteers":11,"sex":54,"minAge":4,"maxAge":249,"enrollmentInfo":358,"targetDuration":4,"studyType":23,"phases":359,"briefSummary":360,"conditions":361,"keywords":363,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":366,"startDateStruct":367,"completionDateStruct":369,"leadSponsor":371,"locationsCount":82},"100644017","NCT07668245","Effectiveness of Attention Focus Training on Attention and Quality of Life in Stroke","AQoLStroke","Inclusion Criteria:\n\n* Participants diagnosed with stroke\n* Able to ambulate at least with assistance\n* Medically stable\n\nExclusion Criteria:\n\n* Severe cognitive impairment (MMSE \\\u003C 24)\n* Pre-existing dementia\n* Visual\u002Fhearing impairment",{"count":204,"type":22},[93],"This RCT will determine the effects of attention focus training which is a comprehensive intervention to improve cognitive outcomes. Attention is one of the major cognitive outcome and problems with attention can deteriorate the quality of life of people suffering from stroke. Intervention will be provided for 4 weeks. Outcomes will be assessed at baseline and after provision of intervention.",[362],"Stroke",[364,365,362],"Attention","Quality of life",{"date":321,"type":39},{"date":368,"type":22},"2026-07-03",{"date":370,"type":22},"2026-10-03",{"name":372,"class":46},"Shifa Tameer-e-Millat University",{"id":374,"slug":4,"hasResults":11,"nctId":375,"briefTitle":376,"officialTitle":376,"acronym":4,"eligibilityCriteria":377,"healthyVolunteers":11,"sex":54,"minAge":89,"maxAge":332,"enrollmentInfo":378,"targetDuration":4,"studyType":23,"phases":380,"briefSummary":381,"conditions":382,"keywords":384,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":387,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":391,"locationsCount":82},"100643666","NCT07617623","Effects of Telerehabilitation and Supervised Clinic Based Rehab With Pain Neuroscience Education for Pain,Kinesiophobia and Functional Disability Among Chronic Non-Specific Neck Pain Patients","Inclusion Criteria:\n\n1. Age between 18-40 years of both male and female gender.\n2. Currently suffering from neck pain \\& bilateral neck pain for at least three months.\n3. Moderate pain intensity (30mm to 70mm) on Visual Analogue Scale .\n4. Access \\& knowledge of mobile phone and internet use .\n\nExclusion Criteria:\n\n1. Any previous neck surgery or cervical trauma .\n2. Fibromyalgia \\& Myelopathy .\n3. Spinal deformities like thoracic hyper kyphosis or scoliosis .\n4. Cervical radiculopathy ,vertigo, cancer \\& vertebral fractures.\n5. Infection or inflammatory arthritis in cervical spine .\n6. History of the whiplash injury .\n7. Physiotherapeutic treatment in the last six months .\n8. Cognitive disorder that prohibited the pain neuroscience education intervention from being followed .",{"count":379,"type":22},45,[93],"Chronic non-specific neck pain is a common musculoskeletal condition affecting a large proportion of the population worldwide. It is characterized by persistent neck pain lasting more than three months without a specific underlying pathology. Many patients experience ongoing symptoms such as pain, reduced range of motion, functional limitations, and psychological factors like kinesiophobia, which can negatively affect recovery and quality of life.\n\nConventional physiotherapy, including supervised clinic-based rehabilitation, is widely used for the management of chronic non-specific neck pain. These programs typically involve exercise therapy and patient education; however, access to regular in-clinic treatment can be limited due to factors such as travel, cost, and time constraints.\n\nTelerehabilitation has emerged as an alternative approach that allows delivery of physiotherapy services through online platforms, improving accessibility and convenience for patients. In addition, pain neuroscience education (PNE) is an evidence-based strategy that helps patients understand pain mechanisms, reduce fear-avoidance behaviors, and improve treatment outcomes when combined with exercise therapy.\n\nAlthough both telerehabilitation and supervised clinic-based rehabilitation are effective, there is limited evidence directly comparing these two approaches when combined with standardized pain neuroscience education.\n\nTherefore, this randomized controlled trial aims to compare the effects of telerehabilitation with pain neuroscience education and supervised clinic-based rehabilitation with pain neuroscience education on pain intensity, functional disability, and kinesiophobia in individuals with chronic non-specific neck pain.",[383],"Chronic Non-Specific Neck Pain",[385,285,386,344,383],"Pain Neuroscience Education","Supervised Clinic Based Rehab",{"date":346,"type":39},{"date":389,"type":22},"2026-06",{"date":350,"type":22},{"name":296,"class":46},{"id":393,"slug":4,"hasResults":11,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":4,"eligibilityCriteria":397,"healthyVolunteers":11,"sex":54,"minAge":89,"maxAge":55,"enrollmentInfo":398,"targetDuration":4,"studyType":23,"phases":400,"briefSummary":401,"conditions":402,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":405,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":82},"100644105","NCT07665528","Comparative Outcomes of Inj Botox Alone vs Inj Botox Combined With Fissurectomy and Anoplasty in the Management of Chronic Anal Fissure","Comparative Outcomes of Injection Botox Alone Versus Injection Botox Combined With Fissurectomy and Anoplasty in the Management of Chronic Anal Fissure","Inclusion Criteria:\n\nAdults aged 18 to 65 years, regardless of sex Diagnosis of chronic anal fissure persisting for more than 6 weeks Failure of at least 6 weeks of standardized conservative treatment Fit for anesthesia and surgical intervention Willing and able to provide written informed consent\n\nExclusion Criteria:\n\nAcute anal fissure Inflammatory bowel disease Anal malignancy Previous anal surgery Pregnancy Pre-existing fecal incontinence Immunocompromised patients",{"count":399,"type":22},108,[93],"Chronic anal fissure is a common benign anorectal condition characterized by severe pain during defecation, rectal bleeding, and reduced quality of life. Injection Botox is a widely used sphincter-preserving treatment that produces temporary relaxation of the internal anal sphincter and promotes fissure healing. However, healing rates with injection Botox alone are variable and recurrence remains a concern.\n\nThis prospective comparative trial aims to compare the effectiveness and safety of injection Botox alone versus injection Botox combined with fissurectomy and anoplasty in adults with chronic anal fissure. The study will evaluate healing rate, pain relief, time to healing, recurrence, postoperative complications, continence outcomes, and patient satisfaction.\n\nA total of 108 eligible patients with chronic anal fissure will be enrolled and allocated to one of the two treatment groups. Participants will be followed after treatment to assess clinical outcomes. The results of this study are expected to provide evidence regarding the optimal sphincter-preserving treatment approach for chronic anal fissure and help improve patient care and quality of life.",[403],"Anal Fissure Chronic","2026-06-24",{"date":211,"type":39},{"date":407,"type":39},"2026-06-03",{"date":409,"type":22},"2026-12-03",{"name":411,"class":46},"Islamabad Medical and Dental College",{"id":413,"slug":4,"hasResults":11,"nctId":414,"briefTitle":415,"officialTitle":416,"acronym":417,"eligibilityCriteria":418,"healthyVolunteers":17,"sex":54,"minAge":4,"maxAge":4,"enrollmentInfo":419,"targetDuration":4,"studyType":23,"phases":421,"briefSummary":422,"conditions":423,"keywords":428,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":435,"startDateStruct":436,"completionDateStruct":438,"leadSponsor":439,"locationsCount":82},"100644982","NCT07677527","Efficacy of Vicarious Post-Traumatic Growth Intervention for Nurses in Emergency Units","Efficacy of Vicarious Post-Traumatic Growth Intervention for Nurses in Emergency Units: A Randomized Controlled Trial","VPTG-RCT","Inclusion Criteria:\n\n1. Registered nurses currently employed in emergency departments.\n2. Minimum six months of emergency department work experience.\n3. Able to read and understand English or Urdu.\n4. Willing to provide informed consent.\n5. Available to participate throughout intervention and follow-up assessments.\n\nExclusion Criteria:\n\n1. Current diagnosis of severe psychiatric disorder requiring intensive treatment.\n2. Current participation in trauma-focused psychotherapy.\n3. Cognitive impairment affecting study participation.\n4. Planned transfer from emergency unit during study period.\n5. Refusal to provide informed consent.",{"count":420,"type":22},60,[93],"This randomized controlled trial aims to evaluate the efficacy of a Vicarious Post-Traumatic Growth (VPTG) Intervention among nurses working in emergency units. Emergency nurses are frequently exposed to traumatic events through patient care, which may contribute to vicarious trauma and psychological distress. The intervention is designed to facilitate positive psychological growth, resilience, adaptive coping, and psychological well-being while reducing the adverse impact of indirect trauma exposure. Participants will be randomly assigned to intervention and control groups. Outcomes will be assessed at baseline, post-intervention, and follow-up periods to determine the effectiveness of the intervention in promoting vicarious post-traumatic growth and reducing vicarious trauma among emergency nurses.",[424,425,426,427],"Vicarious Trauma","Psychological Distress","Post-Traumatic Growth, Psychological","Psychological Well-being in Emergency Unit Nurses",[429,430,431,432,424,433,434],"Vicarious Post-Traumatic Growth","Emergency Nurses","Randomized Controlled Trial","Resilience","Mental Health","Psychological Intervention",{"date":321,"type":39},{"date":437,"type":39},"2026-03-01",{"date":216,"type":22},{"name":440,"class":46},"Fatima Jinnah Women University",{"id":442,"slug":4,"hasResults":11,"nctId":443,"briefTitle":444,"officialTitle":444,"acronym":445,"eligibilityCriteria":446,"healthyVolunteers":17,"sex":447,"minAge":89,"maxAge":448,"enrollmentInfo":449,"targetDuration":4,"studyType":23,"phases":450,"briefSummary":451,"conditions":452,"keywords":456,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":464,"startDateStruct":465,"completionDateStruct":467,"leadSponsor":469,"locationsCount":82},"100638737","NCT07584941","Effect of Upper-limb Plyometric Training Versus Strength Training for Enhancing Serve Velocity, Strength, and Power in Competitive Tennis Players","ULPT-ST","Inclusion Criteria:\n\n* Age 18-30 years (male tennis players).\n* Currently training\u002Fcompeting in tennis ≥3 sessions\u002Fweek.\n* Minimum of 4 years of systematic tennis training experience\n* Provide written informed consent.\n\nExclusion Criteria:\n\n* Recent musculoskeletal surgery\n* Upper-limb (shoulder\u002Felbow) or lower-limb injury that limits training in past 6 months.\n* Participation in structured strength or agility programs outside routine tennis training\n* Neurological or cardiovascular disorders or other medical condition contraindicating high-intensity exercise","MALE","30 Years",{"count":204,"type":22},[93],"This study aims to compare the effects of upper-limb plyometric training and traditional strength training on serve velocity, muscular strength, and power in competitive tennis players. Serve velocity is a critical performance factor in tennis, and optimizing upper-limb function is essential for enhancing performance.\n\nParticipants will be randomly assigned to either a plyometric training group or a strength training group. Both groups will undergo structured training programs over a defined intervention period. Outcome measures, including serve velocity, upper-limb strength, and power, will be assessed at baseline and after the completion of the intervention.\n\nThe findings of this study will help determine the most effective training approach for improving performance in tennis players and may guide coaches, athletes, and rehabilitation professionals in designing evidence-based training programs.",[453,454,455],"Upper Limb Strength","Upper Limb Power","Upper Limb Serve Velocity",[457,458,459,460,461,462,463],"Plyometric Training","Strength Training","Upper Limb Training","Sports Performance","Tennis Players","Serve Velocity","Power",{"date":211,"type":39},{"date":466,"type":39},"2026-05-15",{"date":468,"type":22},"2026-07-20",{"name":108,"class":46},{"id":471,"slug":4,"hasResults":11,"nctId":472,"briefTitle":473,"officialTitle":473,"acronym":4,"eligibilityCriteria":474,"healthyVolunteers":11,"sex":447,"minAge":475,"maxAge":476,"enrollmentInfo":477,"targetDuration":4,"studyType":23,"phases":478,"briefSummary":479,"conditions":480,"keywords":482,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":496,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":500,"locationsCount":82},"100632622","NCT07516080","Feasibility Trial of a Correctional Management for Juvenile Offenders","Inclusion Criteria:\n\n1. Male juvenile offenders aged 11 to 17 years\n2. Currently residing in a correctional institution\n3. Able to understand Urdu and participate in group-based sessions\n4. Provide informed assent\n\nExclusion Criteria:\n\n1. Presence of a severe psychiatric condition requiring immediate or intensive clinical treatment\n2. Significant cognitive impairment or developmental condition that limits ability to engage in the intervention\n3. Currently receiving another structured psychological or behavioral intervention\n4. Medical or behavioral condition that would interfere with safe participation, as determined by institutional staff or the researcher","11 Years","17 Years",{"count":420,"type":22},[93],"The goal of this clinical trial is to learn if a structured Correctional Management intervention can be feasibly implemented with incarcerated juveniles in a correctional institution. It will also assess whether the research procedures can be successfully carried out with this population.\n\nThe main questions it aims to answer are:\n\n1. Can participants be effectively recruited, retained, and engaged, and can the intervention be delivered acceptably with adequate therapist adherence and complete outcome data collection?\n2. Does the intervention demonstrate preliminary effectiveness? Researcher will compare an experimental (intervention) group to a control group receiving standard institutional management to see if the intervention can be practically delivered and is associated with initial changes in outcomes.\n\nParticipants will:\n\n1. Be randomly assigned to either the intervention group or the control group\n2. Complete assessments at baseline (before the intervention) and post-intervention\n3. Attend structured intervention sessions (if assigned to the experimental group)\n4. Complete standardized self-report measures assessing emotional and behavioral difficulties, psychological capital, criminal thinking styles, attitudes toward seeking mental health services, emotion regulation, and moral disengagement",[481],"Juvenile Delinquency",[483,484,485,486,487,488,489,490,491,492,493,494,495],"Juvenile offenders","Incarcerated Juveniles","delinquency","juvenile delinquent","feasibility trial","rct","randomized controlled trial","correctional management","psychological intervention","behavioral intervention","Youth in detention","adolescents","pilot study",{"date":346,"type":39},{"date":498,"type":39},"2026-03-11",{"date":321,"type":22},{"name":168,"class":46},{"id":502,"slug":4,"hasResults":11,"nctId":503,"briefTitle":504,"officialTitle":505,"acronym":4,"eligibilityCriteria":506,"healthyVolunteers":11,"sex":54,"minAge":4,"maxAge":507,"enrollmentInfo":508,"targetDuration":4,"studyType":23,"phases":509,"briefSummary":510,"conditions":511,"keywords":513,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":516,"startDateStruct":517,"completionDateStruct":519,"leadSponsor":521,"locationsCount":82},"100645031","NCT07675239","Comparison of Itraconazole With Itraconazole and Isotretinoin in the Treatment Duration, Safety a n d Cure Rate in Adult Patients of Tinea Corporis\u002F Cruris-A Randomised Controlled Trail","Comparison of Itraconazole With Itraconazole and Isotretinoin in the Treatment Duration, Safety, and Cure Rate in Adult Patients With Tinea Corporis\u002FCruris: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Al newly diagnosed cases with typical tinea lesion involving at least 5% body surface area (BSA) with no nail\u002Fscalp\u002Fpalm\u002Fsole involvement and no history of intake of any oral antifungal in the preceding 4 weeks or of a topical antifungal\u002Fsteroid in the preceding 2 weeks. Presenting to the outpatient department or the emergency department of PEMH or CMH will be included in the study.\n\nExclusion Criteria:\n\n* 1\\. Patients with chronic liver and renal diseases. 2. Patients with ischaemic heart diseases. 3. Patients with hyperlipidemia. 4. 5. Those on chronic immunosuppressive therapy. Pregnant and lactating women and females of reproductive age. 6. Elderly patients above 75 years 7. Patient who had taken oral antifungal in the preceding 4 weeks or of a topical antifungal\u002Fsteroid in the preceding 2 weeks","75 Years",{"count":420,"type":22},[59],"Tinea corporis and tinea cruris are common superficial fungal infections that have become increasingly difficult to treat because of prolonged disease duration, frequent recurrences, and suboptimal response to standard antifungal therapy. Itraconazole is widely used for the treatment of dermatophytosis; however, treatment failures and relapses remain a significant concern. Isotretinoin has been proposed as an adjuvant therapy because of its effects on epidermal differentiation, keratinization, and follicular function, which may enhance antifungal penetration and improve treatment outcomes.\n\nThis randomized controlled trial aims to compare itraconazole monotherapy with a combination of itraconazole and isotretinoin in adult patients with tinea corporis and\u002For tinea cruris. The study will evaluate treatment duration, cure rate, and safety profile of both regimens. The findings may provide evidence regarding the potential benefit of adding isotretinoin to conventional antifungal therapy and help optimize management strategies for adult patients with dermatophytosis.",[512],"Tinea Corporis",[514],"Tinea, itraconazol, isotretinoin","2026-06-23",{"date":321,"type":39},{"date":518,"type":22},"2026-10-01",{"date":520,"type":22},"2027-03-01",{"name":522,"class":46},"Pak Emirates Military Hospital",{"id":524,"slug":4,"hasResults":11,"nctId":525,"briefTitle":526,"officialTitle":527,"acronym":4,"eligibilityCriteria":528,"healthyVolunteers":11,"sex":54,"minAge":4,"maxAge":4,"enrollmentInfo":529,"targetDuration":4,"studyType":23,"phases":531,"briefSummary":532,"conditions":533,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":535,"startDateStruct":536,"completionDateStruct":538,"leadSponsor":540,"locationsCount":82},"100644722","NCT07673302","Safety and Efficacy of Hemoglobin F Inducers in Patients With Beta Thalassemia","Safety and Efficacy of Hemoglobin F Inducers in Patients With Beta Thalassemia: a Prospective 12 Months Study","Inclusion criteria:\n\n* Confirmed diagnosis of Beta thalassemia Major (BTM) ascertained by Hemoglobin Electrophoresis or HPLC report performed pre-transfusion or genetic testing profile (comprising PCR or HBB gene sequencing) suggestive of β-thalassemia syndrome.\n* All ages and both genders will be included\n* Written informed consent\n\nExclusion criteria:\n\n* Pregnancy or unwilling to follow contraception or planning conception (Enrolled female patients will be strictly advised to avoid pregnancy during the study period and until 6 months after thalidomide withdrawal.\n* Hemoglobinopathies other than beta thalassemia\n* History of neurological problems\n* Inability to regularly follow up",{"count":530,"type":22},240,[93],"The aim of this study is to determine the safety and therapeutic effect of HbF inducers (combination therapy: thalidomide and hydroxyurea) on beta thalassemia patients. The main objectives of this study are:\n\n* To determine the therapeutic efficacy of HbF inducers (combination therapy: thalidomide and hydroxyurea) on hemoglobin level and blood transfusion in beta thalassemia patients.\n* To determine the safety of HbF inducers (combination therapy: thalidomide and hydroxyurea) in beta thalassemia patients\n* To determine effect of HbF inducers (combination therapy: thalidomide and hydroxyurea) on quality of life of beta thalassemia patients",[534],"Thalassemia",{"date":346,"type":39},{"date":537,"type":22},"2026-06-20",{"date":539,"type":22},"2027-06-19",{"name":541,"class":46},"Riphah International University",{"id":543,"slug":4,"hasResults":11,"nctId":544,"briefTitle":545,"officialTitle":546,"acronym":547,"eligibilityCriteria":548,"healthyVolunteers":11,"sex":54,"minAge":89,"maxAge":549,"enrollmentInfo":550,"targetDuration":4,"studyType":23,"phases":552,"briefSummary":553,"conditions":554,"keywords":556,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":563,"startDateStruct":564,"completionDateStruct":565,"leadSponsor":566,"locationsCount":82},"100644080","NCT07667062","Effects of Thoracolumbar Fascia Myofascial Release in Chronic Low Back Pain","Effects of Myofascial Release Targeting the Thoracolumbar Fascia on Fascial Morphology, Functional Outcomes, and Pain Self-Efficacy in Adults With Chronic Non-Specific Low Back Pain: A Randomized Controlled Trial","TLF-MFR-LBP","Inclusion Criteria:\n\n* Adults aged 18-60 years\n* Non-specific low back pain duration \\> 12 weeks\n* Average pain intensity NRS ≥ 3 over the past week\n* Able to provide written informed consent\n* Able to attend 18 supervised sessions over 6 weeks (3 sessions\u002Fweek)\n\nExclusion Criteria:\n\n* Specific spinal pathology (fracture, disc herniation with neurological deficit, spinal stenosis, inflammatory arthropathy, malignancy)\n* Previous lumbar surgery\n* Current pregnancy\n* Severe psychiatric disorder or active psychosis\n* Manual therapy or physiotherapy for LBP within the previous 3 months\n* Systemic connective tissue disorder (e.g., Ehlers-Danlos syndrome, Marfan syndrome)\n* Contraindication to ultrasound imaging or manual therapy.","60 Years",{"count":551,"type":22},65,[93],"The thoracolumbar fascia (TLF) is thickened and stiffer in individuals with chronic non-specific low back pain (CNSLBP) and may contribute to pain persistence. Myofascial release (MFR) has been shown to reduce TLF stiffness acutely; however, its longer-term effects on fascial morphology and pain self-efficacy remain unclear. This randomized controlled trial will investigate the effects of a standardized 6-week MFR program targeting the thoracolumbar fascia compared with sham MFR in adults with CNSLBP. A total of 65 participants aged 18-60 years with CNSLBP will be randomized in a 1:1 ratio to either standardized MFR or sham MFR. The intervention will consist of 18 treatment sessions delivered over 6 weeks. Primary outcomes include thoracolumbar fascia thickness measured by B-mode ultrasound, thoracolumbar fascia stiffness measured by shear-wave elastography, and pain self-efficacy measured using the Pain Self-Efficacy Questionnaire (PSEQ). Secondary outcomes include pain intensity, functional disability, lumbar flexion range of motion, and patient global impression of change. Outcomes will be assessed at baseline and after completion of the 6-week intervention period.",[555],"Chronic Non-specific Low Back Pain",[557,558,559,560,561,562],"Thoracolumbar fascia","Myofascial release","Chronic low back pain","Fascia thickness","Fascial stiffness","Pain self-efficacy",{"date":211,"type":39},{"date":537,"type":22},{"date":43,"type":22},{"name":567,"class":46},"University of Health Sciences Lahore",{"id":569,"slug":4,"hasResults":11,"nctId":570,"briefTitle":571,"officialTitle":572,"acronym":4,"eligibilityCriteria":573,"healthyVolunteers":11,"sex":54,"minAge":89,"maxAge":549,"enrollmentInfo":574,"targetDuration":4,"studyType":23,"phases":576,"briefSummary":577,"conditions":578,"keywords":581,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":588,"startDateStruct":589,"completionDateStruct":591,"leadSponsor":593,"locationsCount":82},"100644547","NCT07672145","Comparison of Gallbladder Extraction Via Subxiphoid vs Infraumbilical Port in Laparoscopic Cholecystectomy","Comparison of Gallbladder Extraction Via the Subxiphoid Port and the Infraumbilical Port During Laparoscopic Cholecystectomy: A Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients aged between 18 to 60 years.\n* Diagnosed with symptomatic gallstones on ultrasonography.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n* Scheduled for elective laparoscopic cholecystectomy.\n* Presence of acute or empyematous cholecystitis\n\nExclusion Criteria:\n\n* Intraoperative conversion to open cholecystectomy.\n* Diagnosed with Diabetes mellitus type 2.",{"count":575,"type":22},66,[93],"Laparoscopic cholecystectomy is the standard surgical treatment for symptomatic gallstone disease due to its advantages in reducing postoperative pain and recovery times. However, surgeons continue to debate the optimal port site for retrieving the gallbladder specimen from the abdominal cavity, as this choice can influence wound-related morbidity.\n\nTraditionally, the gallbladder is extracted through the infraumbilical port site. While effective, this route is associated with a potential risk of port-site infections due to bacterial colonization within the umbilicus and risk of contamination during specimen extraction. Retrieving the gallbladder through the subxiphoid port has been proposed as an alternative technique that may utilize a cleaner surgical site, potentially reducing patient pain scores and regional wound complications.\n\nThis prospective randomized clinical trial aims to directly compare the clinical outcomes of extracting the gallbladder through the subxiphoid port versus the traditional infraumbilical port. The study will evaluate and compare mean postoperative pain intensity within the first 24 hours, as well as the regional development of port-site infections, seromas, or hematomas within 7 days following elective laparoscopic surgery.",[579,580],"Cholelithiasis (Without Cholecystitis)","Cholecystitis, Acute",[582,583,584,585,586,587],"Laparoscopic Cholecystectomy","Gallbladder Extraction","Subxiphoid Port","Infraumbilical Port","Postoperative Pain","Port-Site Infection",{"date":211,"type":39},{"date":590,"type":39},"2026-05-20",{"date":592,"type":22},"2026-08-15",{"name":594,"class":46},"King Edward Medical University",{"id":596,"slug":4,"hasResults":11,"nctId":597,"briefTitle":598,"officialTitle":599,"acronym":600,"eligibilityCriteria":601,"healthyVolunteers":11,"sex":54,"minAge":305,"maxAge":602,"enrollmentInfo":603,"targetDuration":4,"studyType":23,"phases":605,"briefSummary":606,"conditions":607,"keywords":609,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":611,"startDateStruct":612,"completionDateStruct":613,"leadSponsor":614,"locationsCount":82},"100644727","NCT07673263","Effects of X Box Kinect 360 in Alzheimer's Disease","Effect of 3D Kinect Games With Google Cardboard on Motor Control, Cognition, and Quality of Life in Mild to Moderate Alzheimer's Patient","AD Alzheimer'","Inclusion Criteria\n\n* Alzheimer's disease of age between 50-85 years.\n* Diagnosed AD stage Mild to Moderate.\n\nExclusion Criteria:\n\n* Undiagnosed AD patients.\n* Mental or neurological conditions like schizophrenia, Parkinson's, or stroke.","85 Years",{"count":604,"type":22},38,[93],"Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia that accounting for 60% to 80% of all cases (Better, et al., 2023). According to world health organization (WHO), more than 55 million people globally live with dementia, and this number is expected to rise to 78 million by 2023 and 139 million by 2050 (WHO, 2021).",[608],"Alzheimer s Disease",[610],"Alzheimer Disease, Virtual Reality, Kinect xbox 360",{"date":346,"type":39},{"date":404,"type":22},{"date":592,"type":22},{"name":615,"class":46},"Ziauddin University",{"id":617,"slug":4,"hasResults":11,"nctId":618,"briefTitle":619,"officialTitle":620,"acronym":4,"eligibilityCriteria":621,"healthyVolunteers":11,"sex":54,"minAge":622,"maxAge":623,"enrollmentInfo":624,"targetDuration":4,"studyType":23,"phases":625,"briefSummary":626,"conditions":627,"keywords":628,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":630,"startDateStruct":631,"completionDateStruct":633,"leadSponsor":634,"locationsCount":82},"100644666","NCT07673289","Comparative Effect of CIMT and PNFTechnique on Hands Dexterity in Cerebral Palsy","Comparative Effect of Constraint Induced Movement Therapy and Proprioceptive Neuromuscular Facilitation Technique on Hands Dexterity in Cerebral Palsy","Inclusion Criteria:\n\n* 8 to 13 years of age\n* Both male and female\n* Children with moderate level of mental retardation who are able to follow commands\n\nExclusion Criteria:\n\n* Children with other musculoskeletal and neurological issues.\n* Children who have complications such as epilepsy, congenital heart condition","8 Years","13 Years",{"count":307,"type":22},[93],"Cerebral Palsy (CP) is a group of permanent disorders of the development of movement and posture, causing activity limitations that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The primary motor impairments in CP often include issues with muscle tone, reflexes, and coordination. Among the various motor disorders associated with CP, impairment of the upper extremities is particularly common and functionally debilitating. Specifically, reduced hand dexterity the ability to perform coordinated, fine motor tasks significantly impacts a child's independence in daily activities such as feeding, dressing, and school-related tasks like writing. Therefore, improving hand function is a critical goal in physiotherapy for this population The objective of this study was to compare the effectiveness of a constraint induced movement therapy ( CIMT ) and Proprioceptive neuromuscular facilitation technique on dexterous movement of hands in cerebral palsy .The study design will be Randomized Controlled Trail. The study setting will be Pediatric Rehabilitation Center or Physiotherapy Department. The duration of study will be 10 months after approval of synopsis. The sample size will be 20 which is calculated by epitools. The sampling technique will be Non-probability convenient sampling . Children who are diagnosed with cerebral palsy will be included. Children with other musculoskeletal and neurological issues will be excluded. Data Collection Tools will be Box and Block test and Pediatric Evaluation of Disability Inventory.. The data will be analyzed using SPSS 23.\n\nKeyword Cerebral Palsy, Constraint induced movement therapy (CIMT), dexterous movement, Proprioceptive neuromuscular facilitation",[123],[123,629],"Constraint induced movement therapy",{"date":346,"type":39},{"date":632,"type":39},"2026-01-11",{"date":77,"type":22},{"name":541,"class":46},{"id":636,"slug":4,"hasResults":11,"nctId":637,"briefTitle":638,"officialTitle":638,"acronym":639,"eligibilityCriteria":640,"healthyVolunteers":11,"sex":18,"minAge":304,"maxAge":332,"enrollmentInfo":641,"targetDuration":4,"studyType":23,"phases":643,"briefSummary":644,"conditions":645,"keywords":646,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":648,"startDateStruct":649,"completionDateStruct":650,"leadSponsor":652,"locationsCount":82},"100644970","NCT07676058","Comparative Effects of Myofascial Release and Instrument Assisted Soft Tissue Moblization in Pregnant Women With Plantar Fasciitis","MFR-IASM-PF","Inclusion Criteria:\n\n* Pregnant women aged 20-40 years.\n* In the second and third trimester of pregnancy (gestational weeks 12-34).\n* Clinically diagnosed with plantar fasciitis, with symptoms of heel pain at the medial calcaneal insertion of the plantar fascia.\n* The pain is most intense with the first few steps in the morning or after prolonged rest. Positive findings from a Windlass test or palpation-provoked pain indicating plantar fasciitis.\n\nExclusion Criteria:\n\n* Known foot fractures or significant foot deformities.\n* Systemic inflammatory diseases (e.g., rheumatoid arthritis) that may affect tissue healing and response to therapy.\n* Active obstetric complications that contraindicate physiotherapy.\n* Recent corticosteroid injections to the heel (\\\u003C6 months prior).\n* Inability or unwillingness to comply with follow-up visits or the intervention protocol.",{"count":642,"type":22},44,[93],"Plantar fasciitis is a common musculoskeletal disorder characterized by heel pain and functional limitations, which may become more pronounced during pregnancy due to weight gain, hormonal changes, and altered biomechanics. Conservative physiotherapy interventions are commonly used to manage symptoms; however, evidence regarding the comparative effectiveness of different manual therapy techniques in pregnant women remains limited.\n\nThis randomized clinical trial aims to compare the effects of Myofascial Release (MFR) and Instrument-Assisted Soft Tissue Mobilization (IASTM) on pain intensity and foot function in pregnant women diagnosed with plantar fasciitis. A total of 44 pregnant women aged 20-40 years in their second or third trimester will be recruited and randomly allocated into two treatment groups. Both groups will receive baseline treatment consisting of therapeutic ultrasound, gastrocnemius and soleus stretching exercises, tibialis anterior strengthening, and a home exercise program. In addition, Group A will receive Myofascial Release, while Group B will receive Instrument-Assisted Soft Tissue Mobilization.\n\nThe intervention will be delivered over a period of four weeks, with three supervised sessions per week. Pain intensity will be assessed using the Numerical Pain Rating Scale (NPRS), while foot-related pain, disability, and functional limitations will be measured using the Foot Function Index (FFI). Outcomes will be evaluated at baseline and after completion of the intervention.\n\nThe findings of this study are expected to provide evidence regarding the most effective manual therapy approach for reducing pain and improving functional outcomes in pregnant women suffering from plantar fasciitis.",[96],[96,647,341],"Myofascial Release",{"date":321,"type":39},{"date":321,"type":22},{"date":651,"type":22},"2026-07-31",{"name":653,"class":46},"University of Lahore",""]