[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anesthetic-efficacy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anesthetic-efficacy":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100624458",false,"NCT07409896","Comparison of Anesthetic Efficacy OF 2% Lidocaine Inferior Alveolar Nerve (IANB) Block Versus Primary Buccal Infilteration With 4% Articaine in Symptomatic Irreversible Pulpitis(SIP) IN Mandibular First Molars","IANB SIP EPT","Inclusion Criteria:\n\n* Systemically healthy patients classified as ASA I, aged 18-55 years.\n* Permanent mandibular first molar tooth requiring endodontic therapy.\n* Diagnosed with symptomatic irreversible pulpitis without swelling or sinus.\n* Normal periapical radiographic appearance (no evidence of periapical pathology).\n* Moderate pain as assessed by the Heft-Parker VAS (\\>54 mm and \\\u003C114 mm).\n* Lingering pain or prolonged response to cold testing (lasting more than 10 seconds).\n* Positive response to electric pulp testing.\n* Outcome assessed must be pulpal anesthesia\n\nExclusion Criteria:\n\n* • Pregnant or lactating mothers.\n\n  * Teeth with reversible pulpitis, previously treated, or with calcified canals.\n  * Teeth with severe periodontal disease or periapical radiolucency.\n  * Patients who have taken analgesics or anti-inflammatory drugs within 6 hours before the treatment visit.\n  * Patients on medications that could potentially interact with the anesthetic solution (e.g., antihypertensives, anticoagulants).\n  * History of allergy to 4% articaine, lidocaine, or epinephrine.\n  * Systemic diseases, immunocompromised states, or significant anxiety\u002Fmental health disorders.\n  * History of vasovagal syncope on local anesthetic administration","ALL","18 Years","55 Years",{"count":19,"type":20},330,"ESTIMATED","INTERVENTIONAL",[23],"NA","This randomized controlled trial aims to compare the anesthetic efficacy of 2% lignocaine administered through an inferior alveolar nerve block (IANB) in one group of participants with 4% articaine delivered via primary buccal infiltration in other group in patients with symptomatic irreversible pulpitis in mandibular first molars.",[26],"Anesthetic Efficacy","NOT_YET_RECRUITING","2026-02-07",{"date":30,"type":31},"2026-02-13","ACTUAL",{"date":33,"type":20},"2026-02-01",{"date":35,"type":20},"2027-02-01",{"name":37,"class":38},"Armed Forces Institute of Dentistry, Pakistan","OTHER",""]