[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anxiety-disorders-or-anxiety-and-phobic-neuroses\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anxiety-disorders-or-anxiety-and-phobic-neuroses":145},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,84,110],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100645295",false,"NCT07682064","Effectiveness of the Group Unified Protocol for Emotional Disorders in Adults in a Public Mental Health Setting","Effectiveness of the Group Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al. 2011, 2019a, 2019b) in Adults in a Public Mental Health Setting","PSIGTE","Inclusion Criteria:\n\n* Aged 18 to 65 years.\n* Ability and willingness to provide written informed consent.\n* Sufficient proficiency in Spanish to participate in the intervention and complete study assessments.\n* Sufficient cognitive capacity to understand the intervention content.\n* A primary diagnosis of an emotional disorder with mild, moderate, or severe symptom severity, including Depressive Disorders, Anxiety Disorders, Obsessive-Compulsive and Related Disorders, Trauma and Stressor-Related Disorders, Dissociative Disorders and Somatic Symptom and Related Disorders.\n* Presence of emotional symptoms (e.g., anxiety, depressive, or phobic symptoms), somatic symptoms, obsessive symptoms, and\u002For avoidance behaviors associated with clinically significant impairment, as indicated by moderate or higher scores on the GAD-7, PHQ-9, and\u002For PHQ-15.\n\nExclusion Criteria:\n\n* Refusal to provide informed consent or withdrawal of consent during the study.\n* Current severe substance use disorder or behavioral addiction.\n* Current high suicide risk.\n* Current psychotic symptoms or psychotic disorder.\n* Neurological disorders or severe medical conditions that could interfere with participation in or adherence to the intervention.\n* Intellectual disability, significant language difficulties, or any other condition that may impair the participant's ability to understand the intervention content.","ALL","18 Years","65 Years",{"count":20,"type":21},106,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study has three primary objectives:\n\n1. To adapt the Spanish version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al., 2011, 2019a, 2019b) for delivery in a group format within the Spanish Public Mental Health System for adults diagnosed with emotional disorders.\n2. To evaluate the effectiveness of the intervention.\n3. To assess its clinical feasibility and acceptability in routine clinical practice.\n\nOutcomes will include anxiety, depression, somatic symptoms, transdiagnostic variables, functional impairment, quality of life, and participant satisfaction. These outcomes will be assessed at baseline, post-treatment, and 3-month follow-up.\n\nThe intervention is expected to improve emotional symptoms, functional impairment, and quality of life. In addition, the study will explore whether this group-based transdiagnostic approach may help lower demand on public mental health services.",[27,28,29,30],"Emotional Disorders","ANXIETY DISORDERS (or Anxiety and Phobic Neuroses)","Depressive Disorder","Somatic Disorders",[32,33,34,35],"Unified Protocol","emotional disorder","UP","treatment","RECRUITING","2026-06-30",{"date":39,"type":40},"2026-07-02","ACTUAL",{"date":42,"type":40},"2024-04-27",{"date":44,"type":21},"2026-12",{"name":46,"class":47},"Patricia Fernández Couto","OTHER",1,{"id":50,"slug":4,"hasResults":10,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100575800","NCT06776991","Reward Processing and Exposure Therapy for Social Anxiety Disorder","Reward Processing and Exposure Therapy","METER","Inclusion Criteria:\n\n* Diagnosis of social anxiety disorder from the Structural Clinical Interview for DSM 5.\n* Elevated fear of public speaking, defined as a score of \\>= 66 (+1SD from the mean of population norms on a scale of 17-85) on the Public Speaking Anxiety Scale (PSAS; Bartholomay, E. M., \\& Houlihan, D. D. (2016). Public Speaking Anxiety Scale: Preliminary psychometric data and scale validation. Personality and individual differences, 94, 211-215), which is a self-report scale measuring anxiety of public speaking.\n* Low reward processing, defined as a score of \\\u003C56 (less than the population mean) on the Dimensional Anhedonia Rating Scale (DARS) (Rizvi, S. J., Quilty, L. C., Sproule, B. A., Cyriac, A., Bagby, R. M., \\& Kennedy, S. H. (2015). Dimensional Anhedonia Rating Scale (DARS) \\[Database record\\]. APA PsycTests).\n* Medication-free or stabilized on psychotropic medications for a minimum standard length of time (1 month for benzodiazepines and beta blockers, 3 months for SRIs\u002FSNRIs and heterocyclics).\n* Psychotherapy-free or stabilized on alternative psychotherapies other than cognitive or behavioral therapies that were not focused on their anxiety disorder for at least 6 months prior to study entry.\n* Age 18-60.\n* Fluent in English.\n* To conduct MRI version of fear conditioning task, must have no MRI contraindications.\n\nExclusion Criteria (none of the following):\n\n* Recent suicidal ideation with intent or plan - defined as suicidal ideation with intent or plan in the past year.\n* Lifetime history of suicide attempts.\n* History of bipolar disorder, psychosis, intellectual disability, or organic brain damage.\n* Substance use disorder within the last 6 months.\n* Major respiratory, cardiovascular, pulmonary, neurological, or muscular-skeletal diseases.\n* Pregnant or planning to become pregnant for next 6 months.","60 Years",{"count":58,"type":21},94,[24],"The investigators are conducting a clinical trial of therapy for public speaking anxiety. There are many eligibility criteria, but the main ones are that participants need to be socially anxious and have public speaking anxiety. In this clinical trial, all participants will do exposure therapy. Before doing exposure therapy in the study, though, participants will be randomized to do one of two treatments: i) a positive mood treatment, which is designed to increase how positive people feel, and ii) a relaxation treatment, which is designed to help people feel more relaxed. The investigators are doing this study to see whether doing the positive mood treatment or relaxation treatment first will affect how well exposure therapy works.",[62,63,64,28,65],"Social Anxiety Disorder (Social Phobia)","Public Speaking Anxiety","Anhedonia","Phobic Disorders",[67,68,69,63,64,70,71,72,73],"Exposure Therapy","Anxiety","Social Anxiety","Reward Processing","Inhibitory Retrieval","Positive Affect Treatment","Relaxation Treatment","2026-04-01",{"date":76,"type":40},"2026-04-02",{"date":78,"type":40},"2024-09-26",{"date":80,"type":21},"2029-04-30",{"name":82,"class":47},"University of California, Los Angeles",2,{"id":85,"slug":4,"hasResults":10,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":10,"sex":16,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":48},"100619614","NCT07346911","Digital Interventions for Relapse Prevention in Adolescence","DigiTIFF","Inclusion Criteria:\n\n* Currently in full or partial remission for a minimum of 2 months from a depressive disorder or an anxiety disorder as defined by self-reported scores on RCADS-47: previous episode(s) of t-score \\> 65 and current t-score =\\\u003C65.\n* Native or fluent Scandinavian language skills.\n* Willingness to take part even when allocated to the non-preferred arm of the trial.\n\nExclusion Criteria:\n\n* Ongoing depressive disorder, ongoing anxiety disorder as defined by current t-score =\\\u003C65 on RCADS-47.\n* Recent completion of one of the interventions in the two interventional arms.\n* no available smartphone.","16 Years","19 Years",{"count":93,"type":21},495,[24],"Some adolescents experience periods of anxiety and\u002For depression, and some find that these periods return over time. The purpose of this study is to examine whether digital interventions-where individuals work systematically with their own thoughts and feelings during periods when they feel well-can help them maintain well-being for longer.\n\nThe study includes adolescents aged 16-19 who have previously experienced episodes of depression and\u002For anxiety to a degree that led them to seek help (e.g., from a school nurse, general practitioner, health clinic, or child and adolescent mental health service). Through a research app on their smartphones, participants complete tasks and answer questionnaires. The study is fully digital. Some participants meet with a therapist in digital group sessions, while others work independently with the digital content.\n\nWe will also examine the cost-benefit aspects of offering such interventions. If the study achieves its goals, digital interventions may eventually become a service offered to adolescents recovering from depression and anxiety.",[97,28],"Major Depression Disorder",[99],"Transdiagnostic interventions","NOT_YET_RECRUITING","2026-03-12",{"date":103,"type":40},"2026-03-13",{"date":105,"type":21},"2026-04-07",{"date":107,"type":21},"2027-06-01",{"name":109,"class":47},"University of Oslo",{"id":111,"slug":4,"hasResults":10,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":10,"sex":16,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":121,"conditions":122,"keywords":129,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":143,"locationsCount":48},"100566921","NCT06661460","Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders","Development and Preliminary Evaluation of a New Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders","Inclusion Criteria:\n\n1\\) 8 to \\\u003C18 years of age.\n\n* Confirmed by the child\u002Fcaregiver and subsequently by the medical record system. 2) A principal DSM-5-TR anxiety disorder of specific phobia, separation anxiety disorder, social anxiety disorder, generalized anxiety disorder, panic disorder or agoraphobia.\n* Confirmed by the Diagnostic Interview for Anxiety, Mood, and OCD and related Neuropsychiatric Disorders - Child and Adolescent Version (DIAMOND-KID).\n\n  3\\) Child and caregiver able to read, write and communicate in Swedish.\n* Confirmed by the child\u002Fcaregiver. 4) An available caregiver who can support the child in treatment.\n* Confirmed by the caregiver. 5) Access to a smartphone, tablet, or laptop\u002Fdesktop device, and the internet.\n* Confirmed by the child\u002Fcaregiver.\n\nExclusion Criteria:\n\n1\\) Principal DSM-5-TR anxiety disorder of specific phobia concerning the domain of blood-injection-injury (due to the ICBT program not including relevant information on applied-tension techniques to avoid fainting during exposure exercises).\n\n* Confirmed by a blood-injection-injury phobia being classified as the principal anxiety disorder as assessed by the DIAMOND-KID.\n\n  2\\) Established or suspected intellectual disability.\n* Confirmed by the caregiver (through previous diagnosis) and\u002For by attending a special needs school for learning difficulties.\n\n  3\\) Another mental disorder in more immediate need of management than an anxiety disorder (e.g., schizophrenia spectrum and other psychotic disorders, bipolar disorder, anorexia nervosa, substance use disorders).\n* According to the DIAMOND-KID and\u002For other available sources. 4) Social\u002Ffamilial\u002Feducational difficulties in more immediate need of management than an anxiety disorder.\n* Confirmed by the assessor through information from the child\u002Fcaregiver and\u002For other available sources.\n\n  5\\) Immediate risk to self or others that require urgent attention, such as acute suicidality.\n* Confirmed by the assessor through information from the child\u002Fcaregiver and other available sources.\n\n  6\\) Previous CBT for an anxiety disorder, defined as five or more sessions with a certified CBT therapist within the 12 months prior to assessment.\n* Confirmed by the child\u002Fcaregiver or the medical record system. 7) Ongoing psychological treatment for an anxiety disorder.\n* Confirmed by the child\u002Fcaregiver or the medical record system. 8) Initiation or adjustment of any psychotropic medication for anxiety (i.e., selective serotonin reuptake inhibitors, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitor or antipsychotics) within 8 weeks prior to assessment.\n* Confirmed by the child\u002Fcaregiver or the medical record system. 9) Participation in user involvement sessions in the present study.\n* Confirmed by the researcher.","8 Years","17 Years",{"count":119,"type":21},48,[24],"The goal of this study is to develop a new internet-delivered cognitive behavioral therapy (ICBT) intervention for youths with anxiety disorders based on the best current knowledge about effective cognitive behavioral therapy for the target group, refine the intervention in collaboration with patient and public representatives, and conduct a preliminary evaluation of the treatment effects in an open clinical trial.\n\nThe primary objective of the study is:\n\n1\\. To evaluate the preliminary efficacy of a newly developed ICBT intervention for children and adolescents with anxiety disorders in reducing anxiety severity, as measured by the Pediatric Anxiety Rating Scale (PARS).\n\nSecondary objectives of the study are:\n\n1. To examine the preliminary efficacy (PARS) of the ICBT intervention at 3 months post-treatment.\n2. To examine how youths with anxiety disorders, their caregivers, therapists, and healthcare leadership experience the ICBT intervention.\n3. To examine factors (e.g., age, type of anxiety disorder, presence of depressive symptoms, experiences of ICBT) that predict treatment outcome.\n4. To examine how the ICBT intervention can be improved (e.g., treatment content and technical delivery) for future use.\n\nParticipants will:\n\n* Undergo ICBT treatment for anxiety disorders during 12 weeks\n* Complete questionnaires at multiple time points throughout the study\n* Participate in follow-ups post-treatment and 3 months post-treatment\n* A selection of participants will also be invited to focus group interviews with the aim to generate ideas on how the intervention may be improved for future use",[28,123,124,125,126,127,128],"Specific Phobia","Social Anxiety Disorder","Separation Anxiety Disorder","Generalized Anxiety Disorder","Panic Disorder","Agoraphobia",[130,131,132,133,134,135,136],"Anxiety disorders","Children","Adolescents","Cognitive Behavioral Therapy","Remote delivery","Internet","Internet-delivered cognitive behavioral therapy","2026-02-19",{"date":139,"type":40},"2026-02-20",{"date":141,"type":40},"2025-12-12",{"date":107,"type":21},{"name":144,"class":47},"Lund University",""]