[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bipolar-disorder-1\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bipolar-disorder-1":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100451370",false,"NCT05157620","Exercise-based Program for Rehabilitation of Veterans With Severe Mental Illness","ESHANTI","Inclusion Criteria:\n\n* Written informed consent;\n* age 18-70 years;\n* DSM-5 diagnosis of\n\n  * schizophrenia,\n  * schizoaffective disorder,\n  * bipolar 1 disorder,\n* DSM-5 diagnosis of schizophrenia, schizoaffective disorder, or bipolar 1 disorder including those with a co-morbid\n\n  * alcohol use disorder or substance use disorder;\n  * clinically stable;\n* clinical global impression-severity (CGI-S) scores mild to moderately ill\n\nExclusion Criteria:\n\n* Unable to provide written informed consent;\n* intellectual disability (i.e., severe enough to impact understanding of yoga-based exercises) based on chart or IQ\\\u003C80 on the Wechslet Abbreviated Scale of Intelligence-II (WASI-II);\n* disability or illness precluding yoga-based exercises or wellness lifestyle program, e.g.,\n\n  * current or recent angina (\\\u003C6 months),\n  * history of myocardial infarction in the past year (unless permission is obtained from the primary care physician),\n  * uncontrolled hypertension or hypotension;\n* neurological illness complicating diagnosis \u002F cognitive evaluation, e.g.,\n\n  * dementia,\n  * stroke or head injury;\n* physical problems that preclude training for yoga-based exercises \u002F wellness lifestyle program, e.g.,\n\n  * severely impaired vision;\n  * ongoing treatment that includes more than one hour per week of relaxation and mind-body based stress reduction strategies related to yoga","ALL","18 Years","70 Years",{"count":19,"type":20},112,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a hybrid1, effectiveness-implementation study of yoga-based exercises (YE) as an adjunctive tool for rehabilitation among persons with Severe Mental Illness (SMI). The two-arm randomized controlled trial will compare the efficacy of YE compared to the Wellness Lifestyle Program (WLP). Primary outcomes of the study will be self-report and performance-based measures of community functioning, defined in the investigators study as social, leisure, employment, and life skills functioning in the community. Secondary outcomes will include cognition and physical fitness measures.",[26,27,28],"Schizophrenia","Schizoaffective","Bipolar Disorder 1",[30,31,32,33,34,35,36,37],"schizophrenia","psychotic disorders","schizoaffective","bipolar disorder 1","exercise","yoga","community function","quality of life","RECRUITING","2026-06-29",{"date":41,"type":42},"2026-07-01","ACTUAL",{"date":44,"type":42},"2022-10-24",{"date":46,"type":20},"2026-12-31",{"name":48,"class":49},"VA Office of Research and Development","FED",""]