[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bladder-hyperactivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bladder-hyperactivity":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100549500",false,"NCT06434831","Evaluation of Autonomic Nervous System Changes in Response to Stimulation by Sacral Neuromodulation","ESTIME","Inclusion Criteria:\n\n* Male of female ≥ 18 years\n* OAB syndrome\n* Indication for a two-staged SNM\n* Under general anaesthesia with Remifentanil and Propofol\n* Patient who has given written consent to participate in the trial\n* Patient willing to comply with all study procedures and duration\n\nExclusion Criteria:\n\n* Tibial neuro-stimulation (last 3 months)\n* Sacral neuromodulation (last 3 months)\n* Botulinum toxin A intra-detrusor injection (last 9 months)\n* Pregnancy in progress\n* Administrative reasons\n* Guardianship\u002Fcuratorship","ALL","18 Years",{"count":18,"type":19},40,"ESTIMATED","INTERVENTIONAL",[22],"NA","Overactive bladder syndrome (OAB) is defined by urgent and frequent urges to urinate associated with frequent night-time urination and sometimes urinary incontinence. Sacral neuromodulation (SNM) is now one of the second-line treatments for OAB.\n\nThe mode of action of SNM is still poorly understood but a number of data from recent scientific literature suggest that SNM may act, among other things, by altering the balance of the autonomic nervous system (ANS) - located at the interface between the urinary tract and the brain structures regulating the functioning of the urinary tract.\n\nThe aim of this study would therefore be to develop a predictive tool for the effectiveness of SNM.",[25,26],"Bladder Hyperactivity","Sacral Neuromodulation",[28,29,30,31,32],"Bladder hyperactivity","autonomic nervous system","sacral neuromodulation","urodynamic assessment","heart rate variability","RECRUITING","2026-04-29",{"date":36,"type":37},"2026-05-06","ACTUAL",{"date":39,"type":37},"2024-02-14",{"date":41,"type":19},"2026-12-02",{"name":43,"class":44},"University Hospital, Lille","OTHER",""]