[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bone-loss-in-jaw\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bone-loss-in-jaw":69},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,38],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100603516",false,"NCT07137533","Mandibular Overdentures vs All-on-4 With PEEK","Long-Term Peri-Implant Outcomes of Mandibular Overdentures and All-on-4 Prostheses With PEEK Frameworks","Inclusion Criteria:\n\nAdults aged ≥40 years.\n\nCompletely edentulous mandible for at least 6 months prior to implant placement.\n\nTreated with either:\n\nFour-implant-retained mandibular overdenture with a PEEK framework, or\n\nMandibular All-on-4 fixed prosthesis with a PEEK framework.\n\nAll implants placed in the lateral incisor and first premolar regions (per respective protocol).\n\nRestorations fabricated via CAD\u002FCAM-milled PEEK framework with acrylic denture teeth.\n\nProsthesis delivered with a delayed loading protocol.\n\nMinimum clinical and radiographic follow-up of 4 years.\n\nAvailability of standardized baseline and follow-up periapical radiographs for marginal bone level assessment.\n\nTreated by the same surgical and prosthodontic team.\n\nExclusion Criteria:\n\nHistory of uncontrolled systemic diseases that could affect bone healing (e.g., uncontrolled diabetes, osteoporosis under bisphosphonate therapy).\n\nHistory of head and neck radiotherapy.\n\nActive periodontal or peri-implant infection at the time of implant placement.\n\nInsufficient bone volume in the interforaminal region requiring grafting beyond minor augmentation.\n\nHeavy smoking habit (\\>10 cigarettes\u002Fday) at the time of treatment.\n\nParafunctional habits (e.g., severe bruxism or clenching) documented in patient records.\n\nUse of medications known to affect bone metabolism (e.g., high-dose corticosteroids, antiresorptive drugs).\n\nPregnancy at the time of implant placement.\n\nIncomplete clinical or radiographic records.\n\nFollow-up period of less than 4 years.","ALL","40 Years","70 Years",{"count":19,"type":20},40,"ESTIMATED","OBSERVATIONAL","This study compares long-term peri-implant outcomes between two mandibular full-arch rehabilitation approaches-four-implant-retained overdentures and All-on-4 fixed prostheses-when both are fabricated with polyetheretherketone (PEEK) frameworks. While overdentures and All-on-4 prostheses are widely used, evidence on the clinical performance of PEEK frameworks in these modalities is scarce. By evaluating marginal bone loss and other peri-implant parameters, the research aims to clarify whether prosthetic design influences biological outcomes when using this high-performance polymer.",[24],"Bone Loss in Jaw","RECRUITING","2025-08-15",{"date":28,"type":29},"2025-08-22","ACTUAL",{"date":31,"type":29},"2025-08-01",{"date":33,"type":20},"2025-10-25",{"name":35,"class":36},"Menoufia University","OTHER",1,{"id":39,"slug":4,"hasResults":10,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":4,"eligibilityCriteria":43,"healthyVolunteers":44,"sex":15,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":37},"100600843","NCT07102758","L-PRF vs Connective Tissue With Customized Healing Abutment in Immediate Implant Placement","Evaluation of Soft and Hard Tissue Augmentation by Connective Tissue Graft or Leukocyte-Platelet Rich Fibrin in Immediate Implant Placement With Customized Healing Abutment: A Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n* Intact labial\u002Fbuccal bone plate\n* The presence of non-restorable single-rooted maxillary centrals, canines or premolars.\n* Sufficient bone volume.\n* Good oral hygiene.\n* Nonsmokers.\n* Sufficient bone width (≥ 1 mm) in the buccal plate of the remaining bone to place an implant confirmed by cone beam computer tomography (CBCT).\n\nExclusion Criteria:\n\n* Insufficient bone volume.\n* Active infection.\n* Patients on chemotherapy or radiotherapy.\n* Patients who have systemic disorders {uncontrolled diabetes mellitus, autoimmune disease, …etc},\n* Pregnant patients,\n* Patients with bone diseases\n* Presence of periapical pathology.",true,"21 Years","45 Years",{"count":48,"type":20},16,"INTERVENTIONAL",[51],"NA","comparison between L-prf and connective tissue with dental implant",[54,24],"Recession, Gingival",[56,57,58,59],"L-prf","connective tissue","customized healing abutment","implant","2025-08-10",{"date":62,"type":29},"2025-08-14",{"date":64,"type":20},"2025-08-05",{"date":66,"type":20},"2027-08-20",{"name":68,"class":36},"Kafrelsheikh University",""]