[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bowens-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bowens-disease":53},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":5},"100622473",false,"NCT07384078","High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease in Adults","HIFU vs. CRYO - High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease - a Randomized Controlled Trial","HIFUvsCRYO","Inclusion Criteria:\n\n* age 18 years or older at the time of informed consent\n* ability to give informed consent and comply with the treatment protocol and follow-up plan\n* study lesion located between neck and knees\n* one of following histologically confirmed diagnosis: Superficial BCC with maximum diameter of 2.0 cm \u002F Nodular BCC with max. diameter of 1.5 cm \u002F BD with max. diameter of 2.0 cm\n\nExclusion Criteria:\n\n* Study lesion location in face, head, genitals, hands, or below the knee\n* Clinical\u002Fdermoscopical\u002Fhistological feature for high-risk\u002Faggressive BCC\n* Clinical\u002Fhistological sign for hypertrophic BD\n* Clinical\u002Fdermoscopical\u002Fhistological feature for Squamous cell carcinoma\n* Gorlin Golz syndrome\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":19,"type":20},294,"ESTIMATED","INTERVENTIONAL",[23],"NA","This prospective, randomized, controlled, and single-blinded non-inferiority clinical trial compare the efficacy and tolerability of high intensity focused ultrasound (HIFU) to standard cryotherapy in the treatment of low-risk basal cell carcinomas (BCCs) and Bowen's disease (BD) in adults. The main questions it aims to answer are:\n\n* Is HIFU an efficient treatment option for BCCs and BD?\n* What medical problems do participants get after HIFU?\n\nResearchers will compare HIFU to standard cryotherapy with liquid nitrogen to see if the ultrasound works to treat these local and low-risk non-melanosytic skin cancers.\n\nParticipants will:\n\n* Be treated either with HIFU (intervention) or cryotherapy (control).\n* Visit the clinic 4 weeks, 1-, 3- and 5 years after the treatment for check-ups, tests and survey questions.",[26,27,28,29,30],"Superficial Basal Cell Carcinoma","Nodular Basal Cell Carcinoma","Bowen's Disease","BCC","BD",[32,33,34,35,36,37,38,39,40],"HIFU","cryo","cryotherapy","high intensity focused ultrasound","basal cell carcinoma","Bowen's disease","superficial basal cell carcinoma","nodular basal cell carcinoma","non-surgical treatment","NOT_YET_RECRUITING","2026-01-26",{"date":44,"type":45},"2026-02-03","ACTUAL",{"date":47,"type":20},"2026-04-01",{"date":49,"type":20},"2032-12-31",{"name":51,"class":52},"Jussi Salonen","OTHER",""]