[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"calcium-hypophosphite\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:calcium-hypophosphite":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100598185",false,"NCT07068204","Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)","Caries-preventing Effect of 2% Calcium Hypophosphite Toothpaste Compared to a Sodium Fluoride Toothpaste (1450ppm F) in Adults","Inclusion Criteria:\n\n* A minimum of 10 healthy molars and premolars (DMFS of these teeth = 0)\n* Willingness to use an electric (powered) toothbrush\n* Willingness to use interdental floss\n* Willingness to have bitewing radiographs taken\n* Willingness to undergo an oral examination by an intraoral camera (DIAGNOcam)\n\nExclusion Criteria:\n\n* Untreated caries \\[clinical investigation and analysis with an intraoral camera (DIAGNOcam)\\] (→ unsuitable subjects with one or two untreated caries in need of a restoration can become eligible after restorative therapy. If there are three or more untreated caries patients will be excluded)\n* Xerostomia (medication, radiation, disease induced)\n* Chemo\u002Fradiation therapy\n* Physical or mental disability which prevents proper oral health care\n* Orthodontic treatment\n* Severe periodontitis at the Baseline Visit (pocket depth on at least one tooth ≥ 5.5 mm)\n* Known hypersensitivity to one of the ingredients of the toothpastes to be tested\n* Regular medication intake interfering with salivary function or flow\n* Current pregnancy, the wish to become pregnant, the suspicion of being pregnant, or breastfeeding or in the course of the study\n* 3 or more carious lesions\u002Frestorations in last 36 months until Baseline Visit\n* Teeth missing due to caries in last 36 months until Baseline Visit",true,"ALL","18 Years","45 Years",{"count":20,"type":21},164,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of the study is to compare the caries-preventive effect of the test and control toothpaste in order to proof the non-inferiority of the test toothpaste compared to the control.",[27,28,29],"Caries, Dental","Calcium Hypophosphite","Fluoridation","RECRUITING","2026-04-10",{"date":33,"type":34},"2026-04-13","ACTUAL",{"date":36,"type":34},"2026-01-22",{"date":38,"type":21},"2028-01",{"name":40,"class":41},"Dr. Joachim Enax","INDUSTRY",2,""]