[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"calcium-release-deficiency-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:calcium-release-deficiency-syndrome":38},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100555136",false,"NCT06508164","International CRDS Registry","International Calcium Release Deficiency Syndrome Registry","CRDS Registry","CRDS Cohort\n\nInclusion Criterion:\n\n\\- Presence of a rare\\* RYR2 variant that is characterized to be loss-of-function based on in vitro testing#\n\nRYR2 Truncating and Large CNV Cohort\n\nInclusion Criterion:\n\n\\- Presence of a rare\\* RYR2 truncating variant and\u002For large copy number variant involving the RYR2 gene.\n\nCarriers of a Non-Functional RYR2 variant\n\nInclusion Criterion:\n\n\\- Presence of a rare\\* RYR2 variant that is characterized to be neither loss- nor gain-of-function based on in vitro testing#\n\n\\*rare defined as gnomAD prevalence \\\u003C 0.1%\n\n#RYR2 in vitro functional testing will be performed in the laboratory of Dr. Wayne Chen (University of Calgary)","ALL",{"count":18,"type":19},500,"ESTIMATED","26 Years","OBSERVATIONAL","Calcium Release Deficiency Syndrome (CRDS) is a newly discovered genetic arrhythmia syndrome that confers a risk of life-threatening arrhythmias secondary to RYR2 loss-of-function. The International CRDS registry has been designed to facilitate large-scale evaluation of CRDS, including its phenotypic spectrum, approaches to risk stratification, and optimal treatment strategies.",[24],"Calcium Release Deficiency Syndrome","RECRUITING","2026-06-11",{"date":28,"type":29},"2026-06-15","ACTUAL",{"date":31,"type":29},"2024-11-21",{"date":33,"type":19},"2050-12-31",{"name":35,"class":36},"Population Health Research Institute","OTHER",18,""]