Cariesdental

17

Review clinical trials related to Cariesdental. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Artificial Intelligence (AI) for Proximal Caries Detection and Its Impact on Treatment Threshold

The purpose of this study is to assess the impact of artificial intelligence on proximal caries detection and subsequent treatment decisions of early learners and compare those with outcomes of experienced learners.

Participants needed: 60
Trial details
Age: 18-99Biological sex: AllType: InterventionalSponsor: University of MichiganUpdated: Jun 15, 2026Locations: 1
Eligibility criteria

Provide informed consent [+5]

Dental students who do not have previous experience with caries detection (such... [+1]

Status: Recruiting

Efficacy of a Chitosan Dressing in Pulpotomy of Immature Permanent Teeth

Immature permanent teeth, also known as young permanent teeth, are used to describe teeth with incomplete root formation. Immature permanent teeth are prone to caries and trauma which can cause exposure and degeneration of pulp. Pulp degeneration stops root formation, leaving teeth with open apex. It is vital to preserve the pulp vitality otherwise the incompletion of root might result in the fragility of teeth. Pulpotomy is one of the most widely used methods in preserving vital pulp in teeth, which is of great significance in achieving continue root formation in immature permanent teeth suffering from dental caries or trauma. Pulpotomy is recommended by the American Association of Pediatric Dentistry for the management of pulp exposure in immature permanent teeth to achieve apexogenesis (continued root formation and closure of apex). In this procedure, coronal pulp tissue is removed in order to eliminate the infected or contaminated pulp and to reach the healthy vital pulp followed by coverage with biocompatible material.

Participants needed: 26
Trial details
Age: 7-15Biological sex: AllType: InterventionalSponsor: Minia UniversityUpdated: Jan 7, 2026Locations: 1
Eligibility criteria

Patients with immature maxillary anterior teeth. [+3]

Patients with mature roots. [+7]

Status: Recruiting

Caries Detection With Two Different Caries Detecting Devices

The primary aim of this study will be to compare the effectiveness of the novel LumiCare™ rinse and with QLF in determining caries progression. The secondary aim is to compare the progression of carious lesions between patients who reported use of e-cigarettes/vapes and those who did not.

Participants needed: 60
Trial details
Age: 21+Biological sex: AllType: InterventionalSponsor: Tufts UniversityUpdated: Aug 5, 2025Locations: 1
Eligibility criteria

Patients of TUSDM Comprehensive Care Clinic [+7]

Low or moderate caries risk classification per TUSDM CAMBRA form [+4]

Status: Not yet recruiting

Surface Caries Feature Study

Dental caries (dental cavity) is very common and can impact oral health and oral health-related quality of life. Dental caries is when the tooth surfaces break down, and if left untreated, can cause tooth pain. In routine clinical practice, dental professionals typically assess caries lesions by looking at patients' teeth, touching the areas of interest with a dental probe, and running a probe over the teeth to check the buildup of bacteria. Dentists often use x-rays to help find cavities, and they can also take pictures of the teeth to show what the problem looks like. New tools called intraoral scanners are becoming more useful for finding cavities. These scanners do not use radiation and do not hurt. Some computer programs that use artificial intelligence (AI) can also help dentists find cavities. AI can study the spots on patients' teeth and help make better, faster decisions. The purpose of this study is to collect data that will be used to develop and test an AI software that can help dentists in the detection of caries.

Participants needed: 88
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: 3Shape A/SUpdated: Jul 2, 2025
Eligibility criteria

Willing and able to give informed consent for participation in the study [+6]

Patients with orthodontic appliances and permanent retainers [+3]

Status: Recruiting

Ozone Application Before Fissure Sealants

Decay is a multifactorial infective degenerative disease of hard dental tissues, caused by Streptococcus mutans and Lactobacillus forming the bacterial biofilm of teeth surfaces. Decays generally evolve in fissures and pits of secondary molars. Pits and fissure sealants prevent decays if performed in two years from eruption. Ozone has bactericidal effect and remineralizing capacity on enamel. The aim of this study is to assess the effectiveness of ozone application before sealants in increasing their duration in time.

Participants needed: 67
Trial details
Age: 6-16Biological sex: AllType: InterventionalSponsor: IRCCS Burlo GarofoloUpdated: May 16, 2025Locations: 1
Eligibility criteria

first or second secondary molars to be sealed [+3]

latex allergy [+5]

Status: Recruiting

Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial

Dental caries, particularly in primary molars, significantly affects children's oral health and overall well-being. Traditional management with stainless steel crowns (SSCs) involves significant tooth reduction and advanced dental skills. Introduced in the 1970s, the Hall technique offers a less invasive alternative, minimizing tooth reduction compared to SSCs. The SMART Hall technique represents a further evolution, emphasizing atraumatic cavity preparation using hand instruments. It offers advantages like minimal or no tooth reduction, minimized discomfort, improved patient cooperation, shorter treatment times, and cost-effectiveness. Silver Diamine Fluoride (SDF) emerges as a promising non-invasive approach for managing dental caries in primary teeth, though it may cause temporary tooth discoloration. However, comparative evaluation with traditional SSC restorations remains limited. To address this gap, a randomized clinical trial will evaluate the treatment outcomes of the SMART Hall technique versus conventional SSC restoration for managing occluso-proximal carious lesions (ICDAS CODE 3/4/5) in primary molars of young patients. Children aged 3 to 9 years requiring restorations will be included, assessing clinical outcomes, treatment time duration, and radiographical outcomes of both techniques at specific follow-up intervals of 3 months \& 6 months. This split mouth study will explore Clinical outcomes, radiographical outcomes, treatment time duration, and patient's pain perception with the chosen treatment modality. The findings will provide insights into the effectiveness and feasibility of the SMART Hall technique compared to the traditional SSC approach, informing evidence-based decision-making in pediatric dentistry and influencing treatment recommendations for preserving the health and function of primary molars in young children.

Participants needed: 30
Trial details
Age: 3-9Biological sex: AllType: InterventionalSponsor: C K S Teja Institute Of Dental Sciences & ResearchUpdated: Mar 3, 2025Locations: 1
Eligibility criteria

Children aged 3 to 9 years old. [+4]

Presence of severe systemic medical conditions (e.g., uncontrolled diabetes, imm... [+4]

Status: Not yet recruiting

Caries-associated Saliva Biomarkers Among Different Races

discover possible differences and develop effective preventative interventions by examining the relationship between salivary biomarkers and caries prevalence across different racial groups and Detect risk factors involved in caries incidence .

Participants needed: 22
Trial details
Age: 18-25Biological sex: AllType: ObservationalSponsor: Cairo UniversityUpdated: Feb 20, 2025
Eligibility criteria

Age : 19-25 [+1]

: Those who reported daily use of alcohol or tobacco . [+2]

Status: Recruiting

Effect of Er,Cr:YSGG Sub-Ablative Laser Irradiation on Fissure Caries Prevention in Permanent Molars

Background: Subjecting human dental enamel to sub-ablative laser has been suggested as a novel way of caries prevention. However, further studies are needed to establish its use as a routine clinical procedure for caries prevention. The aim of this study: This study aims to evaluate the effect of Er,Cr:YSGG subablative laser irradiation on caries resistance of occlusal fissures of permanent molars. Materials and methods: In-vivo study, a split mouth randomized controlled trial with sixty patients having two fully erupted bilateral first permanent molars (ICDAS-II score 0,1 or 2). The pits and fissures will be subjected to sub-ablative power of Er,Cr:YSGG Laser (Group 1, n=90) and will be compared with fluoride varnish application on the first permanent molars in the same arch(Group 2,n=90). DIAGNOdentTM readings and changes in ICDAS-II score will be assessed at base line and at 3,6,9 and 12 months follow-up.

Participants needed: 60
Trial details
Age: 6-12Biological sex: AllType: InterventionalSponsor: Alexandria UniversityUpdated: Feb 14, 2025Locations: 1
Eligibility criteria

Participants of age 6-12 years old [+4]

Patients with any known medical history of systemic diseases [+4]

Status: Not yet recruiting

Coronal and Radicular Caries Prevalence and Related Risk Factor in Diabetic Patient

This study aims to investigate the prevalence and risk factors of coronal and radicular caries in middle-aged individuals with Type 2 diabetes. It focuses on how poor blood sugar control, reduced saliva production, increased plaque accumulation, and periodontal disease contribute to a higher risk of dental decay in this population. The study examines the relationship between glycemic control (e.g., HbA1c levels) and the severity of caries, as well as the impact of diabetes-related changes in oral health, such as gum recession and dry mouth, on the development of both coronal and radicular caries. The findings could inform preventive strategies and dental care guidelines tailored for diabetic patients.

Participants needed: 265
Trial details
Age: 35-60Biological sex: AllType: ObservationalSponsor: Cairo UniversityUpdated: Dec 4, 2024
Eligibility criteria

Patient whose age between 30-65 [+5]

Patients under or over this age group [+3]

Status: Not yet recruiting

Artificial Intellegence Rivals Digital Bitewing in Detect Secondary Caries

This study uses digital bitewing radiography as a standard for diagnosing proximal secondary caries. Patients will undergo imaging with a parallel technique and fixed settings to ensure high-quality, consistent images. Radiographs are interpreted by experienced dental professionals to maintain diagnostic accuracy. Machine learning models YOLO and Mask-RCNN will analyze these images in three phases: pre-analytical, analytical, and post-analytical. A dataset of 322 labeled images, annotated by experts, is used to train these models. Data augmentation methods enhance model performance, and accuracy is assessed against radiographic results to confirm reliability.

Participants needed: 322
Trial details
Age: 22-60Biological sex: AllType: ObservationalSponsor: Cairo UniversityUpdated: Oct 31, 2024Duration: 1 Year
Eligibility criteria

Adult Patients Aged 22-60 Patient [+3]

Patients with orthodontic appliances, or bridge work that might interfere with e... [+3]

Status: Recruiting

Oral Health Education and Message Framing Effect on Oral Health Status of Refugees in Egypt

Refugees, facing forced displacement and often exposed to traumatic experiences, represent a vulnerable population with unique healthcare needs. Oral health is considered a prominent factor that contributes to quality of life. Therefore, this study aim at assessing the effect of message framing on enhancing oral health practices in a group of refugees in Alexandria, Egypt. A three-arm cluster randomized controlled clinical trial will compare a gain-framed mobile text messages group, a loss-framed mobile text messages group, and a control group. The primary outcome is the improvement in oral health practices measured by changes in dental plaque and secondary outcome is to assess change in oral health-related quality of life. In addition, oral health knowledge, attitudes, and practices of refugees will be assessed.

Participants needed: 510
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Alexandria UniversityUpdated: Oct 21, 2024Locations: 1
Eligibility criteria

Refugees older than 18 years old. [+4]

Planning to move away during 1 year study period. [+1]

Status: Recruiting

Comparison of the Treatment Outcomes of the Conventional Stainless Steel Crown Restorations and the Hall Technique in the Treatment of Carious Primary Molars

Stainless steel crowns have shown high success in restoring carious primary molars over a longer period of time than conventional restorations. This study aims to evaluate the treatment effectiveness of conventional SSCs restoration and Hall technique in treating carious primary molars

Participants needed: 100
Trial details
Age: 3-9Biological sex: AllType: InterventionalSponsor: Hue University of Medicine and PharmacyUpdated: Sep 19, 2024Locations: 1
Eligibility criteria

Agree and voluntarily participate in the research (with the patient's parent/gua... [+1]

Children with systemic diseases such as immunodeficiency, cardiovascular disease... [+4]

Status: Recruiting

Evaluation of Antimicrobial, Post Operative Pain of Cinnamon Extract Versus Sodium Hypochlorite Irrigant Following Pulpectomy of Primary Teeth

The aim of the study is to evaluate effectiveness of cinnamon extract versus sodium hypochlorite as root canal irrigant for in pulpectomy of primary teeth in reduction of bacterial count .

Participants needed: 26
Trial details
Age: 4-8Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Aug 22, 2024Locations: 1
Eligibility criteria

Aged 4 to 8, in good general health, and medically free. [+7]

Children with medical, physical, or mental conditions. [+4]

Status: Recruiting

Caries Prevalence, Experience and Risk Related Factors Among Early Middle-aged Patients Attending Cairo University

Dental caries, a widespread oral health issue, results from a complex interplay of factors including behavior, hygiene, diet, and socio-demographic aspects. While preventive measures are available, it remains prevalent globally, affecting numerous teeth per individual. Improved oral hygiene practices and increased awareness have led to a reduction in caries prevalence. However, rising sugar consumption exceeds dietary guidelines, contributing to the problem. Despite limited epidemiological studies in Egypt, addressing individual-level factors is crucial. Surveillance of oral health in the early middle age group is standard, allowing decision-makers to assess the impact of caries and oral health care provision. Stratifying data by age, geography, and gender aids in understanding prevalence and planning effective prevention strategies. Overall, promoting awareness of dietary habits and preventive practices is vital for improving oral health outcome So, The purpose of this study is to assess the prevalence of dental caries among early middle age patients attending dental hospital in Faculty of Dentistry, Cairo university and to analyze the related risk factors utilizing WHO Oral Health Questionnaire for Adults.

Participants needed: 350
Trial details
Age: 35-44Biological sex: AllType: ObservationalSponsor: Cairo UniversityUpdated: Aug 21, 2024Locations: 1Duration: 1 Day
Eligibility criteria

Patients whose age between 35 to 44 years old. [+5]

Patients under or over this age group [+2]

Status: Not yet recruiting

KAP of Dental Practitioners Regarding CRA

The aim of the study is to evaluate the knowledge, attitude, and practice of a group of dental practitioners from Cairo and Riyadh regarding caries risk assessment and management.

Participants needed: 174
Trial details
Biological sex: AllType: ObservationalSponsor: Cairo UniversityUpdated: Aug 2, 2024
Eligibility criteria

Licensed Egyptian and Saudi general dentists.

Undergraduate dental students [+2]

Status: Not yet recruiting

Accuracy of ICCMS Versus Simplified Cariogram

The study aims to compare the validity of the caries risk assessment regarding the comprehensive ICCMs Caries risk and likelihood matrix versus the simplified Cariogram aiming to see if there is a significant difference in the caries risk levels between both models.

Participants needed: 323
Trial details
Age: 18-29Biological sex: AllType: ObservationalSponsor: Kirolos Hisham Nadi SedekUpdated: Jun 7, 2024
Eligibility criteria

Age ranging from 18 to 29 years. [+1]

Patients with no caries. [+2]

Status: Recruiting

CARDEC-PEL: Comparison of Two Methods of Caries Risk Assessment in Children

The aim of the study was to compare dental caries treatment and follow-up based on an elaborate and individualized assessment of caries risk in children, to a simpler risk assessment strategy by means of a double-blind randomized clinical trial of two years monitoring. Participants will be children from 7 to 11 years old, who pass through the screening of the Children's Clinic of the Faculty of Dentistry of the Federal University of Pelotas and fulfill the inclusion criteria. A randomized, stratified sample of approximately 250 children will be included in the study, one group will be composed of children undergoing dental caries-related treatment and maintenance, guided by an individualized and multivariate risk assessment, and another group of children treated based on dental caries experience alone in the deciduous and / or permanent dentition. Recruitment will begin at the beginning of 2019, and participants will be followed up for 24 months. Parents will respond to an anamnesis, 24-hour dietary recall, food frequency questionnaire, and oral and general health-related quality of life questionnaire, children will undergo a clinical examination to assess caries, according to the International Caries Detection and Assessment System (ICDAS) in its simplified form and evaluation of caries activity. Dental treatments and return intervals will be designated according to the individual risk of the patient detected in the initial approach according to the group. The study evaluations consist of baseline, 12 months and 24 months, data will be transferred to spreadsheets after the different phases of the study. Primary outcomes (number of dental surfaces requiring operative intervention) and secondary outcomes will be analyzed by Student's t test, quality of life and quality of life related to oral health, will be assessed at the beginning of the study and at the end of treatment, and compared between the groups.

Participants needed: 250
Trial details
Age: 7-11Biological sex: AllType: InterventionalSponsor: Federal University of PelotasUpdated: Apr 25, 2023Locations: 1
Eligibility criteria

Individuals aged 7 years months to 11 years; [+1]

Medical and/or behavioral conditions that requires special considerations regard...