[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-stroke-related-upper-extremity-motor-impairment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-stroke-related-upper-extremity-motor-impairment":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100633790",false,"NCT07531264","Neuro-Intermuscular Coordination Enhancement (NICE) Rehabilitation Through Human-Machine Interaction in Chronic Stroke","Neuro-Intermuscular Coordination Enhancement (NICE) Rehabilitation","NICE","Inclusion criteria for individuals after stroke are:\n\n* Hemiparetic chronic stroke survivors more than 6 months after stroke onset\n* Adults aged 21-80 years, including both female and male participants\n* Individuals with a single unilateral ischemic or hemorrhagic stroke\n* Individuals with Upper Extremity Fugl-Meyer Assessment score between 10 and 59 out of 66\n* Individuals who have not received botulinum toxin injections in the upper extremity within the past 3 months\n* Individuals without severe spasticity, defined as Modified Ashworth Scale score ≤3 at the elbow and shoulder\n\nExclusion criteria for individuals after stroke are:\n\n* Individuals younger than 21 years of age or older than 80 years of age\n* Individuals with an orthopedic disorder involving the upper limbs\n* Individuals unable to produce voluntary upper-extremity muscle EMG activity;\n* Individuals with cognitive impairment sufficient to interfere with informed consent or successful completion of the protocol, assessed using the Montreal Cognitive Assessment or other IRB-approved screening procedures.\n* Individuals whose stroke-affected arm has an intermuscular coordination pattern similarity score \\>0.80 relative to the non-affected arm\n\nInclusion criteria for healthy individuals are:\n\n* Healthy adults aged 21-80 years, including both female and male participants\n* Individuals with no known neurological or orthopedic injuries\n\nExclusion criteria for healthy individuals are:\n\n* Individuals younger than 21 years of age or older than 80 years of age\n* Individuals with known neurological disorders\n* Individuals with orthopedic injuries or conditions affecting upper-extremity movement\n* Individuals unable to provide informed consent",true,"ALL","21 Years","80 Years",{"count":21,"type":22},48,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","The objective of this study is to develop Neuro-Intermuscular Coordination Enhancement (NICE) rehabilitation, a novel neuromuscular control signal-guided strategy that visually guides stroke patients to individually activate motor modules through human-machine interaction. Ultimately, the development will lead to better clinical motor recovery, better quality of life, and lowered healthcare costs associated with the impairment.",[28,29],"Chronic Stroke-related Upper-extremity Motor Impairment","Motor Module-guided Rehabilitation Targeting Impaired Intermuscular Coordination and Motor Recovery",[31,32,33,34,35],"Muscle Synergy","Non-invasive Rehabilitation","Intermuscular Coordination","Stroke","Motor module","NOT_YET_RECRUITING","2026-06-15",{"date":39,"type":40},"2026-06-18","ACTUAL",{"date":42,"type":22},"2027-08",{"date":44,"type":22},"2032-08",{"name":46,"class":47},"University of Houston","OTHER",""]