[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"class-ii-lesions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:class-ii-lesions":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100625985",false,"NCT07429747","Performance of Reinforced 3D-Printed Versus Direct Bulk-Filled Resin Composites for Restoring Extensive Class II Cavities in Vital Molars","Performance of Reinforced 3D-Printed Versus Direct Bulk-Filled Resin Composites for Restoring Extensive Class II Cavities in Vital Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\nPatient-related:\n\n* Adults aged 22 to 45 years.\n* Low to moderate caries risk.\n* Normal occlusion.\n* No signs or symptoms of temporomandibular joint disorders.\n* Satisfactory oral hygiene.\n* Medically fit to receive routine restorative dental treatment.\n\nLesion-related:\n\n* Permanent molar requiring a compound Class II restoration.\n* Primary carious lesion classified as ICDAS score 5.\n* Presence of an adjacent tooth and a sound opposing tooth in occlusion.\n* No clinical signs or symptoms of irreversible pulpitis in the involved, adjacent, or opposing teeth.\n* No radiographic evidence of periapical pathology.\n\nExclusion Criteria:\n\nPatient-related:\n\n* Bruxism.\n* Poor cooperation.\n* Inability or unwillingness to attend follow-up visits.\n* Anticipated travel during the study period.\n* Poor oral hygiene.\n* Chronic or advanced periodontitis.\n* Known allergy to any study materials.\n* Pregnant or breastfeeding women.\n\nLesion-related:\n\n* Teeth with visible fractures or cracks.\n* Rampant caries.\n* Defective restorations on adjacent or opposing teeth.\n* Atypical extrinsic staining that may interfere with evaluation.\n* Radiographic signs of apical pathology.","ALL","22 Years","45 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","Most published research on 3D-printed restorative materials is laboratory-based, focusing primarily on mechanical performance and material properties under controlled conditions. While such studies provide important foundational data, they do not fully replicate the complexity of the oral environment. Only a limited number of clinical investigations have directly compared 3D-printed restorations with conventional direct composite restorations in Class II cavities Furthermore, the integration of a digital workflow introduces additional costs and time requirements related to equipment, software, and training. These factors must be justified by demonstrable improvements in clinical outcomes or cost-effectiveness. By evaluating both clinical performance and economic impact, this trial aims to generate practical, real-world evidence that can guide clinicians in selecting appropriate restorative materials and techniques for routine dental practice.",[26,27,28,29,30],"Class II Lesions","3D Printing","Bulk Fill","Proximal Cavities of Posterior Teeth","Composite Restorations","NOT_YET_RECRUITING","2026-03-02",{"date":34,"type":35},"2026-03-04","ACTUAL",{"date":37,"type":20},"2026-02-20",{"date":39,"type":20},"2027-10-01",{"name":41,"class":42},"Ahmed Reda Abd EL Rahman","OTHER",""]