[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"clinical-efficacy-of-submucosal-dexamethasone-and-oral-trypsin-chymotrypsin-for-reduction-of-postoperative-sequelae-after-lower-third-molar-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:clinical-efficacy-of-submucosal-dexamethasone-and-oral-trypsin-chymotrypsin-for-reduction-of-postoperative-sequelae-after-lower-third-molar-surgery":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":14,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100570937",false,"NCT06713733","Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery","Inclusion Criteria:\n\n* Clinically healthy patients (ASA I) patient free of any systemic diseases that could interfere with wound healing or surgical operation.\n* Free of any recent anti-inflammatory drug intake or being under long term treatment with medicaments that will obscure the assessment of the inflammatory response as NSAIDs, steroids, or antihistamines\n* Free from allergy to the drugs used in the study\n* Patients requiring surgical removal of the mandibular impacted third molar\n\nExclusion Criteria:\n\n* Patients who are ASA II to ASA VI.\n* Patients already on corticosteroids through any route.\n* Patients with known allergy to any drugs.\n* Pregnant and lactating females\n* Patient not consenting to participate in the study",true,"ALL","18 Years",{"count":18,"type":19},50,"ESTIMATED","INTERVENTIONAL",[22],"NA","Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response.\n\nUse of corticosteroids decrease tissue mediators of inflammation and reduce edema.\n\nUse of trypsin-chymotrypsin elaborates the enzymes esterase in blood plasma that inhibits inflammation by hydrolytic degradation of the inflammatory peptides.",[25],"Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin Chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery",[27,28],"Dexamethasone","Trypsin-chymotrypsin","RECRUITING","2024-11-27",{"date":32,"type":33},"2024-12-03","ACTUAL",{"date":35,"type":33},"2024-09-25",{"date":37,"type":19},"2025-01-25",{"name":39,"class":40},"B.P. Koirala Institute of Health Sciences","OTHER",""]