[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"closed-loop-brain-stimulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:closed-loop-brain-stimulation":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100644519",false,"NCT07671079","Closed-loop tES-non-invasive Stimulation","Closed-loop Non-invasive Stimulation for Improving Brain and Mental Health in Healthy Individuals","CLIBM","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study\n* Aged between 18 and 40\n* Good general health\n* Not consume alcohol 48 hours prior study visit\n* Not currently taking any medications (except contraceptive pills) or if on long-term medication for a non-neurological\u002Fnon-psychiatric condition (r.g. inhalers) to be considered otherwise healthy and stable with no symptoms\n* Be right handedness\n\nExclusion Criteria:\n\n* Inability to complete MRI\u002FFUS\u002FTMS\u002FtES safety questionnaire and \u002F or informed consent process.\n* Current or previous diagnosis of a neurological, neurosurgical, psychiatric disorders.\n* Other significant medical condition (specific details to be reviewed by the CI prior to inclusion).\n* Currently pregnant, breast feeding, or on planned pregnancy.\n* Medication intake (such as beta-blocker, glucocorticoids, anti-depressants, anti-inflammatory drugs in the last 7d).\n* Medication intake (such as beta-blocker, glucocorticoids, anti-depressants) in the last 7d that are likely to affect brain function.\n* Significant use of medication or recreational drugs that affect the nervous system.\n* Excessive consumption of alcohol (\\>2 alcohol beverages per day).\n* Known allergy to any required consumables (such as aquasonic gel).\n* History of anaphylaxis to any substance\n* Have tightly coiled, curly or voluminous texture hair type (e.g., hair type 3, 4, or afro hair).\n* Having skin disease or sensitive skin on or close to the head.",true,"ALL","18 Years","40 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study is to establish if non-invasive closed-loop neuromodulation is an effective approach to enhance cognitive function in healthy 18-40 years old volunteers. The main questions it aims to answer are:\n\n* Can closed-loop stimulation increase stimulation effectiveness?\n* Can closed-loop focused ultrasound specifically engage with excitatory or inhibitory neural populations in the target structure as measured through MRS?\n* Can observed stimulation outcomes for FUS be predicted through connectome analysis and computational models of indirect changes?\n\nResearchers will compare different closed-loop options to their open-loop counterpart to see if closed-loop approaches can increase efficacy and reduce the variability of the stimulation compared to open-loop approaches.\n\nParticipants will:\n\n* Answer some questionnaires at the start of the study and after each intervention session.\n* Undertake a MRI scanning session.\n* Undertake one open-loop FUS session.\n* Undertake one tES session.\n* Undertake one closed-loop FUS sessions involving tES and FUS, followed by a MRI scanning\n* Undertake one sham FUS session\n* Attend one visit in person to assess eligibility through questionnaires and one cognitive task",[28],"Closed-loop Brain Stimulation",[30,31,32,33],"neuromodulation","electrical stimulation","transcranial low-intensity focused ultrasound stimulation","closed-loop neuromodulation","NOT_YET_RECRUITING","2026-06-22",{"date":37,"type":38},"2026-06-26","ACTUAL",{"date":40,"type":22},"2026-07",{"date":42,"type":22},"2027-12",{"name":44,"class":45},"University of Nottingham","OTHER",""]