[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"clozapine-resistant-schizophrenia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:clozapine-resistant-schizophrenia":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100554611",false,"NCT06501339","Maintenance Electroconvulsive Therapy (ECT) Versus Aripiprazole in Clozapine-resistant Schizophrenia","Maintenance Electroconvulsive Therapy (ECT) Versus Aripiprazole on Psychopathology and Cerebral Perfusion in Clozapine-resistant Schizophrenia: a Randomized, Double-blind Controlled Trial","Inclusion Criteria:\n\n1. Patients clinically diagnosed with CRS (currently under clozapine)\n2. Patients aged 18-60 years of either sex.\n3. LAR giving voluntary written consent for participation in the study\n\nExclusion Criteria:\n\n1. Patient already on ECT or aripiprazole.\n2. History of psychoactive substance abuse or dependence.\n3. Co-morbid psychiatric, major medical or neurological disorders.\n4. History of organicity or significant head injury.\n5. Pacemaker or metal in any body part, excluding the mouth. Pregnant and breastfeeding females.","ALL","18 Years","60 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The pharmacological treatment options in schizophrenia developing resistance to clozapine are limited. Few studies have found ECT as beneficial in TRS, including CRS. However, literature on the role of M-ECT in maintaining the therapeutic gains of acute ECT in CRS is lacking. The objective of the study is to compare the efficacy of M-ECT vs aripiprazole as an add-on to ongoing clozapine on the severity of symptom dimensions, cerebral perfusion, global functioning and cognitions in patients with CRS.",[26],"Clozapine Resistant Schizophrenia",[28,29,30,31],"Clozapine resistant","schizophrenia","Aripiprazole","m-ECT","NOT_YET_RECRUITING","2024-07-15",{"date":35,"type":36},"2024-07-16","ACTUAL",{"date":38,"type":20},"2024-08-10",{"date":40,"type":20},"2026-03-31",{"name":42,"class":43},"All India Institute of Medical Sciences, Bhubaneswar","OTHER",""]