[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"complicated-parapneumonic-effusion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:complicated-parapneumonic-effusion":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100637813",false,"NCT07592520","Flush, Lyse, Operate","Flush, Lyse, Operate: A Pilot Trial of Step-Wise Escalation for Pleural Infection: FLO Trial","FLO","Inclusion Criteria:\n\n* Age 18+\n* Complicated Parapneumonic Effusion or Empyema Requiring Thoracostomy\n* Are able to personally or have a designated medical decision maker provide consent\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Have received any intrapleural medications prior to enrolment via current chest tube\n* Have a contraindication to tPA\u002FDNase:\n\n  * Anticoagulation\n  * Active hemorrhage\n  * Allergy to tPA\u002FDNase\n  * Pregnancy\n* Are unable to personally or do not have a designated medical decision maker provide consent","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space. The main question it aims to answer is:\n\nWhat is the time to chest tube removal? Do these patients after need to escalate to fibrinolytics? Do these patients after need to escalate to surgery?\n\nParticipants will:\n\n* Receive receive saline into their pleural space through an existing chest tube\n* If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will receive fibrynolytics through an existing chest tube\n* If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will be referred to surgery.",[26,27],"Complicated Parapneumonic Effusion","Empyema, Pleural","NOT_YET_RECRUITING","2026-05-11",{"date":31,"type":32},"2026-05-18","ACTUAL",{"date":34,"type":20},"2026-04",{"date":36,"type":20},"2027-04",{"name":38,"class":39},"Dartmouth-Hitchcock Medical Center","OTHER",""]