[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"concussion-brain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:concussion-brain":537},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,54,85,107,134,159,172,201,230,261,282,306,340,369,390,414,435,459,485,507],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":35,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100053319",false,"NCT05663034","CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms","CoMBat Insomnia: A Randomized Controlled Trial of Cognitive-Behavioral vs. Mindfulness-Based Treatment for TBI-Related Insomnia and Post-Traumatic Stress Symptoms","Inclusion Criteria:\n\n1. Current or former member of the uniform services\n2. Meet the Veterans Affairs Medical Center (VAMC) Department of Defense (DoD) criteria for TBI;\n3. Time duration since traumatic brain injury (TBI) injury \\>90 days\n4. Insomnia symptom duration \\>90 days\n5. Endorse insomnia symptoms (Insomnia Severity Index \\[ISI\\] score \\> 10)\n6. Display sufficient cognitive capacity to provide informed consent (Montreal Cognitive Assessment (MoCA) Z-score \\> -2)\n7. \\>18 years of age\n8. Access to and ability and to use computer.\n\nExclusion Criteria:\n\n1. History of neurological diseases other than TBI and not attributable to TBI\n2. Sleep apnea \\[apnea hypopnea index (AHI) \\>15; individuals with mild apnea (AHI \\> 5 and \\\u003C15) will be informed, but allowed to participate\\]. Participants who use a continuous positive airway pressure (CPAP) device for sleep apnea will be eligible for participation if they are below the apnea\u002Fhypopnea cutoff while using CPAP, are adherent to using the device (\\> 4 hours\u002Fnight 21\u002F30 consecutive days) and agree to continue using the device during study participation.\n3. Lastly, people using psychotropic medications may be included if they are on a stable dosage for the last three weeks prior to the study.","ALL","18 Years",{"count":18,"type":19},360,"ESTIMATED","INTERVENTIONAL",[22],"NA","This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and mindfulness-based treatment for insomnia (MBTI) in treating insomnia symptoms and ameliorating depressive symptoms in persons with mild to moderate TBI and comorbid Post-Traumatic Stress Symptoms (PTSS) and insomnia symptoms in a 360 patients. Participants will undergo assessment (psychosocial questionnaires, neurocognitive testing, sleep monitoring) at baseline, at the end of treatment, and at 2-, 6- and 12-weeks post-treatment. The primary outcome is sleep as measured by the Insomnia Severity Index (ISI).",[25,26,27,28,29,30,31,32,33,34],"Traumatic Brain Injury","Insomnia","Depression","Post-traumatic Stress","Sleep","Memory Impairment","Cognitive Behavioral Therapy","Concussion, Brain","Head Injury","Brain Injury Traumatic Mild",[25,26,36,27,37,33,38,39,40],"Posttraumatic Stress Symptoms","Concussion","Brain Injury","Cognitive Behavioral Therapy for Insomnia","Mindfulness-based Treatment for Insomnia","RECRUITING","2026-07-10",{"date":44,"type":45},"2026-07-13","ACTUAL",{"date":47,"type":45},"2024-05-10",{"date":49,"type":19},"2027-06",{"name":51,"class":52},"Johns Hopkins University","OTHER",5,{"id":55,"slug":4,"hasResults":10,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":15,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":20,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":4},"100644586","NCT07670195","BCAAs in Concussion 3.0","HIT HEADS 3.0: Head Injury Treatment: A Randomized, Placebo-controlled, Double-blinded, Therapeutic Clinical Trial of Branched Chain Amino Acids (BCAAs) in the Treatment of Concussion","Inclusion Criteria:\n\n1. Males and females,11 - 23 years of age.\n2. Weigh at least 40kg.\n3. Meeting concussion criteria for the American Congress of Rehabilitative Medicine.\n\n   a. One or more clinical signs or two or more acute symptoms with at least one VVE abnormality.\n4. Present within 4 days of injury.\n5. Post-menarchal females must have a negative urine pregnancy test.\n6. Informed consent by the participant, or for participants \\\u003C18 years old both informed consent by a parent\u002Fguardian and child assent.\n\nExclusion Criteria:\n\n1. Evidence of moderate or severe TBI, including GCS \\\u003C13, TBI requiring hospital admission, or TBI requiring neurosurgical intervention.\n2. Prior concussion or TBI within 90 days.\n3. Known history of maple syrup urine disease or known family history of maple syrup urine disease.\n4. Any investigational drug use within 30 days prior to enrollment.\n5. Participants who are pregnant, planning on becoming pregnant during the study duration, or breastfeeding.\n6. Non-English speaking participants or parent\u002Fguardian.",true,"11 Years","23 Years",{"count":64,"type":19},150,[66],"PHASE2","This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion. The aim of the study is to determine whether administration of high-dose BCAAs compared to placebo promotes concussion recovery.",[69,70,32,37],"Concussion (Diagnosis)","MTBI - Mild Traumatic Brain Injury",[37,72,73,74],"mTBI","BCAAs","Branched Chain Amino Acids","NOT_YET_RECRUITING","2026-06-19",{"date":78,"type":45},"2026-06-26",{"date":80,"type":19},"2026-07",{"date":82,"type":19},"2027-12",{"name":84,"class":52},"Akiva Cohen",{"id":86,"slug":4,"hasResults":10,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":20,"phases":94,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100532131","NCT06208813","Creatine Supplementation in Concussion Recovery","Assigned Creatine Ingestion With Usual Diet or Usual Diet Alone.","CSCR","Inclusion Criteria:\n\n* 18-35 years old with a diagnosed concussion within 72 hours post-injury\n\nExclusion Criteria:\n\n* Learning disability, renal disease, mental behavior or migraine history, and current creatine use or have not taken creatine in the past 6 weeks","35 Years",{"count":5,"type":19},[22],"The proposed study aims to compare concussion recovery in those supplementing creatine and those not supplementing creatine. Specific aim 1: To compare number of days until asymptomatic between those taking creatine vs. those not taking creatine following a concussion. Hypothesis: The investigators hypothesize that individuals taking creatine will become asymptomatic sooner than those not taking creatine.Specific aim 2: To compare typical concussion assessment scores (i.e., symptom score, mental status, neurocognition, balance, motor coordination, and visual performance) between those taking creatine vs those not taking creatine following a concussion once asymptomatic.Hypothesis: The investigators hypothesize that individuals taking creatine will have better symptom scores, balance, mental status, and neurocognition assessment scores than those not taking creatine once asymptomatic.\n\nThe investigators will calculate descriptive statistics for all demographic, days to asymptomatic, and concussion assessments. For specific aim 1, The investigators will calculate a t-test to determine if days to asymptomatic differed in those taking creatine vs. those not taking creatine. For specific aim 2, the investigators will calculate t-tests with Bonferonni corrections to determine if concussion assessment scores (Sport Concussion Office Assessment Tool-6 assessments, CNS Vital Signs, visual assessment) differed in those taking creatine vs. those not taking creatine.",[32],"2026-06-17",{"date":99,"type":45},"2026-06-18",{"date":101,"type":45},"2024-02-01",{"date":103,"type":19},"2027-05-31",{"name":105,"class":52},"San Diego State University",1,{"id":108,"slug":4,"hasResults":10,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":60,"sex":15,"minAge":114,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":106},"100536858","NCT06270290","The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls","Observational Cross-sectional Study Investigating the History of Concussion and Exposure to Contact Sports in Patients With REM Sleep Behaviour Disorder (RBD) Versus Controls (Without a Diagnosis of RBD)","COSP-RBD","Inclusion criteria group with RBD:\n\n* Patient at the SDC with diagnosis of RBD (Guy's and St Thomas' NHS Foundation Trust).\n* 50 years of age or above (patients below this age would not be expected to have a RBD related to a synucleinopathy and other causes of RBD would need to be considered instead - e.g. narcolepsy, post-traumatic stress disorder).\n\nInclusion criteria control group:\n\n* Patients who have undergone a v-PSG at the SDC (Guy's and St Thomas' NHS Foundation Trust) and who do not have history of suspected RBD or RBD confirmed by v-PSG.\n* 50 years of age or above This group will be age- and sex-matched to the RBD group.\n\nExclusion criteria group with RBD:\n\n* Age \\\u003C 50 years of age.\n* Diagnoses of narcolepsy or post-traumatic stress disorder.\n* Subjects lacking capacity or literacy.\n* Non-English speakers.\n\nExclusion criteria control group:\n\n* Age \\\u003C 50 years of age (in order to match RBD group).\n* REM sleep without atonia or confirmed RBD on v-PSG.\n* Diagnosis of neurological diseases, cognitive complaints or motor complaints.\n* Clinical history suggestive of parasomnia that may be included in the differential of RBD.\n* Subjects lacking capacity or literacy.\n* Non-English speakers.","50 Years",{"count":116,"type":19},140,"OBSERVATIONAL","The goal of this observational study is to investigate concussions and contact sports practices in REM sleep behaviour disorder (RBD).\n\nThe main questions it aims to answer are:\n\n* What is the proportion of patients with RBD that have a history of concussions or exposure to contact sports?\n* Is this proportion higher to that in control patients without a diagnosis of RBD?\n\nParticipants will undergo an interview with a sleep medicine specialist to answer questions about history of concussions and contact sports practices.\n\nResearchers will compare an RBD group and a control group (without RBD) to see if the proportion of concussions and exposure to contact sports differ.",[120,32],"REM Sleep Behavior Disorder",[122,123,124],"REM sleep behaviour disorder","concussion","contact sports","2026-06-03",{"date":127,"type":45},"2026-06-04",{"date":129,"type":45},"2024-04-23",{"date":131,"type":19},"2026-09-30",{"name":133,"class":52},"Guy's and St Thomas' NHS Foundation Trust",{"id":135,"slug":4,"hasResults":10,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":20,"phases":143,"briefSummary":144,"conditions":145,"keywords":147,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":158},"100589592","NCT06956417","REhabilitation of MEMory Symptoms After BRain Concussion","REMEMBR","Inclusion Criteria:\n\n1. Age 18-59\n2. Concussion diagnosis confirmed with structured interview based on American Congress of Rehabilitation Medicine diagnostic criteria\n3. Concussion occurred between 6 and 36 months before enrollment\n4. Ongoing memory concerns\n5. Fluent in English\n6. Stable access to a computer, tablet, or smartphone with internet capability\n\nExclusion Criteria:\n\n1. Fail performance validity testing\n2. Comorbid psychiatric or neurological disorder or is taking a medication that could fully account for their memory symptoms","59 Years",{"count":142,"type":19},184,[22],"Persistent memory symptoms after concussion are common, and likely perpetuated by unhelpful illness beliefs and coping behaviors. Results from a pilot study suggested that traditional cognitive rehabilitation and a novel cognitive-behavioral therapy (CBT) protocol were both associated with improvements in subjective memory functioning. The present study will more definitively compare the effectiveness of these interventions for improving subjective memory functioning after concussion.",[32,146],"Mild Traumatic Brain Injury",[148],"Functional cognitive disorder","2026-05-29",{"date":151,"type":45},"2026-06-02",{"date":153,"type":45},"2025-07-02",{"date":155,"type":19},"2029-04-30",{"name":157,"class":52},"University of British Columbia",8,{"id":160,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":20,"phases":162,"briefSummary":23,"conditions":163,"keywords":164,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":169,"leadSponsor":171,"locationsCount":53},"100490200",{"count":18,"type":19},[22],[25,26,27,28,29,30,31,32,33,34],[25,26,36,27,37,33,38,39,40],"2026-05-26",{"date":167,"type":45},"2026-05-28",{"date":47,"type":45},{"date":170,"type":19},"2026-09",{"name":51,"class":52},{"id":173,"slug":4,"hasResults":10,"nctId":174,"briefTitle":175,"officialTitle":175,"acronym":176,"eligibilityCriteria":177,"healthyVolunteers":10,"sex":15,"minAge":178,"maxAge":4,"enrollmentInfo":179,"targetDuration":4,"studyType":20,"phases":181,"briefSummary":182,"conditions":183,"keywords":187,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":199,"locationsCount":106},"100473568","NCT05446584","Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History","PATH","Inclusion Criteria:\n\n1. Active diagnosis of amnestic mild cognitive impairment\n2. Presence of an mTBI history for the mTBI+ group; absence of an mTBI history for a control sample\n3. Female and male subjects\n4. All races\u002Fethnicities\n5. Age 55 years and older\n6. Fluent in English\n\nExclusion Criteria:\n\n1. Mild traumatic brain injury within past year\n2. Lifetime history of moderate or severe brain injury\n3. Lifetime major neurologic syndromes (e.g., stroke, epilepsy, brain tumor)\n4. Lifetime major cardiovascular conditions (e.g., heart attack, heart failure)\n5. Current substance use disorder\n6. Current major psychiatric disorders (e.g., major depressive disorder, bipolar disorder)\n7. Current vision or hearing impairment that interferes with testing\n8. Any electronic and or metallic implants in the skull or brain\n9. Current medication use known to alter HD-tDCS reactivity","55 Years",{"count":180,"type":19},75,[66],"This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.",[184,185,186,146,32],"Mild Cognitive Impairment","Amnestic Mild Cognitive Disorder","Amnestic Mild Cognitive Impairment",[188,189,190,191,192],"MCI","TBI","memory","biomarker","Alzheimer","2026-05-05",{"date":195,"type":45},"2026-05-06",{"date":197,"type":45},"2023-04-20",{"date":103,"type":19},{"name":200,"class":52},"University of Texas Southwestern Medical Center",{"id":202,"slug":4,"hasResults":10,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":10,"sex":15,"minAge":208,"maxAge":16,"enrollmentInfo":209,"targetDuration":4,"studyType":20,"phases":211,"briefSummary":212,"conditions":213,"keywords":218,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":229},"100472611","NCT05434130","Modulating Exercise Dosage to Improve Concussion Recovery","Modulating Exercise Dosage to Improve Concussion Recovery: A Randomized Clinical Trial","MEDIC","Inclusion Criteria:\n\n* 13-18 years of age\n* Post-Concussion Symptom Scale (PCSS) score \\>10 to ensure participants are not recovered by enrollment\n* Concussion diagnosis by a sports medicine physician\n\nExclusion Criteria:\n\n* Pre-existing neurological disorders\n* Exercise contraindications\n* Concussion \\\u003C6 months before enrollment (excluding the current injury)","13 Years",{"count":210,"type":19},216,[66],"Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 14 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.",[32,214,215,216,217],"Treatment","Aerobic Exercise","Inflammation","Depression, Anxiety",[219,220],"intervention","mild traumatic brain injury","2026-05-04",{"date":195,"type":45},{"date":224,"type":45},"2022-08-05",{"date":226,"type":19},"2027-02-01",{"name":228,"class":52},"University of Colorado, Denver",3,{"id":231,"slug":4,"hasResults":10,"nctId":232,"briefTitle":233,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":235,"enrollmentInfo":236,"targetDuration":4,"studyType":20,"phases":238,"briefSummary":239,"conditions":240,"keywords":241,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":106},"100491711","NCT05682677","Combined Neuromodulation and Cognitive Training for Post-mTBI Depression","Inclusion Criteria:\n\n1. Male or female\n2. All racial and ethnic groups\n3. Ages 18 to 65\n4. Military service members receiving treatment at NMCSD or civilians receiving treatment at UCSD Health\n5. History of mild TBI (as defined by the DoD\u002FVA criteria used in conjunction with the OSU TBI-ID method) over 3 months prior to study entry\n6. Meets criteria for current Major Depressive Episode within the context of Major Depressive Disorder, per MINI\n7. Score of 18 or higher on the HAMD-17, indicating moderate to severe depressive symptoms\n8. Stable on psychiatric medications for 6 weeks, with no changes to psychiatric medications expected during the study period\n9. No contraindications to TMS (passes the TMS Adult Safety Screening questionnaire)\n10. No contraindications to MRI (passes MRI safety screening questionnaire)\n11. Able to commit to the treatment schedule\n12. Able to complete assessment procedures in English\n13. Intact decision-making capacity and ability to provide voluntary informed consent\n\nExclusion Criteria:\n\n1. History of moderate, severe, or penetrating TBI\n2. History of other neurological condition unrelated to TBI, including but not limited to: conditions associated with increased intracranial pressure; space occupying brain lesions; cerebral aneurysm; stroke; transient ischemic attack within past two years; Parkinson's disease; Huntington's disease; dementia; multiple sclerosis; history of brain surgery; epilepsy; seizure except those therapeutically induced by electroconvulsive therapy (ECT) or a febrile seizure of infancy\n3. Implanted medical devices including cardiac pacemaker, medication pump, aneurysm clip, shunt, stimulator, cochlear implant, electrodes, or any other metal object within or near the head (excluding the mouth) that cannot be safely removed\n4. Active manic or psychotic illness per MINI\n5. Current substance use disorder per MINI\n6. Current active suicidal or homicidal ideation\n7. Pregnant or intending to become pregnant within the study period; breastfeeding\n8. Other sensory conditions or illnesses precluding participation in assessments or treatment\n9. Current dose of lorazepam 2 mg or greater daily (or benzodiazepine equivalent) or any anticonvulsant due to the potential to limit iTBS efficacy\n10. Taking medication that lowers seizure threshold\n11. Previous failed treatment with rTMS, iTBS, or ECT\n12. Completed \\>4 sessions of cognitive rehabilitation within the last 3 years","65 Years",{"count":237,"type":19},72,[22],"The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive PACT plus 20 sessions of iTBS or sham iTBS over 4 weeks. Assessments will occur at baseline, 2 weeks, 4 weeks, and 8 weeks. Researchers will compare the PACT+iTBS group to the PACT+sham iTBS group to see if PACT+iTBS is associated with more depression improvement.",[27,146,32],[242,243,244,245,246,247,248,249,250,251],"brain stimulation","neuromodulation","transcranial magnetic stimulation","theta burst stimulation","TMS","TBS","rTMS","iTBS","cognitive training","cognitive rehabilitation","2026-04-27",{"date":254,"type":45},"2026-05-01",{"date":256,"type":45},"2023-09-19",{"date":258,"type":19},"2027-06-30",{"name":260,"class":52},"University of California, San Diego",{"id":262,"slug":4,"hasResults":10,"nctId":263,"briefTitle":264,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":60,"sex":267,"minAge":61,"maxAge":268,"enrollmentInfo":269,"targetDuration":4,"studyType":20,"phases":271,"briefSummary":272,"conditions":273,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":106},"100494566","NCT05719844","Interest of an Attentional Evaluation by a Computerized Battery in the Management of Concussion in Young Rugby Players","NeuropsyCor","Inclusion Criteria:\n\n* Patients :\n* concussion in the context of the practice of rugby\n* French or reading French without help\n* Controls :\n* no concussion\n* practicing a non-contact sport (athletics, rowing, badminton, capoeira, circus, running, crossfit, cycling, dancing, climbing, fencing, fitness, golf, gymnastics, bodybuilding, swimming, skating, Qi Gong, Taï chi, tennis, table tennis, shooting, trail running, volleyball, water polo) within a sports association\n* age matched to patient (+\u002F- 1 year)\n* study level matched to patient (+\u002F- 1 year)\n* French or reading French without help\n\nExclusion Criteria:\n\n* Patients :\n* Legal protection measure\n* Other neurological or psychiatric pathologies prior to concussion episodes\n* Diagnosis of a neurodevelopmental disorder in childhood\n* Score less than or equal to 5\u002F19 on the \"Matrix\" subtest (intellectual retardation)\n* Addictive behaviors\n* Current major depressive disorder or treated with antidepressants or benzodiazepines for less than 3 months\n* Severe visual or motor problems that may interfere with the performance of the tests\n* Controls :\n* Legal protection measure\n* History of proven concussion\n* Other neurological or psychiatric pathologies\n* Diagnosis of a neurodevelopmental disorder in childhood\n* Score less than or equal to 5\u002F19 on the \"Matrix\" subtest (intellectual retardation)\n* Addictive behaviors\n* Current major depressive episode or treated with antidepressants or benzodiazepines for less than 3 months\n* Severe visual or motor problems that may interfere with the performance of the tests","MALE","25 Years",{"count":270,"type":19},90,[22],"The goal of this study is to test the ability of a computerized neuropsychological battery to identify attentional disorders resulting from a concussion occurring during the practice of rugby. Thirty young people with a concussion (11-25 years old) will take several neuropsychological tests. Researchers will compare their results with those of young athletes without concussion to see the effect of concussion.",[32],{"date":275,"type":45},"2026-04-30",{"date":277,"type":45},"2023-03-09",{"date":279,"type":19},"2027-03-09",{"name":281,"class":52},"University Hospital, Clermont-Ferrand",{"id":283,"slug":4,"hasResults":10,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":60,"sex":15,"minAge":16,"maxAge":289,"enrollmentInfo":290,"targetDuration":4,"studyType":20,"phases":292,"briefSummary":293,"conditions":294,"keywords":295,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":303,"locationsCount":305},"100463909","NCT05320822","A Pragmatic Rehabilitation Intervention: The Active Rehab Study","A Pragmatic Rehabilitation Intervention to Supplement Progressive Return to Activity Following Mild Traumatic Brain Injury in Service Members (SMs): The Active Rehab Study","ARM","Inclusion Criteria:\n\n* Current active duty military personnel stationed at Fort Bragg, North Carolina.\n* Report to clinic\u002Fprovider at Fort Bragg and available for recruitment within 2 weeks of mTBI injury date as indicated in medical record.\n* Initial provider diagnosis of mTBI\u002Fconcussion within 2 weeks of injury, confirmed via medical record.\n\nExclusion Criteria:\n\n* Third mTBI\u002Fconcussion in the past 12 months as indicated by the medical record and\u002For participant self-report.\n* Symptoms clear at rest and exertion within 48 hours as indicated in medical record and or during study enrollment process.\n* Moderate-Severe TBI, or TBI not meeting the criteria for mTBI as indicated by provider diagnosis.\n* Polytrauma or other injuries preventing completion of initial study assessments in the 2-week window as indicated in initial screening\u002Fmedical record.\n\nTBI, per the funding opportunity announcement is defined as: \"being caused by (1) a direct blow or impact to the head, (2) a penetrating head injury, or (3) an exposure to external forces such as blast waves that disrupt the function of the brain.\" For the proposed study, only those meeting the VA\u002FDepartment of Defense severity criteria of mild (normal structural imaging, loss of consciousness 0-30 minutes, alteration of consciousness or mental state up to 24 hours, posttraumatic amnesia up to 24 hours, and Glasgow Coma Scale of 13-15) will be targeted.","99 Years",{"count":291,"type":19},130,[22],"The strategic objective of this research line is to examine improving short- and long-term outcomes for soldiers following mild traumatic brain injury (mTBI). The technical objectives are to: 1) conduct a Phase 1 quasi-experimental pragmatic trial testing the potential benefit of provider directed active rehabilitation therapies (\"Active Rehab\") in accelerating return of injured soldiers back to active duty and improving cognitive and functional limitations following mTBI, and 2) operationalize and disseminate a clinical active rehabilitation algorithm for use in military settings. The central hypothesis is that an active rehabilitation algorithm in the context of the progressive return to activity will improve clinical and functional outcomes, including time to return to duty.\n\nThe Active Rehab intervention expands on progressive return to activity guidelines by providing activities that can be completed and progressed during Stage 1 of the progressive return to activity protocol, when the participant is at least 24 hours postinjury. Active Rehab includes an adaptive paradigm based on personal characteristics, symptom presentation, and duty requirements that integrate with current progressive return to activity guidelines. Activity progressions consider the initial presentation and changes in participant status during treatment, with the goal of safely accelerating recovery. Severity and presence of symptoms will guide progression: worse, same or better as reported by the participant.",[32],[296],"Concussion, Rehabilitation","2026-02-25",{"date":299,"type":45},"2026-02-27",{"date":301,"type":45},"2024-06-04",{"date":170,"type":19},{"name":304,"class":52},"University of North Carolina, Chapel Hill",2,{"id":307,"slug":4,"hasResults":10,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":235,"enrollmentInfo":312,"targetDuration":4,"studyType":20,"phases":313,"briefSummary":314,"conditions":315,"keywords":324,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":106},"100521768","NCT06073886","Personalized Brain Stimulation to Treat Chronic Concussive Symptoms","Personalized Circuit-Based Frontoamygdala Neuromodulation for Persistent Post-Concussive Symptoms","Inclusion Criteria:\n\n* Mild traumatic brain injury (mTBI) defined in accord with the World Health Organization criteria in the last 12 months\n* age 18-65 at the time of the mTBI\n* high burden of post-concussive symptoms defined as a score \\>=20 on the Rivermead Post-Concussion Symptoms Questionnaire\n\nExclusion Criteria:\n\n* objective neurologic deficits\n* ongoing or prolonged (\\>3 months) post-concussive symptoms from a prior mTBI within 2 years of the index injury\n* history of transcranial magnetic stimulation (TMS) therapy\n* contraindications for TMS or magnetic resonance imaging (MRI) (e.g., metallic implant other than dental, pacemaker)\n* severe mental, physical, or medical problems that would impede participation or pose a risk for the planned intervention (e.g., liver, kidney, or heart disease, uncontrolled diabetes or hypertension, malignancy, psychosis, previous seizure, pregnancy)\n* active alcohol or illicit drug abuse\n* inability to speak and read English",{"count":180,"type":19},[66],"The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old. Chronic symptoms could include dizziness, headache, fatigue, brain fog, memory difficulty, sleep disruption, irritability, or anxiety that occurred or worsened after the injury. These symptoms can interfere with daily functioning, causing difficulty returning to physical activity, work, or school. Previous concussion therapies have not been personalized nor involved direct treatments to the brain itself. The treatment being tested in the present study is a noninvasive, personalized form of brain stimulation, called transcranial magnetic stimulation (TMS).\n\nThe investigators intend to answer the questions:\n\n1. Does personalized TMS improve brain connectivity after concussion?\n2. Does personalized TMS improve avoidance behaviors and chronic concussive symptoms?\n3. Do the improvements last up to 2 months post-treatment?\n4. Are there predictors of treatment response, or who might respond the best?\n\nParticipants will undergo 14 total visits to University of California Los Angeles (UCLA):\n\n1. One for the baseline symptom assessments and magnetic resonance imaging (MRI)\n2. Ten for TMS administration\n3. Three for post-treatment symptom assessments and MRIs\n\nParticipants will have a 66% chance of being assigned to an active TMS group and 33% chance of being assigned to a sham, or inactive, TMS group. The difference is that the active TMS is more likely to cause functional changes in the brain than the inactive TMS.",[316,32,146,33,317,318,319,320,321,322,27,323],"Post-Concussion Syndrome","Headache","Dizziness","Cognitive Symptom","Dysautonomia","Anxiety","Irritability; Syndrome","Post-traumatic Stress Disorder",[325,326,327,328,329,330],"Transcranial Magnetic Stimulation","Magnetic Resonance Imaging","Functional MRI","Personalized neuromodulation","Amygdala","Prefrontal Cortex","2026-02-21",{"date":333,"type":45},"2026-02-24",{"date":335,"type":45},"2024-03-06",{"date":337,"type":19},"2027-01",{"name":339,"class":52},"University of California, Los Angeles",{"id":341,"slug":4,"hasResults":10,"nctId":342,"briefTitle":343,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":60,"sex":267,"minAge":346,"maxAge":4,"enrollmentInfo":347,"targetDuration":4,"studyType":20,"phases":349,"briefSummary":350,"conditions":351,"keywords":356,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":106},"100626106","NCT07431320","Ecological Test Standardization for Concussion Assessment in Football Players","COMOFOOT","Inclusion Criteria:\n\nProfessional football players:\n\n* Male professional football players from French clubs\n* Aged 18 years and older\n* Provided written informed consent to participate\n* Adequate understanding of written and spoken French\n\nYouth football players from training centers:\n\n* Registered in a training center affiliated with a French football club\n* Aged 16 years and older\n* Provided written assent to participate, with parental or legal guardian consent for minors\n* Adequate understanding of written and spoken French\n\nExclusion Criteria:\n\nAll players:\n\n* History of concussion in the past 6 months (for inclusion, a statement from the club physician confirming no concussion in the past 6 months will be requested)\n* Physically unfit (if applicable, a medical certificate from the club physician will be required, e.g., incapacitating musculoskeletal injury)","16 Years",{"count":348,"type":19},100,[22],"Concussion is a major concern in the sports world. It represents an immediate and transient alteration of neurological functions due to a direct or indirect trauma, with or without loss of consciousness. Concussions affect between 1.6 and 3.8 million people per year in the United States across all sports. The prevalence varies depending on the sport. In France, the incidence of sport-related concussions is estimated at 200,000 cases. According to the French Academy of Medicine (March 2025), concussions account for between 5% and 9% of all sports-related injuries. Among these cases, 30% involve individuals aged 5 to 19. Football (soccer) is one of the most affected sports, with its 2 million registered players. In French professional football (Ligue 1 and 2), during the 2023-2024 season, one concussion was recorded every 55 matches on average (declared concussion). During the 2018-2019 and 2019-2020 seasons, the rate of matches with concussion was approximately 2.5%. In professional rugby, it is estimated that one concussion occurs every three matches in France.\n\nThere are no precise statistics on the number or frequency of concussions in amateur football in France, due to a lack of reporting and insufficient diagnosis. Currently, practical recommendations exist for managing football players from the moment of impact on the field, implemented within the French Football Federation. The current concussion protocol includes a standardized tool for evaluating concussion intended for healthcare professionals, the SCAT6. However, this protocol is not always sufficient, and return-to-play sometimes occurs too early. Indeed, current assessments are too brief and do not evaluate all cognitive functions. They do not allow a clear understanding of the real on-field consequences. It is estimated that 50% of athletes return to play too early after a concussion, with risks of neurological complications or prolonged symptoms.\n\nHowever, defining rest time and return-to-play criteria is not straightforward. In practice, return to play relies, among other things, on neuropsychological tests, whose interpretation is difficult in the absence of baseline data. The concussion protocol does not allow for an accurate determination of whether performance has normalized without this neuropsychological baseline.\n\nRecent European and international recommendations advise conducting pre-season assessments to provide comparative values. Several studies have been published on the type of pre-season assessments to perform, most using paper-and-pencil or computerized neurocognitive tests.\n\nThe current concussion protocol relies mainly on paper-and-pencil tests. However, the literature shows dissociations between cognitive performance measured in ecological environments and performance measured through paper-and-pencil tests. Ecological tasks have the advantage of closely approximating the daily actions of a player and assessing cognitive functioning more precisely.\n\nThus, these ecological tasks, combined with a baseline assessment, would improve the evaluation of athletes following a concussion. These tasks would facilitate return-to-play decisions through more objective observations and normed data. Finally, ecological tasks would enhance player monitoring and allow a more accurate understanding of their health status.\n\nFor this reason, it seems necessary to develop a standardized ecological test performed in real-game situations. This would improve decision-making regarding return to play without medically endangering the player and would allow better understanding of the cognitive effects of concussion. These tasks will first be reviewed and tested by experts (players, football staff members, national concussion reference physician, and neuropsychologists) for feedback and refinement.",[32,352,353,354,355],"Sports-related Concussion","Football Players","Traumatic Brain Injury, Mild","Healthy Volunteer Male Subjects",[357,358,359,360],"ecological test","reliability","standardization","cognitive assessments","2026-02-18",{"date":333,"type":45},{"date":364,"type":19},"2026-04",{"date":366,"type":19},"2028-04",{"name":368,"class":52},"Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape",{"id":370,"slug":4,"hasResults":10,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":374,"eligibilityCriteria":375,"healthyVolunteers":10,"sex":15,"minAge":61,"maxAge":376,"enrollmentInfo":377,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":379,"conditions":380,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":106},"100502651","NCT05825027","Risk Stratification in Children With Concussion","A Risk Stratification Model for Health and Academic Outcomes in Children With Concussion Based on Novel Symptom Trajectory Typologies","RSiCC","Inclusion Criteria:\n\n* Diagnosed with concussion that occurred within the past 7 days\n* Glasgow Coma Scale (GCS) score between 13-15\n* English speaking\n\nExclusion Criteria:\n\n* Diagnosed with moderate or severe traumatic brain injury\n* Polytrauma\n* Nontraumatic brain injury\n* Pregnancy","17 Years",{"count":378,"type":19},500,"This project will measure concussion symptoms, biological markers, and academic and social factors across the first year postconcussion to develop a model that enables early identification of and symptom management for children at higher risk for persistent postconcussive symptoms. Findings will provide novel insights into the longer-term effects of concussion on children's physical, psychological, and social well-being and support the development of personalized healthcare and school-based plans to reduce disparities in children's ability to return-to-learn and -play and improve postconcussion quality of life.",[32,146],"2025-07-30",{"date":383,"type":45},"2025-08-01",{"date":385,"type":45},"2023-05-23",{"date":387,"type":19},"2028-02-28",{"name":389,"class":52},"Duke University",{"id":391,"slug":4,"hasResults":10,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":4,"eligibilityCriteria":395,"healthyVolunteers":60,"sex":15,"minAge":396,"maxAge":114,"enrollmentInfo":397,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":398,"conditions":399,"keywords":400,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":106},"100515580","NCT05993351","Objective Concussion Assessment Using MRI and Metabolomics","Correlating Advanced MRI Techniques With Neuropsychological Analysis and Immunosensing Assays for Assessment of Sport-related Mild Traumatic Brain Injuries (mTBI)","Inclusion Criteria:\n\n* Aged between 9-50\n* Recently sustained a concussion (within the last 2 weeks)\n\nExclusion Criteria:\n\n* Aged 8 and younger or 51 and older\n* Unable to provide consent (e.g., poor English language skills, etc.)\n* History of liver or kidney disease\n* MRI contraindications:\n\n  * Pacemaker\n  * Stent\n  * Joint prothesis\n  * Implanted devices\n  * Claustrophobia\n  * Pregnant\n  * Permanent piercings\n* Chronic\u002Fabusive use of alcohol and\u002For illicit drugs\n* Previous stroke or moderate\u002Fsevere traumatic brain injury, subarachnoid hemorrhage, or intracranial hemorrhage\n* Healthy control participants must not have a concussion history or recently sustained a concussion","9 Years",{"count":348,"type":19},"Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects. Unfortunately, concussions can be hard to diagnose and many people have lasting post-concussion symptoms such as headaches, difficulty concentrating, and light sensitivity. Recent studies have shown that advanced magnetic resonance imaging (MRI) techniques can identify subtle brain changes caused by a concussion. This study aims to track concussions over time measuring MRI brain scans and post-concussion symptoms to gain a better understand how the brain is affected in comparison to symptoms.",[32],[401,402,403,404],"functional magnetic resonance imaging","diffusion tensor imaging","symptom tracking","sport-related concussions","2025-05-12",{"date":407,"type":45},"2025-05-15",{"date":409,"type":45},"2023-08-11",{"date":411,"type":19},"2026-12-15",{"name":413,"class":52},"St. Joseph's Healthcare Hamilton",{"id":415,"slug":4,"hasResults":10,"nctId":416,"briefTitle":417,"officialTitle":418,"acronym":419,"eligibilityCriteria":420,"healthyVolunteers":10,"sex":15,"minAge":61,"maxAge":16,"enrollmentInfo":421,"targetDuration":4,"studyType":20,"phases":423,"briefSummary":424,"conditions":425,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":106},"100518869","NCT06036147","Concussion Health Improvement Program","Optimizing Collaborative Care for Youth With Persistent Post-Concussive Symptoms","CHIP","Inclusion Criteria:\n\n* 11-18 years old\n* Health care provider diagnosed concussion within 1-12 months\n\n  ≥ 3 new onset or worsening post-concussive symptoms (measured with the HBI)\n* Can be located anywhere as study is all completed remotely\n\nExclusion Criteria:\n\n* Active suicidal ideation, diagnosis of psychosis or psychiatric hospitalization within 6 months\n* Spinal cord injury or other severe injury or illness that might impede participation\n* Youth or parent not fluent in Spanish or English\n* Chronic illness or medical conditions that prevent participation in concussion-focused treatment",{"count":422,"type":19},304,[22],"More than 1 million U.S. youth sustain a concussion each year, and up to 30% report persistent post-concussive symptoms (PPCS) lasting 1 month or more. PPCS can interfere with normal adolescent development, resulting in issues with socioemotional dysfunction and even school failure. However, few evidence based treatments are available for youth with PPCS. The investigators conducted extensive work adapting a collaborative care framework for youth with PPCS, combining concussion-focused cognitive behavioral therapy (cf-CBT), parent skills training (PST) and care management (CM) to create a wraparound treatment for youth with PPCS that can be delivered either in-person or virtually. They completed an R01-funded randomized controlled trial with this approach, finding effectiveness for youth with PPCS, with improvements in concussive symptoms and quality of life at one year, and 60% of participants completing the intervention entirely virtually. Of note, this intervention is unique in that two of the components are focused on parents or parents and youth together (PST, CM), and only one of the components (cf-CBT) is solely youth focused. The investigators now propose to optimize and refine this approach, conducting a high efficiency MOST (multiphase optimization strategy) trial to assess the contribution of each of the three components (cf-CBT, PST and CM) to effectiveness, thereby enabling streamlining of the intervention to only include active components. The analysis will be factorial, with three intervention components and two levels of each (present or absent), resulting in 8 treatment pathways. The benefit of the MOST approach is that it combines all youth who receive a component, allowing assessment of all treatment components with only a modest sample size. The study will recruit 374 youth with PPCS, randomizing them to one of 8 treatment groups. Youth and\u002For parents will attend treatment sessions via video conferencing software over three months, and complete surveys regarding primary outcomes (concussive symptoms and health-related quality of life) and secondary outcomes (sleep, pain, mood and parental distress) at 6 weeks, and 3, 6 and 12 months. Potential mediators and moderators will also be assessed to allow for future tailoring and refinement. At the completion of this study, the investigators will have generated a completely optimized and refined intervention for youth with PPCS ready for large scale implementation and dissemination.",[32,34],"2025-03-10",{"date":428,"type":45},"2025-03-13",{"date":430,"type":45},"2023-11-10",{"date":432,"type":19},"2028-01-31",{"name":434,"class":52},"Seattle Children's Hospital",{"id":436,"slug":4,"hasResults":10,"nctId":437,"briefTitle":438,"officialTitle":439,"acronym":4,"eligibilityCriteria":440,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":268,"enrollmentInfo":441,"targetDuration":4,"studyType":20,"phases":443,"briefSummary":444,"conditions":445,"keywords":446,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":451,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":457,"locationsCount":106},"100535041","NCT06246669","The Influence of Prescribed Exercise on Pain Related Fear Following Concussion in Collegiate Athletes","The Influence of Prescribed Exercise on Pain Related Fear Following Concussion in Collegiate Athletes: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Collegiate athlete (varsity)\n* Symptomatic at time of exercise prescription\n\nExclusion Criteria:\n\n* If advanced neuroimaging was performed, any subject with a structural abnormality will be excluded\n* History of traumatic brain injury requiring hospitalization\n* Not cleared to play their sport by a physician due to some other injury such as an ankle sprain or muscle strain\n* If individual is diagnosed with any condition that is a contraindication to aerobic exercise. Please note that all participants will have already been cleared to participate in their respective collegiate sport after extensive pre-participation physical examinations upon entering the university.",{"count":442,"type":19},46,[22],"The goal of this clinical trial is to compare the effects of acute aerobic exercise at two different intensities on psychological measures, symptomology, and time to symptom free in collegiate student athletes with concussion. The main questions it aims to answer are:\n\n* Does prescribed, acute aerobic exercise influence measures of pain related fear, anxiety, depression, symptoms, and recovery time?\n* Does the intensity of the exercise prescription also influence the aforementioned outcomes?\n\nParticipants will be randomly assigned into either a light intensity or moderate intensity aerobic exercise (treadmill walking) group. They will initiate the exercise protocol 48 hours following their concussion diagnosis, and complete exercise sessions 5 times per week until they report symptom-free. Researchers will compare the light intensity group to the moderate intensity group to see if intensity of exercise influences psychological measures of pain related fear, anxiety, depression, symptomology, and time to symptom-free.",[32],[447,448,449],"kinesiophobia","exercise","anxiety","2024-12-03",{"date":452,"type":45},"2024-12-09",{"date":454,"type":45},"2024-02-27",{"date":456,"type":19},"2025-03",{"name":458,"class":52},"University of Virginia",{"id":460,"slug":4,"hasResults":10,"nctId":461,"briefTitle":462,"officialTitle":463,"acronym":4,"eligibilityCriteria":464,"healthyVolunteers":10,"sex":15,"minAge":465,"maxAge":466,"enrollmentInfo":467,"targetDuration":4,"studyType":20,"phases":469,"briefSummary":470,"conditions":471,"keywords":472,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":476,"lastUpdatePostDateStruct":477,"startDateStruct":479,"completionDateStruct":481,"leadSponsor":483,"locationsCount":106},"100482453","NCT05562232","The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms","The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms - a Pilot Study Protocol","Inclusion Criteria:\n\n* Have had PPCS for a minimum of six months and a maximum of 18 months at the start of the study.\n* Being between 20 and 45 years of age\n\nExclusion Criteria:\n\n* Elite athletes, as well as people who in general is physical active, at an intensity of moderat to high, for more than ten hours a week on average.\n* Participation in other interventions\u002Ftreatment that could affect this study\n* Have had PPCS in:\n* =\\\u003C6 months\n* =\\>18 months\n* Pregnant","20 Years","45 Years",{"count":468,"type":19},45,[22],"The purpose of this study, is to investigate whether creatine monohydrate as a supplement reduces the number and severity of symptoms in patients with persistent post-concussive symptoms through self-reported post-concussion symptoms questionnaires.",[146,32],[37,473,474,475],"Mild traumatic brain injury","Creatine monohydrate","Persistent post-concussive symptoms","2024-07-11",{"date":478,"type":45},"2024-07-12",{"date":480,"type":45},"2023-08-01",{"date":482,"type":19},"2024-12-31",{"name":484,"class":52},"Psychiatric Research Unit, Region Zealand, Denmark",{"id":486,"slug":4,"hasResults":10,"nctId":487,"briefTitle":488,"officialTitle":489,"acronym":4,"eligibilityCriteria":490,"healthyVolunteers":60,"sex":491,"minAge":4,"maxAge":4,"enrollmentInfo":492,"targetDuration":4,"studyType":20,"phases":494,"briefSummary":495,"conditions":496,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":4},"100552499","NCT06473883","The Impact of Eye and Body Training on the Injury Rate of Concussions in Female Soccer Players","Effects of Vestibulo-oculomotor and Neuromuscular Training on the Incidence of Concussions and Musculoskeletal Injuries in Competitive Female Football Players","Inclusion Criteria:\n\n* Registered player for a club in the top Swiss soccer league\n* No symptoms of acute head injury at the start of the study\n* Sufficient language skills to understand the study information and the informed consent form and to answer questionnaires and anamnestic questions correctly.\n\nExclusion Criteria:\n\n* Symptomatic chronic diseases (e.g. tumor diseases, diabetes mellitus, cardiovascular diseases) with the exception of osteoarthritis and controlled (normotensively controlled) arterial hypertension\n* Pregnancy\n* Diagnosis of a psychiatric disorder\u002Fdisease\n* Drug abuse\n* For the neuropsychological test: Known learning disability\u002Fdisorder","FEMALE",{"count":493,"type":19},209,[22],"The research project aims to find out how special training influences the frequency and severity of injuries among female footballers in the top Swiss league. The project also aims to help establish normative values that are specifically tailored to women. The participating clubs will be randomly assigned to a comprehensive pre-season baseline examination with training recommendations based on the performed examinations (intervention group) or control group (normal training). Over the course of the 2024\u002F2025 season, both groups will be compared in terms of the incidence and severity of concussions and musculoskeletal injuries. Initial results will be available in spring 2025 to coincide with the start of the European Women's Football Championship.\n\nThe investigators' hypothesis is that the training recommendations in the intervention group will lead to a lower incidence of concussions and that the players will show better injury prevention as a result of these exercises.",[32,497],"Musculoskeletal Pain","2024-06-19",{"date":500,"type":45},"2024-06-25",{"date":502,"type":19},"2024-06-30",{"date":504,"type":19},"2025-09-30",{"name":506,"class":52},"BrainCare Medical Group",{"id":508,"slug":4,"hasResults":10,"nctId":509,"briefTitle":510,"officialTitle":511,"acronym":4,"eligibilityCriteria":512,"healthyVolunteers":10,"sex":267,"minAge":16,"maxAge":513,"enrollmentInfo":514,"targetDuration":4,"studyType":20,"phases":516,"briefSummary":517,"conditions":518,"keywords":524,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":529,"lastUpdatePostDateStruct":530,"startDateStruct":532,"completionDateStruct":534,"leadSponsor":535,"locationsCount":106},"100371853","NCT04121780","Growth Hormone Replacement Therapy for Retried Professional Football Players","Interventional Study of Growth Hormone Replacement Therapy in Retired Professional Football Players With Growth Hormone Deficiency","Inclusion Criteria:\n\n* The subject is willing to provide a signed and dated informed consent indicating that he understands the purpose and procedures required for the study and is willing to participate in the study.\n* Former NFL player\n* At least one year since retirement from football\n* Less than 76 years of age\n* Diagnosis of GHD on clinical grounds by a neurologist and an endocrinologist GHD\n\nExclusion Criteria:\n\n* History of pre-existing brain disease other than concussion or TBI\n* History of a premorbid disabling condition that interferes with outcome assessments\n* Contraindication to GH therapy\n* Type I and II Diabetes mellitus\n* Active malignant disease\n* Acute critical illness, heart failure, or acute respiratory failure\n* Subjects who are deficient in cortisol, testosterone or thyroid at screening will be excluded until hormone abnormalities have been corrected.","76 Years",{"count":515,"type":19},42,[66],"This is a randomized, double-blind, placebo-controlled, parallel-group trial with an open-label extension to evaluate the efficacy of growth hormone (GH) on cognitive functions of retired professional football players with growth hormone deficiency (GHD).",[519,32,520,521,522,523],"TBI (Traumatic Brain Injury)","Sport Injury","Anterior Pituitary Hyposecretion Syndrome","Hypopituitarism","Growth Hormone Deficiency",[189,525,526,527,528],"GHD","Growth Hormone","Norditropin Flexpro","cognition disorders","2023-02-06",{"date":531,"type":45},"2023-02-08",{"date":533,"type":45},"2019-10-08",{"date":170,"type":19},{"name":536,"class":52},"Center for Neurological Studies",""]