[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"congenital-pulmonary-airway-malformation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:congenital-pulmonary-airway-malformation":71},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100539372",false,"NCT06302985","Atomized Inhalation ICG for Treatment of Congenital Lung Malformations","Application of Atomized Inhalation ICG in Thoracoscopic Surgery for Pulmonary Sequestration in Children: a Multicentre Prospective Study","Inclusion Criteria:\n\n* children with congenital lung malformations diagnosed by CT or MRI scan\n\nExclusion Criteria:\n\n* 1\\. ages \\\u003C3 months and \\>14 years 2. complicated other life-threatening disease; 3. complicated severely pulmonary infection","ALL","3 Months","14 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","To investigate the safety and effectiveness of preoperative aerosol inhalation ICG solution for thoracoscopic accurate resection of congenital lung malformations in children.",[26,27,28,29,30],"Pulmonary Sequestration","Congenital Pulmonary Airway Malformation","Indocyanine Green","Thoracoscopic Surgery","Children","RECRUITING","2024-10-13",{"date":34,"type":35},"2024-10-16","ACTUAL",{"date":37,"type":35},"2024-03-01",{"date":39,"type":20},"2050-12-31",{"name":41,"class":42},"Jiexiong Feng","OTHER",1,{"id":45,"slug":4,"hasResults":10,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":10,"sex":15,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":5},"100493158","NCT05701514","The COllaborative Neonatal Network for the First CPAM Trial","The COllaborative Neonatal Network for the First Congenital Pulmonary Airway Malformation (CPAM) Trial","CONNECT","Inclusion Criteria:\n\n* Lesion detected during routine prenatal ultrasound screening\n* Delivery at term: gestational age ≥37 weeks\n* Birthweight \\> -2SD or \\>P10\n* Asymptomatic at birth defined as no prolonged respiratory distress or oxygen support (\\\u003C 24 hours)\n* Asymptomatic up to the moment of inclusion\n* Confirmation of CPAM on postnatal chest CT-scan at 3-9 months of age, according to structured report form (34)\n* Unilateral lesion occupying no more than one lung lobe as assessed on chest CT-scan at 3-9 months of age\n\nExclusion Criteria:\n\n* Bilateral lesion\n* Development of symptoms before randomization, considered by treating physician as caused by CPAM with reasonable certainty\n* Complicated pregnancy defined as (pre-)eclampsia, pregnancy diabetes in mother, foetal hydrops or severe polyhydramnios on prenatal ultrasound\n* Syndrome associated anomalies on genetic analysis confirmed by genetic expert\n* Major associated malformations. Anomalies include cardiac malformations requiring surgical correction or follow-up by a paediatric cardiologist, congenital malformations requiring major surgical intervention, and anomalies that affect normal lung growth and development.\n* Suspicion of malignancy on chest CT scan evaluation at the age of 3-9 months\n* Participation in another randomised controlled trial","1 Month","1 Year",{"count":54,"type":20},176,[23],"The goal of this clinical trial is to compare conservative wait-and-see management to elective surgical intervention, in asymptomatic Congenital Pulmonary Airway Malformation (CPAM) children.\n\nChildren assigned to the intervention group will undergo surgical resection of the CPAM between 6 and 9 months of age. Children assigned to the control group will be monitored conservatively. The follow-up scheme will be uniform for both treatment groups and last for 5 years.\n\nThe primary outcome is the difference in maximal endurance at five years of age between the surgical and conservative group. Secondary outcome measures are molecular genetic diagnostics, validated questionnaires - on parental anxiety, quality of life and health care consumption -, repeated imaging, and pulmonary morbidity during follow-up, as well as surgical complications and histopathology.",[27],[59,60,61,62],"Asymptomatic CPAM","Optimal management","Conservative vs surgical","Randomized",{"date":64,"type":35},"2024-03-04",{"date":66,"type":35},"2023-01-01",{"date":68,"type":20},"2030-12-31",{"name":70,"class":42},"Erasmus Medical Center",""]