[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"conjunctival-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:conjunctival-diseases":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":25,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100313324",false,"NCT03358979","Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)","ALTESSE","Patients:\n\nInclusion criteria\n\n* 18 years and over\n* Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes\n* Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced\n\nExclusion criteria - Known pregnancy or breastfeeding\n\nControl subjects:\n\nInclusion criteria\n\n\\- 18 years and over\n\nExclusion criteria\n\n* Wearer of contact lenses\n* Topical ocular treatment\n* Known pregnancy or breastfeeding","ALL","18 Years",{"count":18,"type":19},100,"ESTIMATED","OBSERVATIONAL","Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers before and after initiation of a treatment.",[23,24],"Conjunctival Diseases","Dry Eye Syndromes",[23,24,26,27],"Antigens","CD147","RECRUITING","2025-12-02",{"date":31,"type":32},"2025-12-08","ACTUAL",{"date":34,"type":32},"2017-12-14",{"date":36,"type":19},"2027-03",{"name":38,"class":39},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",""]