[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"contracture-scar\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:contracture-scar":61},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100581987",false,"NCT06857448","Autologous Point-of-Care Adipose Therapy: Recent Injury","Autologous Point-of-Care Adipose Therapy for Reconstruction and Regeneration of Traumatized Skin: Recent Injury","Inclusion Criteria:\n\n* The proposed study will include adult patients 18 years of age or older,\n* male or female,\n* civilian, military, active duty or retired veterans\n* presenting for unilateral or bilateral fasciotomy of the extremity at any level necessary\n* secondary to non-infectious etiology,\n* unilateral or bilateral traumatic full-thickness skin loss of the face, head, neck or extremities necessitating reconstruction, and\u002For\n* full or partial thickness burn injury of the face, neck, or extremity requiring excision and\u002For reconstruction.\n* Additional inclusion criteria includes willingness to be randomized to receive a fat graft.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years of age,\n* active infection,\n* medical co-morbidities or anatomic configuration deemed by the physician to be a concern for safety,\n* unwilling or unable to comply with study procedures,\n* radiation to the site of interest,\n* prisoners and\u002For vulnerable populations.\n* In addition, candidates that are pregnant or plan to become pregnant in the next year, will be excluded.","ALL","18 Years",{"count":18,"type":19},68,"ESTIMATED","INTERVENTIONAL",[22],"NA","The goal of this study is to explore if an adipose-based therapeutic strategy can treat full-thickness soft-tissue trauma wounds in injured individuals, especially those with severe burns or soft-tissue loss. The main question it aims to answer are:\n\n\\- Can immediate autologous adipose and autologous layered composite grafting be effective for acute functional soft-tissue reconstruction?\n\nResearchers will compare the single-stage autologous layered composite grafting method to traditional methods to see if it improves healing outcomes, minimizes scarring, and reduces infection risk.\n\nParticipants will:\n\n* Receive immediate fat grafting into the wound.\n* Undergo simultaneous split-thickness skin grafting for full soft-tissue reconstruction.",[25,26,27],"Burns","Contracture Scar","Surgical Injury",[29,30],"fasciotomy","trauma","NOT_YET_RECRUITING","2025-11-03",{"date":34,"type":35},"2025-11-05","ACTUAL",{"date":37,"type":19},"2025-12",{"date":39,"type":19},"2028-10-30",{"name":41,"class":42},"University of Pittsburgh","OTHER",{"id":44,"slug":4,"hasResults":10,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":20,"phases":51,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":57,"startDateStruct":58,"completionDateStruct":59,"leadSponsor":60,"locationsCount":5},"100581986","NCT06857435","Autologous Point-of-Care Adipose Therapy: Delayed Injury\u002FScar","Autologous Point-of-Care Adipose Therapy for Reconstruction and Regeneration of Traumatized Skin: Delayed Injury\u002FScar","Inclusion Criteria:\n\n* The proposed study will include adult patients 18 years of age or older,\n* male or female,\n* civilian, military, active duty or retired veterans\n* presenting for scar contracture release and reconstruction at any level.\n* Additional inclusion criteria includes willingness to be randomized to receive a fat graft.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years of age,\n* active infection,\n* medical co-morbidities or anatomic configuration deemed by the physician to be a concern for safety,\n* unwilling or unable to comply with study procedures,\n* radiation to the site of interest,\n* prisoners and\u002For vulnerable populations.\n* In addition, candidates that are pregnant or plan to become pregnant in the next year, will be excluded.",{"count":50,"type":19},40,[22],"The goal of this study is to explore if an adipose-based therapeutic strategy can treat contracted scars secondary to soft-tissue burn wounds in injured individuals, especially those with severe burns or soft-tissue loss. The main question it aims to answer are:\n\n\\- Can autologous layered composite grafting demonstrate non-inferiority compared to full-thickness skin grafting for delayed reconstruction of post-burn or trauma scar contracture?\n\nResearchers will compare the single-stage autologous layered composite grafting method to traditional methods to see if it improves healing outcomes, minimizes scarring, and reduces infection risk.\n\nParticipants will:\n\n* Receive fat grafting at time of scar revision.\n* Undergo simultaneous split-thickness skin grafting for full soft-tissue reconstruction.",[25,26,27],[55,56],"burns","scar contracture",{"date":34,"type":35},{"date":37,"type":19},{"date":39,"type":19},{"name":41,"class":42},""]