[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cough-reflex-sensitivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cough-reflex-sensitivity":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":14,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100633839",false,"NCT07531901","Evaluating the Feasibility and Reliability of Using Handheld Nebulizers to Conduct Cough Sensitivity Testing With Citric Acid","Inclusion Criteria:\n\n* Healthy adults at least 18 years of age\n* Consent to audio\u002Fvideo recording of the research sessions for research purposes\n* Spirometry testing results obtained by study team on same day of first testing session with FEV1\u002FFVC ratio and FEV1 percent predicted values of at least 0.70\n\nExclusion Criteria:\n\n* Pregnant or trying to become pregnant (if capable of becoming pregnant- a urine pregnancy test will be provided onsite and a negative result must be obtained prior to the first testing session)\n* Smoking of any substance in the last six months\n* Diagnosed or suspected pulmonary disease (e.g., asthma, COPD)\n* History of chronic cough\n* History of head or neck cancer\n* History of neurological disease (e.g., cerebrovascular accident)\n* History of dysphagia (swallowing difficulty)\n* Current complaint of a voice problem\n* Current upper respiratory infection",true,"ALL","18 Years","89 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"NA","Objective cough reflex sensitivity testing is typically restricted to specialized research laboratories due to reliance on expensive dosimeter-controlled aerosol delivery systems. This study evaluates the feasibility and reliability of a low-cost alternative method using a handheld nebulizer for citric acid cough challenge testing. Healthy adult participants will complete cough reflex sensitivity testing using both a standard dosimeter-controlled nebulizer system (Cosmed QuarkSpiro) and a handheld nebulizer (DeVilbiss 45). The study will compare cough threshold outcomes between methods to determine whether handheld nebulizer-based testing produces comparable and reproducible measurements.",[26],"Cough Reflex Sensitivity",[28,29],"cough challenge testing","cough reflex sensitivity testing","RECRUITING","2026-06-01",{"date":33,"type":34},"2026-06-03","ACTUAL",{"date":36,"type":20},"2026-06-05",{"date":38,"type":20},"2027-02-28",{"name":40,"class":41},"University of Montana","OTHER",""]