[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"crystalloid-solutions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:crystalloid-solutions":49},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100613511",false,"NCT07267546","Heart-Lung Machine: Impact of the Priming Solution on Acid-Base Balance, Electrolytes and Outcome on Patients Undergoing Cardiac Surgery","Heart-Lung Machine: Impact of the Priming Solution on the Body's Acid-Base Balance, Electrolyte Composition and Clinical Outcome (PRIMEII)","PRIMEII","Inclusion Criteria:\n\n* Patients 18 years and above\n* Undergoing coronary artery bypass graft (CABG) surgery as single surgery\n* Undergoing aortic valve replacement (AVR) as single surgery (AtriClip is allowed)\n* Given consent to participate, both verbal and written\n\nExclusion Criteria:\n\n* Subnormal heart function (defined as an ejection fraction \\\u003C45%), and no signs of heart failure (edema).\n* Body weight \\\u003C60 kg or \\>120 kg\n* Preoperative hemoglobin \\\u003C120 g\u002FL,\n* Subnormal kidney function (defined as GFR \\\u003C30 ml\u002Fmin),\n* Blood sodium outside normal range (135-145 mmol\u002Fl),\n* Need of acute surgery\n* AVR due to aortic valve insufficiency\n* Changes in operating method or addition of intraoperative procedures.","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","Most cardiac surgery procedures requires the use of heart-lung machine. The heart-lung machine circuit needs to be filled with a fluid before connecting it to the patients circulation. This is called priming and is accomplished by filling the circuit with a solution used for fluid replacement. The circuit in our institution requires 1100 mL to be filled.\n\nThe body has several mechanisms with the purpose to maintain its state of balance. When a large amount of clear solution suddenly enters the blood stream this balance can be altered. The goal of this clinical trial is to investigate different priming solutions in the heart-lung machine circuit. The main questions it aims to answer are:\n\nHow do different priming solutions alter the acid-base balance, osmolality and electrolytes which reflects the body's water balance for patients undergoing cardiac surgery with the use of heart-lung machine?\n\nThere will be 4 different groups:\n\n1. Ringer-Acetate, 1100 mL \u002F no addition\n2. Ringer-Acetate, 1100 mL + 80 mmol sodium chloride (NaCl)\n3. Ringer-Acetate, 1100 mL + 160 mmol NaCl\n4. Plasmalyte, 1100 mL \u002F no addition Blood samples will be taken before, during and after surgery, post operative day 1 and 4 to analyze acid-base balance, electrolytes, and plasma osmolality. Urine output and hydration status will also be collected until post operative day 1. After 3 months, a blood sample will be taken for analysis of electrolytes and kidney function.",[26,27,28,29,30],"Acid Base Imbalance","Osmolality Disturbance","Crystalloid Solutions","Electrolyte Changes","Cardiopulmonary Bypass",[32,33,34,35,36],"cardiopulmonary bypass","priming solution","acid base balance","electrolytes","plasma osmolality","RECRUITING","2025-12-04",{"date":40,"type":41},"2025-12-05","ACTUAL",{"date":43,"type":41},"2025-09-01",{"date":45,"type":20},"2026-11-01",{"name":47,"class":48},"Region Skane","OTHER",""]