[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cytomegalovirus-prophylaxis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cytomegalovirus-prophylaxis":51},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":4,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100053802",false,"NCT07199465","A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)","A Phase 1, Open-label, Single-arm Study to Evaluate the Pharmacokinetics and Safety of Letermovir in Pediatric Kidney Transplant (KT) Recipients Less Than 18 Years of Age and Weighing Less Than 40 Kilograms","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Is a recipient of a primary or secondary allograft kidney\n* Is at least 4 weeks posttransplant and not more than 52 weeks posttransplant at the time of enrollment (Day 1) and is being managed per local standard of care\n* Has stable kidney function posttransplant\n* Has undetectable CMV deoxyribonucleic acid (DNA) from a plasma or whole blood sample collected within 14 days prior to enrollment\n* Must be able to take (as assessed by the investigator) letermovir tablets or oral pellets by mouth, or via gastrostomy or nasogastric tube (oral pellets only)\n* Does not have a condition that may interfere with the absorption of oral medication (e.g., vomiting, diarrhea, or a malabsorptive condition) from the day of enrollment (Day 1) until the intensive pharmacokinetics (IPK) sampling is completed\n* Weighs ≥2.5 and \\\u003C40 kg at enrollment (Day 1)\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has CMV disease or suspected CMV disease between screening and enrollment\n* Is on dialysis or plasmapheresis at the time of enrollment\n* Has evidence of CMV viremia at any time from screening until the time of enrollment\n* Has Child-Pugh B or C hepatic insufficiency within 14 days before enrollment\n* Is a multi-organ transplant recipient (e.g., kidney-pancreas)\n* Has any uncontrolled infection on the day of enrollment\n* Requires mechanical ventilation, or is hemodynamically unstable, at the time of enrollment\n* Has received or is receiving protocol-specified prohibited medications","ALL","17 Years",{"count":18,"type":19},40,"ESTIMATED","INTERVENTIONAL",[22],"PHASE1","Researchers are looking for a way to prevent cytomegalovirus (CMV) in children and adolescents who receive a kidney transplant (KT) and weigh less than 40 kilograms (88.2 pounds). The goals of the study are to:\n\n* Learn what happens to letermovir in the body over time\n* Learn about the safety of letermovir and if participants tolerate it",[25],"Cytomegalovirus Prophylaxis","RECRUITING","2026-07-10",{"date":29,"type":30},"2026-07-13","ACTUAL",{"date":32,"type":30},"2026-03-30",{"date":34,"type":19},"2028-05-19",{"name":36,"class":37},"Merck Sharp & Dohme LLC","INDUSTRY",18,{"id":40,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":4,"maxAge":16,"enrollmentInfo":41,"targetDuration":4,"studyType":20,"phases":42,"briefSummary":23,"conditions":43,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":47,"completionDateStruct":48,"leadSponsor":49,"locationsCount":50},"100608277",{"count":18,"type":19},[22],[25],"2026-06-10",{"date":46,"type":30},"2026-06-12",{"date":32,"type":30},{"date":34,"type":19},{"name":36,"class":37},17,""]