[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ded\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ded":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100636872",false,"NCT07571330","Upper Punctal Plug Occlusion in Previous Lower Punctal Occlusion.","Effectiveness of Upper Punctal Plug Occlusion in Patients With Dry Eye Disease With Previous Lower Punctal Occlusion.","Inclusion Criteria:\n\n* Patients of both sexes\n* One or both eyes may be included\n* Inferior lacrimal punctum occluded (with a punctal plug or cauterization), clinically sealed under slit-lamp examination\n* Functional superior lacrimal punctum\n* Aqueous-deficient dry eye (such as Sjögren's disease, graft-versus-host disease, or primary dry eye disease.)\n* Age \\>18 years\n* OSDI score \\>13 and one of the following signs: Tear film markers (Fluorescein tear break up-time \\\u003C5, First non-invasive tear breakup time \\\u003C10, Schirmer test without anesthesia \\\u003C10 mm, Schirmer test with anesthesia \\\u003C10 mm), Ocular surface markers (corneal staining \\>5 spots or conjunctival staining \\>9 spots).\n\nExclusion Criteria:\n\n* Active ocular surface infection.\n* Patients who are unwilling to participate or to provide written informed consent.","ALL","18 Years",{"count":18,"type":19},36,"ESTIMATED","INTERVENTIONAL",[22],"NA","This study evaluates the therapeutic effect of upper punctal plug occlusion in patients with dry eye disease with previous lower punctal occlusion.",[25,26],"DED","Aqueous-deficient Dry Eye Disease",[28,25,29,30],"Aqueous-deficient dry eye disease","Punctual plug","Superior punctual plug","RECRUITING","2026-05-04",{"date":34,"type":35},"2026-05-06","ACTUAL",{"date":37,"type":35},"2026-02-12",{"date":39,"type":19},"2026-11-01",{"name":41,"class":42},"Universidad Autonoma de Nuevo Leon","OTHER",""]