[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diving-medicine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diving-medicine":54},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100613193",false,"NCT07263399","Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity","Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity - A Randomized Controlled Cross-Over Trial","Inclusion Criteria:\n\n* Military divers actively serving, aged 20-64 years\n* Meeting the Swedish Armed Forces physical standards for diving\n\nExclusion Criteria:\n\n* Ongoing infection or illness that may impact pulmonary function\n* Use of alcohol or smoking cigarettes within 48 hours\n* Diving with any breathing gas within 48 hours\n* Diving with oxygen-enriched gas (100% O₂) within 2 weeks\n* Use of medications that could affect oxidative stress, lung function, or neurological status\n* Medical history of serious diving-related injuries or long-term complications",true,"ALL","20 Years","64 Years",{"count":20,"type":21},32,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this trial is to investigate whether adding a small fraction of hydrogen gas to an oxygen-enriched breathing mixture can reduce pulmonary oxygen toxicity (POT) in healthy and active divers from the Swedish Armed Forces. The main questions it aims to answer are:\n\n* Does hydrogen gas reduce oxidative stress and changes in pulmonary function associated with prolonged hyperbaric oxygen exposure?\n* What are the underlying pathophysiological mechanisms of pulmonary oxygen toxicity?\n\nResearchers will compare oxygen-enriched breathing gas with 1-2% hydrogen to oxygen-enriched gas with 1-2% nitrogen (control) to see if hydrogen provides protective effects against POT during hyperbaric exposure.\n\nParticipants will:\n\n* Complete two hyperbaric exposure sessions (hydrogen vs. nitrogen), each lasting 240 minutes at 1.75 ATA\n* Undergo pulmonary function tests and sampling of blod and urin before and after each session\n* Serve as their own controls in a double-blind, randomized, crossover study design",[27,28,29,30,31,32,33],"Oxygen Toxicity","Oxidative Stress","Hyperoxia","Hyperbaric Oxygen","Healthy Subjects (HS)","Diving Medicine","Hydrogen-oxygen Gas",[35,36,37,38,30,39,40],"Pulmonary Oxygen Toxicity","Hydrogen Gas","Diving Physiology","Lung Function","Human Study","Military Divers","NOT_YET_RECRUITING","2025-12-01",{"date":44,"type":45},"2025-12-04","ACTUAL",{"date":47,"type":21},"2026-01",{"date":49,"type":21},"2030-12",{"name":51,"class":52},"Blekinge Institute of Technology","OTHER",2,""]