Early Alzheimers Disease

6

Review clinical trials related to Early Alzheimers Disease. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease (AD). AD is a type of dementia that can cause loss of memory, communication (such as speech), and decision-making skills. It can limit a person's ability to do daily tasks. MK-2214 is a study treatment designed to slow down AD. The goals of the study are to learn: * If MK-2214 slows the spread of tau in the brain compared to placebo. Tau is a protein that accumulates in AD \& damages brain cells. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of a study treatment. * About the safety of MK-2214 and if people tolerate it

Participants needed: 340
Trial details
Phase: Phase 2Age: 50-85Biological sex: AllType: InterventionalSponsor: Merck Sharp & Dohme LLCUpdated: Jun 23, 2026Locations: 78
Eligibility criteria

Has mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease... [+2]

Has a known history of stroke or cerebrovascular disease [+13]

Status: Recruiting

Human Mesenchymal Stem Cells & Monoclonal Antibodies in the Treatment for Mild Cognitive Impairment or Early Alzheimer's Disease.

The purpose of this study is to test if adding one infusion of (Human Mesenchymal Stem Cells) hMSCs to the treatment with standard of care (SOC) monoclonal antibodies (mAb) will stabilize the rate of cognitive and functional decline associated with mild Alzheimer's Disease.

Participants needed: 10
Trial details
Phase: Phase 2Age: 55-90Biological sex: AllType: InterventionalSponsor: Bernard (Barry) BaumelUpdated: May 28, 2026Locations: 1
Eligibility criteria

Adults 55-90 years at the time of signing consent [+4]

Dementia other than AD [+10]

Status: Recruiting

Safety and Efficacy of L. Lactis CKDB001 in Subjects With Early Alzheimer's Disease

Randomized, Placebo-Controlled, Double-Blind, 24-Week Proof-of-Concept Study to Evaluate the Safety and Efficacy of L. Lactis CKDB001 in Subjects With Early Alzheimer's Disease

Participants needed: 60
Trial details
Age: 55-85Biological sex: AllType: InterventionalSponsor: CKD Bio CorporationUpdated: Mar 30, 2026Locations: 2
Eligibility criteria

Male and female adults aged ≥55 and ≤85 years at the time of written consent [+3]

Subjects with clinically significant diseases other than Alzheimer's disease tha... [+17]

Status: Not yet recruiting

A Study to Compare Two Different Sleep Tests in Participants With No Symptoms or Early Symptoms of Alzheimer's Disease

The purpose of this study is to compare the results of two different sleep tests in Alzheimer's patients with no symptoms or early symptoms. Participants will undergo two simultaneous sleep tests (polysomnography) in a sleep laboratory for two nights and one sleep test at home for three nights. For each participant, the study will last at least a week and will last up to three months.

Participants needed: 35
Trial details
Age: 55-85Biological sex: AllType: ObservationalSponsor: Eli Lilly and CompanyUpdated: Mar 20, 2026Locations: 1
Eligibility criteria

Have mild cognitive impairment, subjective memory complaints, or normal cognitio... [+6]

Severe illness that in the investigator's judgement would adversely affect the p... [+9]

Status: Recruiting

A Study to Evaluate the Efficacy and Safety of TTYP01 Tablets in Early Symptomatic Alzheimer's Disease

This is a multicenter, randomized, double-blind, placebo-controlled parallel Phase II core period study to evaluate the efficacy and safety of TTYP01 Tablets in early symptomatic AD (Mild cognitive impairment \[MCI\] due to AD, or mild AD dementia). A total of 180 participants will be randomized into 3 parallel groups: 2 TTYP01 dose groups and 1 placebo group.

Participants needed: 180
Trial details
Phase: Phase 2Age: 60-85Biological sex: AllType: InterventionalSponsor: Shanghai Auzone Biological Technology Co., Ltd.Updated: Nov 26, 2025Locations: 1
Eligibility criteria

Age between 60 and 85 years (inclusive, based on the date of signing the informe... [+18]

History of intracranial infection or traumatic brain injury. [+35]

Status: Recruiting

Effect of Transcranial Alternating Current Stimulation(tACS) for Early Alzheimer's Disease

To investigate the clinical effect neural mechanism of transcranial alternating current stimulation in early Alzheimer's disease

Participants needed: 40
Trial details
Age: 50-85Biological sex: AllType: InterventionalSponsor: Anhui Medical UniversityUpdated: Aug 21, 2024Locations: 1
Eligibility criteria

Subject diagnosed with early Alzheimer's disease or related diseases according t... [+4]

CDR > 2 [+7]