Health Trials

Eye Disorders Congenital

2

Review clinical trials related to Eye Disorders Congenital. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)

The purpose of this double-masked, randomized, placebo-controlled, paired-eye study is to evaluate the efficacy, safety and tolerability of Sepofarsen in subjects with Leber Congenital Amaurosis (LCA) due to the c.2991+1655A\>G (p.Cys998X) mutation in the CEP290.

Participants needed: 32
Trial details
Phase: Phase 3Age: 6+Biological sex: AllType: InterventionalSponsor: Laboratoires TheaUpdated: Jun 25, 2026Locations: 17
Eligibility criteria

Confirmed clinical diagnosis of LCA10 and a molecular diagnosis of homozygosity... [+4]

Mutations in genes other than the CEP290 gene associated with other IRD diseases... [+4]

Read more
Status: Recruiting

Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

The purpose of this Phase 2b study is to evaluate the safety and tolerability of ultevursen administered via intravitreal injection (IVT) in subjects with Retinitis Pigmentosa (RP) due to mutations in exon 13 of the USH2A gene. This is a multicenter Double-masked, Randomized, Sham-controlled study which will enroll 81 subjects.

Participants needed: 81
Trial details
Phase: Phase 2Age: 8+Biological sex: AllType: InterventionalSponsor: Laboratoires TheaUpdated: Jun 18, 2026Locations: 28
Eligibility criteria

An adult (≥18 years) willing and able to provide informed consent for participat... [+8]

Presence of additional non-exon 13 USH2A pathogenic or likely pathogenic variant... [+7]

Read more