[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"folate-bioavailability\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:folate-bioavailability":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100565366",false,"NCT06641245","PREconception Folic Acid Clinical Efficacy (PREFACE) Trial","PREFACE","Inclusion Criteria:\n\n* Non-pregnant females who are:\n* Currently trying to become pregnant;\n* Aged 19-42 years;\n* Low risk for an NTD-affected pregnancy\n\nExclusion Criteria:\n\n* Trying to conceive for ≥6 months (as \\~90% of pregnancies occur after 6 months of trying);\n* Diagnosed ovulatory disorders (polycystic ovary syndrome, endometriosis, or menstrual irregularity);\n* More than 2 miscarriages in the past year;\n* Undergoing fertility assistance (including current IVF or intrauterine insemination);\n* Pre-existing medical condition known to impact maternal folate status (malabsorptive and inflammatory bowel diseases, active celiac disease, gastric bypass surgery, type 1 or 2 diabetes mellitus);\n* Lifestyle factors known to impact maternal folate status (current smoking, \\>6 alcoholic drinks per week, recreational drug use);\n* On the female or male side of those trying to conceive: personal NTD history, previous NTD-affected pregnancy, or personal or family history of other folate sensitive congenital anomalies;\n* Use of folate-inhibiting medications (Chloramphenicol, Methotrexate, Metformin, Sulfasalazine, Phenobarbital, Phenytoin, Primidone, Triamterene, Barbiturates).","FEMALE","19 Years","42 Years",{"count":19,"type":20},272,"ESTIMATED","INTERVENTIONAL",[23],"NA","A study to help understand what forms of folic acid are most effective to increase folate status during pregnancy for the best protection against neural tube defects",[26,27,28,29],"Folate","Folate Bioavailability","Clinical Trials","Pregnancy",[31,26,32,33,34,35],"Folic acid","Methylfolate","5-MTHF","RBC Folate","Placental Growth Factor","NOT_YET_RECRUITING","2024-10-17",{"date":39,"type":40},"2024-10-21","ACTUAL",{"date":42,"type":20},"2025-01-31",{"date":44,"type":20},"2030-01-31",{"name":46,"class":47},"University of British Columbia","OTHER",""]