[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gastrointestinal-carcinoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gastrointestinal-carcinoma":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100549158",false,"NCT06430372","Study of VEGF-A Targeting NIR-II Fluorescence Endoscopy in the Gastrointestinal Tract","Study of Vascular Endothelial Growth Factor A Targeting NIR-II Fluorescence in the Endoscopy of Gastrointestinal Tract","Inclusion Criteria:\n\n* Known or suspected gastrointestinal lesions.\n* Scheduled for a clinically-indicated endoscopy.\n* Mentally competent person, 18 years or older.\n* Approved to sign the informed consent.\n* Adequate potential for follow-up.\n\nExclusion Criteria:\n\n* Subjects with known allergy or negative reaction to ICG or derivatives.\n* Undesirable function of heart, lung, kidney, or any other organs.\n* Enrolled in other trials in the past 3 months.\n* Pregnant or trying to conceive.\n* Unable to tolerate an endoscopy.\n* Medical or psychiatric conditions that compromise the patient's ability to give informed consent.\n* The researchers considered inappropriate to be included.","ALL","18 Years","75 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"PHASE1","In this study, the investigators are studying new ways to look for abnormal tissues of the gastrointestinal tract during an endoscopy. We are using a VEGF-A targeting fluorescent probe and a NIR-II fluorescent endoscope to help detect abnormal tissues that are hard to see by the naked eye.\n\nThe main purposes of this study include:\n\n1. To translate the NIR-II approach into the endoscopy, and understand its advantages and limitations on detecting abnormal tissues in gastrointestinal.\n2. To validate whether topical administration of a targeting probe can stick to abnormal tissues and be detected by the NIR-II endoscope.\n3. To validate the safety and effectiveness of the topical administration of VEGF-A targeting probes for clinical application.",[26,27,28],"Gastrointestinal Carcinoma","Dysplasia","Gastrointestinal Polyp","RECRUITING","2025-05-08",{"date":32,"type":33},"2025-05-13","ACTUAL",{"date":35,"type":33},"2023-07-20",{"date":37,"type":20},"2026-05-30",{"name":39,"class":40},"Institute of Automation, Chinese Academy of Sciences","OTHER",""]