[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gonarthrosis-primary\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gonarthrosis-primary":136},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,70,96],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100643541",false,"NCT07618403","Physical Therapy Program and Treatment Expectations in Knee Osteoarthritis","Evaluating The Predictive Effect of Treatment Expectations on Response to A Physical Therapy Program in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Agreeing to participate in the study\n* Being over 50 years of age\n* Having a clinically and radiographically confirmed diagnosis of knee osteoarthritis\n* Having grade 2-3-4 knee osteoarthritis according to the Kellgren-Lawrence grading system\n* Being literate\n\nExclusion Criteria:\n\n* Previous knee surgery\n* Conditions that prevent exercise (such as incurable malignancy, active systemic infection, non-union fracture)\n* Presence of accompanying neurological disease affecting the lower extremity\n* Severe cognitive impairment (neuropsychiatric disease or condition that will impede cooperation, such as psychosis, dementia)\n* History of having received injections or other procedures to the knee joint or physical therapy within the last 6 months","ALL","50 Years",{"count":18,"type":19},84,"ESTIMATED","OBSERVATIONAL","To our knowledge, no studies have been conducted in the literature investigating the relationship between the success of physical therapy programs applied in knee osteoarthritis and patients' pre-treatment expectations. The rationale for this study is to demonstrate the possible relationship between treatment expectations and the benefits seen from conventional physical therapy programs in patients with knee osteoarthritis, and to provide clinicians with a different perspective in knee osteoarthritis treatment planning.",[23,24,25],"Gonarthrosis; Primary","Physical Therapy","Patients' Expectations",[27,28,29],"treatment expectations","gonarthrosis","physical treatment","RECRUITING","2026-06-08",{"date":33,"type":34},"2026-06-10","ACTUAL",{"date":36,"type":34},"2026-01-01",{"date":38,"type":19},"2027-09-15",{"name":40,"class":41},"Gazi University","OTHER",1,{"id":44,"slug":4,"hasResults":10,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":42},"100626990","NCT07442812","Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty","The Role of Dexamethasone in Total Knee Arthroplasty: Effects of Oral and Intravenous Administration on Early Postoperative Pain and Mobilization","TKA","Inclusion Criteria:\n\n* Age between 50 and 80 years\n* Diagnosis of primary knee osteoarthritis (primary gonarthrosis)\n* Scheduled for elective primary total knee arthroplasty\n* ASA physical status I or II\n* Ability to ambulate independently (with or without assistive devices) preoperatively\n* Ability to understand study procedures and complete pain and functional assessments\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Revision total knee arthroplasty\n* History of knee joint infection\n* Inflammatory arthritis (e.g., rheumatoid arthritis)\n* Chronic systemic corticosteroid use\n* Uncontrolled diabetes mellitus\n* Known endocrine disorders affecting glucose metabolism\n* Active infection at any site\n* Known hypersensitivity to corticosteroids\n* Severe hepatic, renal, or cardiac disease\n* Neurological or musculoskeletal disorders affecting gait or balance\n* Inability or unwillingness to comply with study procedures","80 Years",{"count":52,"type":19},270,"This prospective observational cohort study aims to evaluate the association between perioperative dexamethasone administration and early postoperative recovery following primary total knee arthroplasty. In routine clinical practice, dexamethasone may be administered orally, intravenously, or not administered, depending on the surgeon's established perioperative protocol.\n\nThe primary objective is to assess early postoperative recovery in terms of pain intensity, functional mobility, and knee joint range of motion. Secondary objectives include evaluation of inflammatory response, postoperative metabolic changes, opioid requirement, and the severity of postoperative nausea and vomiting (PONV).\n\nGroup allocation is non-randomized and determined solely by the standard perioperative management approach routinely applied by the surgeon selected by the patient. No additional interventions are introduced for research purposes. All outcomes are assessed prospectively during the early postoperative period.",[55,23,56],"Knee Osteoarthritis","Total Knee Arthroplasty",[56,58,55,59,60],"Intravenous Dexamethasone","Gonarthrosis","Multimodal Analgesia","2026-05-19",{"date":63,"type":34},"2026-05-20",{"date":65,"type":34},"2026-03-31",{"date":67,"type":19},"2027-10",{"name":69,"class":41},"Haseki Training and Research Hospital",{"id":71,"slug":4,"hasResults":10,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":42},"100585707","NCT06905860","Intra-articular Infiltration of Platelet-Rich Fibrin vs Corticosteroid in Mild to Moderate Knee Osteoarthritis","iPRF","Inclusion Criteria:The following inclusion criteria will be followed:\n\n* Age 50 years or older\n* Who have not improved with non-surgical treatment for at least 3 months, ability to sign a consent form, average visual analog scale \\> 40\u002F100 (over at least 7 days in the previous month)\n* Mild or moderate knee osteoarthritis diagnosed by radiographic imaging grade 2 or 3 according to the Kellgren-Lawrence classification.\n\nExclusion Criteria: The exclusion criteria will be:\n\n-Absence from work due to disability benefits or income reduction assistance (worker's compensation). Whenever one of the investigators believes that a participant may be simulating a worse health condition than reality to receive financial assistance with work absence, they will be excluded from the study.\n\nThe following non-inclusion criteria will be observed:\n\n* Angular deviation \\>10º of varus or valgus in relation to the anatomical neutral axis in the coronal plane assessed clinically with a goniometer (anatomical axis of the femur x anatomical axis of the tibia \\> 4º varus or \\> 16º valgus)\n* Body Mass Index (BMI)\\>35 or \\\u003C18\n* Smoking\n* Autoimmune inflammatory disease - rheumatological\n* Diabetes - with HbA1c \\> 7\n* Chronic kidney disease\n* Coagulopathies\n* severe cardiovascular diseases\n* infections or immunodeficiencies\n* active or treated malignant neoplasia\n* use of NSAIDs in the last month\n* use of corticosteroids in the last 3 months\n* platelets \\\u003C 150,000\n* recent intra-articular corticosteroid injection or recent HA injection (in the last 6 months)\n* pregnancy or suspected pregnancy\n* psychiatric disorders.",true,{"count":78,"type":19},90,"INTERVENTIONAL",[81],"PHASE4","Methodology: Randomized double-blind clinical trial comparing intra-articular injection of Platelet-Rich Fibrin (PRF) versus intra-articular injection of corticosteroids in mild to moderate arthrosis of the knee. Inclusion criteria: Age 50 years or older, who have not improved with non-surgical treatment for at least 3 months, ability to sign informed consent, mean visual analogue scale \\> 40\u002F100 (over at least 7 days during the month anterior), mild or moderate knee arthrosis diagnosed by grade 2 or 3 radiographic imaging according to the Kellgren-Lawrence classification. Inclusion criteria: angular deviation \\>10º of varus or valgus in relation to the anatomical neutral axis in the coronal plane clinically evaluated with a goniometer (femur anatomical axis x tibial anatomical axis \\> 4th varus or \\> 16th valgus), BMI \\>35 or \\\u003C18, smoking , autoimmune inflammatory disease - rheumatologic, diabetes - with glycated Hb \\> 7, chronic kidney disease, coagulopathies, severe cardiovascular diseases, infections or immunodeficiencies, malignant neoplasm in activity or under treatment, use of NSAIDs in the last month, use of corticosteroids in the last 3 months, platelets \\\u003C 150,000, recent intra-articular corticosteroid infiltration or recent Hyaluronic acid infiltration (within the last 6 months), pregnancy or suspected pregnancy, psychiatric disorders. Exclusion criteria: when one of the investigators considers that the participant may be simulating a worse health state than the real one in order to receive financial assistance with the absence from work, he will be excluded from the work. Primary outcome: WOMAC. Secondary outcomes: Visual Analogue Pain Scale. Evaluation moments: inclusion and after the procedure at 3, 6, 12, 18 and 24 months. Sample calculation: 90 patients, 45 patients in each group, considering 15% loss to follow-up and aiming to reach a power of 0.8 and an alpha value of 0.5.",[23],[28,85],"i-PRF","NOT_YET_RECRUITING","2025-03-24",{"date":89,"type":34},"2025-04-02",{"date":91,"type":19},"2025-06-01",{"date":93,"type":19},"2027-09-01",{"name":95,"class":41},"Federal University of São Paulo",{"id":97,"slug":4,"hasResults":10,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":10,"sex":15,"minAge":102,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":79,"phases":105,"briefSummary":107,"conditions":108,"keywords":117,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":4},"100570627","NCT06709703","Kinematic Alignment in Total Knee Arthroplasty - a Double-blind Randomised Controlled Trial Between Robotic and Caliper-based Techniques","L'Alignement cinématique Dans Les prothèses de Totales de Genou : un Essai randomisé contrôlé à Double Insu Comparant la Robotique Aux Instruments Traditionnels","Inclusion Criteria:\n\n* Patient aged 18 or above\n* Patient being consented for a primary total knee arthroplasty (TKA)\n* The primary TKA is planned to be done with kinematic alignment\n* All pre-operative alignments are included\n\nExclusion Criteria:\n\n* Revision TKA (including revision of unicompartimental knee arthroplasty into total knee arthroplasty with primary components). TKA being done in the setting of previous femur or tibia fracture or osteotomy are however included.\n* No available adequate pre-operative imaging\n* Patient who does want to be randomized of the two groups\n* At the discretion of the surgeon, if the patient's pathology or particular anatomy precludes the use of kinematic alignment technique, robotic surgery, or traditional instrument TKA.","18 Years",{"count":104,"type":19},200,[106],"NA","Knee replacement surgery is a surgery designed to treat severe arthritis of the knee. However, as many as 20% of patients are not satisfied with the results of their surgery. To place the knee replacement in correct position, the kinematic alignment method, which tries to reproduce the patient normal anatomy, has shown promise in improving the satisfaction after knee replacement surgery. It is not known if using a robotic arm to assist in surgery is better than the traditional method when trying to recreate kinematic alignment.\n\nThe goal of this study is to learn if robotic assisted surgery is better than traditional method for knee replacement done using kinematic alignment. The main questions the study tries to answer are:\n\n1. Do the radiographs of kinematic knee replacement surgeries done with robotic assistance show better alignment than radiographs of kinematic knee replacements done with the traditional method?\n2. Does robotic assisted kinematic knee replacement give better function to patients than traditional knee replacement done with kinematic alignment?\n3. Does robotic assisted kinematic knee replacement decrease pain, improve knee movement and improve knee stability better than traditional knee replacement done with kinematic alignment?\n4. Are there more complications with robotic assisted kinematic knee replacement in comparison to traditional kinematic knee replacement?\n5. How long long does it take a surgeon to become good a performing a kinematic knee replacement using robotic assistance? Researchers will compare knee replacements done using a robotic to make the bone cuts, and compare it to the usual method using guides and manual instruments. All the knee replacements will be done using the kinematic alignment and with the same type of knee replacement prothesis.\n\nParticipants will:\n\n* Have a knee replacement done with the kinematic alignment technique by an experienced surgeon, with or without robotic assistance during the surgery.\n* Visit the clinic before surgery, six weeks after surgery, three months, six months, twelve months and twenty-four months after the surgery.\n* Fill questionnaire, have their knee examined and have radiographs of their knee done at each visit.",[109,110,111,112,113,114,115,116,23],"Arthritis","Arthritis (Knee)","Osteoarthritis","Osteoarthritis Knee Pain","OA","OA Knee","OA Knee Pain","Osteoarthritis of Knee",[118,119,120,121,122,123,124,125,126],"osteoarthritis","arthritis","knee osteoarthritis","knee OA","knee arthritis","total knee replacement","robotic","kinematic alignment","patient-specific surgery","2024-11-25",{"date":129,"type":34},"2024-11-29",{"date":131,"type":19},"2025-02",{"date":133,"type":19},"2028-09",{"name":135,"class":41},"Université de Sherbrooke",""]