[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healthy-lifestyle\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healthy-lifestyle":430},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,58,85,112,139,160,187,214,236,264,286,309,340,362,384,405],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":34,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100626901",false,"NCT07441655","Families Implementing Good Health Traditions for Life","FIGHT for Life","Inclusion Criteria:\n\n1. Family 1.a.) Black Parent\u002FGuardian: age 18 years or older residing in the same household with child (i.e., biological or have legal guardianship for child) 1.b.) Child: age 8-15 years old\n2. Parent\u002FGuardian have HbA1c level 5.7-6.4% (prediabetes)\n3. Parent\u002FGuardian willing to commit to participation in a 20-month research study and have no plans to move from the area over the next 20-months\n4. Parent\u002Fchild are ambulatory and able to participate in physical activity\n\nExclusion Criteria:\n\n1. Individuals with severe psychological disorders that may prevent\u002Finterfere with study participation\n2. Physical impairments that may prevent participation in moderate intensity physical activity;\n3. Previous diagnosis of diabetes\n4. History of congestive heart failure, renal failure, or recent (\\\u003C12 months) cardiovascular events such as myocardial infarction or stroke;\n5. Person taking medications that may affect endpoint analyses\n6. Persons with co-morbid contraindications to physical activity or dietary changes.\n7. Currently pregnant or planning to become pregnant in the next year.","ALL","18 Years",{"count":18,"type":19},70,"ESTIMATED","INTERVENTIONAL",[22],"NA","This study will provide evidence for the utility of using a community-engaged research approach to implement a tailored, family-oriented adaptation of the Diabetes Prevention Program that will have positive effects on risk factors associated with type 2 diabetes morbidity and mortality among Black families in a Southwest Georgia community.",[25,26,27,28,29,30,31,32,33],"Diabetes","Chronic Disease","Type 2 Diabetes","Healthy Lifestyle","Nutrition, Healthy","Sedentary Behavior","Family","Family Research","Family and Household",[35,36,37,38,39,40,41,42,43,44],"diabetes","rural","type 2 diabetes","nutrition","physical activity","diabetes prevention","family research","family and household","chronic disease","sedentary behavior","RECRUITING","2026-06-18",{"date":48,"type":49},"2026-06-23","ACTUAL",{"date":51,"type":49},"2026-02-04",{"date":53,"type":19},"2028-04-30",{"name":55,"class":56},"Morehouse School of Medicine","OTHER",1,{"id":59,"slug":4,"hasResults":10,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":20,"phases":66,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100514906","NCT05984589","Personalized Health Self-Management Training for Colorectal Cancer Survivors","A Prospective, Randomized, Controlled, Double-Arm Study of RISE (Re-Invent, Integrate, Strengthen, Expand) Personalized Self-Management Training (PSMT) Compared to Standardized Self-Management Training (SSMT) in Gastrointestinal Cancer (GI) Patients","Inclusion Criteria:\n\n* Age ≥18 years at the time of consent.\n* History of Stage I-IV colorectal cancer (CRC) or other gastrointestinal cancer within the past 10 years prior to enrollment.\n* Ability to speak, write, and read English sufficiently to allow for program participation.\n* Identified by self-report as having willingness and interest to work on at least one lifestyle-related risk factor. Lifestyle-related risk factors include diet, physical activity, body composition, alcohol use.\n* Scoring ≤3.5 on the World Cancer Research Fund\u002FAmerican Institute for Cancer Research (WCRF\u002FAICR) Health Behavior Adherence Scale or in the low-to-moderate range in any subcategory consistent with moderate to low adherence to healthy behavior recommendations (HBRs).\n* Ambulatory and independent in activities of daily living (ADL).\n* Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.\n\nExclusion Criteria:\n\n* Cognitive or mental impairments that in the opinion of the Principal Investigator or study physician would hinder the program participation.",{"count":65,"type":19},120,[22],"This is a Phase 2 prospective, randomized, controlled, double-arm study to assess personalized self-management training (PSMT) intervention efficacy and patient experiences compared to standardized self-management training (SSMT). A total of 120 gastrointestinal (GI) cancer patients will be enrolled and randomized 1:1 to complete a 6-week self-management training program (either PSMT or SSMT) to be carried out by licensed occupational therapists with doctoral training.\n\nThis study aims to examine whether PSMT is more effective in increasing adherence to healthy behavior recommendations compared to SSMT in GI cancer patients.",[69,28,70,71,72],"Colorectal Cancer","Behavior, Health","Health Behavior","Gastrointestinal Cancers",[74],"self-management training","2026-06-08",{"date":77,"type":49},"2026-06-10",{"date":79,"type":49},"2024-03-01",{"date":81,"type":19},"2028-11-30",{"name":83,"class":56},"University of Southern California",2,{"id":86,"slug":4,"hasResults":10,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":15,"minAge":16,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":20,"phases":94,"briefSummary":95,"conditions":96,"keywords":100,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":57},"100456084","NCT05218980","Health-related Benefits of Introducing Table Olives Into the Diet of Young Adults: Olives For Health","Inclusion Criteria:\n\n* Yale College Freshman, Sophomore, or Junior\n* Ability and desire to sign informed consent\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Male or female, age 18 on the day of consent\n* Ability and desire to consume 6 olives daily\n\nExclusion Criteria:\n\n* Yale College Senior\n* Unable to provide informed consent form\n* Self-reported pregnancy\n* Unwillingness to comply with all study procedures and\u002For be available for the duration of the study\n* Inability and desire to consistently consume 6 olives per day\n* Inability to consume fruit with pits\n* Current and consistent use of \\> 6 olives per day\n* Current and consistent use of ≥ 1 tablespoon of extra virgin olive oil (EVOO) per day\n* Known allergic reactions to olives and\u002For their derivatives\n* Known reactions to blood draw",true,"23 Years",{"count":93,"type":19},226,[22],"The purpose of this study is to assess whether introducing table olives into the diet results in health-related benefits for young adults. Several studies have shown that addition of olives as part of somebody's diet has a positive impact on cardiovascular, metabolic, and inflammatory factors. However, there have not been many studies among young, healthy adults. This study will compare levels of specific biomarkers, collected through blood draw, at the beginning of the study and after 5 weeks, to evaluate the effects of investigational daily olive consumption.",[97,98,28,99],"Healthy Diet","Cholesterol","Healthy Nutrition",[101],"olives","NOT_YET_RECRUITING","2026-05-11",{"date":105,"type":49},"2026-05-13",{"date":107,"type":19},"2027-01",{"date":109,"type":19},"2027-06",{"name":111,"class":56},"Yale University",{"id":113,"slug":4,"hasResults":10,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":90,"sex":15,"minAge":16,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":20,"phases":122,"briefSummary":123,"conditions":124,"keywords":125,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":57},"100635918","NCT07558928","Effect of Hyperoxygenated Environment on Maximal Muscle Strength","Effect of Hyperoxygenated Environment on Maximal Muscle Strength in the Mid-thigh Pull Test - a Blinded, Randomized, Sham-Controlled Crossover Study","force","Inclusion Criteria:\n\n1. Healthy\n2. Ages 18-45\n3. Participants are physically active and have a recent resistance-training experience of at least six months, ≥ 3 times a week\n4. Participant willing and able to read, understand and sign an informed consent\n\nExclusion Criteria:\n\n1. Inability to attend scheduled clinic visits or comply with the study protocol\n2. Active malignancy\n3. Active smokers\n4. Previous treatment of hyperbaric chamber for any reason prior to study enrollment.\n5. Chest pathology incompatible with pressure changes\n6. Major orthopedic injury at the past 3 months\n7. Inner ear disease\n8. Lung pathology\n9. Claustrophobia\n10. Previous neurologic conditions (e.g., epilepsy, brain tumors or s\u002Fp neurosurgery etc.)\n11. Comorbidities and medications that rule out the subject","45 Years",{"count":121,"type":19},48,[22],"comparing the effect of hyperoxygenated environment on maximal muscle strength in the Mid-thigh Pull Task",[28],[126,127,117,128],"power lifting","gym","imtp","2026-04-26",{"date":131,"type":49},"2026-04-30",{"date":133,"type":49},"2024-01-01",{"date":135,"type":19},"2027-12-31",{"name":137,"class":138},"Assaf-Harofeh Medical Center","OTHER_GOV",{"id":140,"slug":4,"hasResults":10,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":90,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":147,"phases":4,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":57},"100633865","NCT07532239","Survey of Knowledge, Practice, and Recommendation Behaviors Regarding Healthy Lifestyles Among Healthcare Workers","Investigation of Healthy Lifestyle Knowledge, Practice, and Recommendation Behaviors Among Healthcare Workers Across Different Levels of Healthcare Institutions","Inclusion Criteria:\n\n* Healthcare workers employed at participating healthcare institutions\n\nExclusion Criteria:\n\n* Individuals unwilling or unable to provide informed consent",{"count":146,"type":19},150,"OBSERVATIONAL","This cross-sectional observational study aims to assess healthy lifestyle knowledge, personal health practices, and lifestyle recommendation behaviors among healthcare workers across different levels of healthcare institutions. The study will also collect clinical examination and biochemical indicators to evaluate the health status of participants and explore their associations with lifestyle-related knowledge and behaviors.\n\nHealthcare workers play a critical role in promoting healthy lifestyles among patients; however, their own health behaviors and recommendations may vary depending on training background and institutional settings. This study seeks to better understand these differences and identify potential gaps between knowledge and practice.\n\nThe findings of this study may help inform targeted training strategies and support the development of effective health promotion programs for healthcare professionals, ultimately improving the quality of lifestyle guidance provided to patients.",[28,150,71],"Health Knowledge","2026-04-08",{"date":153,"type":49},"2026-04-15",{"date":155,"type":19},"2026-04-10",{"date":157,"type":19},"2026-04-20",{"name":159,"class":56},"Jiangsu Taizhou People's Hospital",{"id":161,"slug":4,"hasResults":10,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":90,"sex":166,"minAge":16,"maxAge":119,"enrollmentInfo":167,"targetDuration":4,"studyType":20,"phases":169,"briefSummary":170,"conditions":171,"keywords":172,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":57},"100629861","NCT07480174","Effects of Tai Chi and Yoga on Flexibility, Anxiety, and Sleep Quality in Women","The Effect of Tai Chi and Yoga on Flexibility, Anxiety, and Sleep Quality in Women","Inclusion Criteria:\n\n* Female, 18-45 years of age\n* BMI \\\u003C30 kg\u002Fm²\n* No history of musculoskeletal surgery\n\nExclusion Criteria:\n\n* Congenital or acquired condition affecting the musculoskeletal system\n* Any systemic disease or condition that makes exercise contraindicated, or pregnancy\n* Chronic neurological, metabolic, or cardiovascular disease","FEMALE",{"count":168,"type":19},40,[22],"Healthy women aged 18-45 years with BMI \\\u003C30 were randomized into two groups to receive either Tai Chi or yoga training. Both interventions were delivered for 8 weeks, 2 sessions per week, 45 minutes per session, at Bahçeşehir University. Flexibility, anxiety, and sleep quality were assessed before and after the intervention using standardized flexibility tests, the Beck Anxiety Inventory, and the Pittsburgh Sleep Quality Index. The outcome assessor was blinded to group assignment.",[28],[173,174,175,176,177],"Flexibility","Anxiety","Sleep Quality","Tai Chi","Yoga","2026-03-24",{"date":180,"type":49},"2026-03-27",{"date":182,"type":49},"2026-03-14",{"date":184,"type":19},"2026-06-02",{"name":186,"class":56},"Istanbul University - Cerrahpasa",{"id":188,"slug":4,"hasResults":10,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":90,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":20,"phases":195,"briefSummary":198,"conditions":199,"keywords":201,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":57},"100489449","NCT05653258","Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects","Single Nuclei RNA-sequencing to Map Adipose Cellular Populations and Senescent Cells in Older Subjects","Inclusion Criteria:\n\n1. Both Sexes\n2. Age: younger lean group 18-30 years with BMI 18.5-24.9 kg\u002Fm2; younger obese group 18-30 with BMI 30.0 -39.9; older obese group ≥ 65 years with BMI 30.0-39.9\n3. All races and ethnic groups\n4. Community dwelling\n5. Sedentary (≤1.5 h of exercise per week)\n6. Nondiabetic (fasting plasma glucose \\\u003C 126 mg\u002Fdl, 2-h glucose during oral glucose tolerance test (OGTT) \\\u003C 140mg\u002Fdl, and A1c \\\u003C 6.5%\n7. For all female participants who are women of childbearing potential (WOCBP), who are not pregnant or breast feeding, at least one of the following conditions must apply:\n\n   A documented hysterectomy, bilateral salpingectomy, or bilateral oophorectomy Use of a contraceptive method that is highly effective (with a failure rate of \\\u003C1% per year), preferably with low user dependency (implantable progesterone-only hormone contraception, intrauterine hormone releasing system, bilateral tubal occlusion, vasectomized partner) during the intervention period of the study and for at least 30 days after the last dose of study intervention to eliminate any reproductive safety risk of the study drug.\n\n   Use of a contraceptive method that is highly effective (with a failure rate of \\\u003C1% per year), with high user dependency, (oral\u002Fintravaginal\u002Finjectable combined estrogen and progesterone contraception, oral\u002Finjectable progesterone only hormone contraception, sexual abstinence) during the intervention period and for at least 30 days after the last dose of study intervention to eliminate any reproductive safety risk of the study drug. In addition to the highly effective methods: male or female condom with or without spermicide; cervical cap, diaphragm, or sponge with spermicide; a combination of male condom with either cervical cap, diaphragm, or sponge with spermicide.\n8. ECG value after 10 minutes of resting in the supine position in the following ranges:\n\n120ms\\\u003CPR\\\u003C220ms: QRS\\\u003C120ms; QTc\\\u003C430ms for males and QTc\\\u003C450ms for females and normal ECG tracing, unless the investigator considers the ECG abnormality to be not clinically relevant.\n\nExclusion Criteria:\n\n1. Diabetes, clinically diagnosed or HbA1c \\> 6.5% and\u002For fasting plasma glucose \\> 126 mg\u002Fdl and\u002For use of anti-diabetic medications.\n2. Participating in \\> 1.5 h of structured exercise\u002Fweek\n3. Unstable weight (\\>3% change in last 3 months)\n4. Neurological, musculoskeletal, or other conditions that may limit subject's ability to complete study physical assessment and training\n5. Active autoimmune\u002Finflammatory disease including: rheumatoid arthritis, multiple sclerosis, systemic lupus erythematous, inflammatory bowel disease\n6. Laboratory parameters outside the normal range:\n\n   * impaired kidney function (eGFR \\\u003C 30ml\u002Fmin\u002F1.73m² as calculated by the CKD-EPI equation);\n   * impaired liver function (AST or ALT level \\> 2 times upper limit of normal (ULN);\n   * total Bilirubin level \\> 1.5 times ULN;\n   * TSH \\> 1.5 times ULN or \\\u003C lower limit of normal (LLN);\n   * Hemoglobin \\\u003C10.0 g\u002Fdl; Platelets \\\u003C125,000 cell\u002Fmm³;\n   * Platelets \\\u003C 125,000 cell\u002Fmm³\n   * Prothrombin time (PT) \\> 1.0 times ULN\n   * Partial prothrombin time (PTT) \\> 1.0 times ULN.\n7. Active gastrointestinal disease; coagulopathy; GI bleed within 6 months\n8. Clinically significant heart disease (e.g. NYH Classification \\>II; ischemia)\n9. Peripheral vascular disease (claudication)\n10. QTc prolongation \\>45 msec\n11. Use of anti-arrhythmic medications known to cause QTc prolongation, anti-platelet or anti-coagulant medication (see section 5.3)\n12. Use of quinolone antibiotics or any other drugs that may prolong the QTc interval (see section 5.3)\n13. Pulmonary disease (COPD), severe asthma or exercise-induced asthma\n14. Recent systemic or pulmonary embolus\n15. Uncontrolled blood pressure (systolic BP\\>170, diastolic BP\\>95 mmHg)\n16. Smoking, alcohol use (history of regular alcohol consumption exceeding 7 drinks\u002Fweek for female participants or 14 drinks\u002Fweek for male participants. 1 drink = 5 ounces \\[150ml\\] of wine or 12 ounces \\[360ml\\] of beer or 1.5 ounces \\[45ml\\] of hard liquor) or recreational drug use (other than marijuana)\n17. Pregnant or breastfeeding\n18. Postmenopausal women new (within 6 months) to systemic hormone replacement therapy\n19. Previous bariatric surgery\n20. History of stroke with motor disability\n21. Recent (3 years) treated cancer other than basal cell carcinoma\n22. Acute or chronic infection\n23. Medication that might interfere with metabolic studies (weight loss medication, systemic steroids, immunosuppressants) within 6 months (see section 5.3)\n24. Potentially senolytic agents within the last 6 months: fisetin, quercetin, luteolin, dasatinib, piperlongumine, or navitoclax (see section 5.3)\n25. History of allergy to dasatinib, quercetin and\u002For lidocaine.\n26. Concurrent enrollment in another interventional trial.",{"count":194,"type":19},160,[196,197],"PHASE2","PHASE3","All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for cellular\u002Fmolecular profiling via snRNA-seq and metabolic\u002Fphysiological assessments (insulin sensitivity, glucose tolerance, and β-cell function). Older obese participants will be randomized into three arms: lifestyle intervention (n=24), senolytics (n=24), or placebo (n=24).",[200,28],"Obesity",[202,203,204],"Lifestyle intervention","Single RNA sequencing","Cell Senescence","2026-03-16",{"date":207,"type":49},"2026-03-18",{"date":209,"type":49},"2023-10-17",{"date":211,"type":19},"2028-02-01",{"name":213,"class":56},"Cedars-Sinai Medical Center",{"id":215,"slug":4,"hasResults":10,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":218,"eligibilityCriteria":219,"healthyVolunteers":90,"sex":15,"minAge":220,"maxAge":221,"enrollmentInfo":222,"targetDuration":4,"studyType":20,"phases":224,"briefSummary":225,"conditions":226,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":57},"100492255","NCT05689762","Promotion of Healthy Lifestyle Habits in Primary Care Settings","PCrorelse","Inclusion Criteria:\n\n* age, high metabolic risk- poor lifestyle habits (diet and physical activity)\n\nExclusion Criteria:\n\n* overt disease","40 Years","70 Years",{"count":223,"type":19},100,[22],"Intervention aiming to promote healthy dietary and physical activity behaviors in adults with different socioeconomic status primary care settings",[28],"2026-02-13",{"date":229,"type":49},"2026-02-18",{"date":231,"type":49},"2022-06-22",{"date":233,"type":19},"2028-01-10",{"name":235,"class":56},"Örebro University, Sweden",{"id":237,"slug":4,"hasResults":10,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":241,"eligibilityCriteria":242,"healthyVolunteers":90,"sex":15,"minAge":243,"maxAge":4,"enrollmentInfo":244,"targetDuration":4,"studyType":20,"phases":246,"briefSummary":247,"conditions":248,"keywords":249,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":57},"100607513","NCT07189533","SENior PRIorat: Participatory Research for the Improvement of Lifestyles, Quality of Life, Emotional Well-being, and Locomotor Abilities of Older Adults in the Priorat","SENior PRIorat: Ciencia Participativa Para la Mejora de Los Estilos de Vida, la Calidad de Vida, el Bienestar Emocional y Las Capacidades Locomotoras de Las Personas Mayores Del Priorat","SENPRI","Inclusion Criteria:\n\n* Aged 60 years or older\n* Signed informed consent\n* Living independently\n* Capacity to follow and complete the study\n* Resident in one of the villages of the Priorat region\n\nExclusion Criteria:\n\nFailure to meet any of the inclusion criteria will be considered grounds for exclusion.","60 Years",{"count":245,"type":19},80,[22],"Spain is experiencing a demographic shift towards an ageing population. In 2022, 20.1% of Spaniards were 65 or older, a figure projected to reach 30.4% by 2050. The trend is especially marked in rural areas, where outmigration of younger generations has left a high concentration of older residents. In Catalonia's Priorat county, the share of people aged 65+ already exceeds 20%, reaching 30%, and even 40% in some villages.\n\nThe ageing process brings biological changes that reduce locomotor and cognitive abilities, limiting autonomy and quality of life. In rural areas, these challenges are compounded by social isolation and the lack of support networks, making older adults more vulnerable. Healthy lifestyle habits-such as balanced nutrition, regular exercise, avoiding tobacco and alcohol, and good sleep-can help delay dependence, lower the risk of chronic disease, and improve well-being. To promote these habits, social innovation must generate new services and approaches that address real needs, barriers, and motivations in adopting healthier lifestyles.\n\nOur group's research shows that participatory science is an effective tool to promote healthy ageing in rural settings. A three-month intervention co-designed with older adults in villages of ≤2,000 inhabitants led to improvements in locomotor function, measured through sarcopenia parameters, and enhanced quality of life in areas such as vitality, mental health, and social functioning. A distinctive feature of this approach is shared decision-making between residents and policymakers, ensuring that solutions are adapted to local realities. This fosters greater adherence, empowerment, and long-term sustainability of co-created strategies.\n\nThis project is directly relevant to public policy through collaboration with the Consell Comarcal del Priorat, which represents 23 municipalities. Their recent report identified ageing as a major concern for both institutions and residents. The project's results can therefore guide health policies-decisions, plans, and actions-that address local needs while considering available resources and ensuring long-term sustainability.\n\nBy focusing on health promotion and disease prevention, the project ensures that policies are evidence-based and subject to evaluation. The partnership with the Consell Comarcal also aligns with Sustainable Development Goal 3 (Health and Well-being) of the 2030 WHO Agenda and supports the \"Health in All Policies\" approach, fostering integrated strategies across sectors.\n\nThe principal aim of the study is to evaluate the effectiveness of a participatory science intervention study in improving lifestyle habits (dietary habits, physical activity, substance use, and sleep quality), quality of life, emotional well-being, and locomotor capacities through the assessment of sarcopenia parameters (muscle strength, muscle mass, and physical function) in young-old adults (≥60 years) living in rural areas of the Priorat region (Catalonia, Spain).\n\nSpecific Objectives:\n\n1. To describe the health status of older people residing in the Priorat region by evaluating: lifestyle habits (diet, substance use, physical activity, and sleep), risk of malnutrition, functional capacity based on sarcopenia parameters, mental capacity (mental health and emotional well-being), and quality of life.\n2. To improve lifestyle habits (diet, physical activity, sedentary behaviour, sleep habits, and substance use-alcohol and smoking), emotional well-being and personal relationships to avoid unwanted loneliness, quality of life, and locomotor abilities based on sarcopenia parameters (muscle strength, muscle mass, and physical function).\n3. To reduce the risk of malnutrition.\n4. To compare the health status of two groups: those aged 60-74 (young-old adults) and those aged 75 and over (older people).\n5. To identify the needs, barriers, and motivations of older people through focus groups, including participants aged 60-74, those over 75, and stakeholders such as members of the public administration supporting the project.\n6. To compare the differences in needs, barriers, and motivations identified by the young-old adults (60-74 years) and the older people (≥75 years).\n7. To actively involve older participants in the co-creation of health promotion activities and an intervention designed for them and their peers.\n8. To implement an intervention based on proposals generated during the co-creation process to improve their lifestyle (dietary habits, physical activity, substance use, well-being, and sleep behaviours), quality of life, and locomotor abilities.\n9. To analyse environmental barriers, using the \"Age-Friendly Cities and Communities Questionnaire (AFCCQ)\", in the villages of the Priorat region that may influence the ability to maintain a healthy lifestyle and quality of life for people aged 60-74 and those aged 75 and over.",[28],[250,251,252,253,254],"Participatory research","healthy lifestyle","quality of life","older adults","rural environment","2025-09-16",{"date":257,"type":49},"2025-09-24",{"date":259,"type":19},"2025-10-06",{"date":261,"type":19},"2027-04-30",{"name":263,"class":56},"University Rovira i Virgili",{"id":265,"slug":4,"hasResults":10,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":90,"sex":15,"minAge":270,"maxAge":271,"enrollmentInfo":272,"targetDuration":4,"studyType":20,"phases":274,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":57},"100572298","NCT06731452","Exploring Neurophysiological Markers of Brain Health","Exploring Markers of Brain Health With EEG and TMS: A Pilot Study","Inclusion Criteria:\n\n* Must be an active brain imaging participant in The BrainHealth Project (NCT04869111)\n* Minimum age of 22\n* Fluent in English\n* Able to read \\& hear information over a computer\n* Must pass an MRI safety screener to assess the presence of contraindicators for MRI compatibility (i.e., non-removable metal within\u002Fon the body, claustrophobia, pregnancy, non-correctable vision problems, head trauma, and CNS disease)or other standard requirements as determined by the Imaging Center.\n* Must pass a modified TMS Adult Safety Screen\n* Meet all criteria for study as determined by the study physician\n\nExclusion Criteria:\n\n* A diagnosis of a neurodegenerative disease\n* A history of stroke, concussion, or brain injury that currently hinders them from functioning at their prior level\n* A diagnosis of autism spectrum disorder that currently hinders them from functioning independently.\n* Metallic brain implants or fragments (like a shunt, pacemaker, clips, coils, bullet fragments, cochlear implants)\n* Magnetically activated implants or electronically implanted devices\n* Medication pumps\n* Personal or family history of epilepsy, seizure(s), seizure disorder.\n* History of, or risk factors for syncope (fainting)\n* Report significant cognitive challenges\n* Report untreated health issues (like substance abuse, hypertension, hypo- or hyper-thyroidism)\n* Have claustrophobia","22 Years","100 Years",{"count":273,"type":19},63,[22],"The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been suggested as a promising brain imaging tool for identifying biomarkers of brain health.\n\nIn this pilot study, study investigators will explore the neurophysiological metrics of brain health with a non-invasive brain imaging technique, alongside behavioral and fMRI metrics collected through another study (NCT04869111).",[28,277],"Health-Related Behavior","2025-09-09",{"date":255,"type":49},{"date":281,"type":49},"2025-09-03",{"date":283,"type":19},"2027-05-31",{"name":285,"class":56},"The University of Texas at Dallas",{"id":287,"slug":4,"hasResults":10,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":4,"eligibilityCriteria":291,"healthyVolunteers":90,"sex":15,"minAge":292,"maxAge":4,"enrollmentInfo":293,"targetDuration":4,"studyType":20,"phases":295,"briefSummary":296,"conditions":297,"keywords":298,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":57},"100585336","NCT06901037","A Pilot Randomized Controlled Trial of Chatbot Use in Older Adults for Lifestyle Change","The Acceptability and Preliminary Effectiveness of Using A Smartphone-delivered AI-Based Chatbot in Older Adults for Lifestyle Modification: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* aged 65 or above.\n* are community-dwelling.\n* are proficient in Mandarin.\n* have an Internet connection.\n* have at least one instant messaging app on the smartphone or agree to download one.\n\nExclusion Criteria:\n\n* have any neurocognitive disorders.\n* are unable to engage in moderate-intensity level of physical activity due to a preexisting medical condition.\n* live with another participant who will participate in this study.","65 Years",{"count":294,"type":19},84,[22],"The purpose of this study is to evaluate the acceptability and preliminary effectiveness of a smartphone-delivered AI-based chatbot in promoting healthy dietary behavior and physical activity participation among older adults.",[28],[299],"Chatbot, older adults","2025-09-08",{"date":302,"type":49},"2025-09-15",{"date":304,"type":49},"2025-05-01",{"date":306,"type":19},"2025-12-31",{"name":308,"class":56},"The Hong Kong Polytechnic University",{"id":310,"slug":4,"hasResults":10,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":4,"eligibilityCriteria":314,"healthyVolunteers":90,"sex":15,"minAge":16,"maxAge":315,"enrollmentInfo":316,"targetDuration":4,"studyType":20,"phases":318,"briefSummary":319,"conditions":320,"keywords":326,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":338,"locationsCount":57},"100553901","NCT06492109","The Peripheral Blood Multi-Omics Study on Sleep Loss","The Peripheral Blood Multi-Omics Study on the Association of Sleep Loss With Aging and Alzheimer's Disease","Inclusion Criteria:\n\n1. Signed informed consent form；\n2. Meet the inclusion criteria for each arms.\n\nExclusion Criteria:\n\n1. Failure to provide informed consent;\n2. Inability to follow study procedures due to issues such as language barriers or cognitive impairment;\n3. Regular use of medications that may alter the relationship between sleep and outcome variables (e.g., opioid medications, benzodiazepines, and Z drugs \\[non-benzodiazepine hypnotics\\]);\n4. History of alcohol abuse, substance abuse, consciousness disorders, cerebrovascular disease, head injury, epilepsy, encephalitis, or other neurological disorders;\n5. Diagnosis of schizophrenia, severe depression, anxiety disorders, or other severe psychiatric conditions;\n6. Presence of severe arrhythmias, myocardial infarction within the last 6 months, severe pulmonary dysfunction, renal or hepatic insufficiency, severe anemia, severe gastrointestinal diseases, tumors, or other severe medical conditions.","80 Years",{"count":317,"type":19},60,[22],"Sleep plays a role in cognitive processes such as memory processing, attention processing, and overall cognitive function. In recent years, the bidirectional relationship between sleep loss and aging, as well as related neurodegenerative diseases, has garnered widespread attention. Sleep disorders are a typical clinical manifestation of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease and are closely related to the progression of these diseases. However, current research has yet to fully elucidate the physiological responses to sleep loss across different ages and cognitive levels, as well as the association and molecular basis between sleep loss, aging, and neurodegenerative diseases. This study aims to comprehensively characterize the transcriptional and metabolic changes in peripheral blood under sleep loss in populations of different ages and cognitive levels using multi-omics approaches and to preliminarily explore the role of sleep loss in aging and AD.",[321,322,323,28,324,325],"Sleep Deprivation","Aging","Alzheimer Disease","Cognitive Decline","Shift-work Disorder",[327,328,329,330,331],"sleep loss","multi-omics","Metabolome","aging","alzheimer's disease","2025-07-30",{"date":334,"type":49},"2025-07-31",{"date":336,"type":49},"2024-06-20",{"date":306,"type":19},{"name":339,"class":56},"First Affiliated Hospital of Zhejiang University",{"id":341,"slug":4,"hasResults":10,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":346,"targetDuration":4,"studyType":20,"phases":347,"briefSummary":348,"conditions":349,"keywords":351,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":57},"100559403","NCT06563674","Acceptance-based Healthy Lifestyles Program for Patients With Pneumoconiosis","Nurse-led Acceptance-based Healthy Lifestyles Program for Community-dwelling Patients With Pneumoconiosis: A Waitlist Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n1. Ethnic Chinese who is able read and speak Chinese.\n2. Adults aged 18 or over.\n3. Taking compensation for pneumoconiosis.\n\nExclusion Criteria:\n\n1. Those who have mental, visual, hearing, or cognitive impairments with regular medical follow-ups and treatment.\n2. Those who are unable to give written consent.",{"count":245,"type":19},[22],"Symptoms, such as cough and shortness of breath, are common among patients with pneumoconiosis. Depression and anxiety can be elicited by the symptoms, while avoidance of daily activities is believed to reduce trigger of symptoms. The lung function is then declined and the risk of having stroke and heart failure is increased. The objectives of this 2-arm waitlist pilot randomized controlled trial are to test the effects and feasibility of an acceptance-based educational program among patients with pneumoconiosis. 80 participants will be recruited from community centers and randomly assigned to intervention group or waitlist-control group in a ratio of 1:1. The 6-week group-based educational program will be provided to the intervention group first, then the waitlist-control group. The program consists of 4 sessions integrated with acceptance components and care of pneumoconiosis. Their psychological health, healthy lifestyles, and cardiometabolic profiles will be assessed at baseline, week 6, and week 14. Data will be analyzed using a statistical package. The feasibility of the program will be evaluated by interview. The findings of this study can inform the integration of acceptance-based intervention into pneumoconiosis management in Hong Kong, and future study on chronic progressive lung diseases.",[350,28],"Pneumoconiosis",[350,28,352],"Acceptance-based","2025-04-09",{"date":355,"type":49},"2025-04-13",{"date":357,"type":49},"2024-11-01",{"date":359,"type":19},"2026-01",{"name":361,"class":56},"Chinese University of Hong Kong",{"id":363,"slug":4,"hasResults":10,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":90,"sex":15,"minAge":16,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":147,"phases":4,"briefSummary":370,"conditions":371,"keywords":372,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":4},"100505568","NCT05863078","The Menus of Change Health and Heart Benefits for University Students","The Menus of Change Health and Heart Benefits for University Students (The MOCHAHS Trial): a Cross-sectional Study","Inclusion Criteria:\n\n* Adults\n* Home students living in university halls\n* Undergraduates\n* Can understand participant information sheet and willing to comply with the study design\n\nExclusion Criteria:\n\n* International students\n* postgraduates\n* living outside the university halls\n* participating in other studies","25 Years",{"count":223,"type":19},"The goal of this cross-sectional study is to investigate the health benefits of the Menus of Change in undergraduate university students, by comparing 2 groups: Students eating in the Menus of change catered halls, versus students eating outside the Menus of change meal plan. The main question it aims to answer is:\n\nWhat are the effects of the menus of change on other vascular outcomes, namely blood pressure? What are the effects of the menus of change on other health markers?",[28],[373,374],"Menus of Change","Arterial stiffness","2024-11-20",{"date":377,"type":49},"2024-11-22",{"date":379,"type":19},"2025-01-01",{"date":381,"type":19},"2026-12",{"name":383,"class":56},"University of Reading",{"id":385,"slug":4,"hasResults":10,"nctId":386,"briefTitle":387,"officialTitle":387,"acronym":388,"eligibilityCriteria":389,"healthyVolunteers":90,"sex":15,"minAge":16,"maxAge":390,"enrollmentInfo":391,"targetDuration":4,"studyType":20,"phases":392,"briefSummary":393,"conditions":394,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":57},"100467022","NCT05361343","First Line Prevent Age Study","FLIPS","Inclusion Criteria:\n\n* Men and women over 18;\n* No significant (affecting the functional state) \"active\" diseases: acute diseases and exacerbations of chronic diseases;\n* Interest in active longevity and willingness to participate in research.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Age up to 18 years;\n* Severe or moderate comorbidities;\n* Rheumatological (systemic \u002F autoimmune) diseases of any severity;\n* Intestinal infections (within 3 months);\n* SARS \u002F pneumonia, other diseases accompanied by systemic inflammation during the last 2 months;\n* Chronic inflammatory bowel disease;\n* Major surgery within the last 3 months\n* Intoxication (alcohol, drugs, other toxins);\n* Oncological disease (except for basalioma) out of remission;\n* Persons with mental illness;\n* Diabetes;\n* Syndrome of obstructive sleep apnea of moderate and severe severity;\n* Low adherence to lifestyle interventions, including physical activity of less than 150 minutes of aerobic activity per week (at least two days per week) or 75 minutes of vigorous exercise (at least 3 days per week).","90 Years",{"count":223,"type":19},[22],"To prove the effectiveness of complex wellness programs in terms of maintaining active longevity, including motivational counseling, high-intensity training, intermittent fasting, hypoxic training, as well as practices for achieving healthy sleep and mental well-being.\n\nClinical-instrumental, single-centre, prospective, open-label, non-randomized, sequential enrollment study with blinded endpoint analysis",[395,28,97],"Healthy Aging","2024-11-05",{"date":398,"type":49},"2024-11-07",{"date":400,"type":19},"2025-02",{"date":402,"type":19},"2026-09",{"name":404,"class":56},"Prevent Age Resort \"Pervaya Liniya\"",{"id":406,"slug":4,"hasResults":10,"nctId":407,"briefTitle":408,"officialTitle":408,"acronym":4,"eligibilityCriteria":409,"healthyVolunteers":90,"sex":15,"minAge":292,"maxAge":410,"enrollmentInfo":411,"targetDuration":4,"studyType":20,"phases":412,"briefSummary":413,"conditions":414,"keywords":417,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":84},"100555863","NCT06517615","The Effect of Home Visit Supported Nursing Education Program on Some Parameters in Elderly People Living Alone at Home","Inclusion Criteria:\n\n* Being 65 years or older\n* receiving home care services\n* agreeing to participate in the study\n* be literate\n\nExclusion Criteria:\n\n* Individuals under the age of 65\n* be mentally retarded\n* not volunteering","95 Years",{"count":121,"type":19},[22],"It is aimed to develop healthy lifestyle behaviors of elderly people living alone at home, reduce their loneliness levels and increase their social support capacity.The research was planned as a quasi-experimental research. The research population consists of elderly people living alone at home who are registered to the Elderly and Home Care Unit of a Municipality of a province.",[415,416,28],"Old Age; Debility","Loneliness",[418,419,420],"elderly","home visit","nursing","2024-07-18",{"date":423,"type":49},"2024-07-24",{"date":425,"type":49},"2024-04-25",{"date":427,"type":19},"2024-12-29",{"name":429,"class":56},"Kastamonu University",""]