[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healthy-obesity-metabolically\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healthy-obesity-metabolically":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":14,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100577561",false,"NCT06799897","Natural Course of Initially Metabolic Healthy Obese Individuals (Healthy Obesity)?","Inclusion Criteria:\n\n* Signed Informed Consent Form\n* Age between 18 and 60 years\n* BMI 30-50 kg\u002Fm2\n* Knowledge of German, which requires sufficient written and allow oral patient education\n\nInclusion criteria for initially healthy group\n\n* Blood pressure \\\u003C 140\u002F90 mmHg\n* Normal glucose metabolism\n\n  * HbA1c \\\u003C 6.5 %\n  * Fasting Glucose \\\u003C 7.0 mmol\u002Fl\n* Normal lipid metabolism\n\n  o LDL-cholesterol \\\u003C 5.0 mmol\u002Fl\n* ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference)\n* TG \\> 1.7 mmol\u002Fl\n* HDL-cholesterol \\> 1.0 mmol\u002Fl (male) \u002F \\> 1.3 mmol\u002Fl (female)\n* Fasting glucose ≥ 5.6 mmol\u002Fl\n* BP ≥ 130\u002F85 mmHg\n\nExclusion Criteria:\n\n* Pregnancy\n* Medication and \u002F or pathologies that prevent a safe execution of the fat tissue biopsies\n* History of or planned bariatric operation\n* Medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases)\n* Active Malignant tumor (\\\u003C2a remission)",true,"ALL","18 Years","60 Years",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","The main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. Therefore, the investigators want to understand:\n\n1. What distinguishes obese persons without metabolic diseases from those with medical diseases in a cross-sectional comparison?\n2. Which factors drive the conversions from metabolically healthy obesity into a metabolically unhealthy obesity in a longitudinal approach?",[24],"Healthy Obesity, Metabolically",[26,27],"Obesity","Healthy","RECRUITING","2025-05-26",{"date":31,"type":32},"2025-05-30","ACTUAL",{"date":34,"type":32},"2023-01-18",{"date":36,"type":20},"2026-01-18",{"name":38,"class":39},"ETH Zurich","OTHER",""]