[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemiarch-cardiac-procedure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemiarch-cardiac-procedure":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100591941",false,"NCT06986967","Retrograde Versus Antegrade Perfusion in Low-Moderate Hypothermia for Aortic Arch Surgery","ACP vs RCP","Inclusion Criteria:\n\n1. \\> 18 years of age\n2. Participant's that are scheduled for elective proximal aortic reconstructive surgery (ascending aorta + aortic valve or root) with concomitant proximal hemi-arch replacement via median sternotomy\n\nExclusion Criteria:\n\n1. \\\u003C 18 years of age\n2. history of symptomatic cerebrovascular disease, e.g., prior stroke with residual deficit\n3. current alcoholism (\\> 2 drinks\u002Fday)\n4. current psychiatric illness requiring pharmacotherapy\n5. current drug abuse (any illicit drug use in the past 3 months)\n6. hepatic insufficiency (liver function tests \\> 1.5 times the upper limit of normal)\n7. severe pulmonary insufficiency (requiring home oxygen therapy)\n8. renal failure (serum creatinine \\> 2.0 mg\u002FdL)\n9. claustrophobic fear\n10. unable to read and thus unable to complete the cognitive testing\n11. pregnant women\n12. patients who score \\\u003C19 om the Montreal Cognitive Assessment (MoCA) or ≥27 on the baseline Center for Epidemiological Studies Depression (CES-D) scale\n13. patients who have pre-existing unsafe implants for 3 Tesla magnetic resonance imaging (MRI)\n14. Patients who have received chemotherapy in the last 12 months or radiation to the brain","ALL","18 Years",{"count":18,"type":19},30,"ESTIMATED","INTERVENTIONAL",[22],"NA","The purpose of this study is to compare brain function after surgical circulatory arrest using either antegrade perfusion or retrograde perfusion.",[25,26],"Brain Function","Hemiarch Cardiac Procedure",[28,29,30,31],"Antegrade Perfusion","Retrograde Perfusion","Brain Perfusion","Circulatory Arrest","RECRUITING","2025-08-13",{"date":35,"type":36},"2025-08-15","ACTUAL",{"date":38,"type":36},"2025-04-18",{"date":40,"type":19},"2027-03",{"name":42,"class":43},"Duke University","OTHER",2,""]