[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"high-physical-activity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:high-physical-activity":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100576380",false,"NCT06784544","The Effects of Repeated Operational Stress and Limited Recovery on Resilience Capacity","REP DEF","Inclusion Criteria:\n\n* Men and women aged 18 - 39 years (17 - 39 years if military personnel)\n* Weight stable in the past 2 months (± approximately 5 kg)\n* Healthy without evidence of chronic illness or musculoskeletal injury as determined by the USARIEM Office of Medical Support and Oversight (OMSO) or home duty station medical support (HMS)\n* Functional exercise (i.e., step ups, box jumps, body mass movements) and\u002For aerobic exercise trained defined by self-report as performing ≥ 2 sessions\u002Fwk for previous 6 months\n* Willing to refrain from alcohol, smoking any nicotine product (includes e-cigarettes); vaping, chewing tobacco, caffeine not provided in the study, and dietary supplement use throughout the dietary interventions\n* Biological females must be on sustained (i.e., approximately \\>3 months) oral\u002Fhormonal contraceptive use which acts to maintain continuous hormonal levels (i.e., contains low-dose estrogen\u002Fprogesterone with no oral placebos, hormonal IUD)\n* Supervisor approval for federal civilian employees and non-HRV active duty military personnel)\n\nExclusion Criteria:\n\n* Musculoskeletal injuries that compromise exercise capability as determined by OMSO or HMS\n* Metabolic or cardiovascular abnormalities, sleep disorders (i.e., sleep apnea) gastrointestinal disorders (e.g., kidney disease, diabetes, cardiovascular disease, etc.) as determined by OMSO or HMS\n* Abnormal or problems with blood clotting as determined by OMSO or HMS\n* History of complications with lidocaine or similar local anesthetic analogue\n* Present condition of alcoholism, anabolic steroids, or other substance abuse issues\n* Blood donation within 8-wk of beginning or completing study blood draws\n* Current diagnosis of Anemia (hemoglobin \\\u003C 13 g\u002FdL for males, hemoglobin \\\u003C 12 g\u002FdL for females) and Sickle Cell Anemia\u002FTrait as determined by OMSO or HMS\n* Pregnant, trying to become pregnant, and\u002For breastfeeding (results of urine pregnancy test or self-report for breastfeeding will be obtained before body composition testing)\n* Claustrophobia or discomfort related to having enclosed equipment around the head\n* Unwillingness or inability to consume study diets or foods provided due to personal preference or food allergies\u002Fsensitivities\n* Unwillingness or inability to adhere to study exercise restrictions and prescriptions",true,"ALL","17 Years","39 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","This longitudinal study will examine the effects of repeated bouts of operational stress and limited recovery on integrated MPS, whole-body protein balance, iron absorption, and aerobic performance. Following baseline characterization measures, active adults (n=24) representative of normal weight phenotype (NW; n=12) and overweight phenotype (OW; n=12) will complete a 48h balance phase preceding two rounds of repeated 72h energy deficit exposure each immediately followed by a 48h recovery phase. NW cutoff will be defined ≤ 22% body fat for males and ≤ 32% body fat for females. OW cutoff will be defined as \\>22% body fat for males and \\>32% body fat for females. These body composition cutoffs are informed by the maximum allowable percent body fat standards outlined in current Army Regulation 600-9. Additional details for determining % body fat are outlined in the experimental procedures section of the protocol.",[27,28,29,30],"Sleep, Inadequate","Energy Deficit","Iron Absorption","High Physical Activity","NOT_YET_RECRUITING","2025-01-14",{"date":34,"type":35},"2025-01-20","ACTUAL",{"date":37,"type":21},"2025-05",{"date":39,"type":21},"2025-11",{"name":41,"class":42},"United States Army Research Institute of Environmental Medicine","FED",""]