[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hpv-1618\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hpv-1618":49},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100616487",false,"NCT07306247","Multicenter Prospective Non-randomized Controlled Study of ALA-PDT for LSIL With HPV16\u002F18 Infection","Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical Low-grade Squamous Intraepithelial Lesions With HPV16\u002F18 Infection","PDT for LSIL","Inclusion Criteria:\n\n1. Female, 20-60 years, understands study procedures and consents to participate;\n2. HPV 16 or 18 positive;\n3. Colposcopy-guided cervical biopsy within 3 months showing LSIL;\n4. Provides written informed consent.\n\nExclusion Criteria:\n\n1. Cytology showing ASC-H, HSIL, AGC, or AIS; or evidence of malignant cells on cytology\u002Fhistology, or suspicion of malignancy or invasive cancer;\n2. Colposcopy findings suggestive of invasive cancer or lesion extension to the vaginal wall;\n3. Severe pelvic, cervical, or other gynecological inflammatory conditions identified clinically;\n4. Undiagnosed vaginal bleeding;\n5. Active allergic disease, porphyria, or history of allergy to the study drug or structurally similar agents;\n6. Severe cardiovascular, neurological, psychiatric, endocrine, hepatic, or hematologic disorders; known immunodeficiency; long-term glucocorticoid or immunosuppressant use; active autoimmune disease; or other malignancies;\n7. Pregnant or breastfeeding women;\n8. History of hysterectomy, cervical cancer treatment, or cervical excision\u002Fablation within 6 months (e.g., conization, LEEP, laser);\n9. Use of interferon or antiviral therapy within 3 months;\n10. Any other condition deemed unsuitable for participation by the investigator.",true,"FEMALE","20 Years","60 Years",{"count":21,"type":22},225,"ESTIMATED","INTERVENTIONAL",[25],"NA","This multicenter, prospective trial assesses ALA-PDT versus observation for efficacy and safety in treating cervical LSIL with HPV16\u002F18 infection.",[28,29,30],"HPV-16\u002F18","Photodynamic Therapy (PDT)","LSIL, Low Grade Squamous Intraepithelial Lesion",[32,33,34,35],"cervical low-grade squamous intraepithelial lesions","aminolevulinic acid-mediated photodynamic therapy","efficacy","human papillomavirus","NOT_YET_RECRUITING","2025-12-14",{"date":39,"type":40},"2025-12-29","ACTUAL",{"date":42,"type":22},"2026-01",{"date":44,"type":22},"2027-12",{"name":46,"class":47},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",5,""]