[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypertension-resistant\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypertension-resistant":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100568079",false,"NCT06676553","INtraprocedural Feedback-Optimized Renal Denervation Based on Measurements Obtained Through Renal Artery Stimulation: a Randomized Controlled Trial (INFORM)","INtraprocedural Feedback-Optimized Renal Denervation Based on Measurements Obtained Through Renal Artery Stimulation: a Randomized Controlled Proof-of-concept Trial to Assess Whether Renal Denervation Guided by Renal Artery Stimulation Outperforms Conventional Renal Denervation in 6-month Ambulatory Blood Pressure Reductions","INFORM","Inclusion Criteria:\n\n* Patients with hypertension and are willing to undergo renal denervation.\n* Patients are treated with antihypertensive medications, or with an office systolic blood pressure (SBP) \\>140 mm Hg or diastolic blood pressure (DBP) \\>90 mm Hg, and 24-hour SBP of \\>130 mmHg or DBP \\>80 mm Hg, irrespective of antihypertensive treatment.\n\nExclusion Criteria:\n\n* An unsuitable renal artery anatomy for renal denervation, assessed by computed tomographic angiography (main renal artery lumen diameter \\\u003C3 mm or a total length \\\u003C20 mm).\n* Secondary hypertension, including hyperaldosteronism, pheochromocytoma, and renal artery stenosis (\\>50% stenosis in one or both arteries).","ALL","18 Years",{"count":19,"type":20},32,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Our previous study (Huang HC, Pan HY, Wang TD, Circ Cardiovasc Interv 2023;16:e012779) demonstrated that when renal artery stimulation continues to trigger systolic blood pressure increases (\\>=20 mmHg increase compared to baseline) after the initial procedure, patients show poor blood pressure reduction 6 months following renal denervation. Based on this finding, we designed a proof-of-concept trial comparing two approaches: a guided strategy versus conventional renal denervation. In the guided strategy, we perform additional ablations of main and\u002For branch renal arteries if immediate post-procedure stimulation still elevates systolic blood pressure (\\>=20 mmHg increase compared to baseline). The conventional approach involves no repeat procedures. This trial aims to determine whether the guided strategy leads to better clinical outcomes, measured by 6-month ambulatory blood pressure changes, and to establish the value of using intraprocedural feedback to assess and guide renal denervation treatment.",[26,27,28],"Hypertension, Uncontrolled","Hypertension, Resistant","Hypertension",[28,30,31,32,33],"Renal denervation","Electric stimulation","Renal artery","Radiofrequency ablation","RECRUITING","2024-11-04",{"date":37,"type":38},"2024-11-06","ACTUAL",{"date":40,"type":38},"2024-10-14",{"date":42,"type":20},"2028-06-30",{"name":44,"class":45},"National Taiwan University Hospital","OTHER",""]